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CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.
As a drug target, BCR signaling & Structure
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ligands cell signaling cells immunoglobulin bcr protein acid domain sialic tyrosine extracellular specifically gene surface binding receptor molecule bp shown
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| CD22 | Aliases | CD22, SIGLEC-2, SIGLEC2, CD22 molecule | 1.00 | infobox |
| CD22 | Band | 7 B1|7 19.26 cM | 1.00 | infobox |
| CD22 | Bgee | spleen | 1.00 | infobox |
| CD22 | Bgee | appendix | 1.00 | infobox |
| CD22 | Bgee | lymph node | 1.00 | infobox |
| CD22 | Bgee | right uterine tube | 1.00 | infobox |
| CD22 | Bgee | sural nerve | 1.00 | infobox |
| CD22 | Bgee | corpus callosum | 1.00 | infobox |
| CD22 | Bgee | putamen | 1.00 | infobox |
| CD22 | Bgee | inferior olivary nucleus | 1.00 | infobox |
| CD22 | Bgee | caudate nucleus | 1.00 | infobox |
| CD22 | Bgee | amygdala | 1.00 | infobox |
| CD22 | Bgee | mesenteric lymph nodes | 1.00 | infobox |
| CD22 | Bgee | blood | 1.00 | infobox |
| CD22 | Bgee | tibiofemoral joint | 1.00 | infobox |
| CD22 | Bgee | subcutaneous adipose tissue | 1.00 | infobox |
| CD22 | Bgee | submandibular gland | 1.00 | infobox |
| CD22 | Bgee | granulocyte | 1.00 | infobox |
| CD22 | Bgee | calvaria | 1.00 | infobox |
| CD22 | Bgee | morula | 1.00 | infobox |
| CD22 | Bgee | tunica adventitia of aorta | 1.00 | infobox |
| CD22 | BioGPS | More reference expression data | 1.00 | infobox |
| CD22 | Chr. | Chromosome 7 (mouse) | 1.00 | infobox |
| CD22 | Databases | NCBI: entry | 1.00 | infobox |
| CD22 | End | 30,579,767 bp | 1.00 | infobox |
| CD22 | Ensembl | n/a | 1.00 | infobox |
| CD22 | Entrez | 933 | 1.00 | infobox |
| CD22 | External IDs | OMIM: 107266; MGI: 88322; GeneCards: CD22 | 1.00 | infobox |
| CD22 | Gene location (Mouse) | Gene location (Mouse)Chr.Chromosome 7 (mouse)Band7 B1|7 19.26 cMStart30,564,827 bpEnd30,579,767 bp | 1.00 | infobox |
| CD22 | Gene ontology | protein binding | 1.00 | infobox |
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