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SOS1: Interactions, Function & Inhibitors and activators

Son of sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene.

Language: English [EN]
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SOS1 topic overview

The analysis highlights Interactions, Function and Inhibitors and activators as prominent areas in the source structure around SOS1.

Related topics
34
Source areas
5
Connected nodes
39
Extracted relationships
148
Concept neighborhoods
15
Bridge connections
39

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 15 topics
Function · 7 topics
Inhibitors and activators · 6 topics
Clinical significance · 4 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
SOS1, GF1, GGF1, GINGF, HGF, NS4, SOS Ras/Rac guanine nucleotide exchange factor 1, SOS-1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1AWE, 1BKD, 1DBH, 1NVU, 1NVV, 1NVW, 1NVX, 1Q9C, 1XD2, 1XD4, 1XDV, 3KSY, 4NYI, 4NYJ, 4NYM, 4URU, 4URV, 4URW,…
Band
2p22.1 · 17 E3|17 50.67 cM
Bgee
epithelium of colon · jejunal mucosa · tendon of biceps brachii · trigeminal ganglion · spinal ganglia
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 17 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Inhibitors and activators

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How SOS1 connects Entity context

The extracted context around SOS1 shows recurring relationship patterns in the source. For example, SOS1 → axon guidance, B cell homeostasis, blood vessel morphogenesis, cardiac atrium morphogenesis, cytokine-mediated signaling pathway, cytoplasm, cytosol, DNA binding, epidermal growth factor receptor signaling pathway, ERBB2 signaling pathway, eyelid development in camera-type eye, Fc-epsilon receptor signaling pathway, G protein-coupled receptor signaling pathway, GTPase activator activity, guanyl-nucleotide exchange factor activity, hair follicle development, heart morphogenesis, heart trabecula morphogenesis, insulin receptor signaling pathway, leukocyte migration Another extracted example is SOS1 → Achilles tendon, anterior horn of spinal cord, arcuate nucleus, corpus callosum, dorsomedial hypothalamic nucleus, epithelium of colon, facial motor nucleus, jejunal mucosa, lateral hypothalamus, mammillary body, median eminence, paraventricular nucleus of hypothalamus, pylorus, seminal vesicula, spinal ganglia, subcutaneous adipose tissue, tendon of biceps brachii, trigeminal ganglion, ventral tegmental area, ventromedial nucleus. Use these groups to spot repeated connection types before inspecting the individual relationships.

SOS1

Top relations

Gene ontology · 47
SOS1 → axon guidance, B cell homeostasis, blood vessel morphogenesis, cardiac atrium morphogenesis, cytokine-mediated signaling pathway, cytoplasm, cytosol, DNA binding, epidermal growth factor receptor signaling pathway, ERBB2 signaling pathway, eyelid development in camera-type eye, Fc-epsilon receptor signaling pathway, G protein-coupled receptor signaling pathway, GTPase activator activity, guanyl-nucleotide exchange factor activity, hair follicle development, heart morphogenesis, heart trabecula morphogenesis, insulin receptor signaling pathway, leukocyte migration
Bgee · 20
SOS1 → Achilles tendon, anterior horn of spinal cord, arcuate nucleus, corpus callosum, dorsomedial hypothalamic nucleus, epithelium of colon, facial motor nucleus, jejunal mucosa, lateral hypothalamus, mammillary body, median eminence, paraventricular nucleus of hypothalamus, pylorus, seminal vesicula, spinal ganglia, subcutaneous adipose tissue, tendon of biceps brachii, trigeminal ganglion, ventral tegmental area, ventromedial nucleus
RNA expression pattern · 20
SOS1 → Achilles tendon, anterior horn of spinal cord, arcuate nucleus, corpus callosum, dorsomedial hypothalamic nucleus, epithelium of colon, facial motor nucleus, jejunal mucosa, lateral hypothalamus, mammillary body, median eminence, paraventricular nucleus of hypothalamus, pylorus, seminal vesicula, spinal ganglia, subcutaneous adipose tissue, tendon of biceps brachii, trigeminal ganglion, ventral tegmental area, ventromedial nucleus
related to Interactions · 14
SOS1 → ABI1, BCR, CRK, Epidermal, EPS8, FRS2, Grb2, HRAS, ITSN1, MUC1, NCK1, PLCG1, PTPN11, SH3KBP1
related to Function · 13
SOS1 → Binding, Cdc25, GAPs, GDP, GEF, Genetic, GTP, GTPase-activating, In Drosophila, MIM, Ras, Sos, The
related to Inhibitors and activators · 6
SOS1 → BAY-293, BI-3406, Donated Chemical Probe, Fesik, Structural Genomics Consortium, VUBI1
related to Clinical significance · 5
SOS1 → KRAS, MAP, Noonan, PTPN11, Recent
Band · 2
SOS1 → 17 E3|17 50.67 cM, 2p22.1
Chr. · 2
SOS1 → Chromosome 17 (mouse), Chromosome 2 (human)
End · 2
SOS1 → 39,124,345 bp, 80,787,882 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

ras gene bp chr human band exchange factor chromosome guanine cdc25 proteins protein nucleotide location function activators also mouse sos

