Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

CD22: As a drug target, BCR signaling & Structure

CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

CD22 topic overview

The analysis highlights As a drug target, BCR signaling and Structure as prominent areas in the source structure around CD22.

Related topics
72
Source areas
6
Connected nodes
78
Extracted relationships
158
Concept neighborhoods
28
Bridge connections
78

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

As a drug target · 19 topics
Overview · 18 topics
BCR signaling · 13 topics
Structure · 10 topics
Autoimmunity · 6 topics
Interactions · 6 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CD22, SIGLEC-2, SIGLEC2, CD22 molecule
Band
7 B1|7 19.26 cM
Bgee
spleen · appendix · lymph node · right uterine tube · sural nerve
BioGPS
More reference expression data
Chr.
Chromosome 7 (mouse)
Databases
NCBI: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

BCR signaling

Autoimmunity

As a drug target

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CD22 connects Entity context

The extracted context around CD22 shows recurring relationship patterns in the source. For example, CD22 → B cell activation, carbohydrate binding, CD4 receptor binding, cell adhesion, cell surface, cytoplasm, early endosome, extracellular exosome, IgM binding, integral component of membrane, membrane, negative regulation of B cell receptor signaling pathway, negative regulation of calcium-mediated signaling, neuronal cell body membrane, plasma membrane, protein binding, protein phosphatase binding, recycling endosome, regulation of B cell proliferation, regulation of endocytosis Another extracted example is CD22 → amygdala, appendix, blood, calvaria, caudate nucleus, corpus callosum, granulocyte, inferior olivary nucleus, lymph node, mesenteric lymph nodes, morula, putamen, right uterine tube, spleen, subcutaneous adipose tissue, submandibular gland, sural nerve, tibiofemoral joint, tunica adventitia of aorta. Use these groups to spot repeated connection types before inspecting the individual relationships.

CD22

Top relations

Gene ontology · 23
CD22 → B cell activation, carbohydrate binding, CD4 receptor binding, cell adhesion, cell surface, cytoplasm, early endosome, extracellular exosome, IgM binding, integral component of membrane, membrane, negative regulation of B cell receptor signaling pathway, negative regulation of calcium-mediated signaling, neuronal cell body membrane, plasma membrane, protein binding, protein phosphatase binding, recycling endosome, regulation of B cell proliferation, regulation of endocytosis
Bgee · 19
CD22 → amygdala, appendix, blood, calvaria, caudate nucleus, corpus callosum, granulocyte, inferior olivary nucleus, lymph node, mesenteric lymph nodes, morula, putamen, right uterine tube, spleen, subcutaneous adipose tissue, submandibular gland, sural nerve, tibiofemoral joint, tunica adventitia of aorta
RNA expression pattern · 19
CD22 → amygdala, appendix, blood, calvaria, caudate nucleus, corpus callosum, granulocyte, inferior olivary nucleus, lymph node, mesenteric lymph nodes, morula, putamen, right uterine tube, spleen, subcutaneous adipose tissue, submandibular gland, sural nerve, tibiofemoral joint, tunica adventitia of aorta
related to As a drug target · 12
CD22 → An, Because CD22, BL22, CAR-T, CAT-3888, CAT-8015, EU, HA22, Moxetumomab, NIH, There, USA
related to External links · 12
CD22 → Antigen, B-cell, Human CD22, Medicine Medical Subject Headings, MeSH, National Library, Overview, P20273, PDB, PDBe-KB, UCSC Genome Browser, UniProt
related to BCR signaling · 10
CD22 → BCR, Because, ITAM, ITIM, Lyn, Phosphorylation, PTK, Src, The, This
related to Extracellular part · 10
CD22 → B-cell, However, IgM, N-terminus, Such, The, Therefore, This, To, V-like
related to Inotuzumab · 9
CD22 → August, CD22-targeting, DNA, FDA, G4, Inotuzumab, It, One, The
related to Activation role · 8
CD22 → After CD22, BCR, ITAM, Lyn, SH2, Src-family, Syk, Thus
related to Inhibitory role · 7
CD22 → After CD22, BCR, ITIM, MAPK, SH2, SHP-1, That

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

ligands cell signaling cells immunoglobulin bcr protein acid domain sialic tyrosine extracellular specifically gene surface binding receptor molecule bp shown

