PTPN1

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Explore the main themes, entities and connections around PTPN1. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Structure and function

Endoplasmic reticulum Phosphotyrosine Insulin receptor Genetic ablation Tyrosine kinases

18 related topics

Clinical significance

Obesity Wild-type HepG2 A431 P53

8 related topics

Interactions

Interact Grb2 IRS1 Vascular endothelial growth factor Receptor-2 Vascular endothelial growth factor

7 related topics

Regulation

Reactive oxygen species Hydrogen peroxide EGF Insulin Sulfenic acid

6 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.1.3.48: ↗
Aliases: PTPN1, PTP1B, protein tyrosine phosphatase, non-receptor type 1, protein tyrosine phosphatase non-receptor type 1
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A5Y, 1AAX, 1BZC, 1BZH, 1BZJ, 1C83, 1C84, 1C85, 1C86, 1C87, 1C88, 1ECV, 1EEN, 1EEO, 1G1F, 1G1G, 1G1H, 1G7F,…
Band: 20q13.13 · 2|2 H3
Bgee: upper lobe of left lung · right lung · spleen · appendix · monocyte
BioGPS: n/a

Topics to explore

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Overview

Structure and function

Mechanism

Regulation

Interactions

Interact Protein-protein interaction
Grb2
IRS1
Vascular endothelial growth factor Receptor-2 Kinase insert domain receptor
Vascular endothelial growth factor Vascular endothelial growth factor A
PGC1-alpha PPARGC1A
ERR-alpha Estrogen-related receptor alpha

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Nodes52

Edges51

Triples148

Avg. degree1.96

Density0.038462

Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

PTPN1

Top relations

Gene ontology · 53

PTPN1 → actin cytoskeleton reorganization, cadherin binding, cytoplasm, cytoplasmic side of endoplasmic reticulum membrane, cytoplasmic vesicle, cytosol, dephosphorylation, early endosome, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum unfolded protein response, enzyme binding, ephrin receptor binding, growth hormone receptor signaling pathway via JAK-STAT, hydrolase activity, insulin receptor binding, insulin receptor signaling pathway, IRE1-mediated unfolded protein response, membrane, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

Bgee · 18

PTPN1 → appendix, ascending aorta, corneal stroma, decidua, granulocyte, Ileal epithelium, lactiferous gland, left adrenal gland, lymph node, mesenteric lymph nodes, monocyte, right lung, Rostral migratory stream, spleen, stroma of bone marrow, tibial arteries, tibiofemoral joint, upper lobe of left lung

RNA expression pattern · 18

related to Structure and function · 16

PTPN1 → Asp181, BCAR1, DOK1, Gln262, In, Janus, Phe182, PTP1B, Several, Src, The, This, TYK2, Tyr46, Upon, WPD

related to Clinical significance · 12

PTPN1 → A431, Although PTP1B, As, Cys215, Gene, HepG2, HER2, In, Murine, PTP1B, ROS, The

related to Interactions · 6

PTPN1 → BCAR1, Grb2, IRS1, PGC1-alpha/ERR-alpha, Receptor-2, Vascular

Band · 2

PTPN1 → 20q13.13, 2|2 H3

Chr. · 2

PTPN1 → Chromosome 2 (mouse), Chromosome 20 (human)

End · 2

PTPN1 → 167,821,305 bp, 50,585,241 bp

3.1.3.48 · 1

PTPN1 → ↗

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

ptp1b insulin enzyme tyrosine human residue protein type bp gene also activity chr band phosphatase cancer chromosome 20 growth regulation

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
PTPN1	3.1.3.48	↗	1.00	infobox
PTPN1	Aliases	PTPN1, PTP1B, protein tyrosine phosphatase, non-receptor type 1, protein tyrosine phosphatase non-receptor type 1	1.00	infobox
PTPN1	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A5Y, 1AAX, 1BZC, 1BZH, 1BZJ, 1C83, 1C84, 1C85, 1C86, 1C87, 1C88, 1ECV, 1EEN, 1EEO, 1G1F, 1G1G, 1G1H, 1G7F,…	1.00	infobox
PTPN1	Band	20q13.13	1.00	infobox
PTPN1	Band	2\|2 H3	1.00	infobox
PTPN1	Bgee	upper lobe of left lung	1.00	infobox
PTPN1	Bgee	right lung	1.00	infobox
PTPN1	Bgee	spleen	1.00	infobox
PTPN1	Bgee	appendix	1.00	infobox
PTPN1	Bgee	monocyte	1.00	infobox
PTPN1	Bgee	lymph node	1.00	infobox
PTPN1	Bgee	granulocyte	1.00	infobox
PTPN1	Bgee	tibial arteries	1.00	infobox
PTPN1	Bgee	ascending aorta	1.00	infobox
PTPN1	Bgee	left adrenal gland	1.00	infobox
PTPN1	Bgee	tibiofemoral joint	1.00	infobox
PTPN1	Bgee	corneal stroma	1.00	infobox
PTPN1	Bgee	Rostral migratory stream	1.00	infobox
PTPN1	Bgee	mesenteric lymph nodes	1.00	infobox
PTPN1	Bgee	stroma of bone marrow	1.00	infobox
PTPN1	Bgee	Ileal epithelium	1.00	infobox
PTPN1	Bgee	decidua	1.00	infobox
PTPN1	Bgee	lactiferous gland	1.00	infobox
PTPN1	BioGPS	n/a	1.00	infobox
PTPN1	Chr.	Chromosome 20 (human)	1.00	infobox
PTPN1	Chr.	Chromosome 2 (mouse)	1.00	infobox
PTPN1	Databases	NCBI: entry; OMA: entry	1.00	infobox
PTPN1	End	50,585,241 bp	1.00	infobox
PTPN1	End	167,821,305 bp	1.00	infobox
PTPN1	Ensembl	ENSG00000196396	1.00	infobox

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