Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

SHC1

SHC-transforming protein 1 is a protein that in humans is encoded by the SHC1 gene. SHC has been found to be important in the regulation of apoptosis and drug resistance in mammalian cells.

Gene and expression, Function & Overview

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Research this topic

Explore the main themes, entities and connections around SHC1. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Gene and expression

3 related topics

Function

1 related topics

Overview

5 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
SHC1, SHC, SHCA, SHC adaptor protein 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MIL, 1N3H, 1OY2, 1QG1, 1SHC, 1TCE, 2L1C, 4JMH, 4XWX, 5CZI
Band
1q21.3 · 3 F1|3 39.11 cM
Bgee
stromal cell of endometrium · gallbladder · smooth muscle tissue · Descending thoracic aorta · gastric mucosa
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 3 (mouse)

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Gene and expression

Function

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

SHC1

Nodes13
Edges12
Triples160
Avg. degree1.85
Density0.153846
Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

SHC1

Top relations

Gene ontology · 51
SHC1 → actin cytoskeleton reorganization, angiogenesis, axon guidance, cell-cell adhesion, cellular response to growth factor stimulus, cytokine-mediated signaling pathway, cytoplasm, cytosol, defense response to bacterium, development of the heart, ephrin receptor binding, epidermal growth factor binding, epidermal growth factor receptor binding, epidermal growth factor receptor signaling pathway, ERBB2 signaling pathway, Fc-epsilon receptor signaling pathway, insulin receptor binding, insulin receptor signaling pathway, insulin-like growth factor receptor binding, interleukin-15-mediated signaling pathway
Bgee · 20
SHC1 → anterior pituitary, canal of the cervix, cartilage tissue, Descending thoracic aorta, epiblast, gallbladder, gastric mucosa, genital tubercle, granulocyte, islet of Langerhans, left uterine tube, lens, lung, right lobe of thyroid gland, smooth muscle tissue, stomach, stromal cell of endometrium, tail of embryo, uterus, yolk sac
RNA expression pattern · 20
SHC1 → anterior pituitary, canal of the cervix, cartilage tissue, Descending thoracic aorta, epiblast, gallbladder, gastric mucosa, genital tubercle, granulocyte, islet of Langerhans, left uterine tube, lens, lung, right lobe of thyroid gland, smooth muscle tissue, stomach, stromal cell of endometrium, tail of embryo, uterus, yolk sac
related to Gene and expression · 11
SHC1 → All, Both, C-terminal Src-homology2, N-terminal, N-terminal CH2, P66SHC, PTB, RAS, SH2, The, These
related to Clinical significance · 7
SHC1 → In, SgK269, SHC, Src, The, This, When SgK269
related to EGFR pathway · 7
SHC1 → Activated, After, EGF, EGFR, PTPN122, SgK269-mediated, This
related to Life span · 6
SHC1 → DAF-2, IIS, It, SHC, The SHC-1, There
related to Oxidative stress · 6
SHC1 → ERK, Oxidative, ROS, Selective, The SHC, There
Band · 2
SHC1 → 1q21.3, 3 F1|3 39.11 cM
Chr. · 2
SHC1 → Chromosome 1 (human), Chromosome 3 (mouse)

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

p66shc shc proteins gene protein stress oxidative cell bp signaling pathway mct-1 chr human band expression cells chromosome regulation also

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
SHC1AliasesSHC1, SHC, SHCA, SHC adaptor protein 11.00infobox
SHC1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MIL, 1N3H, 1OY2, 1QG1, 1SHC, 1TCE, 2L1C, 4JMH, 4XWX, 5CZI1.00infobox
SHC1Band1q21.31.00infobox
SHC1Band3 F1|3 39.11 cM1.00infobox
SHC1Bgeestromal cell of endometrium1.00infobox
SHC1Bgeegallbladder1.00infobox
SHC1Bgeesmooth muscle tissue1.00infobox
SHC1BgeeDescending thoracic aorta1.00infobox
SHC1Bgeegastric mucosa1.00infobox
SHC1Bgeeanterior pituitary1.00infobox
SHC1Bgeeleft uterine tube1.00infobox
SHC1Bgeecartilage tissue1.00infobox
SHC1Bgeeright lobe of thyroid gland1.00infobox
SHC1Bgeecanal of the cervix1.00infobox
SHC1Bgeelens1.00infobox
SHC1Bgeetail of embryo1.00infobox
SHC1Bgeegranulocyte1.00infobox
SHC1Bgeeuterus1.00infobox
SHC1Bgeegenital tubercle1.00infobox
SHC1Bgeelung1.00infobox
SHC1Bgeeyolk sac1.00infobox
SHC1Bgeeislet of Langerhans1.00infobox
SHC1Bgeeepiblast1.00infobox
SHC1Bgeestomach1.00infobox
SHC1BioGPSMore reference expression data1.00infobox
SHC1Chr.Chromosome 1 (human)1.00infobox
SHC1Chr.Chromosome 3 (mouse)1.00infobox
SHC1DatabasesNCBI: entry; OMA: entry1.00infobox
SHC1End154,974,395 bp1.00infobox
SHC1End89,337,334 bp1.00infobox

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

    Connections between topic areas Semantic bridges

    Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

    Min side: 3
    For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.