CD22 relationships Subject–Predicate–Object triples

TTTA extracted 158 structured relationships around CD22. Examples in this analysis include CD22 → Aliases → CD22, SIGLEC-2, SIGLEC2, CD22 molecule and CD22 → Band → 7 B1|7 19.26 cM. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
CD22AliasesCD22, SIGLEC-2, SIGLEC2, CD22 molecule1.00infobox
CD22Band7 B1|7 19.26 cM1.00infobox
CD22Bgeespleen1.00infobox
CD22Bgeeappendix1.00infobox
CD22Bgeelymph node1.00infobox
CD22Bgeeright uterine tube1.00infobox
CD22Bgeesural nerve1.00infobox
CD22Bgeecorpus callosum1.00infobox
CD22Bgeeputamen1.00infobox
CD22Bgeeinferior olivary nucleus1.00infobox
CD22Bgeecaudate nucleus1.00infobox
CD22Bgeeamygdala1.00infobox
CD22Bgeemesenteric lymph nodes1.00infobox
CD22Bgeeblood1.00infobox
CD22Bgeetibiofemoral joint1.00infobox
CD22Bgeesubcutaneous adipose tissue1.00infobox
CD22Bgeesubmandibular gland1.00infobox
CD22Bgeegranulocyte1.00infobox
CD22Bgeecalvaria1.00infobox
CD22Bgeemorula1.00infobox
CD22Bgeetunica adventitia of aorta1.00infobox
CD22BioGPSMore reference expression data1.00infobox
CD22Chr.Chromosome 7 (mouse)1.00infobox
CD22DatabasesNCBI: entry1.00infobox
CD22End30,579,767 bp1.00infobox
CD22Ensembln/a1.00infobox
CD22Entrez9331.00infobox
CD22External IDsOMIM: 107266; MGI: 88322; GeneCards: CD221.00infobox
CD22Gene location (Mouse)Gene location (Mouse)Chr.Chromosome 7 (mouse)Band7 B1|7 19.26 cMStart30,564,827 bpEnd30,579,767 bp1.00infobox
CD22Gene ontologyprotein binding1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CD22 bring nearby vocabulary together. In this analysis, examples include Signaling, Cell and Ligands. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • CD22
    • Signaling
    • Cell
    • Ligands
    • Gene
    • Trans
    • Extracellular
    • Tyrosine
    • Acid
    • Bcr
    • Domain
    • Activation
    • Autoimmune
  • cd22
    • Signaling
    • Cell
    • Ligands
    • Gene
    • Trans
    • Extracellular
    • Tyrosine
    • Acid
    • Bcr
    • Domain
    • Activation
    • Autoimmune
  • sialic acid
    • Sialic
    • Binding
    • Binds
    • Specifically
    • Extracellular
    • Immunoglobulin
    • Protein
    • Domain
    • Band
    • Ligands
    • Mouse
    • Activation
  • protein tyrosine kinase
    • Phosphorylated
    • Domain
    • Lyn
    • Shp-1
    • Protein
    • Sialic
    • Tyrosine
    • Signaling
    • Band
    • Ig
    • Mouse
    • N-terminus
  • transmembrane protein
    • Shp-1
    • Sialic
    • Tyrosine
    • Domain
    • Signaling
    • Band
    • Ig
    • Mouse
    • N-terminus
    • Activation
    • Bp
    • Chr
  • mitogen-activated protein kinase
    • Shp-1
    • Sialic
    • Tyrosine
    • Domain
    • Signaling
    • Band
    • Ig
    • Mouse
    • N-terminus
    • Activation
    • Bp
    • Chr
  • bcr signaling
    • Signaling
    • Inhibitory
    • Shp-1
    • Cell
    • Mouse
    • Cd22
    • Activation
    • Band
    • Bp
    • Chr
    • Inotuzumab
    • Location
  • b cell receptor
    • Signaling
    • Band
    • Mouse
    • Receptor
    • Activation
    • Bp
    • Chr
    • Location
    • Surface
    • Extracellular
    • Gene
    • Ligands

Connections between topic areas Semantic bridges

For CD22, one of the stronger structural bridges in this analysis connects CD22 with As a drug target. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
CD22As a drug target · splits 59 ⟂ 20
CD22Overview · splits 60 ⟂ 19
CD22BCR signaling · splits 65 ⟂ 14
CD22Structure · splits 68 ⟂ 11
CD22Autoimmunity · splits 72 ⟂ 7
CD22Interactions · splits 72 ⟂ 7

Map overview Semantic statistics

CD22

Nodes79
Edges78
Triples158
Avg. degree1.97
Density0.025316
Components1

Source & methodology

TTTA analyzes the structure around CD22 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as As a drug target, BCR signaling & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CD22 · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.