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SOS1

Son of sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene.

Interactions, Function & Inhibitors and activators

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Key facts & relationships

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Aliases
SOS1, GF1, GGF1, GINGF, HGF, NS4, SOS Ras/Rac guanine nucleotide exchange factor 1, SOS-1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1AWE, 1BKD, 1DBH, 1NVU, 1NVV, 1NVW, 1NVX, 1Q9C, 1XD2, 1XD4, 1XDV, 3KSY, 4NYI, 4NYJ, 4NYM, 4URU, 4URV, 4URW,…
Band
2p22.1 · 17 E3|17 50.67 cM
Bgee
epithelium of colon · jejunal mucosa · tendon of biceps brachii · trigeminal ganglion · spinal ganglia
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 17 (mouse)

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Overview

Function

Clinical significance

Inhibitors and activators

Interactions

Advanced semantic analysis

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Map overview Semantic statistics

SOS1

Nodes40
Edges39
Triples148
Avg. degree1.95
Density0.05
Components1

How this topic connects Entity context

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SOS1

Top relations

Gene ontology · 47
SOS1 → axon guidance, B cell homeostasis, blood vessel morphogenesis, cardiac atrium morphogenesis, cytokine-mediated signaling pathway, cytoplasm, cytosol, DNA binding, epidermal growth factor receptor signaling pathway, ERBB2 signaling pathway, eyelid development in camera-type eye, Fc-epsilon receptor signaling pathway, G protein-coupled receptor signaling pathway, GTPase activator activity, guanyl-nucleotide exchange factor activity, hair follicle development, heart morphogenesis, heart trabecula morphogenesis, insulin receptor signaling pathway, leukocyte migration
Bgee · 20
SOS1 → Achilles tendon, anterior horn of spinal cord, arcuate nucleus, corpus callosum, dorsomedial hypothalamic nucleus, epithelium of colon, facial motor nucleus, jejunal mucosa, lateral hypothalamus, mammillary body, median eminence, paraventricular nucleus of hypothalamus, pylorus, seminal vesicula, spinal ganglia, subcutaneous adipose tissue, tendon of biceps brachii, trigeminal ganglion, ventral tegmental area, ventromedial nucleus
RNA expression pattern · 20
SOS1 → Achilles tendon, anterior horn of spinal cord, arcuate nucleus, corpus callosum, dorsomedial hypothalamic nucleus, epithelium of colon, facial motor nucleus, jejunal mucosa, lateral hypothalamus, mammillary body, median eminence, paraventricular nucleus of hypothalamus, pylorus, seminal vesicula, spinal ganglia, subcutaneous adipose tissue, tendon of biceps brachii, trigeminal ganglion, ventral tegmental area, ventromedial nucleus
related to Interactions · 14
SOS1 → ABI1, BCR, CRK, Epidermal, EPS8, FRS2, Grb2, HRAS, ITSN1, MUC1, NCK1, PLCG1, PTPN11, SH3KBP1
related to Function · 13
SOS1 → Binding, Cdc25, GAPs, GDP, GEF, Genetic, GTP, GTPase-activating, In Drosophila, MIM, Ras, Sos, The
related to Inhibitors and activators · 6
SOS1 → BAY-293, BI-3406, Donated Chemical Probe, Fesik, Structural Genomics Consortium, VUBI1
related to Clinical significance · 5
SOS1 → KRAS, MAP, Noonan, PTPN11, Recent
Band · 2
SOS1 → 17 E3|17 50.67 cM, 2p22.1
Chr. · 2
SOS1 → Chromosome 17 (mouse), Chromosome 2 (human)
End · 2
SOS1 → 39,124,345 bp, 80,787,882 bp

Important terminology Word statistics

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Important terminology

ras gene bp chr human band exchange factor chromosome guanine cdc25 proteins protein nucleotide location function activators also mouse sos

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
SOS1AliasesSOS1, GF1, GGF1, GINGF, HGF, NS4, SOS Ras/Rac guanine nucleotide exchange factor 1, SOS-11.00infobox
SOS1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1AWE, 1BKD, 1DBH, 1NVU, 1NVV, 1NVW, 1NVX, 1Q9C, 1XD2, 1XD4, 1XDV, 3KSY, 4NYI, 4NYJ, 4NYM, 4URU, 4URV, 4URW,…1.00infobox
SOS1Band2p22.11.00infobox
SOS1Band17 E3|17 50.67 cM1.00infobox
SOS1Bgeeepithelium of colon1.00infobox
SOS1Bgeejejunal mucosa1.00infobox
SOS1Bgeetendon of biceps brachii1.00infobox
SOS1Bgeetrigeminal ganglion1.00infobox
SOS1Bgeespinal ganglia1.00infobox
SOS1BgeeAchilles tendon1.00infobox
SOS1Bgeeseminal vesicula1.00infobox
SOS1Bgeecorpus callosum1.00infobox
SOS1Bgeesubcutaneous adipose tissue1.00infobox
SOS1Bgeepylorus1.00infobox
SOS1Bgeedorsomedial hypothalamic nucleus1.00infobox
SOS1Bgeearcuate nucleus1.00infobox
SOS1Bgeeventromedial nucleus1.00infobox
SOS1Bgeeparaventricular nucleus of hypothalamus1.00infobox
SOS1Bgeefacial motor nucleus1.00infobox
SOS1Bgeelateral hypothalamus1.00infobox
SOS1Bgeeanterior horn of spinal cord1.00infobox
SOS1Bgeeventral tegmental area1.00infobox
SOS1Bgeemammillary body1.00infobox
SOS1Bgeemedian eminence1.00infobox
SOS1BioGPSMore reference expression data1.00infobox
SOS1Chr.Chromosome 2 (human)1.00infobox
SOS1Chr.Chromosome 17 (mouse)1.00infobox
SOS1DatabasesNCBI: entry; OMA: entry1.00infobox
SOS1End39,124,345 bp1.00infobox
SOS1End80,787,882 bp1.00infobox

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