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Dedicator of cytokinesis protein 1

Dedicator of cytokinesis protein 1 (Dock1), also (DOCK180), is a large (~180 kDa) protein encoded in the human by the DOCK1 gene, involved in intracellular signalling networks. It is the mammalian ortholog of the C. elegans protein CED-5 and belongs to the DOCK family of guanine nucleotide exchange factors (GEFs).

Structure and function, Regulation of DOCK180 Activity & Signalling Downstream of DOCK180

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Structure and function

17 related topics

Regulation of DOCK180 Activity

16 related topics

Signalling Downstream of DOCK180

13 related topics

Discovery

7 related topics

Key facts & relationships

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Aliases
DOCK1, DOCK180, ced5, Dock180, dedicator of cytokinesis 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3L4C
Band
10q26.2 · 7|7 F3
Bgee
corpus callosum · internal globus pallidus · olfactory bulb · stromal cell of endometrium · sural nerve
BioGPS
n/a
Chr.
Chromosome 10 (human) · Chromosome 7 (mouse)

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Overview

Discovery

Structure and function

Regulation of DOCK180 Activity

Signalling Downstream of DOCK180

Interactions

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Map overview Semantic statistics

Dedicator of cytokinesis protein 1

Nodes70
Edges69
Triples99
Avg. degree1.97
Density0.028571
Components1

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Dedicator of cytokinesis protein 1

Top relations

Gene ontology · 24
Dedicator of cytokinesis protein 1 → apoptotic process, blood coagulation, cell migration, cytoplasm, cytoskeleton organization, cytosol, Fc-gamma receptor signaling pathway involved in phagocytosis, GTPase activator activity, guanyl-nucleotide exchange factor activity, guanyl-nucleotide exchange factor complex, integrin-mediated signaling pathway, membrane, nuclear speck, nucleus, phagocytosis, phagocytosis, engulfment, positive regulation of epithelial cell migration, positive regulation of GTPase activity, positive regulation of substrate adhesion-dependent cell spreading, protein binding
Bgee · 20
Dedicator of cytokinesis protein 1 → Achilles tendon, adrenal gland, amygdala, C1 segment, corpus callosum, endothelial cell of lymphatic vessel, inferior ganglion of vagus nerve, internal globus pallidus, mandibular prominence, maxillary prominence, molar, olfactory bulb, Paneth cell, stria vascularis, stromal cell of endometrium, subthalamic nucleus, sural nerve, ureter, vas deferens, vestibular membrane of cochlear duct
RNA expression pattern · 20
Dedicator of cytokinesis protein 1 → Achilles tendon, adrenal gland, amygdala, C1 segment, corpus callosum, endothelial cell of lymphatic vessel, inferior ganglion of vagus nerve, internal globus pallidus, mandibular prominence, maxillary prominence, molar, olfactory bulb, Paneth cell, stria vascularis, stromal cell of endometrium, subthalamic nucleus, sural nerve, ureter, vas deferens, vestibular membrane of cochlear duct
related to External links · 12
Dedicator of cytokinesis protein 1 → Cell Migration Gateway Archived, Dedicator, DOCK1, DOCK180 Info, Medicine Medical Subject Headings, MeSH, National Library, PDB, PDBe-KB, Q14185, UniProt, Wayback MachineOverview
Band · 2
Dedicator of cytokinesis protein 1 → 10q26.2, 7|7 F3
Chr. · 2
Dedicator of cytokinesis protein 1 → Chromosome 10 (human), Chromosome 7 (mouse)
End · 2
Dedicator of cytokinesis protein 1 → 127,452,517 bp, 134,775,368 bp
Aliases · 1
Dedicator of cytokinesis protein 1 → DOCK1, DOCK180, ced5, Dock180, dedicator of cytokinesis 1
Available structures · 1
Dedicator of cytokinesis protein 1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3L4C
BioGPS · 1
Dedicator of cytokinesis protein 1 → n/a

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Important terminology

dock180 protein human bp chr band proteins signalling dock1 exchange gene chromosome 10 domain binding small involved crk elmo activity

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Dedicator of cytokinesis protein 1AliasesDOCK1, DOCK180, ced5, Dock180, dedicator of cytokinesis 11.00infobox
Dedicator of cytokinesis protein 1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3L4C1.00infobox
Dedicator of cytokinesis protein 1Band10q26.21.00infobox
Dedicator of cytokinesis protein 1Band7|7 F31.00infobox
Dedicator of cytokinesis protein 1Bgeecorpus callosum1.00infobox
Dedicator of cytokinesis protein 1Bgeeinternal globus pallidus1.00infobox
Dedicator of cytokinesis protein 1Bgeeolfactory bulb1.00infobox
Dedicator of cytokinesis protein 1Bgeestromal cell of endometrium1.00infobox
Dedicator of cytokinesis protein 1Bgeesural nerve1.00infobox
Dedicator of cytokinesis protein 1BgeeAchilles tendon1.00infobox
Dedicator of cytokinesis protein 1Bgeeinferior ganglion of vagus nerve1.00infobox
Dedicator of cytokinesis protein 1BgeeC1 segment1.00infobox
Dedicator of cytokinesis protein 1Bgeeamygdala1.00infobox
Dedicator of cytokinesis protein 1Bgeesubthalamic nucleus1.00infobox
Dedicator of cytokinesis protein 1BgeePaneth cell1.00infobox
Dedicator of cytokinesis protein 1Bgeemolar1.00infobox
Dedicator of cytokinesis protein 1Bgeeendothelial cell of lymphatic vessel1.00infobox
Dedicator of cytokinesis protein 1Bgeevas deferens1.00infobox
Dedicator of cytokinesis protein 1Bgeemandibular prominence1.00infobox
Dedicator of cytokinesis protein 1Bgeeureter1.00infobox
Dedicator of cytokinesis protein 1Bgeevestibular membrane of cochlear duct1.00infobox
Dedicator of cytokinesis protein 1Bgeestria vascularis1.00infobox
Dedicator of cytokinesis protein 1Bgeemaxillary prominence1.00infobox
Dedicator of cytokinesis protein 1Bgeeadrenal gland1.00infobox
Dedicator of cytokinesis protein 1BioGPSn/a1.00infobox
Dedicator of cytokinesis protein 1Chr.Chromosome 10 (human)1.00infobox
Dedicator of cytokinesis protein 1Chr.Chromosome 7 (mouse)1.00infobox
Dedicator of cytokinesis protein 1DatabasesNCBI: entry; OMA: entry1.00infobox
Dedicator of cytokinesis protein 1End127,452,517 bp1.00infobox
Dedicator of cytokinesis protein 1End134,775,368 bp1.00infobox

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