VAV2

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Interactions

GEF RAC1 DH domain Dominant negative PH domain

8 related topics

Overview

Protein Gene

2 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: VAV2, VAV-2, vav guanine nucleotide exchange factor 2
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2DLZ, 2DM1, 2LNW, 2LNX, 4ROJ
Band: 9q34.2 · 2 A3|2 19.36 cM
Bgee: parotid gland · ganglionic eminence · ventricular zone · body of pancreas · right lobe of liver
BioGPS: More reference expression data
Chr.: Chromosome 9 (human) · Chromosome 2 (mouse)

Topics to explore

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Overview

Interactions

GEF Guanine nucleotide exchange factor
RAC1
DH domain RhoGEF domain
Dominant negative Dominance (genetics)
PH domain Pleckstrin homology domain
Interact Protein-protein interaction
CD19
Grb2

Advanced semantic analysis

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Map overview Semantic statistics

Nodes13

Edges12

Triples105

Avg. degree1.85

Density0.153846

Components1

How this topic connects Entity context

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VAV2

Top relations

Gene ontology · 27

VAV2 → angiogenesis, cell migration, cell projection assembly, cytoplasm, cytosol, ephrin receptor signaling pathway, epidermal growth factor receptor binding, Fc-epsilon receptor signaling pathway, Fc-gamma receptor signaling pathway involved in phagocytosis, G protein-coupled receptor signaling pathway, guanyl-nucleotide exchange factor activity, intracellular signal transduction, lamellipodium assembly, metal ion binding, phosphotyrosine residue binding, plasma membrane, platelet activation, positive regulation of apoptotic process, positive regulation of phosphatidylinositol 3-kinase activity, protein binding

Bgee · 19

VAV2 → body of pancreas, caput epididymis, conjunctival fornix, corpus epididymis, cumulus cell, ganglionic eminence, habenula, jejunal mucosa, left adrenal cortex, lumbar spinal ganglion, medullary collecting duct, mesenteric lymph nodes, molar, parotid gland, right adrenal cortex, right lobe of liver, seminal vesicula, seminiferous tubule, ventricular zone

RNA expression pattern · 19

related to Interactions · 10

VAV2 → CD19, Double DH, GEF, Grb2, L342R/L343SVav2, PH, RAC, RAC1, RAC1-dependent, VAV2 GEF

related to External links · 6

VAV2 → Guanine, Overview, P52735, PDB, PDBe-KB, UniProt

Band · 2

VAV2 → 2 A3|2 19.36 cM, 9q34.2

Chr. · 2

VAV2 → Chromosome 2 (mouse), Chromosome 9 (human)

End · 2

VAV2 → 133,992,604 bp, 27,317,045 bp

Aliases · 1

VAV2 → VAV2, VAV-2, vav guanine nucleotide exchange factor 2

Available structures · 1

VAV2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2DLZ, 2DM1, 2LNW, 2LNX, 4ROJ

Important terminology Word statistics

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Important terminology

bp chr human band factor gene exchange chromosome guanine nucleotide location protein mouse vav expressed external pdb uniprot p52735 search

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
VAV2	Aliases	VAV2, VAV-2, vav guanine nucleotide exchange factor 2	1.00	infobox
VAV2	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2DLZ, 2DM1, 2LNW, 2LNX, 4ROJ	1.00	infobox
VAV2	Band	9q34.2	1.00	infobox
VAV2	Band	2 A3\|2 19.36 cM	1.00	infobox
VAV2	Bgee	parotid gland	1.00	infobox
VAV2	Bgee	ganglionic eminence	1.00	infobox
VAV2	Bgee	ventricular zone	1.00	infobox
VAV2	Bgee	body of pancreas	1.00	infobox
VAV2	Bgee	right lobe of liver	1.00	infobox
VAV2	Bgee	caput epididymis	1.00	infobox
VAV2	Bgee	right adrenal cortex	1.00	infobox
VAV2	Bgee	corpus epididymis	1.00	infobox
VAV2	Bgee	left adrenal cortex	1.00	infobox
VAV2	Bgee	jejunal mucosa	1.00	infobox
VAV2	Bgee	habenula	1.00	infobox
VAV2	Bgee	mesenteric lymph nodes	1.00	infobox
VAV2	Bgee	lumbar spinal ganglion	1.00	infobox
VAV2	Bgee	medullary collecting duct	1.00	infobox
VAV2	Bgee	seminal vesicula	1.00	infobox
VAV2	Bgee	cumulus cell	1.00	infobox
VAV2	Bgee	seminiferous tubule	1.00	infobox
VAV2	Bgee	conjunctival fornix	1.00	infobox
VAV2	Bgee	molar	1.00	infobox
VAV2	BioGPS	More reference expression data	1.00	infobox
VAV2	Chr.	Chromosome 9 (human)	1.00	infobox
VAV2	Chr.	Chromosome 2 (mouse)	1.00	infobox
VAV2	Databases	NCBI: entry; OMA: entry	1.00	infobox
VAV2	End	133,992,604 bp	1.00	infobox
VAV2	End	27,317,045 bp	1.00	infobox
VAV2	Ensembl	ENSG00000160293	1.00	infobox

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