CDKN1B

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Explore the main themes, entities and connections around CDKN1B. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Function

DNA sequence P21 P57 Catalytic Phosphate

11 related topics

Interactions

Interact AKT1 CKS1B Cyclin D3 Cyclin E1

10 related topics

Role in Regeneration

Regeneration Hair cell Organ of Corti Cochlea Hearing loss

6 related topics

Regulation in specific cancers

Primary hyperparathyroidism Pituitary adenomas Multiple endocrine neoplasia

3 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1, cyclin-dependent kinase inhibitor 1B, cyclin dependent kinase inhibitor 1B
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2AST, 1H27, 1JSU
Band: 12p13.1 · 6 G1|6 65.77 cM
Bgee: retinal pigment epithelium · ventricular zone · ganglionic eminence · pons · lateral nuclear group of thalamus
BioGPS: More reference expression data
Chr.: Chromosome 12 (human) · Chromosome 6 (mouse)

Topics to explore

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Overview

Function

Regulation

Structured cis-regulatory element P27 cis-regulatory element
MRNA

Role in cancer

SRC SRC (gene)
Glioblastoma

Regulation in specific cancers

Role in Regeneration

Interactions

Advanced semantic analysis

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Map overview Semantic statistics

Nodes53

Edges52

Triples160

Avg. degree1.96

Density0.037736

Components1

How this topic connects Entity context

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CDKN1B

Top relations

Gene ontology · 61

CDKN1B → autophagic cell death, cell cycle, cell death, cellular response to antibiotic, cellular response to lithium ion, cellular response to organic cyclic compound, chaperone binding, Cul4A-RING E3 ubiquitin ligase complex, cyclin binding, cyclin-dependent protein serine/threonine kinase activity, cyclin-dependent protein serine/threonine kinase inhibitor activity, cytoplasm, cytosol, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, endosome, G1/S transition of mitotic cell cycle, hearing, Hsp70 protein binding, inner ear development, intracellular membrane-bounded organelle

Bgee · 17

CDKN1B → blood, cerebellar vermis, cumulus cell, ganglionic eminence, germinal epithelium, granulocyte, habenula, lateral nuclear group of thalamus, lobe of cerebellum, parietal pleura, pineal gland, pons, retinal pigment epithelium, seminal vesicula, superficial temporal artery, trabecular bone, ventricular zone

RNA expression pattern · 17

related to Interactions · 8

CDKN1B → AKT1, CKS1B, Cyclin D3, Cyclin E1, Cyclin-dependent, Grb2, NUP50SKP2, SPDYA

related to Transcription · 8

CDKN1B → Akt, COP9, COPS5, Forkhead, FoxO, MEN1, P27, Transcription

related to External links · 7

CDKN1B → Cyclin-dependent, Overview, P46527, PDB, PDBe-KB, UCSC Genome Browser, UniProt

related to Role in Regeneration · 6

CDKN1B → Because, Corti, In, Knockdown, Lack, Since CDKN1B

related to Translation · 6

CDKN1B → CDKN1b IRES, ELAVL1, ELAVL4, G1, PTB, Translation

related to Multiple Endocrine Neoplasia · 5

CDKN1B → MEN, MEN1/RET, MEN4, Mutations, Testing

Band · 2

CDKN1B → 12p13.1, 6 G1|6 65.77 cM

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

p27 levels cell cancer protein gene cells also g1 cyclin inhibitor cycle kinase cancers human cytoplasm translation breast p27kip1 transcription

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
CDKN1B	Aliases	CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1, cyclin-dependent kinase inhibitor 1B, cyclin dependent kinase inhibitor 1B	1.00	infobox
CDKN1B	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2AST, 1H27, 1JSU	1.00	infobox
CDKN1B	Band	12p13.1	1.00	infobox
CDKN1B	Band	6 G1\|6 65.77 cM	1.00	infobox
CDKN1B	Bgee	retinal pigment epithelium	1.00	infobox
CDKN1B	Bgee	ventricular zone	1.00	infobox
CDKN1B	Bgee	ganglionic eminence	1.00	infobox
CDKN1B	Bgee	pons	1.00	infobox
CDKN1B	Bgee	lateral nuclear group of thalamus	1.00	infobox
CDKN1B	Bgee	trabecular bone	1.00	infobox
CDKN1B	Bgee	parietal pleura	1.00	infobox
CDKN1B	Bgee	superficial temporal artery	1.00	infobox
CDKN1B	Bgee	germinal epithelium	1.00	infobox
CDKN1B	Bgee	cerebellar vermis	1.00	infobox
CDKN1B	Bgee	lobe of cerebellum	1.00	infobox
CDKN1B	Bgee	blood	1.00	infobox
CDKN1B	Bgee	pineal gland	1.00	infobox
CDKN1B	Bgee	cumulus cell	1.00	infobox
CDKN1B	Bgee	granulocyte	1.00	infobox
CDKN1B	Bgee	habenula	1.00	infobox
CDKN1B	Bgee	seminal vesicula	1.00	infobox
CDKN1B	BioGPS	More reference expression data	1.00	infobox
CDKN1B	Chr.	Chromosome 12 (human)	1.00	infobox
CDKN1B	Chr.	Chromosome 6 (mouse)	1.00	infobox
CDKN1B	Databases	NCBI: entry; OMA: entry	1.00	infobox
CDKN1B	End	12,722,369 bp	1.00	infobox
CDKN1B	End	134,902,476 bp	1.00	infobox
CDKN1B	Ensembl	ENSG00000111276	1.00	infobox
CDKN1B	Entrez	1027	1.00	infobox
CDKN1B	External IDs	OMIM: 600778; MGI: 104565; GeneCards: CDKN1B	1.00	infobox

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