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ETV6

ETV6 (i.e. translocation-Ets-leukemia virus) protein is a transcription factor that in humans is encoded by the ETV6 (previously known as TEL) gene. The ETV6 protein regulates the development and growth of diverse cell types, particularly those of hematological tissues. However, its gene, ETV6 frequently suffers various mutations that lead to an array of…

Art, Medical significance & Protein

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Aliases
ETV6, TEL, TEL/ABL, THC5, ETS variant 6, ETS variant transcription factor 6
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1JI7, 1LKY, 2DAO, 2QAR, 2QB0, 2QB1
Band
12p13.2 · 6 G1|6 64.58 cM
Bgee
mucosa of paranasal sinus · parotid gland · lactiferous duct · olfactory zone of nasal mucosa · epithelium of nasopharynx
BioGPS
More reference expression data
Chr.
Chromosome 12 (human) · Chromosome 6 (mouse)

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Overview

Gene

Protein

Medical significance

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Map overview Semantic statistics

ETV6

Nodes123
Edges122
Triples144
Avg. degree1.98
Density0.01626
Components1

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ETV6

Top relations

Gene ontology · 24
ETV6 → cell differentiation, cytosol, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, hematopoietic stem cell proliferation, mesenchymal cell apoptotic process, negative regulation of transcription by RNA polymerase II, neurogenesis, nucleolus, nucleus, positive regulation of transcription by RNA polymerase II, protein binding, protein domain specific binding, regulation of transcription by RNA polymerase II, regulation of transcription, DNA-templated, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding
Bgee · 20
ETV6 → conjunctival fornix, cumulus cell, epithelium of nasopharynx, external carotid artery, genital tubercle, granulocyte, internal carotid artery, lacrimal gland, lactiferous duct, minor salivary glands, monocyte, mucosa of paranasal sinus, olfactory zone of nasal mucosa, parotid gland, saphenous vein, submandibular gland, tail of embryo, tibial arteries, tonsil, vestibular membrane of cochlear duct
RNA expression pattern · 20
ETV6 → conjunctival fornix, cumulus cell, epithelium of nasopharynx, external carotid artery, genital tubercle, granulocyte, internal carotid artery, lacrimal gland, lactiferous duct, minor salivary glands, monocyte, mucosa of paranasal sinus, olfactory zone of nasal mucosa, parotid gland, saphenous vein, submandibular gland, tail of embryo, tibial arteries, tonsil, vestibular membrane of cochlear duct
related to Inherited mutations · 15
ETV6 → Afflicted, Both, DNA, Duodenal, Fifteen, In, L249P, L349P, Myelodysplastic, N385fs, Rare, The, The L249P, Thrombocytopenia, Two
related to Protein · 12
ETV6 → C-terminal DNA-binding, Cellular, DNA, ETS, ETV6's, FLI1, GGAA/T-3, HTATIP, It, N-terminal, PNT, The
related to External links · 7
ETV6 → Drosophila, Medicine, Medicine Medical Subject Headings, MeSH, National Library, The Interactive Fly This, United States National Library
related to Acquired mutations · 4
ETV6 → It, The ETV6, These, This
related to Gene · 4
ETV6 → Gene, Mice, Other, The
related to Solid Tumors · 4
ETV6 → ETV6-NTRK3, In, Mutations, These
Band · 2
ETV6 → 12p13.2, 6 G1|6 64.58 cM

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Important terminology

gene protein mutations associated hematological genes fusion malignancies leukemia tyrosine kinase transcription factor cell may human acute types chromosome bp

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ETV6AliasesETV6, TEL, TEL/ABL, THC5, ETS variant 6, ETS variant transcription factor 61.00infobox
ETV6Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1JI7, 1LKY, 2DAO, 2QAR, 2QB0, 2QB11.00infobox
ETV6Band12p13.21.00infobox
ETV6Band6 G1|6 64.58 cM1.00infobox
ETV6Bgeemucosa of paranasal sinus1.00infobox
ETV6Bgeeparotid gland1.00infobox
ETV6Bgeelactiferous duct1.00infobox
ETV6Bgeeolfactory zone of nasal mucosa1.00infobox
ETV6Bgeeepithelium of nasopharynx1.00infobox
ETV6Bgeesaphenous vein1.00infobox
ETV6Bgeemonocyte1.00infobox
ETV6Bgeetibial arteries1.00infobox
ETV6Bgeeminor salivary glands1.00infobox
ETV6Bgeetonsil1.00infobox
ETV6Bgeetail of embryo1.00infobox
ETV6Bgeegenital tubercle1.00infobox
ETV6Bgeelacrimal gland1.00infobox
ETV6Bgeecumulus cell1.00infobox
ETV6Bgeevestibular membrane of cochlear duct1.00infobox
ETV6Bgeeinternal carotid artery1.00infobox
ETV6Bgeeexternal carotid artery1.00infobox
ETV6Bgeeconjunctival fornix1.00infobox
ETV6Bgeegranulocyte1.00infobox
ETV6Bgeesubmandibular gland1.00infobox
ETV6BioGPSMore reference expression data1.00infobox
ETV6Chr.Chromosome 12 (human)1.00infobox
ETV6Chr.Chromosome 6 (mouse)1.00infobox
ETV6DatabasesNCBI: entry; OMA: entry1.00infobox
ETV6End11,895,377 bp1.00infobox
ETV6End134,247,121 bp1.00infobox

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