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CD22

CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.

As a drug target, BCR signaling & Structure

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Aliases
CD22, SIGLEC-2, SIGLEC2, CD22 molecule
Band
7 B1|7 19.26 cM
Bgee
spleen · appendix · lymph node · right uterine tube · sural nerve
BioGPS
More reference expression data
Chr.
Chromosome 7 (mouse)
Databases
NCBI: entry

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Overview

Structure

BCR signaling

Autoimmunity

As a drug target

Interactions

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Map overview Semantic statistics

CD22

Nodes79
Edges78
Triples158
Avg. degree1.97
Density0.025316
Components1

How this topic connects Entity context

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CD22

Top relations

Gene ontology · 23
CD22 → B cell activation, carbohydrate binding, CD4 receptor binding, cell adhesion, cell surface, cytoplasm, early endosome, extracellular exosome, IgM binding, integral component of membrane, membrane, negative regulation of B cell receptor signaling pathway, negative regulation of calcium-mediated signaling, neuronal cell body membrane, plasma membrane, protein binding, protein phosphatase binding, recycling endosome, regulation of B cell proliferation, regulation of endocytosis
Bgee · 19
CD22 → amygdala, appendix, blood, calvaria, caudate nucleus, corpus callosum, granulocyte, inferior olivary nucleus, lymph node, mesenteric lymph nodes, morula, putamen, right uterine tube, spleen, subcutaneous adipose tissue, submandibular gland, sural nerve, tibiofemoral joint, tunica adventitia of aorta
RNA expression pattern · 19
CD22 → amygdala, appendix, blood, calvaria, caudate nucleus, corpus callosum, granulocyte, inferior olivary nucleus, lymph node, mesenteric lymph nodes, morula, putamen, right uterine tube, spleen, subcutaneous adipose tissue, submandibular gland, sural nerve, tibiofemoral joint, tunica adventitia of aorta
related to As a drug target · 12
CD22 → An, Because CD22, BL22, CAR-T, CAT-3888, CAT-8015, EU, HA22, Moxetumomab, NIH, There, USA
related to External links · 12
CD22 → Antigen, B-cell, Human CD22, Medicine Medical Subject Headings, MeSH, National Library, Overview, P20273, PDB, PDBe-KB, UCSC Genome Browser, UniProt
related to BCR signaling · 10
CD22 → BCR, Because, ITAM, ITIM, Lyn, Phosphorylation, PTK, Src, The, This
related to Extracellular part · 10
CD22 → B-cell, However, IgM, N-terminus, Such, The, Therefore, This, To, V-like
related to Inotuzumab · 9
CD22 → August, CD22-targeting, DNA, FDA, G4, Inotuzumab, It, One, The
related to Activation role · 8
CD22 → After CD22, BCR, ITAM, Lyn, SH2, Src-family, Syk, Thus
related to Inhibitory role · 7
CD22 → After CD22, BCR, ITIM, MAPK, SH2, SHP-1, That

Important terminology Word statistics

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Important terminology

ligands cell signaling cells immunoglobulin bcr protein acid domain sialic tyrosine extracellular specifically gene surface binding receptor molecule bp shown

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CD22AliasesCD22, SIGLEC-2, SIGLEC2, CD22 molecule1.00infobox
CD22Band7 B1|7 19.26 cM1.00infobox
CD22Bgeespleen1.00infobox
CD22Bgeeappendix1.00infobox
CD22Bgeelymph node1.00infobox
CD22Bgeeright uterine tube1.00infobox
CD22Bgeesural nerve1.00infobox
CD22Bgeecorpus callosum1.00infobox
CD22Bgeeputamen1.00infobox
CD22Bgeeinferior olivary nucleus1.00infobox
CD22Bgeecaudate nucleus1.00infobox
CD22Bgeeamygdala1.00infobox
CD22Bgeemesenteric lymph nodes1.00infobox
CD22Bgeeblood1.00infobox
CD22Bgeetibiofemoral joint1.00infobox
CD22Bgeesubcutaneous adipose tissue1.00infobox
CD22Bgeesubmandibular gland1.00infobox
CD22Bgeegranulocyte1.00infobox
CD22Bgeecalvaria1.00infobox
CD22Bgeemorula1.00infobox
CD22Bgeetunica adventitia of aorta1.00infobox
CD22BioGPSMore reference expression data1.00infobox
CD22Chr.Chromosome 7 (mouse)1.00infobox
CD22DatabasesNCBI: entry1.00infobox
CD22End30,579,767 bp1.00infobox
CD22Ensembln/a1.00infobox
CD22Entrez9331.00infobox
CD22External IDsOMIM: 107266; MGI: 88322; GeneCards: CD221.00infobox
CD22Gene location (Mouse)Gene location (Mouse)Chr.Chromosome 7 (mouse)Band7 B1|7 19.26 cMStart30,564,827 bpEnd30,579,767 bp1.00infobox
CD22Gene ontologyprotein binding1.00infobox

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