CDKN1B

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CDKN1B topic overview

The analysis highlights Function, Interactions and Role in Regeneration as prominent areas in the source structure around CDKN1B.

Related topics: 45
Source areas: 7
Connected nodes: 52
Extracted relationships: 160
Concept neighborhoods: 20
Bridge connections: 52

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 11 topics

Overview · 11 topics

Interactions · 10 topics

Role in Regeneration · 6 topics

Regulation in specific cancers · 3 topics

Regulation · 2 topics

Role in cancer · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1, cyclin-dependent kinase inhibitor 1B, cyclin dependent kinase inhibitor 1B
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2AST, 1H27, 1JSU
Band: 12p13.1 · 6 G1|6 65.77 cM
Bgee: retinal pigment epithelium · ventricular zone · ganglionic eminence · pons · lateral nuclear group of thalamus
BioGPS: More reference expression data
Chr.: Chromosome 12 (human) · Chromosome 6 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Regulation

Structured cis-regulatory element P27 cis-regulatory element
MRNA

Role in cancer

SRC SRC (gene)
Glioblastoma

Regulation in specific cancers

Role in Regeneration

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CDKN1B connects Entity context

The extracted context around CDKN1B shows recurring relationship patterns in the source. For example, CDKN1B → autophagic cell death, cell cycle, cell death, cellular response to antibiotic, cellular response to lithium ion, cellular response to organic cyclic compound, chaperone binding, Cul4A-RING E3 ubiquitin ligase complex, cyclin binding, cyclin-dependent protein serine/threonine kinase activity, cyclin-dependent protein serine/threonine kinase inhibitor activity, cytoplasm, cytosol, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, endosome, G1/S transition of mitotic cell cycle, hearing, Hsp70 protein binding, inner ear development, intracellular membrane-bounded organelle Another extracted example is CDKN1B → blood, cerebellar vermis, cumulus cell, ganglionic eminence, germinal epithelium, granulocyte, habenula, lateral nuclear group of thalamus, lobe of cerebellum, parietal pleura, pineal gland, pons, retinal pigment epithelium, seminal vesicula, superficial temporal artery, trabecular bone, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 61

CDKN1B → autophagic cell death, cell cycle, cell death, cellular response to antibiotic, cellular response to lithium ion, cellular response to organic cyclic compound, chaperone binding, Cul4A-RING E3 ubiquitin ligase complex, cyclin binding, cyclin-dependent protein serine/threonine kinase activity, cyclin-dependent protein serine/threonine kinase inhibitor activity, cytoplasm, cytosol, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, endosome, G1/S transition of mitotic cell cycle, hearing, Hsp70 protein binding, inner ear development, intracellular membrane-bounded organelle

Bgee · 17

CDKN1B → blood, cerebellar vermis, cumulus cell, ganglionic eminence, germinal epithelium, granulocyte, habenula, lateral nuclear group of thalamus, lobe of cerebellum, parietal pleura, pineal gland, pons, retinal pigment epithelium, seminal vesicula, superficial temporal artery, trabecular bone, ventricular zone

RNA expression pattern · 17

related to Interactions · 8

CDKN1B → AKT1, CKS1B, Cyclin D3, Cyclin E1, Cyclin-dependent, Grb2, NUP50SKP2, SPDYA

related to Transcription · 8

CDKN1B → Akt, COP9, COPS5, Forkhead, FoxO, MEN1, P27, Transcription

related to External links · 7

CDKN1B → Cyclin-dependent, Overview, P46527, PDB, PDBe-KB, UCSC Genome Browser, UniProt

related to Role in Regeneration · 6

CDKN1B → Because, Corti, In, Knockdown, Lack, Since CDKN1B

related to Translation · 6

CDKN1B → CDKN1b IRES, ELAVL1, ELAVL4, G1, PTB, Translation

related to Multiple Endocrine Neoplasia · 5

CDKN1B → MEN, MEN1/RET, MEN4, Mutations, Testing

Band · 2

CDKN1B → 12p13.1, 6 G1|6 65.77 cM

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

p27 levels cell cancer protein gene cells also g1 cyclin inhibitor cycle kinase cancers human cytoplasm translation breast p27kip1 transcription

