VAV1

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Interactions

Interact ARHGDIB Abl gene Cbl gene EZH2

18 related topics

Function

Proto-oncogene Guanine nucleotide exchange factors Hematopoiesis T-cell B-cell

7 related topics

Overview

Protein Gene

2 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: VAV1, VAV, vav guanine nucleotide exchange factor 1
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CRH, 2LCT, 2MC1, 2ROR, 3BJI, 3KY9
Band: 19p13.3 · 17 D|17 29.76 cM
Bgee: granulocyte · monocyte · blood · spleen · bone marrow cell
BioGPS: More reference expression data
Chr.: Chromosome 19 (human) · Chromosome 17 (mouse)

Topics to explore

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Overview

Function

Proto-oncogene
Guanine nucleotide exchange factors Guanine nucleotide exchange factor
Hematopoiesis
T-cell
B-cell
Nef proteins Nef (protein)
HIV-1

Interactions

Interact Protein-protein interaction
ARHGDIB
Abl gene
Cbl gene
EZH2
Grb2
JAK2 Janus kinase 2
Ku70
LAT Linker of activated T cells
LCP2 Lymphocyte cytosolic protein 2
MAPK1
PIK3R1
PLCG1
PRKCQ
S100B
SHB SHB (gene)
SIAH2
Syk

Advanced semantic analysis

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Map overview Semantic statistics

Nodes31

Edges30

Triples109

Avg. degree1.94

Density0.064516

Components1

How this topic connects Entity context

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VAV1

Top relations

Gene ontology · 37

VAV1 → cell-cell junction, cytokine-mediated signaling pathway, cytosol, DNA-binding transcription factor activity, Fc-epsilon receptor signaling pathway, Fc-gamma receptor signaling pathway involved in phagocytosis, G protein-coupled receptor signaling pathway, guanyl-nucleotide exchange factor activity, immune response, integrin-mediated signaling pathway, intracellular signal transduction, metal ion binding, neutrophil chemotaxis, phagocytosis, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, phosphotyrosine residue binding, plasma membrane, platelet activation, positive regulation of apoptotic process

Bgee · 17

VAV1 → appendix, blood, bone marrow cell, epithelium of nasopharynx, gallbladder, gastrula, granulocyte, interventricular septum, lumbar subsegment of spinal cord, lymph node, mesenteric lymph nodes, monocyte, palpebral conjunctiva, spleen, superior surface of tongue, thymus, trabecular bone

RNA expression pattern · 17

related to Interactions · 15

VAV1 → Abl, ARHGDIB, Cbl, Grb2, JAK2, Ku70, LAT, LCP2, MAPK1, PIK3R1, PLCG1, PRKCQ, S100B, SHB, SIAH2

Band · 2

VAV1 → 17 D|17 29.76 cM, 19p13.3

Chr. · 2

VAV1 → Chromosome 17 (mouse), Chromosome 19 (human)

End · 2

VAV1 → 57,635,031 bp, 6,857,366 bp

Aliases · 1

VAV1 → VAV1, VAV, vav guanine nucleotide exchange factor 1

Available structures · 1

VAV1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CRH, 2LCT, 2MC1, 2ROR, 3BJI, 3KY9

BioGPS · 1

VAV1 → More reference expression data

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp gene chr human band chromosome 19 protein binding location exchange mouse proto-oncogene vav function encoded factor search 857 366

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
VAV1	Aliases	VAV1, VAV, vav guanine nucleotide exchange factor 1	1.00	infobox
VAV1	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CRH, 2LCT, 2MC1, 2ROR, 3BJI, 3KY9	1.00	infobox
VAV1	Band	19p13.3	1.00	infobox
VAV1	Band	17 D\|17 29.76 cM	1.00	infobox
VAV1	Bgee	granulocyte	1.00	infobox
VAV1	Bgee	monocyte	1.00	infobox
VAV1	Bgee	blood	1.00	infobox
VAV1	Bgee	spleen	1.00	infobox
VAV1	Bgee	bone marrow cell	1.00	infobox
VAV1	Bgee	lymph node	1.00	infobox
VAV1	Bgee	appendix	1.00	infobox
VAV1	Bgee	palpebral conjunctiva	1.00	infobox
VAV1	Bgee	epithelium of nasopharynx	1.00	infobox
VAV1	Bgee	trabecular bone	1.00	infobox
VAV1	Bgee	superior surface of tongue	1.00	infobox
VAV1	Bgee	gallbladder	1.00	infobox
VAV1	Bgee	thymus	1.00	infobox
VAV1	Bgee	mesenteric lymph nodes	1.00	infobox
VAV1	Bgee	interventricular septum	1.00	infobox
VAV1	Bgee	gastrula	1.00	infobox
VAV1	Bgee	lumbar subsegment of spinal cord	1.00	infobox
VAV1	BioGPS	More reference expression data	1.00	infobox
VAV1	Chr.	Chromosome 19 (human)	1.00	infobox
VAV1	Chr.	Chromosome 17 (mouse)	1.00	infobox
VAV1	Databases	NCBI: entry; OMA: entry	1.00	infobox
VAV1	End	6,857,366 bp	1.00	infobox
VAV1	End	57,635,031 bp	1.00	infobox
VAV1	Ensembl	ENSG00000141968	1.00	infobox
VAV1	Entrez	7409	1.00	infobox
VAV1	External IDs	OMIM: 164875; MGI: 98923; GeneCards: VAV1	1.00	infobox

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