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KLF1: Structure, Function & Clinical significance

Krueppel-like factor 1 is a protein that in humans is encoded by the KLF1 gene. The gene for KLF1 is on the human chromosome 19 and on mouse chromosome 8. Krueppel-like factor 1 is a transcription factor that is necessary for the proper maturation of erythroid (red blood) cells.

Language: English [EN]
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KLF1 topic overview

The analysis highlights Structure, Function and Clinical significance as prominent areas in the source structure around KLF1.

Related topics
11
Source areas
4
Connected nodes
15
Extracted relationships
120
Concept neighborhoods
8
Bridge connections
15

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 4 topics
Function · 3 topics
Structure · 3 topics
Clinical significance · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
KLF1, CDAN4, EKLF, HBFQTL6, INLU, Kruppel-like factor 1 (erythroid), Kruppel like factor 1, EKLF/KLF1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2L2I, 2MBH, 2N23
Band
19p13.13 · 8 41.3 cM|8 C3
Bgee
trabecular bone · bone marrow · blood · bone marrow cell · monocyte
BioGPS
n/a
Chr.
Chromosome 19 (human) · Chromosome 8 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How KLF1 connects Entity context

The extracted context around KLF1 shows recurring relationship patterns in the source. For example, KLF1 → Additional, Antigens, AnWj, Aquaporin1, Basal, CD147, CD44, CDA, Colton, Diego, Duffy, Embryonic, EMMPRIN, ERMAP, Fy, HbF, HBFQTL6, HPFH KLF1-related, In, Indian Another extracted example is KLF1 → cellular response to peptide, cis-regulatory region sequence-specific DNA binding, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, erythrocyte differentiation, maternal process involved in female pregnancy, metal ion binding, nucleic acid binding, nucleoplasm, nucleus, positive regulation of transcription by RNA polymerase II, positive regulation of transcription, DNA-templated, protein binding, regulation of transcription by RNA polymerase II, regulation of transcription, DNA-templated, RNA polymerase II cis-regulatory region sequence-specific DNA binding, transcription, DNA-templated. Use these groups to spot repeated connection types before inspecting the individual relationships.

KLF1

Top relations

related to Clinical significance · 40
KLF1 → Additional, Antigens, AnWj, Aquaporin1, Basal, CD147, CD44, CDA, Colton, Diego, Duffy, Embryonic, EMMPRIN, ERMAP, Fy, HbF, HBFQTL6, HPFH KLF1-related, In, Indian
Gene ontology · 19
KLF1 → cellular response to peptide, cis-regulatory region sequence-specific DNA binding, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, erythrocyte differentiation, maternal process involved in female pregnancy, metal ion binding, nucleic acid binding, nucleoplasm, nucleus, positive regulation of transcription by RNA polymerase II, positive regulation of transcription, DNA-templated, protein binding, regulation of transcription by RNA polymerase II, regulation of transcription, DNA-templated, RNA polymerase II cis-regulatory region sequence-specific DNA binding, transcription, DNA-templated
Bgee · 18
KLF1 → abdominal wall, blood, body of femur, bone marrow, bone marrow cell, embryo, female urethra, fetal liver hematopoietic progenitor cell, gonad, granulocyte, human fetus, monocyte, spleen, tibialis anterior muscle, tibiofemoral joint, trabecular bone, urethra, ventricular zone
RNA expression pattern · 18
KLF1 → abdominal wall, blood, body of femur, bone marrow, bone marrow cell, embryo, female urethra, fetal liver hematopoietic progenitor cell, gonad, granulocyte, human fetus, monocyte, spleen, tibialis anterior muscle, tibiofemoral joint, trabecular bone, urethra, ventricular zone
Band · 2
KLF1 → 19p13.13, 8 41.3 cM|8 C3
Chr. · 2
KLF1 → Chromosome 19 (human), Chromosome 8 (mouse)
End · 2
KLF1 → 12,887,201 bp, 85,631,924 bp
related to Function · 2
KLF1 → Over-expression, Studies
Aliases · 1
KLF1 → KLF1, CDAN4, EKLF, HBFQTL6, INLU, Kruppel-like factor 1 (erythroid), Kruppel like factor 1, EKLF/KLF1
Available structures · 1
KLF1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2L2I, 2MBH, 2N23

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene human bp band factor chromosome 19 chr mouse transcription blood function mutations krueppel-like erythroid location humans protein expression cell

