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Transcription factor Jun

Transcription factor Jun, also known as c-Jun, is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with protein c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the JUN gene. c-jun was the first oncogenic transcription…

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39 related topics

Function

19 related topics

Clinical significance

15 related topics

As anti-cancer drug target

1 related topics

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Aliases
JUN, AP-1, AP1, c-Jun, Jun proto-oncogene, AP-1 transcription factor subunit, p39, cJUN
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A02, 1JNM, 1JUN, 1S9K, 1T2K, 1FOS
Band
1p32.1 · 4 C5|4 43.34 cM
Bgee
vena cava · gastric mucosa · cardia · lactiferous duct · saphenous vein
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 4 (mouse)

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Overview

Function

Clinical significance

As anti-cancer drug target

Anti-cancer property of c-jun

Interactions

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Transcription factor Jun

Nodes91
Edges90
Triples160
Avg. degree1.98
Density0.021978
Components1

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Transcription factor Jun

Top relations

Gene ontology · 95
Transcription factor Jun → ageing, angiogenesis, axon regeneration, cAMP response element binding, cellular process or phenomenon, cellular response to cadmium ion, cellular response to calcium ion, cellular response to hormone stimulus, cellular response to potassium ion starvation, cellular response to reactive oxygen species, chromatin binding, circadian rhythm, cytosol, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, double-stranded DNA binding, enzyme binding, eyelid development in camera-type eye
Bgee · 20
Transcription factor Jun → aortic valve, cardia, decidua, dermis, endothelial cell, gastric mucosa, granulocyte, lactiferous duct, left lung lobe, medial head of gastrocnemius muscle, parotid gland, pericardium, pylorus, right lung, right lung lobe, saphenous vein, seminal vesicula, temporal muscle, vena cava, ventricular zone
RNA expression pattern · 20
Transcription factor Jun → aortic valve, cardia, decidua, dermis, endothelial cell, gastric mucosa, granulocyte, lactiferous duct, left lung lobe, medial head of gastrocnemius muscle, parotid gland, pericardium, pylorus, right lung, right lung lobe, saphenous vein, seminal vesicula, temporal muscle, vena cava, ventricular zone
Band · 2
Transcription factor Jun → 1p32.1, 4 C5|4 43.34 cM
Chr. · 2
Transcription factor Jun → Chromosome 1 (human), Chromosome 4 (mouse)
End · 2
Transcription factor Jun → 58,784,048 bp, 94,940,459 bp
Aliases · 1
Transcription factor Jun → JUN, AP-1, AP1, c-Jun, Jun proto-oncogene, AP-1 transcription factor subunit, p39, cJUN
Available structures · 1
Transcription factor Jun → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A02, 1JNM, 1JUN, 1S9K, 1T2K, 1FOS
BioGPS · 1
Transcription factor Jun → More reference expression data
Databases · 1
Transcription factor Jun → NCBI: entry; OMA: entry

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Important terminology

c-jun jun gene cell protein transcription tumor cells cancer human study apoptosis cycle phosphorylation also expression activity factor ap-1 cellular

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Transcription factor JunAliasesJUN, AP-1, AP1, c-Jun, Jun proto-oncogene, AP-1 transcription factor subunit, p39, cJUN1.00infobox
Transcription factor JunAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A02, 1JNM, 1JUN, 1S9K, 1T2K, 1FOS1.00infobox
Transcription factor JunBand1p32.11.00infobox
Transcription factor JunBand4 C5|4 43.34 cM1.00infobox
Transcription factor JunBgeevena cava1.00infobox
Transcription factor JunBgeegastric mucosa1.00infobox
Transcription factor JunBgeecardia1.00infobox
Transcription factor JunBgeelactiferous duct1.00infobox
Transcription factor JunBgeesaphenous vein1.00infobox
Transcription factor JunBgeeseminal vesicula1.00infobox
Transcription factor JunBgeepericardium1.00infobox
Transcription factor JunBgeeparotid gland1.00infobox
Transcription factor JunBgeeendothelial cell1.00infobox
Transcription factor JunBgeepylorus1.00infobox
Transcription factor JunBgeegranulocyte1.00infobox
Transcription factor JunBgeeleft lung lobe1.00infobox
Transcription factor JunBgeedermis1.00infobox
Transcription factor JunBgeeright lung1.00infobox
Transcription factor JunBgeedecidua1.00infobox
Transcription factor JunBgeemedial head of gastrocnemius muscle1.00infobox
Transcription factor JunBgeeright lung lobe1.00infobox
Transcription factor JunBgeeventricular zone1.00infobox
Transcription factor JunBgeetemporal muscle1.00infobox
Transcription factor JunBgeeaortic valve1.00infobox
Transcription factor JunBioGPSMore reference expression data1.00infobox
Transcription factor JunChr.Chromosome 1 (human)1.00infobox
Transcription factor JunChr.Chromosome 4 (mouse)1.00infobox
Transcription factor JunDatabasesNCBI: entry; OMA: entry1.00infobox
Transcription factor JunEnd58,784,048 bp1.00infobox
Transcription factor JunEnd94,940,459 bp1.00infobox

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