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PIK3R1: Measurement, Interactions & Function

Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme that in humans is encoded by the PIK3R1 gene.

Language: English [EN]
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PIK3R1 topic overview

The analysis highlights Measurement, Interactions and Function as prominent areas in the source structure around PIK3R1.

Related topics
44
Source areas
4
Connected nodes
48
Extracted relationships
184
Concept neighborhoods
10
Bridge connections
48

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 33 topics
Function · 7 topics
Clinical significance · 2 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
PIK3R1, AGM7, GRB1, IMD36, p85, p85-ALPHA, phosphoinositide-3-kinase regulatory subunit 1, PI3KR1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A0N, 1AZG, 1H9O, 1PBW, 1PHT, 1PIC, 1PKS, 1PKT, 2IUG, 2IUH, 2IUI, 2RD0, 2V1Y, 3HHM, 3HIZ, 3I5R, 3I5S, 4A55,…
Band
5q13.1 · 13 D1|13 53.92 cM
Bgee
Achilles tendon · caput epididymis · corpus epididymis · postcentral gyrus · lactiferous duct
BioGPS
More reference expression data
Chr.
Chromosome 5 (human) · Chromosome 13 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PIK3R1 connects Entity context

The extracted context around PIK3R1 shows recurring relationship patterns in the source. For example, PIK3R1 → 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-3-kinase regulator activity, axon guidance, B cell differentiation, cell-cell junction, cellular glucose homeostasis, cellular response to insulin stimulus, cellular response to UV, cis-Golgi network, cytokine-mediated signaling pathway, cytoplasm, cytosol, epidermal growth factor receptor signaling pathway, ErbB-3 class receptor binding, ERBB2 signaling pathway, extrinsic apoptotic signaling pathway via death domain receptors, Fc-epsilon receptor signaling pathway, Fc-gamma receptor signaling pathway involved in phagocytosis, G protein-coupled receptor signaling pathway, growth hormone receptor signaling pathway Another extracted example is PIK3R1 → ADAM12, BCAR1, CBL, CBLB, CD117, CD28, CD7, CENTG1, EPHA2, EPOR, ERBB3, EZR, FCGR2A, GAB1, GAB2, Grb2, HRAS, IL1R1, IRS1IRS2, JAK2. Use these groups to spot repeated connection types before inspecting the individual relationships.

PIK3R1

Top relations

Gene ontology · 82
PIK3R1 → 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-3-kinase regulator activity, axon guidance, B cell differentiation, cell-cell junction, cellular glucose homeostasis, cellular response to insulin stimulus, cellular response to UV, cis-Golgi network, cytokine-mediated signaling pathway, cytoplasm, cytosol, epidermal growth factor receptor signaling pathway, ErbB-3 class receptor binding, ERBB2 signaling pathway, extrinsic apoptotic signaling pathway via death domain receptors, Fc-epsilon receptor signaling pathway, Fc-gamma receptor signaling pathway involved in phagocytosis, G protein-coupled receptor signaling pathway, growth hormone receptor signaling pathway
related to Interactions · 30
PIK3R1 → ADAM12, BCAR1, CBL, CBLB, CD117, CD28, CD7, CENTG1, EPHA2, EPOR, ERBB3, EZR, FCGR2A, GAB1, GAB2, Grb2, HRAS, IL1R1, IRS1IRS2, JAK2
Bgee · 20
PIK3R1 → Achilles tendon, aortic valve, caput epididymis, corpus epididymis, cumulus cell, external globus pallidus, genital tubercle, intercostal muscle, lacrimal gland, lactiferous duct, middle temporal gyrus, molar, parotid gland, postcentral gyrus, Rostral migratory stream, skin of external ear, stroma of bone marrow, superior frontal gyrus, tail of epididymis, trigeminal ganglion
RNA expression pattern · 20
PIK3R1 → Achilles tendon, aortic valve, caput epididymis, corpus epididymis, cumulus cell, external globus pallidus, genital tubercle, intercostal muscle, lacrimal gland, lactiferous duct, middle temporal gyrus, molar, parotid gland, postcentral gyrus, Rostral migratory stream, skin of external ear, stroma of bone marrow, superior frontal gyrus, tail of epididymis, trigeminal ganglion
related to Function · 7
PIK3R1 → In, It, ITGB1, Phosphatidylinositol, Suppression, The, The Pik3r1
Band · 2
PIK3R1 → 13 D1|13 53.92 cM, 5q13.1
Chr. · 2
PIK3R1 → Chromosome 13 (mouse), Chromosome 5 (human)
End · 2
PIK3R1 → 101,904,725 bp, 68,301,821 bp
related to Clinical significance · 2
PIK3R1 → Mutations, SHORT
Aliases · 1
PIK3R1 → PIK3R1, AGM7, GRB1, IMD36, p85, p85-ALPHA, phosphoinositide-3-kinase regulatory subunit 1, PI3KR1

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene bp subunit chr human band regulatory phosphatidylinositol chromosome 3-kinase location mouse enzyme function 55 external search 301 821 end

