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Mitogen-activated protein kinase kinase kinase kinase 1 is a protein kinase that in humans is encoded by the MAP4K1 gene. It is also known as HPK1 (Hematopoietic Progenitor Kinase 1). The protein has been shown to play a role in JNK activation.
The analysis highlights Interactions and Overview as prominent areas in the source structure around MAP4K1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around MAP4K1 shows recurring relationship patterns in the source. For example, MAP4K1 → activation of protein kinase activity, ATP binding, cell population proliferation, cellular response to phorbol 13-acetate 12-myristate, cytoplasm, intracellular anatomical structure, intracellular signal transduction, kinase activity, MAP kinase kinase kinase kinase activity, membrane, nucleotide binding, peptidyl-serine phosphorylation, phosphorylation, protein autophosphorylation, protein binding, protein kinase activity, protein phosphorylation, protein serine/threonine kinase activity, regulation of apoptotic process, regulation of mitotic cell cycle Another extracted example is MAP4K1 → ankle joint, appendix, blood, bone marrow cell, embryo, granulocyte, lymph node, mesenteric lymph nodes, monocyte, morula, spermatid, spleen, sural nerve, testicle, thymus, tonsil. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
bp chr human band protein kinase gene chromosome 19 mouse location activity mitogen-activated hpk1 activation shown 618 882 end 38
TTTA extracted 85 structured relationships around MAP4K1. Examples in this analysis include MAP4K1 → 2.7.11.1 → ↗ and MAP4K1 → Aliases → MAP4K1, HPK1, mitogen-activated protein kinase kinase kinase kinase 1. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| MAP4K1 | 2.7.11.1 | ↗ | 1.00 | infobox |
| MAP4K1 | Aliases | MAP4K1, HPK1, mitogen-activated protein kinase kinase kinase kinase 1 | 1.00 | infobox |
| MAP4K1 | Band | 19q13.2 | 1.00 | infobox |
| MAP4K1 | Band | 7|7 B1 | 1.00 | infobox |
| MAP4K1 | Bgee | granulocyte | 1.00 | infobox |
| MAP4K1 | Bgee | lymph node | 1.00 | infobox |
| MAP4K1 | Bgee | spleen | 1.00 | infobox |
| MAP4K1 | Bgee | appendix | 1.00 | infobox |
| MAP4K1 | Bgee | bone marrow cell | 1.00 | infobox |
| MAP4K1 | Bgee | blood | 1.00 | infobox |
| MAP4K1 | Bgee | monocyte | 1.00 | infobox |
| MAP4K1 | Bgee | tonsil | 1.00 | infobox |
| MAP4K1 | Bgee | testicle | 1.00 | infobox |
| MAP4K1 | Bgee | sural nerve | 1.00 | infobox |
| MAP4K1 | Bgee | mesenteric lymph nodes | 1.00 | infobox |
| MAP4K1 | Bgee | thymus | 1.00 | infobox |
| MAP4K1 | Bgee | spermatid | 1.00 | infobox |
| MAP4K1 | Bgee | ankle joint | 1.00 | infobox |
| MAP4K1 | Bgee | morula | 1.00 | infobox |
| MAP4K1 | Bgee | embryo | 1.00 | infobox |
| MAP4K1 | BioGPS | More reference expression data | 1.00 | infobox |
| MAP4K1 | Chr. | Chromosome 19 (human) | 1.00 | infobox |
| MAP4K1 | Chr. | Chromosome 7 (mouse) | 1.00 | infobox |
| MAP4K1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| MAP4K1 | End | 38,618,882 bp | 1.00 | infobox |
| MAP4K1 | End | 28,702,704 bp | 1.00 | infobox |
| MAP4K1 | Ensembl | ENSG00000282928 ENSG00000104814 | 1.00 | infobox |
| MAP4K1 | Entrez | 11184 | 1.00 | infobox |
| MAP4K1 | Enzyme activity | Enzyme activityEC #BRENDAExPASyKEGGMetaCyc2.7.11.1↗↗↗↗ | 1.00 | infobox |
| MAP4K1 | External IDs | OMIM: 601983; MGI: 1346882; GeneCards: MAP4K1 | 1.00 | infobox |
The concept neighborhoods around MAP4K1 bring nearby vocabulary together. In this analysis, examples include Activity, Gene and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For MAP4K1, one of the stronger structural bridges in this analysis connects MAP4K1 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around MAP4K1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — MAP4K1 · EN edition · Analysis: TopicsToTalkAbout