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VAV1: Interactions, Function & Overview

Proto-oncogene vav is a protein that in humans is encoded by the VAV1 gene.

Language: English [EN]
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VAV1 topic overview

The analysis highlights Interactions, Function and Overview as prominent areas in the source structure around VAV1.

Related topics
27
Source areas
3
Connected nodes
30
Extracted relationships
109
Concept neighborhoods
11
Bridge connections
30

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 18 topics
Function · 7 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
VAV1, VAV, vav guanine nucleotide exchange factor 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CRH, 2LCT, 2MC1, 2ROR, 3BJI, 3KY9
Band
19p13.3 · 17 D|17 29.76 cM
Bgee
granulocyte · monocyte · blood · spleen · bone marrow cell
BioGPS
More reference expression data
Chr.
Chromosome 19 (human) · Chromosome 17 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How VAV1 connects Entity context

The extracted context around VAV1 shows recurring relationship patterns in the source. For example, VAV1 → cell-cell junction, cytokine-mediated signaling pathway, cytosol, DNA-binding transcription factor activity, Fc-epsilon receptor signaling pathway, Fc-gamma receptor signaling pathway involved in phagocytosis, G protein-coupled receptor signaling pathway, guanyl-nucleotide exchange factor activity, immune response, integrin-mediated signaling pathway, intracellular signal transduction, metal ion binding, neutrophil chemotaxis, phagocytosis, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, phosphotyrosine residue binding, plasma membrane, platelet activation, positive regulation of apoptotic process Another extracted example is VAV1 → appendix, blood, bone marrow cell, epithelium of nasopharynx, gallbladder, gastrula, granulocyte, interventricular septum, lumbar subsegment of spinal cord, lymph node, mesenteric lymph nodes, monocyte, palpebral conjunctiva, spleen, superior surface of tongue, thymus, trabecular bone. Use these groups to spot repeated connection types before inspecting the individual relationships.

VAV1

Top relations

Gene ontology · 37
VAV1 → cell-cell junction, cytokine-mediated signaling pathway, cytosol, DNA-binding transcription factor activity, Fc-epsilon receptor signaling pathway, Fc-gamma receptor signaling pathway involved in phagocytosis, G protein-coupled receptor signaling pathway, guanyl-nucleotide exchange factor activity, immune response, integrin-mediated signaling pathway, intracellular signal transduction, metal ion binding, neutrophil chemotaxis, phagocytosis, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, phosphotyrosine residue binding, plasma membrane, platelet activation, positive regulation of apoptotic process
Bgee · 17
VAV1 → appendix, blood, bone marrow cell, epithelium of nasopharynx, gallbladder, gastrula, granulocyte, interventricular septum, lumbar subsegment of spinal cord, lymph node, mesenteric lymph nodes, monocyte, palpebral conjunctiva, spleen, superior surface of tongue, thymus, trabecular bone
RNA expression pattern · 17
VAV1 → appendix, blood, bone marrow cell, epithelium of nasopharynx, gallbladder, gastrula, granulocyte, interventricular septum, lumbar subsegment of spinal cord, lymph node, mesenteric lymph nodes, monocyte, palpebral conjunctiva, spleen, superior surface of tongue, thymus, trabecular bone
related to Interactions · 15
VAV1 → Abl, ARHGDIB, Cbl, Grb2, JAK2, Ku70, LAT, LCP2, MAPK1, PIK3R1, PLCG1, PRKCQ, S100B, SHB, SIAH2
Band · 2
VAV1 → 17 D|17 29.76 cM, 19p13.3
Chr. · 2
VAV1 → Chromosome 17 (mouse), Chromosome 19 (human)
End · 2
VAV1 → 57,635,031 bp, 6,857,366 bp
Aliases · 1
VAV1 → VAV1, VAV, vav guanine nucleotide exchange factor 1
Available structures · 1
VAV1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CRH, 2LCT, 2MC1, 2ROR, 3BJI, 3KY9
BioGPS · 1
VAV1 → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp gene chr human band chromosome 19 protein binding location exchange mouse proto-oncogene vav function encoded factor search 857 366

