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GRB2

Growth factor receptor-bound protein 2, also known as Grb2, is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2 protein is encoded by the GRB2 gene.

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Aliases
GRB2, ASH, EGFRBP-Grb3-3, MST084, MSTP084, NCKAP2, growth factor receptor bound protein 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1AZE, 1BM2, 1BMB, 1CJ1, 1FHS, 1FYR, 1GCQ, 1GFC, 1GFD, 1GHU, 1GRI, 1IO6, 1JYQ, 1JYR, 1JYU, 1QG1, 1TZE, 1X0N,…
Band
17q25.1 · 11 E2|11 80.91 cM
Bgee
monocyte · blood · superficial temporal artery · granulocyte · lymph node
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)

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Map overview Semantic statistics

GRB2

Nodes105
Edges104
Triples238
Avg. degree1.98
Density0.019048
Components1

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GRB2

Top relations

Gene ontology · 73
GRB2 → 1-phosphatidylinositol-3-kinase activity, ageing, anatomical structure formation involved in morphogenesis, axon guidance, branching involved in labyrinthine layer morphogenesis, cell differentiation, cell migration, cell-cell junction, cell-cell signaling, cellular response to ionizing radiation, COP9 signalosome, cytokine-mediated signaling pathway, cytoplasm, cytosol, endosome, entry of bacterium into host cell, enzyme binding, ephrin receptor binding, epidermal growth factor receptor binding, epidermal growth factor receptor signaling pathway
related to Interactions · 73
GRB2 → A2, Abl, ADAM15, Aldrich, Arachidonate, B-cell, BCAR1, BCR, Beta-2, C-Met, Cbl, CBLB, CD117, CD22, CD28, CDKN1B, Colony, CRK, DCTN1, DNM1
Bgee · 18
GRB2 → blood, cerebellar cortex, dentate gyrus of hippocampal formation granule cell, epithelium of nasopharynx, ganglionic eminence, granulocyte, lip, lower lobe of lung, lymph node, monocyte, muscle of thigh, neural layer of retina, primary visual cortex, spleen, superficial temporal artery, superior frontal gyrus, tonsil, ventricular zone
RNA expression pattern · 18
GRB2 → blood, cerebellar cortex, dentate gyrus of hippocampal formation granule cell, epithelium of nasopharynx, ganglionic eminence, granulocyte, lip, lower lobe of lung, lymph node, monocyte, muscle of thigh, neural layer of retina, primary visual cortex, spleen, superficial temporal artery, superior frontal gyrus, tonsil, ventricular zone
related to External links · 16
GRB2 → Adaptor, Cell Migration Gateway Archived, December, Grb2 Archived August, GRB2 Info, Grb2Human Protein Resource Database, Information Hyperlinked, Medicine Medical Subject Headings, MeSH, National Library, Protein, Proteins, The Grb2, The SH2 WebsiteGeneCards, Wayback Machine, Wayback MachineGrb2
related to Function and expression · 8
GRB2 → ERK1, Gads, Grap, Inhibition, It, Ras, SH2, SH3
related to Domains · 5
GRB2 → Ras-guanine, SOS, The N-terminal SH3, The SH2, X-N-X
Band · 2
GRB2 → 11 E2|11 80.91 cM, 17q25.1
Chr. · 2
GRB2 → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
GRB2 → 115,599,423 bp, 75,405,709 bp

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Important terminology

gene protein domain factor growth bp sh3 human chr band binds receptor sh2 two signal transduction proteins chromosome 17 tyrosine

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
GRB2AliasesGRB2, ASH, EGFRBP-Grb3-3, MST084, MSTP084, NCKAP2, growth factor receptor bound protein 21.00infobox
GRB2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1AZE, 1BM2, 1BMB, 1CJ1, 1FHS, 1FYR, 1GCQ, 1GFC, 1GFD, 1GHU, 1GRI, 1IO6, 1JYQ, 1JYR, 1JYU, 1QG1, 1TZE, 1X0N,…1.00infobox
GRB2Band17q25.11.00infobox
GRB2Band11 E2|11 80.91 cM1.00infobox
GRB2Bgeemonocyte1.00infobox
GRB2Bgeeblood1.00infobox
GRB2Bgeesuperficial temporal artery1.00infobox
GRB2Bgeegranulocyte1.00infobox
GRB2Bgeelymph node1.00infobox
GRB2Bgeelower lobe of lung1.00infobox
GRB2Bgeeepithelium of nasopharynx1.00infobox
GRB2Bgeeganglionic eminence1.00infobox
GRB2Bgeespleen1.00infobox
GRB2Bgeetonsil1.00infobox
GRB2Bgeesuperior frontal gyrus1.00infobox
GRB2Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
GRB2Bgeeprimary visual cortex1.00infobox
GRB2Bgeecerebellar cortex1.00infobox
GRB2Bgeeventricular zone1.00infobox
GRB2Bgeemuscle of thigh1.00infobox
GRB2Bgeelip1.00infobox
GRB2Bgeeneural layer of retina1.00infobox
GRB2BioGPSMore reference expression data1.00infobox
GRB2Chr.Chromosome 17 (human)1.00infobox
GRB2Chr.Chromosome 11 (mouse)1.00infobox
GRB2DatabasesNCBI: entry; OMA: entry1.00infobox
GRB2End75,405,709 bp1.00infobox
GRB2End115,599,423 bp1.00infobox
GRB2EnsemblENSG000001778851.00infobox
GRB2Entrez28851.00infobox

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