GAB2

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Interactions

CT10 regulator of kinase Nck PI3K Interact Serine/threonine protein kinase

23 related topics

Structure

Short linear motifs PH domain GAB1 Intrinsically disordered protein Secondary structure

12 related topics

Function

Cytokine receptors Integrins Mutagenesis Binding assays ERK

9 related topics

Clinical Implications

APOE ε4 Dystrophic neuritis Tau Amyloid precursor Gsk3

7 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: GAB2, entrez:9846, GRB2 associated binding protein 2
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2VWF, 2W0Z, 5EXA, 5EWZ
Band: 11q14.1 · 7|7 E1
Bgee: inferior ganglion of vagus nerve · subthalamic nucleus · medulla oblongata · superior vestibular nucleus · corpus callosum
BioGPS: More reference expression data
Chr.: Chromosome 11 (human) · Chromosome 7 (mouse)

Topics to explore

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Overview

Protein
Gene
Receptor tyrosine kinases Receptor tyrosine kinase
SHP2 PTPN11
Phosphatidylinositol 3-kinase
Grb2
ERK Extracellular-signal-regulated kinase
AKT
Leukemia
Alzheimer's disease

Structure

Short linear motifs Short linear motif
PH domain Pleckstrin homology domain
GAB1
Intrinsically disordered protein Intrinsically unstructured proteins
Secondary structure Protein secondary structure
Orthologs Homology (biology)
Phosphatidylinositol 3,4,5-triphosphate Phosphatidylinositol (3,4,5)-trisphosphate
Proline-rich domain
SH3 domains SH3 domain
Grb2
SH2 SH2 domain
PI3K Phosphoinositide 3-kinase

Function

Cytokine receptors Cytokine receptor
Integrins Integrin
Mutagenesis
Binding assays Assay
ERK Extracellular signal-regulated kinases
MAPK Mitogen-activated protein kinase
Rac Rac (GTPase)
Osteopetrosis
Angiopoietin

Interactions

CT10 regulator of kinase CRK (gene)
Nck Non-receptor tyrosine kinase
PI3K
Interact Protein-protein interaction
Serine/threonine protein kinase Akt
GSK3
CRKL
JNK
Growth hormone
Insulin
Epidermal growth factor
Amyloid
Microglia
FceRI Fc receptor
Anaphylaxis
Erythropoietin hormone Erythropoietin
Erythrocytes Red blood cell
Phospholipase C gamma 2 PLCG2
PIP3
Ras Ras subfamily
JMML
Rho GTP-ase activating protein family RICS (gene)
Src homology domain-containing transforming protein 1 SHC1

Clinical Implications

APOE ε4 Apolipoprotein E
Dystrophic neuritis Biochemistry of Alzheimer's disease
Tau Tau protein
Amyloid precursor Amyloid precursor protein
Gsk3 GSK-3
Neurofibrillary tangles Neurofibrillary tangle
Bcr-Abl Philadelphia chromosome

Advanced semantic analysis

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Map overview Semantic statistics

Nodes67

Edges66

Triples211

Avg. degree1.97

Density0.029851

Components1

How this topic connects Entity context

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GAB2

Top relations

Bgee · 20

GAB2 → aortic valve, ascending aorta, C1 segment, ciliary body, corpus callosum, decidua, external globus pallidus, facial motor nucleus, inferior ganglion of vagus nerve, medulla oblongata, pars compacta, renal corpuscle, retinal pigment epithelium, sexually immature organism, spinal cord, stroma of bone marrow, substantia nigra, subthalamic nucleus, superior vestibular nucleus, ventral tegmental area

