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GATA4: Interactions, Function & Clinical relevance

Transcription factor GATA-4 is a protein that in humans is encoded by the GATA4 gene.

Language: English [EN]
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GATA4 topic overview

The analysis highlights Interactions, Function and Clinical relevance as prominent areas in the source structure around GATA4.

Related topics
13
Source areas
4
Connected nodes
17
Extracted relationships
171
Concept neighborhoods
9
Bridge connections
17

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 6 topics
Function · 4 topics
Overview · 2 topics
Clinical relevance · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
GATA4, GATA binding protein 4, ASD2, TACHD, VSD1, TOF
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2M9W
Band
8p23.1 · 14 D1|14 33.24 cM
Bgee
right auricle of heart · left ventricle · duodenum · apex of heart · left ovary
BioGPS
More reference expression data
Chr.
Chromosome 8 (human) · Chromosome 14 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Interactions

Clinical relevance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How GATA4 connects Entity context

The extracted context around GATA4 shows recurring relationship patterns in the source. For example, GATA4 → anatomical structure formation involved in morphogenesis, animal organ morphogenesis, aortic valve morphogenesis, atrial septum morphogenesis, atrial septum primum morphogenesis, atrial septum secundum morphogenesis, atrioventricular valve formation, blood coagulation, cardiac muscle cell differentiation, cardiac muscle tissue development, cardiac muscle tissue regeneration, cardiac right ventricle morphogenesis, cardiac ventricle morphogenesis, cell development, cell growth involved in cardiac muscle cell development, cell-cell signaling, cellular response to glucose stimulus, chromatin binding, cis-regulatory region sequence-specific DNA binding, co-SMAD binding Another extracted example is GATA4 → apex of heart, body of pancreas, duodenum, epithelium of stomach, germinal epithelium, Gonadal ridge, granulosa cell of ovary, left coronary artery, left ovary, left ventricle, Leydig cell, mucous cell of stomach, pyloric antrum, right auricle of heart, right coronary artery, right ovary, right testis, theca folliculi, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.

GATA4

Top relations

Gene ontology · 68
GATA4 → anatomical structure formation involved in morphogenesis, animal organ morphogenesis, aortic valve morphogenesis, atrial septum morphogenesis, atrial septum primum morphogenesis, atrial septum secundum morphogenesis, atrioventricular valve formation, blood coagulation, cardiac muscle cell differentiation, cardiac muscle tissue development, cardiac muscle tissue regeneration, cardiac right ventricle morphogenesis, cardiac ventricle morphogenesis, cell development, cell growth involved in cardiac muscle cell development, cell-cell signaling, cellular response to glucose stimulus, chromatin binding, cis-regulatory region sequence-specific DNA binding, co-SMAD binding
Bgee · 19
GATA4 → apex of heart, body of pancreas, duodenum, epithelium of stomach, germinal epithelium, Gonadal ridge, granulosa cell of ovary, left coronary artery, left ovary, left ventricle, Leydig cell, mucous cell of stomach, pyloric antrum, right auricle of heart, right coronary artery, right ovary, right testis, theca folliculi, yolk sac
RNA expression pattern · 19
GATA4 → apex of heart, body of pancreas, duodenum, epithelium of stomach, germinal epithelium, Gonadal ridge, granulosa cell of ovary, left coronary artery, left ovary, left ventricle, Leydig cell, mucous cell of stomach, pyloric antrum, right auricle of heart, right coronary artery, right ovary, right testis, theca folliculi, yolk sac
related to External links · 13
GATA4 → GATA-4, Medicine, Medicine Medical Subject Headings, MeSH, National Library, Overview, P43694, PDB, PDBe-KB, This, Transcription, UniProt, United States National Library
related to Atrioventricular valve formation · 9
GATA4 → AV, E12, EMT, Endocardial, Erbb3, Erk, GATA4-null, Their, This
related to Interactions · 8
GATA4 → Erbb3, FOG-1, FOG-2, HAND2, HDAC2, NKX2-5, Serum, TBX5
related to Function · 7
GATA4 → As, GATA, Members, Mutations, Nkx2-5, Tbx5, This
related to Clinical relevance · 4
GATA4 → Atrial, Fallot, Mutations, South Indian
Band · 2
GATA4 → 14 D1|14 33.24 cM, 8p23.1
Chr. · 2
GATA4 → Chromosome 14 (mouse), Chromosome 8 (human)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene cardiac transcription factor human bp development chr protein band function also heart formation chromosome ventricular mutations defects gata location

