MAP3K1

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Explore the main themes, entities and connections around MAP3K1. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Function

Kinase Ubiquitin ligase Enzymes TNF receptor superfamily T-cell receptor

23 related topics

Interaction partners

Interact AXIN1 C-Raf MAPK1 Grb2

18 related topics

Mechanism of MAPK activation by MAP3K1

Amino acid Phosphorylated Syngenic MAPK Cell signaling

9 related topics

Cancers, other diseases and therapeutic targeting

Biomarker Adenocarcinoma Prostate Hepatocellular carcinoma Acute respiratory distress syndrome

9 related topics

Key facts & relationships

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2.3.2.27: ↗
2.7.11.25: ↗
Aliases: MAP3K1, MAPKKK1, MEKK, MEKK 1, MEKK1, SRXY6, mitogen-activated protein kinase kinase kinase 1
Band: 5q11.2 · 13 D2.2|13 63.36 cM
Bgee: buccal mucosa cell · skin of thigh · skin of hip · parotid gland · corpus epididymis
BioGPS: More reference expression data

Topics to explore

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Overview

Structure

Protein kinase domain
PHD finger
RING finger domain
E3 ubiquitin ligase
Scaffold protein
Protein–protein interactions Protein–protein interaction

Genetic analyses in murine and avian models

Euteleostomi
Recessive
Homolog
Transgenic mice
C57BL/6
Embryonic stem cells Embryonic stem cell
Cell line
Genetic traits

Mechanism of MAPK activation by MAP3K1

Cancers, other diseases and therapeutic targeting

Interaction partners

Advanced semantic analysis

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Map overview Semantic statistics

Nodes86

Edges85

Triples148

Avg. degree1.98

Density0.023256

Components1

How this topic connects Entity context

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MAP3K1

Top relations

Gene ontology · 24

MAP3K1 → activation of protein kinase activity, ATP binding, cellular response to mechanical stimulus, cytoplasm, cytosol, Fc-epsilon receptor signaling pathway, kinase activity, MAP kinase kinase kinase activity, MAPK cascade, metal ion binding, MyD88-dependent toll-like receptor signaling pathway, nucleotide binding, phosphorylation, protein binding, protein kinase activity, protein kinase binding, protein phosphorylation, protein serine/threonine kinase activity, regulation of apoptotic process, regulation of mitotic cell cycle

related to Function · 20

MAP3K1 → EGFR, Epidermal, Genetics, GWAS, IκB, MAP2Ks, MEKK1, Mitogen-activated, T-cell, TCR, TGF, TGFβR, The MAP3K1, The MAP3K1 E3, TNF, TNFRs, UBE2D2, UBE2D3, UBE2N, UBE2V1

Bgee · 19

MAP3K1 → blood, buccal mucosa cell, corneal stroma, corpus epididymis, cumulus cell, epithelium of stomach, gums, Ileal epithelium, lactiferous duct, lactiferous gland, monocyte, neural layer of retina, oral cavity, parotid gland, skin of hip, skin of thigh, spleen, submandibular gland, vulva

RNA expression pattern · 19

related to Interaction partners · 18

MAP3K1 → ARHGAP4, AXIN1, C-Raf, CDC42, Grb2, MAP2K1, MAP2K4, MAPK1, MAPK8, RAC1, RhoA, Signal, TAB1, TNIP1, TNIP2, TRAF2, Transforming, UBE2I

related to Mechanism of MAPK activation by MAP3K1 · 11

MAP3K1 → Cytokine, E3 Ub, Early, Genetic, Later, MAP2K, Map3k7, MAPK, MAPKs, TRAF2, UBE2N

related to Genetic analyses in murine and avian models · 7

MAP3K1 → C57BL/6, Chromosome, DT40, Euteleostomi, Gates, SELH/Bc, The

related to Cancers, other diseases and therapeutic targeting · 4

MAP3K1 → E6201, Langerhans, MAP2K1, XY

related to Structure · 3

MAP3K1 → E3, PHD, RING

Band · 2

MAP3K1 → 13 D2.2|13 63.36 cM, 5q11.2

Important terminology Word statistics

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Important terminology

kinase human bp protein gene chr band mapk chromosome signal activation enzyme cell transduction mouse mitogen-activated location ligase including 13

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
MAP3K1	2.3.2.27	↗	1.00	infobox
MAP3K1	2.7.11.25	↗	1.00	infobox
MAP3K1	Aliases	MAP3K1, MAPKKK1, MEKK, MEKK 1, MEKK1, SRXY6, mitogen-activated protein kinase kinase kinase 1	1.00	infobox
MAP3K1	Band	5q11.2	1.00	infobox
MAP3K1	Band	13 D2.2\|13 63.36 cM	1.00	infobox
MAP3K1	Bgee	buccal mucosa cell	1.00	infobox
MAP3K1	Bgee	skin of thigh	1.00	infobox
MAP3K1	Bgee	skin of hip	1.00	infobox
MAP3K1	Bgee	parotid gland	1.00	infobox
MAP3K1	Bgee	corpus epididymis	1.00	infobox
MAP3K1	Bgee	monocyte	1.00	infobox
MAP3K1	Bgee	vulva	1.00	infobox
MAP3K1	Bgee	oral cavity	1.00	infobox
MAP3K1	Bgee	lactiferous duct	1.00	infobox
MAP3K1	Bgee	gums	1.00	infobox
MAP3K1	Bgee	corneal stroma	1.00	infobox
MAP3K1	Bgee	submandibular gland	1.00	infobox
MAP3K1	Bgee	lactiferous gland	1.00	infobox
MAP3K1	Bgee	cumulus cell	1.00	infobox
MAP3K1	Bgee	blood	1.00	infobox
MAP3K1	Bgee	epithelium of stomach	1.00	infobox
MAP3K1	Bgee	neural layer of retina	1.00	infobox
MAP3K1	Bgee	Ileal epithelium	1.00	infobox
MAP3K1	Bgee	spleen	1.00	infobox
MAP3K1	BioGPS	More reference expression data	1.00	infobox
MAP3K1	Chr.	Chromosome 5 (human)	1.00	infobox
MAP3K1	Chr.	Chromosome 13 (mouse)	1.00	infobox
MAP3K1	Databases	NCBI: entry; OMA: entry	1.00	infobox
MAP3K1	End	56,896,152 bp	1.00	infobox
MAP3K1	End	111,945,527 bp	1.00	infobox

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