PTPN1

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PTPN1 topic overview

The analysis highlights Structure and function, Clinical significance and Interactions as prominent areas in the source structure around PTPN1.

Related topics: 45
Source areas: 6
Connected nodes: 51
Extracted relationships: 148
Concept neighborhoods: 18
Bridge connections: 51

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Structure and function · 18 topics

Clinical significance · 8 topics

Interactions · 7 topics

Regulation · 6 topics

Overview · 4 topics

Mechanism · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.1.3.48: ↗
Aliases: PTPN1, PTP1B, protein tyrosine phosphatase, non-receptor type 1, protein tyrosine phosphatase non-receptor type 1
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A5Y, 1AAX, 1BZC, 1BZH, 1BZJ, 1C83, 1C84, 1C85, 1C86, 1C87, 1C88, 1ECV, 1EEN, 1EEO, 1G1F, 1G1G, 1G1H, 1G7F,…
Band: 20q13.13 · 2|2 H3
Bgee: upper lobe of left lung · right lung · spleen · appendix · monocyte
BioGPS: n/a

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure and function

Mechanism

Regulation

Interactions

Interact Protein-protein interaction
Grb2
IRS1
Vascular endothelial growth factor Receptor-2 Kinase insert domain receptor
Vascular endothelial growth factor Vascular endothelial growth factor A
PGC1-alpha PPARGC1A
ERR-alpha Estrogen-related receptor alpha

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PTPN1 connects Entity context

The extracted context around PTPN1 shows recurring relationship patterns in the source. For example, PTPN1 → actin cytoskeleton reorganization, cadherin binding, cytoplasm, cytoplasmic side of endoplasmic reticulum membrane, cytoplasmic vesicle, cytosol, dephosphorylation, early endosome, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum unfolded protein response, enzyme binding, ephrin receptor binding, growth hormone receptor signaling pathway via JAK-STAT, hydrolase activity, insulin receptor binding, insulin receptor signaling pathway, IRE1-mediated unfolded protein response, membrane, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Another extracted example is PTPN1 → appendix, ascending aorta, corneal stroma, decidua, granulocyte, Ileal epithelium, lactiferous gland, left adrenal gland, lymph node, mesenteric lymph nodes, monocyte, right lung, Rostral migratory stream, spleen, stroma of bone marrow, tibial arteries, tibiofemoral joint, upper lobe of left lung. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 53

PTPN1 → actin cytoskeleton reorganization, cadherin binding, cytoplasm, cytoplasmic side of endoplasmic reticulum membrane, cytoplasmic vesicle, cytosol, dephosphorylation, early endosome, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum unfolded protein response, enzyme binding, ephrin receptor binding, growth hormone receptor signaling pathway via JAK-STAT, hydrolase activity, insulin receptor binding, insulin receptor signaling pathway, IRE1-mediated unfolded protein response, membrane, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

Bgee · 18

PTPN1 → appendix, ascending aorta, corneal stroma, decidua, granulocyte, Ileal epithelium, lactiferous gland, left adrenal gland, lymph node, mesenteric lymph nodes, monocyte, right lung, Rostral migratory stream, spleen, stroma of bone marrow, tibial arteries, tibiofemoral joint, upper lobe of left lung

RNA expression pattern · 18

related to Structure and function · 16

PTPN1 → Asp181, BCAR1, DOK1, Gln262, In, Janus, Phe182, PTP1B, Several, Src, The, This, TYK2, Tyr46, Upon, WPD

related to Clinical significance · 12

PTPN1 → A431, Although PTP1B, As, Cys215, Gene, HepG2, HER2, In, Murine, PTP1B, ROS, The

related to Interactions · 6

PTPN1 → BCAR1, Grb2, IRS1, PGC1-alpha/ERR-alpha, Receptor-2, Vascular

Band · 2

PTPN1 → 20q13.13, 2|2 H3

Chr. · 2

PTPN1 → Chromosome 2 (mouse), Chromosome 20 (human)

End · 2

PTPN1 → 167,821,305 bp, 50,585,241 bp

3.1.3.48 · 1

PTPN1 → ↗

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

ptp1b insulin enzyme tyrosine human residue protein type bp gene also activity chr band phosphatase cancer chromosome 20 growth regulation

