Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

PLCG1

Phospholipase C, gamma 1, also known as PLCG1 and PLCgamma1, is a protein that in humans involved in cell growth, migration, apoptosis, and proliferation. It is encoded by the PLCG1 gene and is part of the PLC superfamily.

Art, Function & Interactions

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Research this topic

Explore the main themes, entities and connections around PLCG1. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Function

27 related topics

Interactions

26 related topics

Cancer

3 related topics

Overview

7 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.1.4.11
Aliases
PLCG1, NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1, phospholipase C gamma 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1HSQ, 2HSP, 4EY0, 4FBN
Band
20q12 · 2 H2|2 80.97 cM
Bgee
right hemisphere of cerebellum · right lobe of thyroid gland · ganglionic eminence · left lobe of thyroid gland · right ovary
BioGPS
More reference expression data

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Function

Cancer

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

PLCG1

Nodes68
Edges67
Triples164
Avg. degree1.97
Density0.029412
Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

PLCG1

Top relations

Gene ontology · 53
PLCG1 → activation of phospholipase C activity, axon guidance, calcium ion binding, calcium ion transport, calcium-mediated signaling, cell migration, cell projection, cell-cell junction, cellular response to epidermal growth factor stimulus, COP9 signalosome, cytoplasm, cytosol, epidermal growth factor receptor signaling pathway, Fc-epsilon receptor signaling pathway, Fc-gamma receptor signaling pathway involved in phagocytosis, glutamate receptor binding, glutamatergic synapse, hydrolase activity, in utero embryonic development, inositol phosphate metabolic process
related to Interactions · 24
PLCG1 → Aldrich, BAG3, Cbl, CD117, CD31, Eukaryotic, FLT1, GAB1, GIT1, Grb2, HER2/neu, IRS2, ITK, KHDRBS1, Linker, Lymphocyte, PDGFRA, PLD2, RHOA, SOS1
related to Function · 22
PLCG1 → Also, AMPK, DAG, FAK, For, Golgi, In, IP3, It, Mutations, PIK3, PIP3, PLC, PLCγ1, PTPmu, PTPRM, Ras, RASGRP1, SRC, The
Bgee · 20
PLCG1 → aortic valve, ascending aorta, body of uterus, canal of the cervix, condyle, cumulus cell, fossa, ganglionic eminence, hand, internal carotid artery, left lobe of thyroid gland, left ovary, otolith organ, right hemisphere of cerebellum, right lobe of thyroid gland, right ovary, Rostral migratory stream, stromal cell of endometrium, utricle, ventricular zone
RNA expression pattern · 20
PLCG1 → aortic valve, ascending aorta, body of uterus, canal of the cervix, condyle, cumulus cell, fossa, ganglionic eminence, hand, internal carotid artery, left lobe of thyroid gland, left ovary, otolith organ, right hemisphere of cerebellum, right lobe of thyroid gland, right ovary, Rostral migratory stream, stromal cell of endometrium, utricle, ventricular zone
Band · 2
PLCG1 → 2 H2|2 80.97 cM, 20q12
Chr. · 2
PLCG1 → Chromosome 2 (mouse), Chromosome 20 (human)
End · 2
PLCG1 → 160,617,680 bp, 41,196,801 bp
3.1.4.11 · 1
PLCG1 → ↗
Aliases · 1
PLCG1 → PLCG1, NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1, phospholipase C gamma 1

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

plcγ1 growth cell cells protein gene bp also tyrosine chr human band proliferation cancer receptor factor involved cish phospholipase chromosome

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PLCG13.1.4.111.00infobox
PLCG1AliasesPLCG1, NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1, phospholipase C gamma 11.00infobox
PLCG1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1HSQ, 2HSP, 4EY0, 4FBN1.00infobox
PLCG1Band20q121.00infobox
PLCG1Band2 H2|2 80.97 cM1.00infobox
PLCG1Bgeeright hemisphere of cerebellum1.00infobox
PLCG1Bgeeright lobe of thyroid gland1.00infobox
PLCG1Bgeeganglionic eminence1.00infobox
PLCG1Bgeeleft lobe of thyroid gland1.00infobox
PLCG1Bgeeright ovary1.00infobox
PLCG1Bgeeventricular zone1.00infobox
PLCG1Bgeecanal of the cervix1.00infobox
PLCG1Bgeebody of uterus1.00infobox
PLCG1Bgeeleft ovary1.00infobox
PLCG1Bgeestromal cell of endometrium1.00infobox
PLCG1Bgeeotolith organ1.00infobox
PLCG1Bgeehand1.00infobox
PLCG1Bgeeutricle1.00infobox
PLCG1Bgeeaortic valve1.00infobox
PLCG1Bgeeascending aorta1.00infobox
PLCG1BgeeRostral migratory stream1.00infobox
PLCG1Bgeefossa1.00infobox
PLCG1Bgeecumulus cell1.00infobox
PLCG1Bgeeinternal carotid artery1.00infobox
PLCG1Bgeecondyle1.00infobox
PLCG1BioGPSMore reference expression data1.00infobox
PLCG1Chr.Chromosome 20 (human)1.00infobox
PLCG1Chr.Chromosome 2 (mouse)1.00infobox
PLCG1DatabasesNCBI: entry; OMA: entry1.00infobox
PLCG1End41,196,801 bp1.00infobox

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

    Connections between topic areas Semantic bridges

    Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

    Min side: 3
    For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.