PIK3R1 relationships Subject–Predicate–Object triples

TTTA extracted 184 structured relationships around PIK3R1. Examples in this analysis include PIK3R1 → Aliases → PIK3R1, AGM7, GRB1, IMD36, p85, p85-ALPHA, phosphoinositide-3-kinase regulatory subunit 1, PI3KR1 and PIK3R1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A0N, 1AZG, 1H9O, 1PBW, 1PHT, 1PIC, 1PKS, 1PKT, 2IUG, 2IUH, 2IUI, 2RD0, 2V1Y, 3HHM, 3HIZ, 3I5R, 3I5S, 4A55,…. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PIK3R1AliasesPIK3R1, AGM7, GRB1, IMD36, p85, p85-ALPHA, phosphoinositide-3-kinase regulatory subunit 1, PI3KR11.00infobox
PIK3R1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A0N, 1AZG, 1H9O, 1PBW, 1PHT, 1PIC, 1PKS, 1PKT, 2IUG, 2IUH, 2IUI, 2RD0, 2V1Y, 3HHM, 3HIZ, 3I5R, 3I5S, 4A55,…1.00infobox
PIK3R1Band5q13.11.00infobox
PIK3R1Band13 D1|13 53.92 cM1.00infobox
PIK3R1BgeeAchilles tendon1.00infobox
PIK3R1Bgeecaput epididymis1.00infobox
PIK3R1Bgeecorpus epididymis1.00infobox
PIK3R1Bgeepostcentral gyrus1.00infobox
PIK3R1Bgeelactiferous duct1.00infobox
PIK3R1Bgeetail of epididymis1.00infobox
PIK3R1Bgeetrigeminal ganglion1.00infobox
PIK3R1Bgeemiddle temporal gyrus1.00infobox
PIK3R1Bgeesuperior frontal gyrus1.00infobox
PIK3R1Bgeeexternal globus pallidus1.00infobox
PIK3R1Bgeelacrimal gland1.00infobox
PIK3R1Bgeemolar1.00infobox
PIK3R1Bgeeparotid gland1.00infobox
PIK3R1Bgeeintercostal muscle1.00infobox
PIK3R1BgeeRostral migratory stream1.00infobox
PIK3R1Bgeestroma of bone marrow1.00infobox
PIK3R1Bgeecumulus cell1.00infobox
PIK3R1Bgeegenital tubercle1.00infobox
PIK3R1Bgeeaortic valve1.00infobox
PIK3R1Bgeeskin of external ear1.00infobox
PIK3R1BioGPSMore reference expression data1.00infobox
PIK3R1Chr.Chromosome 5 (human)1.00infobox
PIK3R1Chr.Chromosome 13 (mouse)1.00infobox
PIK3R1DatabasesNCBI: entry; OMA: entry1.00infobox
PIK3R1End68,301,821 bp1.00infobox
PIK3R1End101,904,725 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around PIK3R1 bring nearby vocabulary together. In this analysis, examples include Regulatory, Subunit and External. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • PIK3R1
    • Regulatory
    • Subunit
    • External
    • Function
    • Locus
    • Mutations
    • Search
    • Shown
    • Subunits
    • Location
    • Chromosome
    • Human
  • pik3r1
    • Regulatory
    • Subunit
    • External
    • Function
    • Locus
    • Mutations
    • Search
    • Shown
    • Subunits
    • Location
    • Chromosome
    • Human
  • gene
    • Pik3r1
    • Regulatory
    • Subunit
    • Location
    • Phosphatidylinositol
    • Chromosome
    • Human
    • Bp
    • Chr
    • D1
    • End
    • External
  • phosphatidylinositol 3-kinase
    • Phosphatidylinositol
    • Insulin
    • Gene
    • Regulatory
    • Subunit
    • Adhesion
    • Associated
    • Cell-cell
    • D1
    • End
    • Enzyme
    • External
  • phosphatidylinositol
    • Insulin
    • Gene
    • Regulatory
    • Subunit
    • Adhesion
    • Associated
    • Cell-cell
    • D1
    • End
    • Enzyme
    • External
    • Function
  • function
    • External
    • Search
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Regulatory
    • Adhesion
    • Cell-cell
    • D1
    • End
  • insulin
    • Phosphatidylinositol
    • Associated
    • Mouse
    • Search
    • Splicing
    • Location
    • Regulatory
    • Subunit
    • Pik3r1
  • insulin resistance
    • Phosphatidylinositol
    • Associated
    • Mouse
    • Search
    • Splicing
    • Location
    • Regulatory
    • Subunit
    • Pik3r1

Connections between topic areas Semantic bridges

For PIK3R1, one of the stronger structural bridges in this analysis connects PIK3R1 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PIK3R1Interactions · splits 15 ⟂ 34
PIK3R1Function · splits 41 ⟂ 8
PIK3R1Overview · splits 46 ⟂ 3
PIK3R1Clinical significance · splits 46 ⟂ 3

Map overview Semantic statistics

PIK3R1

Nodes49
Edges48
Triples184
Avg. degree1.96
Density0.040816
Components1

Source & methodology

TTTA analyzes the structure around PIK3R1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Interactions & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PIK3R1 · EN edition · Analysis: TopicsToTalkAbout

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