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Granulocyte colony-stimulating factor receptor: Overview, Interactions & Clinical significance

The granulocyte colony-stimulating factor receptor (G-CSF-R) also known as CD114 (Cluster of Differentiation 114) is a protein that in humans is encoded by the CSF3R gene. G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF). The G-CSF receptors belong to a family of cytokine receptors known as the hematopoietin…

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Granulocyte colony-stimulating factor receptor topic overview

The analysis highlights Overview, Interactions and Clinical significance as prominent areas in the source structure around Granulocyte colony-stimulating factor receptor.

Related topics
27
Source areas
3
Connected nodes
30
Extracted relationships
82
Concept neighborhoods
13
Bridge connections
30

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 20 topics
Interactions · 4 topics
Clinical significance · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CSF3R, CD114, GCSFR, colony stimulating factor 3 receptor, SCN7
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2D9Q
Band
1p34.3 · 4 D2.2|4 59.77 cM
Bgee
granulocyte · monocyte · blood · upper lobe of left lung · right lung
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 4 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Granulocyte colony-stimulating factor receptor connects Entity context

The extracted context around Granulocyte colony-stimulating factor receptor shows recurring relationship patterns in the source. For example, Granulocyte colony-stimulating factor receptor → amelogenesis, cell adhesion, cellular response to interleukin-3, cytokine binding, cytokine receptor activity, cytokine-mediated signaling pathway, defense response, external side of plasma membrane, extracellular region, granulocyte colony-stimulating factor binding, integral component of membrane, integral component of plasma membrane, interleukin-3 binding, interleukin-3 receptor activity, interleukin-3-mediated signaling pathway, membrane, neutrophil chemotaxis, plasma membrane, protein binding, receptor complex Another extracted example is Granulocyte colony-stimulating factor receptor → blastocyst, blood, bone marrow, bone marrow cell, granulocyte, lower lobe of lung, mesenteric lymph nodes, monocyte, morula, placenta, right lung, spleen, stroma of bone marrow, tibiofemoral joint, trabecular bone, upper lobe of left lung. Use these groups to spot repeated connection types before inspecting the individual relationships.

Granulocyte colony-stimulating factor receptor

Top relations

Gene ontology · 23
Granulocyte colony-stimulating factor receptor → amelogenesis, cell adhesion, cellular response to interleukin-3, cytokine binding, cytokine receptor activity, cytokine-mediated signaling pathway, defense response, external side of plasma membrane, extracellular region, granulocyte colony-stimulating factor binding, integral component of membrane, integral component of plasma membrane, interleukin-3 binding, interleukin-3 receptor activity, interleukin-3-mediated signaling pathway, membrane, neutrophil chemotaxis, plasma membrane, protein binding, receptor complex
Bgee · 16
Granulocyte colony-stimulating factor receptor → blastocyst, blood, bone marrow, bone marrow cell, granulocyte, lower lobe of lung, mesenteric lymph nodes, monocyte, morula, placenta, right lung, spleen, stroma of bone marrow, tibiofemoral joint, trabecular bone, upper lobe of left lung
RNA expression pattern · 16
Granulocyte colony-stimulating factor receptor → blastocyst, blood, bone marrow, bone marrow cell, granulocyte, lower lobe of lung, mesenteric lymph nodes, monocyte, morula, placenta, right lung, spleen, stroma of bone marrow, tibiofemoral joint, trabecular bone, upper lobe of left lung
related to Interactions · 4
Granulocyte colony-stimulating factor receptor → Granulocyte, Grb2, HCK, SHC1
Band · 2
Granulocyte colony-stimulating factor receptor → 1p34.3, 4 D2.2|4 59.77 cM
Chr. · 2
Granulocyte colony-stimulating factor receptor → Chromosome 1 (human), Chromosome 4 (mouse)
End · 2
Granulocyte colony-stimulating factor receptor → 125,938,233 bp, 36,483,278 bp
Aliases · 1
Granulocyte colony-stimulating factor receptor → CSF3R, CD114, GCSFR, colony stimulating factor 3 receptor, SCN7
Available structures · 1
Granulocyte colony-stimulating factor receptor → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2D9Q
BioGPS · 1
Granulocyte colony-stimulating factor receptor → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

receptor factor colony-stimulating bp granulocyte human differentiation gene chr band csf3r chromosome g-csf-r g-csf also signal transduction known protein external

Granulocyte colony-stimulating factor receptor relationships Subject–Predicate–Object triples