SOS1 relationships Subject–Predicate–Object triples

TTTA extracted 148 structured relationships around SOS1. Examples in this analysis include SOS1 → Aliases → SOS1, GF1, GGF1, GINGF, HGF, NS4, SOS Ras/Rac guanine nucleotide exchange factor 1, SOS-1 and SOS1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1AWE, 1BKD, 1DBH, 1NVU, 1NVV, 1NVW, 1NVX, 1Q9C, 1XD2, 1XD4, 1XDV, 3KSY, 4NYI, 4NYJ, 4NYM, 4URU, 4URV, 4URW,…. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
SOS1AliasesSOS1, GF1, GGF1, GINGF, HGF, NS4, SOS Ras/Rac guanine nucleotide exchange factor 1, SOS-11.00infobox
SOS1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1AWE, 1BKD, 1DBH, 1NVU, 1NVV, 1NVW, 1NVX, 1Q9C, 1XD2, 1XD4, 1XDV, 3KSY, 4NYI, 4NYJ, 4NYM, 4URU, 4URV, 4URW,…1.00infobox
SOS1Band2p22.11.00infobox
SOS1Band17 E3|17 50.67 cM1.00infobox
SOS1Bgeeepithelium of colon1.00infobox
SOS1Bgeejejunal mucosa1.00infobox
SOS1Bgeetendon of biceps brachii1.00infobox
SOS1Bgeetrigeminal ganglion1.00infobox
SOS1Bgeespinal ganglia1.00infobox
SOS1BgeeAchilles tendon1.00infobox
SOS1Bgeeseminal vesicula1.00infobox
SOS1Bgeecorpus callosum1.00infobox
SOS1Bgeesubcutaneous adipose tissue1.00infobox
SOS1Bgeepylorus1.00infobox
SOS1Bgeedorsomedial hypothalamic nucleus1.00infobox
SOS1Bgeearcuate nucleus1.00infobox
SOS1Bgeeventromedial nucleus1.00infobox
SOS1Bgeeparaventricular nucleus of hypothalamus1.00infobox
SOS1Bgeefacial motor nucleus1.00infobox
SOS1Bgeelateral hypothalamus1.00infobox
SOS1Bgeeanterior horn of spinal cord1.00infobox
SOS1Bgeeventral tegmental area1.00infobox
SOS1Bgeemammillary body1.00infobox
SOS1Bgeemedian eminence1.00infobox
SOS1BioGPSMore reference expression data1.00infobox
SOS1Chr.Chromosome 2 (human)1.00infobox
SOS1Chr.Chromosome 17 (mouse)1.00infobox
SOS1DatabasesNCBI: entry; OMA: entry1.00infobox
SOS1End39,124,345 bp1.00infobox
SOS1End80,787,882 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around SOS1 bring nearby vocabulary together. In this analysis, examples include Reported, Syndrome and Encoded. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • protein
    • Encoded
    • Domain
    • Gene
    • Cell
    • E3
    • End
    • Mouse
    • Search
    • Sevenless
    • Son
    • Sos1
    • Binding
  • gene
    • Factor
    • Domain
    • Location
    • Protein
    • Sos1
    • Chromosome
    • Human
    • Bp
    • Chr
    • Exchange
    • E3
    • End
  • guanine nucleotide exchange factors
    • Nucleotide
    • Guanine
    • Ras
    • Factor
    • Search
    • Proteins
    • Binding
    • Cell
    • Gtp
    • Location
    • Sos
    • Function
  • cell growth
    • Function
    • Growth
    • Guanine
    • Proteins
    • E3
    • End
    • Mouse
    • Search
    • Domain
    • Gtp
    • Location
    • Protein
  • gene product
    • Factor
    • Domain
    • Location
    • Protein
    • Sos1
    • Chromosome
    • Human
    • Bp
    • Chr
    • Exchange
    • E3
    • End
  • bcr gene
    • Factor
    • Domain
    • Location
    • Protein
    • Sos1
    • Chromosome
    • Human
    • Bp
    • Chr
    • Exchange
    • E3
    • End
  • epidermal growth factor receptor
    • Gene
    • Search
    • Domain
    • Function
    • Growth
    • Location
    • Sos1
    • Chromosome
    • Guanine
    • Human
    • Nucleotide
    • Proteins
  • function
    • Cell
    • Search
    • Guanine
    • Growth
    • Location
    • Chromosome
    • Factor
    • Human
    • Nucleotide
    • Ras
    • Bp
    • Chr

Connections between topic areas Semantic bridges

For SOS1, one of the stronger structural bridges in this analysis connects SOS1 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
SOS1Interactions · splits 24 ⟂ 16
SOS1Function · splits 32 ⟂ 8
SOS1Inhibitors and activators · splits 33 ⟂ 7
SOS1Clinical significance · splits 35 ⟂ 5
SOS1Overview · splits 37 ⟂ 3

Map overview Semantic statistics

SOS1

Nodes40
Edges39
Triples148
Avg. degree1.95
Density0.05
Components1

Source & methodology

TTTA analyzes the structure around SOS1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Function & Inhibitors and activators, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — SOS1 · EN edition · Analysis: TopicsToTalkAbout

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