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MAP4K1

Mitogen-activated protein kinase kinase kinase kinase 1 is a protein kinase that in humans is encoded by the MAP4K1 gene. It is also known as HPK1 (Hematopoietic Progenitor Kinase 1). The protein has been shown to play a role in JNK activation.

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2.7.11.1
Aliases
MAP4K1, HPK1, mitogen-activated protein kinase kinase kinase kinase 1
Band
19q13.2 · 7|7 B1
Bgee
granulocyte · lymph node · spleen · appendix · bone marrow cell
BioGPS
More reference expression data
Chr.
Chromosome 19 (human) · Chromosome 7 (mouse)

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MAP4K1

Nodes15
Edges14
Triples85
Avg. degree1.87
Density0.133333
Components1

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MAP4K1

Top relations

Gene ontology · 24
MAP4K1 → activation of protein kinase activity, ATP binding, cell population proliferation, cellular response to phorbol 13-acetate 12-myristate, cytoplasm, intracellular anatomical structure, intracellular signal transduction, kinase activity, MAP kinase kinase kinase kinase activity, membrane, nucleotide binding, peptidyl-serine phosphorylation, phosphorylation, protein autophosphorylation, protein binding, protein kinase activity, protein phosphorylation, protein serine/threonine kinase activity, regulation of apoptotic process, regulation of mitotic cell cycle
Bgee · 16
MAP4K1 → ankle joint, appendix, blood, bone marrow cell, embryo, granulocyte, lymph node, mesenteric lymph nodes, monocyte, morula, spermatid, spleen, sural nerve, testicle, thymus, tonsil
RNA expression pattern · 16
MAP4K1 → ankle joint, appendix, blood, bone marrow cell, embryo, granulocyte, lymph node, mesenteric lymph nodes, monocyte, morula, spermatid, spleen, sural nerve, testicle, thymus, tonsil
related to Interactions · 7
MAP4K1 → B-cell, CRK, CRKL, Drebrin-like, GRAP2, Grb2, Linker
Band · 2
MAP4K1 → 19q13.2, 7|7 B1
Chr. · 2
MAP4K1 → Chromosome 19 (human), Chromosome 7 (mouse)
End · 2
MAP4K1 → 28,702,704 bp, 38,618,882 bp
2.7.11.1 · 1
MAP4K1 → ↗
Aliases · 1
MAP4K1 → MAP4K1, HPK1, mitogen-activated protein kinase kinase kinase kinase 1
BioGPS · 1
MAP4K1 → More reference expression data

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Important terminology

bp chr human band protein kinase gene chromosome 19 mouse location activity mitogen-activated hpk1 activation shown 618 882 end 38

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
MAP4K12.7.11.11.00infobox
MAP4K1AliasesMAP4K1, HPK1, mitogen-activated protein kinase kinase kinase kinase 11.00infobox
MAP4K1Band19q13.21.00infobox
MAP4K1Band7|7 B11.00infobox
MAP4K1Bgeegranulocyte1.00infobox
MAP4K1Bgeelymph node1.00infobox
MAP4K1Bgeespleen1.00infobox
MAP4K1Bgeeappendix1.00infobox
MAP4K1Bgeebone marrow cell1.00infobox
MAP4K1Bgeeblood1.00infobox
MAP4K1Bgeemonocyte1.00infobox
MAP4K1Bgeetonsil1.00infobox
MAP4K1Bgeetesticle1.00infobox
MAP4K1Bgeesural nerve1.00infobox
MAP4K1Bgeemesenteric lymph nodes1.00infobox
MAP4K1Bgeethymus1.00infobox
MAP4K1Bgeespermatid1.00infobox
MAP4K1Bgeeankle joint1.00infobox
MAP4K1Bgeemorula1.00infobox
MAP4K1Bgeeembryo1.00infobox
MAP4K1BioGPSMore reference expression data1.00infobox
MAP4K1Chr.Chromosome 19 (human)1.00infobox
MAP4K1Chr.Chromosome 7 (mouse)1.00infobox
MAP4K1DatabasesNCBI: entry; OMA: entry1.00infobox
MAP4K1End38,618,882 bp1.00infobox
MAP4K1End28,702,704 bp1.00infobox
MAP4K1EnsemblENSG00000282928 ENSG000001048141.00infobox
MAP4K1Entrez111841.00infobox
MAP4K1Enzyme activityEnzyme activityEC #BRENDAExPASyKEGGMetaCyc2.7.11.1↗↗↗↗1.00infobox
MAP4K1External IDsOMIM: 601983; MGI: 1346882; GeneCards: MAP4K11.00infobox

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