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ETV6: Art, Medical significance & Protein

ETV6 (i.e. translocation-Ets-leukemia virus) protein is a transcription factor that in humans is encoded by the ETV6 (previously known as TEL) gene. The ETV6 protein regulates the development and growth of diverse cell types, particularly those of hematological tissues. However, its gene, ETV6 frequently suffers various mutations that lead to an array of…

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ETV6 topic overview

The analysis highlights Art, Medical significance and Protein as prominent areas in the source structure around ETV6.

Related topics
118
Source areas
4
Connected nodes
122
Extracted relationships
144
Concept neighborhoods
27
Bridge connections
122

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 62 topics
Medical significance · 30 topics
Protein · 16 topics
Gene · 10 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
ETV6, TEL, TEL/ABL, THC5, ETS variant 6, ETS variant transcription factor 6
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1JI7, 1LKY, 2DAO, 2QAR, 2QB0, 2QB1
Band
12p13.2 · 6 G1|6 64.58 cM
Bgee
mucosa of paranasal sinus · parotid gland · lactiferous duct · olfactory zone of nasal mucosa · epithelium of nasopharynx
BioGPS
More reference expression data
Chr.
Chromosome 12 (human) · Chromosome 6 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Gene

Protein

Medical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How ETV6 connects Entity context

The extracted context around ETV6 shows recurring relationship patterns in the source. For example, ETV6 → cell differentiation, cytosol, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, hematopoietic stem cell proliferation, mesenchymal cell apoptotic process, negative regulation of transcription by RNA polymerase II, neurogenesis, nucleolus, nucleus, positive regulation of transcription by RNA polymerase II, protein binding, protein domain specific binding, regulation of transcription by RNA polymerase II, regulation of transcription, DNA-templated, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding Another extracted example is ETV6 → conjunctival fornix, cumulus cell, epithelium of nasopharynx, external carotid artery, genital tubercle, granulocyte, internal carotid artery, lacrimal gland, lactiferous duct, minor salivary glands, monocyte, mucosa of paranasal sinus, olfactory zone of nasal mucosa, parotid gland, saphenous vein, submandibular gland, tail of embryo, tibial arteries, tonsil, vestibular membrane of cochlear duct. Use these groups to spot repeated connection types before inspecting the individual relationships.

ETV6

Top relations

Gene ontology · 24
ETV6 → cell differentiation, cytosol, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, hematopoietic stem cell proliferation, mesenchymal cell apoptotic process, negative regulation of transcription by RNA polymerase II, neurogenesis, nucleolus, nucleus, positive regulation of transcription by RNA polymerase II, protein binding, protein domain specific binding, regulation of transcription by RNA polymerase II, regulation of transcription, DNA-templated, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding
Bgee · 20
ETV6 → conjunctival fornix, cumulus cell, epithelium of nasopharynx, external carotid artery, genital tubercle, granulocyte, internal carotid artery, lacrimal gland, lactiferous duct, minor salivary glands, monocyte, mucosa of paranasal sinus, olfactory zone of nasal mucosa, parotid gland, saphenous vein, submandibular gland, tail of embryo, tibial arteries, tonsil, vestibular membrane of cochlear duct
RNA expression pattern · 20
ETV6 → conjunctival fornix, cumulus cell, epithelium of nasopharynx, external carotid artery, genital tubercle, granulocyte, internal carotid artery, lacrimal gland, lactiferous duct, minor salivary glands, monocyte, mucosa of paranasal sinus, olfactory zone of nasal mucosa, parotid gland, saphenous vein, submandibular gland, tail of embryo, tibial arteries, tonsil, vestibular membrane of cochlear duct
related to Inherited mutations · 15
ETV6 → Afflicted, Both, DNA, Duodenal, Fifteen, In, L249P, L349P, Myelodysplastic, N385fs, Rare, The, The L249P, Thrombocytopenia, Two
related to Protein · 12
ETV6 → C-terminal DNA-binding, Cellular, DNA, ETS, ETV6's, FLI1, GGAA/T-3, HTATIP, It, N-terminal, PNT, The
related to External links · 7
ETV6 → Drosophila, Medicine, Medicine Medical Subject Headings, MeSH, National Library, The Interactive Fly This, United States National Library
related to Acquired mutations · 4
ETV6 → It, The ETV6, These, This
related to Gene · 4
ETV6 → Gene, Mice, Other, The
related to Solid Tumors · 4
ETV6 → ETV6-NTRK3, In, Mutations, These
Band · 2
ETV6 → 12p13.2, 6 G1|6 64.58 cM

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene protein mutations associated hematological genes fusion malignancies leukemia tyrosine kinase transcription factor cell may human acute types chromosome bp