RNA expression pattern · 20

Gene ontology · 18

GAB2 → 1-phosphatidylinositol-3-kinase activity, axon guidance, cytokine-mediated signaling pathway, cytoplasm, cytosol, Fc-epsilon receptor signaling pathway, membrane, osteoclast differentiation, phosphatidylinositol-3,4,5-trisphosphate binding, phosphatidylinositol-3,4-bisphosphate binding, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol-mediated signaling, plasma membrane, positive regulation of cell population proliferation, positive regulation of mast cell degranulation, protein binding, transmembrane receptor protein tyrosine kinase adaptor activity, transmembrane receptor protein tyrosine kinase signaling pathway

related to Function · 17

GAB2 → AKT, Binding, By, ERK, ERK/MAPK, GAB, Kit-induced Rac, Knockout, Mutagenesis, NRG1, PI3K, RTK, SHP2, The, There, These, While

related to Structure · 16

GAB2 → C-terminal, GAB, GAB1, GAB3, GAB4, Intrinsically, LMD, LMDs, N-terminal, PH, PIP3, Pleckstrin Homology, Some, The, The N-terminal, The PH

related to Alzheimer's disease · 15

GAB2 → AD, Akt, Alzheimer's, APOE, APP, GAB2-Grb2, Gsk3, Gsk3-dependent, However, In LOAD, Interactions, LOAD, Mutations, PI3K, Ten SNPs

related to Cancer · 11

GAB2 → Bcr-Abl, Bcr-Abl-mediated, CML, In, JMML, PTPN11, Ras, RTKs, Studies, The Grb2/GAB2, Y177

related to Interactions · 10

GAB2 → Crk, Grb2, It, Nck, PI3K, SH2, SH2-containing, Src, The C-terminal, These

related to Grb2 · 9

GAB2 → EFG, Grb2, PI3K, PX3RX2KP, SH2, SHC, SHP2, The, Upon

related to PLCG2 · 9

GAB2 → An, Epo, Phospholipase, PIP3, PLCG2, SH2, SHC, SHP2, The

Important terminology Word statistics

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Important terminology

protein pi3k signaling gab binding grb2 cell proteins domain pathways pathway shp2 molecules also membrane tyrosine sh2 activation bp gene

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
GAB2	Aliases	GAB2, entrez:9846, GRB2 associated binding protein 2	1.00	infobox
GAB2	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2VWF, 2W0Z, 5EXA, 5EWZ	1.00	infobox
GAB2	Band	11q14.1	1.00	infobox
GAB2	Band	7\|7 E1	1.00	infobox
GAB2	Bgee	inferior ganglion of vagus nerve	1.00	infobox
GAB2	Bgee	subthalamic nucleus	1.00	infobox
GAB2	Bgee	medulla oblongata	1.00	infobox
GAB2	Bgee	superior vestibular nucleus	1.00	infobox
GAB2	Bgee	corpus callosum	1.00	infobox
GAB2	Bgee	external globus pallidus	1.00	infobox
GAB2	Bgee	ventral tegmental area	1.00	infobox
GAB2	Bgee	spinal cord	1.00	infobox
GAB2	Bgee	C1 segment	1.00	infobox
GAB2	Bgee	pars compacta	1.00	infobox
GAB2	Bgee	ascending aorta	1.00	infobox
GAB2	Bgee	aortic valve	1.00	infobox
GAB2	Bgee	retinal pigment epithelium	1.00	infobox
GAB2	Bgee	substantia nigra	1.00	infobox
GAB2	Bgee	decidua	1.00	infobox
GAB2	Bgee	ciliary body	1.00	infobox
GAB2	Bgee	renal corpuscle	1.00	infobox
GAB2	Bgee	facial motor nucleus	1.00	infobox
GAB2	Bgee	stroma of bone marrow	1.00	infobox
GAB2	Bgee	sexually immature organism	1.00	infobox
GAB2	BioGPS	More reference expression data	1.00	infobox
GAB2	Chr.	Chromosome 11 (human)	1.00	infobox
GAB2	Chr.	Chromosome 7 (mouse)	1.00	infobox
GAB2	Databases	NCBI: entry; OMA: entry	1.00	infobox
GAB2	End	78,418,348 bp	1.00	infobox
GAB2	End	96,958,153 bp	1.00	infobox

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