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CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.
The analysis highlights As a drug target, BCR signaling and Structure as prominent areas in the source structure around CD22.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around CD22 shows recurring relationship patterns in the source. For example, CD22 → B cell activation, carbohydrate binding, CD4 receptor binding, cell adhesion, cell surface, cytoplasm, early endosome, extracellular exosome, IgM binding, integral component of membrane, membrane, negative regulation of B cell receptor signaling pathway, negative regulation of calcium-mediated signaling, neuronal cell body membrane, plasma membrane, protein binding, protein phosphatase binding, recycling endosome, regulation of B cell proliferation, regulation of endocytosis Another extracted example is CD22 → amygdala, appendix, blood, calvaria, caudate nucleus, corpus callosum, granulocyte, inferior olivary nucleus, lymph node, mesenteric lymph nodes, morula, putamen, right uterine tube, spleen, subcutaneous adipose tissue, submandibular gland, sural nerve, tibiofemoral joint, tunica adventitia of aorta. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
ligands cell signaling cells immunoglobulin bcr protein acid domain sialic tyrosine extracellular specifically gene surface binding receptor molecule bp shown
TTTA extracted 158 structured relationships around CD22. Examples in this analysis include CD22 → Aliases → CD22, SIGLEC-2, SIGLEC2, CD22 molecule and CD22 → Band → 7 B1|7 19.26 cM. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| CD22 | Aliases | CD22, SIGLEC-2, SIGLEC2, CD22 molecule | 1.00 | infobox |
| CD22 | Band | 7 B1|7 19.26 cM | 1.00 | infobox |
| CD22 | Bgee | spleen | 1.00 | infobox |
| CD22 | Bgee | appendix | 1.00 | infobox |
| CD22 | Bgee | lymph node | 1.00 | infobox |
| CD22 | Bgee | right uterine tube | 1.00 | infobox |
| CD22 | Bgee | sural nerve | 1.00 | infobox |
| CD22 | Bgee | corpus callosum | 1.00 | infobox |
| CD22 | Bgee | putamen | 1.00 | infobox |
| CD22 | Bgee | inferior olivary nucleus | 1.00 | infobox |
| CD22 | Bgee | caudate nucleus | 1.00 | infobox |
| CD22 | Bgee | amygdala | 1.00 | infobox |
| CD22 | Bgee | mesenteric lymph nodes | 1.00 | infobox |
| CD22 | Bgee | blood | 1.00 | infobox |
| CD22 | Bgee | tibiofemoral joint | 1.00 | infobox |
| CD22 | Bgee | subcutaneous adipose tissue | 1.00 | infobox |
| CD22 | Bgee | submandibular gland | 1.00 | infobox |
| CD22 | Bgee | granulocyte | 1.00 | infobox |
| CD22 | Bgee | calvaria | 1.00 | infobox |
| CD22 | Bgee | morula | 1.00 | infobox |
| CD22 | Bgee | tunica adventitia of aorta | 1.00 | infobox |
| CD22 | BioGPS | More reference expression data | 1.00 | infobox |
| CD22 | Chr. | Chromosome 7 (mouse) | 1.00 | infobox |
| CD22 | Databases | NCBI: entry | 1.00 | infobox |
| CD22 | End | 30,579,767 bp | 1.00 | infobox |
| CD22 | Ensembl | n/a | 1.00 | infobox |
| CD22 | Entrez | 933 | 1.00 | infobox |
| CD22 | External IDs | OMIM: 107266; MGI: 88322; GeneCards: CD22 | 1.00 | infobox |
| CD22 | Gene location (Mouse) | Gene location (Mouse)Chr.Chromosome 7 (mouse)Band7 B1|7 19.26 cMStart30,564,827 bpEnd30,579,767 bp | 1.00 | infobox |
| CD22 | Gene ontology | protein binding | 1.00 | infobox |
The concept neighborhoods around CD22 bring nearby vocabulary together. In this analysis, examples include Signaling, Cell and Ligands. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For CD22, one of the stronger structural bridges in this analysis connects CD22 with As a drug target. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around CD22 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as As a drug target, BCR signaling & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — CD22 · EN edition · Analysis: TopicsToTalkAbout