ETV6 relationships Subject–Predicate–Object triples

TTTA extracted 144 structured relationships around ETV6. Examples in this analysis include ETV6 → Aliases → ETV6, TEL, TEL/ABL, THC5, ETS variant 6, ETS variant transcription factor 6 and ETV6 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1JI7, 1LKY, 2DAO, 2QAR, 2QB0, 2QB1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
ETV6AliasesETV6, TEL, TEL/ABL, THC5, ETS variant 6, ETS variant transcription factor 61.00infobox
ETV6Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1JI7, 1LKY, 2DAO, 2QAR, 2QB0, 2QB11.00infobox
ETV6Band12p13.21.00infobox
ETV6Band6 G1|6 64.58 cM1.00infobox
ETV6Bgeemucosa of paranasal sinus1.00infobox
ETV6Bgeeparotid gland1.00infobox
ETV6Bgeelactiferous duct1.00infobox
ETV6Bgeeolfactory zone of nasal mucosa1.00infobox
ETV6Bgeeepithelium of nasopharynx1.00infobox
ETV6Bgeesaphenous vein1.00infobox
ETV6Bgeemonocyte1.00infobox
ETV6Bgeetibial arteries1.00infobox
ETV6Bgeeminor salivary glands1.00infobox
ETV6Bgeetonsil1.00infobox
ETV6Bgeetail of embryo1.00infobox
ETV6Bgeegenital tubercle1.00infobox
ETV6Bgeelacrimal gland1.00infobox
ETV6Bgeecumulus cell1.00infobox
ETV6Bgeevestibular membrane of cochlear duct1.00infobox
ETV6Bgeeinternal carotid artery1.00infobox
ETV6Bgeeexternal carotid artery1.00infobox
ETV6Bgeeconjunctival fornix1.00infobox
ETV6Bgeegranulocyte1.00infobox
ETV6Bgeesubmandibular gland1.00infobox
ETV6BioGPSMore reference expression data1.00infobox
ETV6Chr.Chromosome 12 (human)1.00infobox
ETV6Chr.Chromosome 6 (mouse)1.00infobox
ETV6DatabasesNCBI: entry; OMA: entry1.00infobox
ETV6End11,895,377 bp1.00infobox
ETV6End134,247,121 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around ETV6 bring nearby vocabulary together. In this analysis, examples include Gene, Protein and Mutations. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • ETV6
    • Gene
    • Protein
    • Mutations
    • Genes
    • Factor
    • Transcription
    • Cell
    • Hematological
    • Associated
    • Malignancies
    • Activity
    • Fusion
  • etv6
    • Gene
    • Protein
    • Mutations
    • Genes
    • Factor
    • Transcription
    • Cell
    • Hematological
    • Associated
    • Malignancies
    • Activity
    • Fusion
  • transcription factor
    • Transcription
    • Protein
    • Activity
    • Chromosome
    • Human
    • Gene
    • Chr
    • Bp
    • Family
    • Target
    • Genes
    • Cell
  • gene
    • Mutations
    • Protein
    • Fusion
    • Associated
    • Transcription
    • Kinase
    • Malignancies
    • Tyrosine
    • Genes
    • Cell
    • May
    • Hematological
  • hematological
    • Malignancies
    • Types
    • Lead
    • Thrombocytopenia
    • Solid
    • Associated
    • May
    • Genes
    • Mutations
    • Cells
    • Tumors
    • Also
  • tumor suppressor gene
    • Mutations
    • Protein
    • Fusion
    • Associated
    • Transcription
    • Kinase
    • Malignancies
    • Tyrosine
    • Genes
    • Cell
    • May
    • Hematological
  • hematological malignancies
    • May
    • Malignancies
    • Treating
    • Types
    • Kinase
    • Tyrosine
    • Fusion
    • Inhibitors
    • Lead
    • Tumors
    • Solid
    • Thrombocytopenia
  • acute lymphoblastic leukemia
    • Lymphoblastic
    • Acute
    • Leukemia
    • Thrombocytopenia
    • Associated
    • Mutations
    • Cell
    • Kinase
    • Tyrosine
    • Two
    • Protein
    • Cancers

Connections between topic areas Semantic bridges

For ETV6, one of the stronger structural bridges in this analysis connects ETV6 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
ETV6Overview · splits 60 ⟂ 63
ETV6Medical significance · splits 92 ⟂ 31
ETV6Protein · splits 106 ⟂ 17
ETV6Gene · splits 112 ⟂ 11

Map overview Semantic statistics

ETV6

Nodes123
Edges122
Triples144
Avg. degree1.98
Density0.01626
Components1

Source & methodology

TTTA analyzes the structure around ETV6 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Medical significance & Protein, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — ETV6 · EN edition · Analysis: TopicsToTalkAbout

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