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KLF1

Krueppel-like factor 1 is a protein that in humans is encoded by the KLF1 gene. The gene for KLF1 is on the human chromosome 19 and on mouse chromosome 8. Krueppel-like factor 1 is a transcription factor that is necessary for the proper maturation of erythroid (red blood) cells.

Structure, Function & Clinical significance

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Structure

3 related topics

Function

3 related topics

Clinical significance

1 related topics

Overview

4 related topics

Key facts & relationships

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Aliases
KLF1, CDAN4, EKLF, HBFQTL6, INLU, Kruppel-like factor 1 (erythroid), Kruppel like factor 1, EKLF/KLF1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2L2I, 2MBH, 2N23
Band
19p13.13 · 8 41.3 cM|8 C3
Bgee
trabecular bone · bone marrow · blood · bone marrow cell · monocyte
BioGPS
n/a
Chr.
Chromosome 19 (human) · Chromosome 8 (mouse)

Topics to explore

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Overview

Structure

Function

Clinical significance

Advanced semantic analysis

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Map overview Semantic statistics

KLF1

Nodes16
Edges15
Triples120
Avg. degree1.88
Density0.125
Components1

How this topic connects Entity context

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KLF1

Top relations

related to Clinical significance · 40
KLF1 → Additional, Antigens, AnWj, Aquaporin1, Basal, CD147, CD44, CDA, Colton, Diego, Duffy, Embryonic, EMMPRIN, ERMAP, Fy, HbF, HBFQTL6, HPFH KLF1-related, In, Indian
Gene ontology · 19
KLF1 → cellular response to peptide, cis-regulatory region sequence-specific DNA binding, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, erythrocyte differentiation, maternal process involved in female pregnancy, metal ion binding, nucleic acid binding, nucleoplasm, nucleus, positive regulation of transcription by RNA polymerase II, positive regulation of transcription, DNA-templated, protein binding, regulation of transcription by RNA polymerase II, regulation of transcription, DNA-templated, RNA polymerase II cis-regulatory region sequence-specific DNA binding, transcription, DNA-templated
Bgee · 18
KLF1 → abdominal wall, blood, body of femur, bone marrow, bone marrow cell, embryo, female urethra, fetal liver hematopoietic progenitor cell, gonad, granulocyte, human fetus, monocyte, spleen, tibialis anterior muscle, tibiofemoral joint, trabecular bone, urethra, ventricular zone
RNA expression pattern · 18
KLF1 → abdominal wall, blood, body of femur, bone marrow, bone marrow cell, embryo, female urethra, fetal liver hematopoietic progenitor cell, gonad, granulocyte, human fetus, monocyte, spleen, tibialis anterior muscle, tibiofemoral joint, trabecular bone, urethra, ventricular zone
Band · 2
KLF1 → 19p13.13, 8 41.3 cM|8 C3
Chr. · 2
KLF1 → Chromosome 19 (human), Chromosome 8 (mouse)
End · 2
KLF1 → 12,887,201 bp, 85,631,924 bp
related to Function · 2
KLF1 → Over-expression, Studies
Aliases · 1
KLF1 → KLF1, CDAN4, EKLF, HBFQTL6, INLU, Kruppel-like factor 1 (erythroid), Kruppel like factor 1, EKLF/KLF1
Available structures · 1
KLF1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2L2I, 2MBH, 2N23

Important terminology Word statistics

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Important terminology

gene human bp band factor chromosome 19 chr mouse transcription blood function mutations krueppel-like erythroid location humans protein expression cell

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
KLF1AliasesKLF1, CDAN4, EKLF, HBFQTL6, INLU, Kruppel-like factor 1 (erythroid), Kruppel like factor 1, EKLF/KLF11.00infobox
KLF1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2L2I, 2MBH, 2N231.00infobox
KLF1Band19p13.131.00infobox
KLF1Band8 41.3 cM|8 C31.00infobox
KLF1Bgeetrabecular bone1.00infobox
KLF1Bgeebone marrow1.00infobox
KLF1Bgeeblood1.00infobox
KLF1Bgeebone marrow cell1.00infobox
KLF1Bgeemonocyte1.00infobox
KLF1Bgeetibialis anterior muscle1.00infobox
KLF1Bgeegranulocyte1.00infobox
KLF1Bgeeventricular zone1.00infobox
KLF1Bgeegonad1.00infobox
KLF1Bgeespleen1.00infobox
KLF1Bgeefetal liver hematopoietic progenitor cell1.00infobox
KLF1Bgeetibiofemoral joint1.00infobox
KLF1Bgeehuman fetus1.00infobox
KLF1Bgeeembryo1.00infobox
KLF1Bgeebody of femur1.00infobox
KLF1Bgeeabdominal wall1.00infobox
KLF1Bgeeurethra1.00infobox
KLF1Bgeefemale urethra1.00infobox
KLF1BioGPSn/a1.00infobox
KLF1Chr.Chromosome 19 (human)1.00infobox
KLF1Chr.Chromosome 8 (mouse)1.00infobox
KLF1DatabasesNCBI: entry; OMA: entry1.00infobox
KLF1End12,887,201 bp1.00infobox
KLF1End85,631,924 bp1.00infobox
KLF1EnsemblENSG000001056101.00infobox
KLF1Entrez106611.00infobox

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