GATA4 relationships Subject–Predicate–Object triples

TTTA extracted 171 structured relationships around GATA4. Examples in this analysis include GATA4 → Aliases → GATA4, GATA binding protein 4, ASD2, TACHD, VSD1, TOF and GATA4 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2M9W. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
GATA4AliasesGATA4, GATA binding protein 4, ASD2, TACHD, VSD1, TOF1.00infobox
GATA4Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2M9W1.00infobox
GATA4Band8p23.11.00infobox
GATA4Band14 D1|14 33.24 cM1.00infobox
GATA4Bgeeright auricle of heart1.00infobox
GATA4Bgeeleft ventricle1.00infobox
GATA4Bgeeduodenum1.00infobox
GATA4Bgeeapex of heart1.00infobox
GATA4Bgeeleft ovary1.00infobox
GATA4Bgeeright coronary artery1.00infobox
GATA4Bgeeright ovary1.00infobox
GATA4Bgeebody of pancreas1.00infobox
GATA4Bgeeleft coronary artery1.00infobox
GATA4Bgeeright testis1.00infobox
GATA4Bgeeepithelium of stomach1.00infobox
GATA4Bgeegerminal epithelium1.00infobox
GATA4Bgeepyloric antrum1.00infobox
GATA4Bgeegranulosa cell of ovary1.00infobox
GATA4Bgeemucous cell of stomach1.00infobox
GATA4BgeeGonadal ridge1.00infobox
GATA4BgeeLeydig cell1.00infobox
GATA4Bgeetheca folliculi1.00infobox
GATA4Bgeeyolk sac1.00infobox
GATA4BioGPSMore reference expression data1.00infobox
GATA4Chr.Chromosome 8 (human)1.00infobox
GATA4Chr.Chromosome 14 (mouse)1.00infobox
GATA4DatabasesNCBI: entry; OMA: entry1.00infobox
GATA4End11,760,002 bp1.00infobox
GATA4End63,509,141 bp1.00infobox
GATA4EnsemblENSG00000136574 ENSG000002851091.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around GATA4 bring nearby vocabulary together. In this analysis, examples include Cardiac, Transcription and Also. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • GATA4
    • Cardiac
    • Transcription
    • Also
    • Development
    • Formation
    • Ventricular
    • Function
    • Heart
    • Essential
    • Defects
    • Protein
    • Human
  • gata4
    • Cardiac
    • Transcription
    • Also
    • Development
    • Formation
    • Ventricular
    • Function
    • Heart
    • Essential
    • Defects
    • Protein
    • Human
  • protein
    • Gata
    • Valve
    • Function
    • Human
    • Atrioventricular
    • Gene
    • Location
    • Transcription
    • Chromosome
    • Bp
    • Chr
    • Formation
  • gene
    • Location
    • Chromosome
    • Bp
    • Chr
    • Mutations
    • Protein
    • Human
    • Mouse
    • Valve
    • Associated
    • Atrioventricular
    • Congenital
  • cardiac septal defects
    • Mutations
    • Septal
    • Development
    • Essential
    • Gata4
    • Congenital
    • Function
    • Heart
    • Important
    • Lead
    • Embryo
    • Survival
  • serum response factor
    • Transcription
    • Gata4
    • Protein
    • Human
    • P43694
    • Uniprot
    • Av
    • Gata
    • Formation
    • Ventricular
    • Heart
    • Development
  • function
    • Formation
    • Protein
    • Cardiac
    • Valve
    • Development
    • Expression
    • Location
    • Chromosome
    • Gata
    • Bp
    • Chr
    • Gata4
  • gata family
    • Protein
    • Valve
    • Human
    • Location
    • Gene
    • Mouse
    • P43694
    • Pdb
    • Transcription
    • Uniprot
    • Expression
    • Genes

Connections between topic areas Semantic bridges

For GATA4, one of the stronger structural bridges in this analysis connects GATA4 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
GATA4Interactions · splits 11 ⟂ 7
GATA4Function · splits 13 ⟂ 5
GATA4Overview · splits 15 ⟂ 3

Map overview Semantic statistics

GATA4

Nodes18
Edges17
Triples171
Avg. degree1.89
Density0.111111
Components1

Source & methodology

TTTA analyzes the structure around GATA4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Function & Clinical relevance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — GATA4 · EN edition · Analysis: TopicsToTalkAbout

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