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KIT gene

Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117) or mast/stem cell growth factor receptor (SCFR). Multiple transcript variants encoding different isoforms have been found for this gene. KIT was first described by the German biochemist Axel Ullrich…

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2.7.10.1
Aliases
KIT, C-Kit, CD117, PBT, SCFR, KIT proto-oncogene receptor tyrosine kinase, MASTC, KIT proto-oncogene, receptor tyrosine kinase
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4U0I, 1PKG, 1T45, 1T46, 2E9W, 2EC8, 2VIF, 3G0E, 3G0F, 4HVS, 4K94, 4K9E, 4PGZ, 2IUH
Band
4q12 · 5 C3.3|5 39.55 cM
Bgee
lateral nuclear group of thalamus · secondary oocyte · skin of thigh · epithelium of lactiferous gland · gonad
BioGPS
n/a

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Function

Structure

Cell surface marker

Mobilization

Role in cancer

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KIT gene

Nodes89
Edges88
Triples197
Avg. degree1.98
Density0.022472
Components1

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KIT gene

Top relations

Gene ontology · 118
KIT gene → acrosomal vesicle, actin cytoskeleton reorganization, ATP binding, B cell differentiation, cell chemotaxis, cell differentiation, cell surface, cell-cell junction, cellular response to thyroid hormone stimulus, cytokine binding, cytokine-mediated signaling pathway, cytoplasm, cytoplasmic side of plasma membrane, dendritic cell cytokine production, detection of mechanical stimulus involved in sensory perception of sound, developmental pigmentation, digestive tract development, ectopic germ cell programmed cell death, embryonic hemopoiesis, epithelial cell proliferation
Bgee · 19
KIT gene → cardia, cerebellar vermis, decidua, dermis, epithelium of lactiferous gland, gastrula, gonad, lactiferous duct, lateral nuclear group of thalamus, liver parenchyma, lobe of cerebellum, muscle layer of urethra, parotid gland, primary oocyte, secondary oocyte, skin of hip, skin of thigh, visceral pleura, zygote
RNA expression pattern · 19
KIT gene → cardia, cerebellar vermis, decidua, dermis, epithelium of lactiferous gland, gastrula, gonad, lactiferous duct, lateral nuclear group of thalamus, liver parenchyma, lobe of cerebellum, muscle layer of urethra, parotid gland, primary oocyte, secondary oocyte, skin of hip, skin of thigh, visceral pleura, zygote
related to External links · 10
KIT gene → C-kit, Cancer TermsHuman KIT, KIT, Medicine Medical Subject Headings, MeSH, National Library, NCI Dictionary, Proteins, Proto-Oncogene, UCSC Genome Browser
Band · 2
KIT gene → 4q12, 5 C3.3|5 39.55 cM
Chr. · 2
KIT gene → Chromosome 4 (human), Chromosome 5 (mouse)
End · 2
KIT gene → 54,740,715 bp, 75,817,382 bp
2.7.10.1 · 1
KIT gene → ↗
Aliases · 1
KIT gene → KIT, C-Kit, CD117, PBT, SCFR, KIT proto-oncogene receptor tyrosine kinase, MASTC, KIT proto-oncogene, receptor tyrosine kinase
Available structures · 1
KIT gene → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4U0I, 1PKG, 1T45, 1T46, 2E9W, 2EC8, 2VIF, 3G0E, 3G0F, 4HVS, 4K94, 4K9E, 4PGZ, 2IUH

Important terminology Word statistics

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Important terminology

kit cell c-kit receptor cells stem gene also hematopoietic used cancer kinase bp mast human tyrosine mobilization signaling chr band

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
KIT gene2.7.10.11.00infobox
KIT geneAliasesKIT, C-Kit, CD117, PBT, SCFR, KIT proto-oncogene receptor tyrosine kinase, MASTC, KIT proto-oncogene, receptor tyrosine kinase1.00infobox
KIT geneAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4U0I, 1PKG, 1T45, 1T46, 2E9W, 2EC8, 2VIF, 3G0E, 3G0F, 4HVS, 4K94, 4K9E, 4PGZ, 2IUH1.00infobox
KIT geneBand4q121.00infobox
KIT geneBand5 C3.3|5 39.55 cM1.00infobox
KIT geneBgeelateral nuclear group of thalamus1.00infobox
KIT geneBgeesecondary oocyte1.00infobox
KIT geneBgeeskin of thigh1.00infobox
KIT geneBgeeepithelium of lactiferous gland1.00infobox
KIT geneBgeegonad1.00infobox
KIT geneBgeelactiferous duct1.00infobox
KIT geneBgeecardia1.00infobox
KIT geneBgeeparotid gland1.00infobox
KIT geneBgeeskin of hip1.00infobox
KIT geneBgeevisceral pleura1.00infobox
KIT geneBgeelobe of cerebellum1.00infobox
KIT geneBgeecerebellar vermis1.00infobox
KIT geneBgeeprimary oocyte1.00infobox
KIT geneBgeezygote1.00infobox
KIT geneBgeegastrula1.00infobox
KIT geneBgeedermis1.00infobox
KIT geneBgeeliver parenchyma1.00infobox
KIT geneBgeemuscle layer of urethra1.00infobox
KIT geneBgeedecidua1.00infobox
KIT geneBioGPSn/a1.00infobox
KIT geneChr.Chromosome 4 (human)1.00infobox
KIT geneChr.Chromosome 5 (mouse)1.00infobox
KIT geneDatabasesNCBI: entry; OMA: entry1.00infobox
KIT geneEnd54,740,715 bp1.00infobox
KIT geneEnd75,817,382 bp1.00infobox

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