CDKN1B relationships Subject–Predicate–Object triples

TTTA extracted 160 structured relationships around CDKN1B. Examples in this analysis include CDKN1B → Aliases → CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1, cyclin-dependent kinase inhibitor 1B, cyclin dependent kinase inhibitor 1B and CDKN1B → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2AST, 1H27, 1JSU. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
CDKN1B	Aliases	CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1, cyclin-dependent kinase inhibitor 1B, cyclin dependent kinase inhibitor 1B	1.00	infobox
CDKN1B	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2AST, 1H27, 1JSU	1.00	infobox
CDKN1B	Band	12p13.1	1.00	infobox
CDKN1B	Band	6 G1\|6 65.77 cM	1.00	infobox
CDKN1B	Bgee	retinal pigment epithelium	1.00	infobox
CDKN1B	Bgee	ventricular zone	1.00	infobox
CDKN1B	Bgee	ganglionic eminence	1.00	infobox
CDKN1B	Bgee	pons	1.00	infobox
CDKN1B	Bgee	lateral nuclear group of thalamus	1.00	infobox
CDKN1B	Bgee	trabecular bone	1.00	infobox
CDKN1B	Bgee	parietal pleura	1.00	infobox
CDKN1B	Bgee	superficial temporal artery	1.00	infobox
CDKN1B	Bgee	germinal epithelium	1.00	infobox
CDKN1B	Bgee	cerebellar vermis	1.00	infobox
CDKN1B	Bgee	lobe of cerebellum	1.00	infobox
CDKN1B	Bgee	blood	1.00	infobox
CDKN1B	Bgee	pineal gland	1.00	infobox
CDKN1B	Bgee	cumulus cell	1.00	infobox
CDKN1B	Bgee	granulocyte	1.00	infobox
CDKN1B	Bgee	habenula	1.00	infobox
CDKN1B	Bgee	seminal vesicula	1.00	infobox
CDKN1B	BioGPS	More reference expression data	1.00	infobox
CDKN1B	Chr.	Chromosome 12 (human)	1.00	infobox
CDKN1B	Chr.	Chromosome 6 (mouse)	1.00	infobox
CDKN1B	Databases	NCBI: entry; OMA: entry	1.00	infobox
CDKN1B	End	12,722,369 bp	1.00	infobox
CDKN1B	End	134,902,476 bp	1.00	infobox
CDKN1B	Ensembl	ENSG00000111276	1.00	infobox
CDKN1B	Entrez	1027	1.00	infobox
CDKN1B	External IDs	OMIM: 600778; MGI: 104565; GeneCards: CDKN1B	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CDKN1B bring nearby vocabulary together. In this analysis, examples include Gene, Human and Cyclin-dependent. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

CDKN1B
- Gene
- Human
- Cyclin-dependent
- Kinase
- Transcription
- Cells
- Inhibitor
- Translation
- G1
- Location
- Also
- Nuclear
cdkn1b
- Gene
- Human
- Cyclin-dependent
- Kinase
- Transcription
- Cells
- Inhibitor
- Translation
- G1
- Location
- Also
- Nuclear
enzyme inhibitor
- Kinase
- Location
- Gene
- Human
- P27kip1
- Cyclin
- Bp
- Chr
- Proliferation
- Regulation
- Metastasis
- Nuclear
gene
- Human
- Location
- Transcription
- Inhibitor
- Bp
- Chr
- Proliferation
- Nuclear
- Prostate
- Kinase
- P27kip1
- Band
cyclin dependent kinase
- Cyclin
- Kinase
- P27kip1
- Cyclin-dependent
- Protein
- Bp
- Chr
- Location
- Proliferation
- Regulation
- Gene
- Inhibitor
cyclin e
- Kinase
- P27kip1
- Cyclin-dependent
- Inhibitor
- Bp
- Chr
- Location
- Proliferation
- Regulation
- Nuclear
- Skp2
- Human
cyclin d
- Kinase
- P27kip1
- Cyclin-dependent
- Inhibitor
- Bp
- Chr
- Location
- Proliferation
- Regulation
- Nuclear
- Skp2
- Human
cell cycle
- Cycle
- Protein
- G1
- Location
- Proliferation
- Cancer
- P27kip1
- P27
- Cells
- Inhibitor
- Prostate
- Levels

Connections between topic areas Semantic bridges

For CDKN1B, one of the stronger structural bridges in this analysis connects CDKN1B with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

CDKN1B — Overview · splits 41 ⟂ 12

CDKN1B — Function · splits 41 ⟂ 12

CDKN1B — Interactions · splits 42 ⟂ 11

CDKN1B — Role in Regeneration · splits 46 ⟂ 7

CDKN1B — Regulation in specific cancers · splits 49 ⟂ 4

CDKN1B — Regulation · splits 50 ⟂ 3

CDKN1B — Role in cancer · splits 50 ⟂ 3

Map overview Semantic statistics

CDKN1B

Nodes53

Edges52

Triples160

Avg. degree1.96

Density0.037736

Components1

Source & methodology

TTTA analyzes the structure around CDKN1B to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Role in Regeneration, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CDKN1B · EN edition · Analysis: TopicsToTalkAbout