VAV1 relationships Subject–Predicate–Object triples

TTTA extracted 109 structured relationships around VAV1. Examples in this analysis include VAV1 → Aliases → VAV1, VAV, vav guanine nucleotide exchange factor 1 and VAV1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CRH, 2LCT, 2MC1, 2ROR, 3BJI, 3KY9. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
VAV1AliasesVAV1, VAV, vav guanine nucleotide exchange factor 11.00infobox
VAV1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CRH, 2LCT, 2MC1, 2ROR, 3BJI, 3KY91.00infobox
VAV1Band19p13.31.00infobox
VAV1Band17 D|17 29.76 cM1.00infobox
VAV1Bgeegranulocyte1.00infobox
VAV1Bgeemonocyte1.00infobox
VAV1Bgeeblood1.00infobox
VAV1Bgeespleen1.00infobox
VAV1Bgeebone marrow cell1.00infobox
VAV1Bgeelymph node1.00infobox
VAV1Bgeeappendix1.00infobox
VAV1Bgeepalpebral conjunctiva1.00infobox
VAV1Bgeeepithelium of nasopharynx1.00infobox
VAV1Bgeetrabecular bone1.00infobox
VAV1Bgeesuperior surface of tongue1.00infobox
VAV1Bgeegallbladder1.00infobox
VAV1Bgeethymus1.00infobox
VAV1Bgeemesenteric lymph nodes1.00infobox
VAV1Bgeeinterventricular septum1.00infobox
VAV1Bgeegastrula1.00infobox
VAV1Bgeelumbar subsegment of spinal cord1.00infobox
VAV1BioGPSMore reference expression data1.00infobox
VAV1Chr.Chromosome 19 (human)1.00infobox
VAV1Chr.Chromosome 17 (mouse)1.00infobox
VAV1DatabasesNCBI: entry; OMA: entry1.00infobox
VAV1End6,857,366 bp1.00infobox
VAV1End57,635,031 bp1.00infobox
VAV1EnsemblENSG000001419681.00infobox
VAV1Entrez74091.00infobox
VAV1External IDsOMIM: 164875; MGI: 98923; GeneCards: VAV11.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around VAV1 bring nearby vocabulary together. In this analysis, examples include Gene, Encoded and Exchange. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • VAV1
    • Gene
    • Encoded
    • Exchange
    • Factor
    • Function
    • Guanine
    • Nucleotide
    • Proto-oncogene
    • Search
    • Vav
    • Location
    • Protein
  • vav1
    • Gene
    • Encoded
    • Exchange
    • Factor
    • Function
    • Guanine
    • Nucleotide
    • Proto-oncogene
    • Search
    • Vav
    • Location
    • Protein
  • protein
    • Activation
    • Encoded
    • Proto-oncogene
    • Vav1
    • Gene
    • Humans
    • Rho
    • End
    • Exchange
    • Factor
    • Function
    • Gef
  • gene
    • Vav1
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • End
    • Exchange
    • Factor
    • Function
    • Guanine
    • Mouse
  • proto-oncogene
    • Encoded
    • Protein
    • Humans
    • Rho
    • Vav1
    • Gene
    • Activation
    • End
    • Exchange
    • Factor
    • Function
    • Gef
  • guanine nucleotide exchange factors
    • Factor
    • Function
    • Guanine
    • Nucleotide
    • Search
    • Location
    • Chromosome
    • Human
    • Interactions
    • Reading
    • References
    • Rho
  • abl gene
    • Vav1
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • End
    • Exchange
    • Factor
    • Function
    • Guanine
    • Mouse
  • cbl gene
    • Vav1
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • End
    • Exchange
    • Factor
    • Function
    • Guanine
    • Mouse

Connections between topic areas Semantic bridges

For VAV1, one of the stronger structural bridges in this analysis connects VAV1 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
VAV1Interactions · splits 12 ⟂ 19
VAV1Function · splits 23 ⟂ 8
VAV1Overview · splits 28 ⟂ 3

Map overview Semantic statistics

VAV1

Nodes31
Edges30
Triples109
Avg. degree1.94
Density0.064516
Components1

Source & methodology

TTTA analyzes the structure around VAV1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — VAV1 · EN edition · Analysis: TopicsToTalkAbout

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