KLF1 relationships Subject–Predicate–Object triples

TTTA extracted 120 structured relationships around KLF1. Examples in this analysis include KLF1 → Aliases → KLF1, CDAN4, EKLF, HBFQTL6, INLU, Kruppel-like factor 1 (erythroid), Kruppel like factor 1, EKLF/KLF1 and KLF1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2L2I, 2MBH, 2N23. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
KLF1AliasesKLF1, CDAN4, EKLF, HBFQTL6, INLU, Kruppel-like factor 1 (erythroid), Kruppel like factor 1, EKLF/KLF11.00infobox
KLF1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2L2I, 2MBH, 2N231.00infobox
KLF1Band19p13.131.00infobox
KLF1Band8 41.3 cM|8 C31.00infobox
KLF1Bgeetrabecular bone1.00infobox
KLF1Bgeebone marrow1.00infobox
KLF1Bgeeblood1.00infobox
KLF1Bgeebone marrow cell1.00infobox
KLF1Bgeemonocyte1.00infobox
KLF1Bgeetibialis anterior muscle1.00infobox
KLF1Bgeegranulocyte1.00infobox
KLF1Bgeeventricular zone1.00infobox
KLF1Bgeegonad1.00infobox
KLF1Bgeespleen1.00infobox
KLF1Bgeefetal liver hematopoietic progenitor cell1.00infobox
KLF1Bgeetibiofemoral joint1.00infobox
KLF1Bgeehuman fetus1.00infobox
KLF1Bgeeembryo1.00infobox
KLF1Bgeebody of femur1.00infobox
KLF1Bgeeabdominal wall1.00infobox
KLF1Bgeeurethra1.00infobox
KLF1Bgeefemale urethra1.00infobox
KLF1BioGPSn/a1.00infobox
KLF1Chr.Chromosome 19 (human)1.00infobox
KLF1Chr.Chromosome 8 (mouse)1.00infobox
KLF1DatabasesNCBI: entry; OMA: entry1.00infobox
KLF1End12,887,201 bp1.00infobox
KLF1End85,631,924 bp1.00infobox
KLF1EnsemblENSG000001056101.00infobox
KLF1Entrez106611.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around KLF1 bring nearby vocabulary together. In this analysis, examples include Gene, Human and Function. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • KLF1
    • Gene
    • Human
    • Function
    • Mutations
    • Cell
    • Expression
    • Mice
    • Rbc
    • Β-globin
    • Blood
    • Mouse
    • Transcription
  • klf1
    • Gene
    • Human
    • Function
    • Mutations
    • Cell
    • Expression
    • Mice
    • Rbc
    • Β-globin
    • Blood
    • Mouse
    • Transcription
  • gene
    • Chromosome
    • Location
    • Klf1
    • Human
    • Mouse
    • Bp
    • Chr
    • Cm
    • End
    • Protein
    • Search
    • Cell
  • transcription factor
    • Krueppel-like
    • Available
    • Pdb
    • Protein
    • Q13351
    • Search
    • Uniprot
    • Β-globin
    • Erythroid
    • Location
    • Gene
    • Blood
  • function
    • Search
    • Cell
    • Expression
    • Location
    • Band
    • Bp
    • Chr
    • Human
    • Klf1
    • Available
    • Cm
    • End
  • erythroid
    • Transcription
    • External
    • Factor
    • Available
    • Clinical
    • Hbfqtl6
    • Pdb
    • Search
    • Gene
    • Cell
    • Krueppel-like
    • Location
  • clinical significance
    • Hbfqtl6
    • External
    • Available
    • Pdb
    • Search
    • Erythroid
    • Location
    • Function
    • Bp
    • Chr
    • Factor
    • Human
  • protein
    • Q13351
    • Search
    • Uniprot
    • Transcription

Connections between topic areas Semantic bridges

For KLF1, one of the stronger structural bridges in this analysis connects KLF1 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
KLF1Overview · splits 11 ⟂ 5
KLF1Structure · splits 12 ⟂ 4
KLF1Function · splits 12 ⟂ 4

Map overview Semantic statistics

KLF1

Nodes16
Edges15
Triples120
Avg. degree1.88
Density0.125
Components1

Source & methodology

TTTA analyzes the structure around KLF1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure, Function & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — KLF1 · EN edition · Analysis: TopicsToTalkAbout

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