PTPN1 relationships Subject–Predicate–Object triples

TTTA extracted 148 structured relationships around PTPN1. Examples in this analysis include PTPN1 → 3.1.3.48 → ↗ and PTPN1 → Aliases → PTPN1, PTP1B, protein tyrosine phosphatase, non-receptor type 1, protein tyrosine phosphatase non-receptor type 1. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
PTPN1	3.1.3.48	↗	1.00	infobox
PTPN1	Aliases	PTPN1, PTP1B, protein tyrosine phosphatase, non-receptor type 1, protein tyrosine phosphatase non-receptor type 1	1.00	infobox
PTPN1	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A5Y, 1AAX, 1BZC, 1BZH, 1BZJ, 1C83, 1C84, 1C85, 1C86, 1C87, 1C88, 1ECV, 1EEN, 1EEO, 1G1F, 1G1G, 1G1H, 1G7F,…	1.00	infobox
PTPN1	Band	20q13.13	1.00	infobox
PTPN1	Band	2\|2 H3	1.00	infobox
PTPN1	Bgee	upper lobe of left lung	1.00	infobox
PTPN1	Bgee	right lung	1.00	infobox
PTPN1	Bgee	spleen	1.00	infobox
PTPN1	Bgee	appendix	1.00	infobox
PTPN1	Bgee	monocyte	1.00	infobox
PTPN1	Bgee	lymph node	1.00	infobox
PTPN1	Bgee	granulocyte	1.00	infobox
PTPN1	Bgee	tibial arteries	1.00	infobox
PTPN1	Bgee	ascending aorta	1.00	infobox
PTPN1	Bgee	left adrenal gland	1.00	infobox
PTPN1	Bgee	tibiofemoral joint	1.00	infobox
PTPN1	Bgee	corneal stroma	1.00	infobox
PTPN1	Bgee	Rostral migratory stream	1.00	infobox
PTPN1	Bgee	mesenteric lymph nodes	1.00	infobox
PTPN1	Bgee	stroma of bone marrow	1.00	infobox
PTPN1	Bgee	Ileal epithelium	1.00	infobox
PTPN1	Bgee	decidua	1.00	infobox
PTPN1	Bgee	lactiferous gland	1.00	infobox
PTPN1	BioGPS	n/a	1.00	infobox
PTPN1	Chr.	Chromosome 20 (human)	1.00	infobox
PTPN1	Chr.	Chromosome 2 (mouse)	1.00	infobox
PTPN1	Databases	NCBI: entry; OMA: entry	1.00	infobox
PTPN1	End	50,585,241 bp	1.00	infobox
PTPN1	End	167,821,305 bp	1.00	infobox
PTPN1	Ensembl	ENSG00000196396	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around PTPN1 bring nearby vocabulary together. In this analysis, examples include Growth, Location and Chromosome. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

enzyme
- Regulation
- Phosphatase
- Protein
- Type
- Tyrosine
- Activity
- Location
- Chromosome
- First
- Bp
- Chr
- Human
protein tyrosine phosphatase
- Protein
- Tyrosine
- Type
- Activity
- Enzyme
- Location
- Chromosome
- Regulation
- Bp
- Chr
- Cleft
- First
gene
- Location
- Chromosome
- Regulation
- Bp
- Chr
- Human
- Ptpn1
- Band
- Phosphatase
- Protein
- Type
- Tyrosine
type 2 diabetes
- Treatment
- Diabetes
- Type
- Tyrosine
- Location
- Signaling
- Chromosome
- Factor
- Regulation
- Target
- Therapeutic
- Bp
insulin receptor
- Signaling
- Obesity
- Tyrosine
- Ptpn1
- Receptor
- Regulation
- Ptp1b
- Type
- Well
- Shown
- Target
- Therapeutic
insulin
- Signaling
- Obesity
- Ptpn1
- Receptor
- Regulation
- Ptp1b
- Type
- Target
- Therapeutic
- Diabetes
- Location
- Potential
epidermal growth factor receptor
- Factor
- Growth
- Receptor
- Well
- Ptpn1
- Type
- Tyrosine
- Location
- Signaling
- Treatment
- Ptp1b
- First
insulin-like growth factor 1 receptor
- Factor
- Growth
- Receptor
- Well
- Ptpn1
- Type
- Tyrosine
- Location
- Signaling
- Treatment
- Ptp1b
- First

Connections between topic areas Semantic bridges

For PTPN1, one of the stronger structural bridges in this analysis connects PTPN1 with Structure and function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

PTPN1 — Structure and function · splits 33 ⟂ 19

PTPN1 — Clinical significance · splits 43 ⟂ 9

PTPN1 — Interactions · splits 44 ⟂ 8

PTPN1 — Regulation · splits 45 ⟂ 7

PTPN1 — Overview · splits 47 ⟂ 5

PTPN1 — Mechanism · splits 49 ⟂ 3

Map overview Semantic statistics

PTPN1

Nodes52

Edges51

Triples148

Avg. degree1.96

Density0.038462

Components1

Source & methodology

TTTA analyzes the structure around PTPN1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure and function, Clinical significance & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PTPN1 · EN edition · Analysis: TopicsToTalkAbout