TTTA extracted 82 structured relationships around Granulocyte colony-stimulating factor receptor. Examples in this analysis include Granulocyte colony-stimulating factor receptor → Aliases → CSF3R, CD114, GCSFR, colony stimulating factor 3 receptor, SCN7 and Granulocyte colony-stimulating factor receptor → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2D9Q. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Granulocyte colony-stimulating factor receptorAliasesCSF3R, CD114, GCSFR, colony stimulating factor 3 receptor, SCN71.00infobox
Granulocyte colony-stimulating factor receptorAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2D9Q1.00infobox
Granulocyte colony-stimulating factor receptorBand1p34.31.00infobox
Granulocyte colony-stimulating factor receptorBand4 D2.2|4 59.77 cM1.00infobox
Granulocyte colony-stimulating factor receptorBgeegranulocyte1.00infobox
Granulocyte colony-stimulating factor receptorBgeemonocyte1.00infobox
Granulocyte colony-stimulating factor receptorBgeeblood1.00infobox
Granulocyte colony-stimulating factor receptorBgeeupper lobe of left lung1.00infobox
Granulocyte colony-stimulating factor receptorBgeeright lung1.00infobox
Granulocyte colony-stimulating factor receptorBgeespleen1.00infobox
Granulocyte colony-stimulating factor receptorBgeebone marrow cell1.00infobox
Granulocyte colony-stimulating factor receptorBgeeplacenta1.00infobox
Granulocyte colony-stimulating factor receptorBgeelower lobe of lung1.00infobox
Granulocyte colony-stimulating factor receptorBgeetrabecular bone1.00infobox
Granulocyte colony-stimulating factor receptorBgeetibiofemoral joint1.00infobox
Granulocyte colony-stimulating factor receptorBgeeblastocyst1.00infobox
Granulocyte colony-stimulating factor receptorBgeebone marrow1.00infobox
Granulocyte colony-stimulating factor receptorBgeemorula1.00infobox
Granulocyte colony-stimulating factor receptorBgeestroma of bone marrow1.00infobox
Granulocyte colony-stimulating factor receptorBgeemesenteric lymph nodes1.00infobox
Granulocyte colony-stimulating factor receptorBioGPSMore reference expression data1.00infobox
Granulocyte colony-stimulating factor receptorChr.Chromosome 1 (human)1.00infobox
Granulocyte colony-stimulating factor receptorChr.Chromosome 4 (mouse)1.00infobox
Granulocyte colony-stimulating factor receptorDatabasesNCBI: entry; OMA: entry1.00infobox
Granulocyte colony-stimulating factor receptorEnd36,483,278 bp1.00infobox
Granulocyte colony-stimulating factor receptorEnd125,938,233 bp1.00infobox
Granulocyte colony-stimulating factor receptorEnsemblENSG000001195351.00infobox
Granulocyte colony-stimulating factor receptorEntrez14411.00infobox
Granulocyte colony-stimulating factor receptorExternal IDsOMIM: 138971; MGI: 1339755; GeneCards: CSF3R1.00infobox
Granulocyte colony-stimulating factor receptorGene location (Human)Gene location (Human)Chr.Chromosome 1 (human)Band1p34.3Start36,466,043 bpEnd36,483,278 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Granulocyte colony-stimulating factor receptor bring nearby vocabulary together. In this analysis, examples include Granulocyte, Factor and Differentiation. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Granulocyte colony-stimulating factor receptor
    • Granulocyte
    • Factor
    • Differentiation
    • Receptor
    • Bone
    • Cell
    • Marrow
    • Response
    • G-csf
    • G-csf-r
    • Protein
    • Csf3r
  • granulocyte colony-stimulating factor receptor
    • Granulocyte
    • Factor
    • Receptor
    • Differentiation
    • Csf3r
    • Bone
    • Cell
    • Marrow
    • Response
    • Gene
    • Cd114
    • External
  • cell
    • Marrow
    • Response
    • Differentiation
    • Colony-stimulating
    • Granulocyte
    • Cytokine
    • D2
    • End
    • External
    • Extracellular
    • Factor
    • Mouse
  • granulocyte colony-stimulating factor
    • Granulocyte
    • Factor
    • Receptor
    • Differentiation
    • Csf3r
    • Bone
    • Cell
    • Marrow
    • Response
    • Gene
    • Cd114
    • External
  • cytokine
    • Bone
    • Cell
    • D2
    • End
    • External
    • Extracellular
    • Marrow
    • Mouse
    • Response
    • Search
    • G-csf
    • Known
  • bone marrow
    • Cell
    • Marrow
    • Response
    • Differentiation
    • Colony-stimulating
    • Granulocyte
    • Cytokine
    • D2
    • End
    • External
    • Extracellular
    • Factor
  • cell proliferation
    • Marrow
    • Response
    • Differentiation
    • Colony-stimulating
    • Granulocyte
    • Cytokine
    • D2
    • End
    • External
    • Extracellular
    • Factor
    • Mouse
  • differentiation
    • Protein
    • Csf3r
    • Bone
    • Cell
    • Granulocyte
    • Marrow
    • Response
    • Factor
    • Gene
    • Human
    • Receptor
    • Cytokine

Connections between topic areas Semantic bridges

For Granulocyte colony-stimulating factor receptor, one of the stronger structural bridges in this analysis connects Granulocyte colony-stimulating factor receptor with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Granulocyte colony-stimulating factor receptorOverview · splits 10 ⟂ 21
Granulocyte colony-stimulating factor receptorInteractions · splits 26 ⟂ 5
Granulocyte colony-stimulating factor receptorClinical significance · splits 27 ⟂ 4

Map overview Semantic statistics

Granulocyte colony-stimulating factor receptor

Nodes31
Edges30
Triples82
Avg. degree1.94
Density0.064516
Components1

Source & methodology

TTTA analyzes the structure around Granulocyte colony-stimulating factor receptor to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Overview, Interactions & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Granulocyte colony-stimulating factor receptor · EN edition · Analysis: TopicsToTalkAbout

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