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HER2

Receptor tyrosine-protein kinase erbB-2 is a protein that normally resides in the membranes of cells and is encoded by the ERBB2 gene. ERBB is abbreviated from erythroblastic oncogene B, a gene originally isolated from the avian genome. The human protein is also frequently referred to as HER2 (human epidermal growth factor receptor 2) or CD340 (cluster…

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2.7.10.1
↗
Aliases
ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1, erb-b2 receptor tyrosine kinase 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MFG, 1MFL, 1MW4, 1N8Z, 1QR1, 1S78, 2A91, 2JWA, 2KS1, 2L4K, 3BE1, 3H3B, 3N85, 3PP0, 3RCD, 3MZW, 3WLW, 3WSQ,…
Band
17q12 · 11 61.75 cM|11 D
Bgee
right uterine tube · sural nerve · skin of leg · skin of abdomen · renal medulla
BioGPS
More reference expression data

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As a drug target

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HER2

Nodes79
Edges78
Triples233
Avg. degree1.97
Density0.025316
Components1

How this topic connects Entity context

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HER2

Top relations

Gene ontology · 86
HER2 → apical plasma membrane, ATP binding, basal plasma membrane, basolateral plasma membrane, cell differentiation, cell population proliferation, cell surface receptor signaling pathway, cellular response to epidermal growth factor stimulus, cellular response to growth factor stimulus, cytoplasm, cytoplasmic vesicle, cytosol, development of the heart, endosome membrane, enzyme linked receptor protein signaling pathway, ErbB-3 class receptor binding, ERBB2 signaling pathway, growth factor binding, identical protein binding, integral component of membrane
Bgee · 20
HER2 → colon, crypt of lieberkuhn of small intestine, esophagus, Eustachian tube, intestinal villus, left colon, left lobe of thyroid gland, lip, middle ear, minor salivary glands, mucosa of transverse colon, olfactory zone of nasal mucosa, oral mucosa, renal medulla, right kidney, right lobe of thyroid gland, right uterine tube, skin of abdomen, skin of leg, sural nerve
RNA expression pattern · 20
HER2 → colon, crypt of lieberkuhn of small intestine, esophagus, Eustachian tube, intestinal villus, left colon, left lobe of thyroid gland, lip, middle ear, minor salivary glands, mucosa of transverse colon, olfactory zone of nasal mucosa, oral mucosa, renal medulla, right kidney, right lobe of thyroid gland, right uterine tube, skin of abdomen, skin of leg, sural nerve
related to External links · 18
HER2 → AACR Cancer Concepts Factsheet, Breast Cancer Patients, HER2 Positive WomenHerceptinR, HER2Breast Friends, Herceptin Resistance Database, Human Receptor, Life Network, Medicine Medical Subject Headings, MeSH, National Library, PDB, PDBe-KB, Rep, Resistance, Sci, South African Breast Cancer, Support Forum, Understanding Mechanism
related to As a drug target · 11
HER2 → An, Another, FDA, HER2-positive, HER3, Herceptin, June, One, Pertuzumab, Randomized, Trastuzumab
related to Fluorescence in situ hybridisation · 11
HER2 → Cells, CEP17, FISH, Hence, HER2/CEP17, It, One, Overlapping, The, This, Two
related to Cancer · 7
HER2 → Amplification, ERBB2, GRB7, HER2-positive, Over-expression, The, The ERBB2
related to Name · 7
HER2 → EGFR, ErbB, ErbB-2, HER1, Molecular, Neu, The Neu
related to Function · 6
HER2 → All, Dimerisation, ErbB, Notably, One, The ErbB
related to Serum · 5
HER2 → ELISA, However, Measurement, Results, The

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Important terminology

cancer receptor erbb trastuzumab breast human gene protein also kinase chromosome 17 bp erbb2 cell growth cells patients epidermal factor

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
HER22.7.10.1↗1.00infobox
HER2AliasesERBB2, CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1, erb-b2 receptor tyrosine kinase 21.00infobox
HER2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MFG, 1MFL, 1MW4, 1N8Z, 1QR1, 1S78, 2A91, 2JWA, 2KS1, 2L4K, 3BE1, 3H3B, 3N85, 3PP0, 3RCD, 3MZW, 3WLW, 3WSQ,…1.00infobox
HER2Band17q121.00infobox
HER2Band11 61.75 cM|11 D1.00infobox
HER2Bgeeright uterine tube1.00infobox
HER2Bgeesural nerve1.00infobox
HER2Bgeeskin of leg1.00infobox
HER2Bgeeskin of abdomen1.00infobox
HER2Bgeerenal medulla1.00infobox
HER2Bgeeminor salivary glands1.00infobox
HER2Bgeeright lobe of thyroid gland1.00infobox
HER2Bgeeolfactory zone of nasal mucosa1.00infobox
HER2Bgeemucosa of transverse colon1.00infobox
HER2Bgeeleft lobe of thyroid gland1.00infobox
HER2Bgeelip1.00infobox
HER2Bgeeintestinal villus1.00infobox
HER2Bgeemiddle ear1.00infobox
HER2BgeeEustachian tube1.00infobox
HER2Bgeeoral mucosa1.00infobox
HER2Bgeeesophagus1.00infobox
HER2Bgeecolon1.00infobox
HER2Bgeecrypt of lieberkuhn of small intestine1.00infobox
HER2Bgeeright kidney1.00infobox
HER2Bgeeleft colon1.00infobox
HER2BioGPSMore reference expression data1.00infobox
HER2Chr.Chromosome 17 (human)1.00infobox
HER2Chr.Chromosome 11 (mouse)1.00infobox
HER2DatabasesNCBI: entry; OMA: entry1.00infobox
HER2End39,730,426 bp1.00infobox

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