Janus kinase 2

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Janus kinase 2 topic overview

The analysis highlights Interactions, Clinical significance and Overview as prominent areas in the source structure around Janus kinase 2.

Related topics: 60
Source areas: 3
Connected nodes: 63
Extracted relationships: 201
Concept neighborhoods: 8
Bridge connections: 63

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 29 topics

Overview · 19 topics

Clinical significance · 12 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.10.2: ↗
Aliases: JAK2, JTK10, THCYT3, Janus kinase 2, MAX2
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5AEP, 2B7A, 2W1I, 2XA4, 3E62, 3E63, 3E64, 3FUP, 3IO7, 3IOK, 3JY9, 3KCK, 3KRR, 3LPB, 3Q32, 3RVG, 3TJC, 3TJD,…
Band: 9p24.1 · 19 C1|19 23.73 cM
Bgee: Achilles tendon · monocyte · popliteal artery · tibial arteries · glutes
BioGPS: n/a

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Non-receptor tyrosine kinase
JAK homology domains Janus kinase
Type II cytokine receptor
Interferon
GM-CSF
IL-3R
IL-5R Interleukin-5 receptor
GM-CSF-R
Gp130
IL-6R Interleukin-6 receptor
Epo-R
Tpo-R Thrombopoietin receptor
GH-R Growth hormone receptor
PRL-R Prolactin receptor
SH2 SH2 domain
SH3 SH3 domain
Pseudokinase domain
Orthologs
Mammals

Clinical significance

Interactions

Interact Protein-protein interaction
DNAJA3
EGFR Epidermal growth factor receptor
EPOR Erythropoietin receptor
FYN
Grb2
IRS1
IL12RB2 Interleukin 12 receptor, beta 2 subunit
IL5RA Interleukin 5 receptor alpha subunit
PIK3R1
PPP2R4
PTK2
PTPN11
PTPN6
PRMT5 Protein arginine methyltransferase 5
SH2B1
SHC1
SOCS3
STAT5A
STAT5B
STAM Signal transducing adaptor molecule
SOCS1 Suppressor of cytokine signaling 1
TEC TEC (gene)
TNFRSF1A
VAV1
YES1
Prolactin
STAT5
RUSH transcription factors RUSH transcription factor?action=edit&redlink=1

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Janus kinase 2 connects Entity context

The extracted context around Janus kinase 2 shows recurring relationship patterns in the source. For example, Janus kinase 2 → acetylcholine receptor binding, actin filament polymerization, activation of cysteine-type endopeptidase activity involved in apoptotic process, activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway, activation of Janus kinase activity, adaptive immune response, apoptotic process, ATP binding, axon regeneration, blood coagulation, caveola, cell differentiation, cell migration, chromatin organization, cytokine-mediated signaling pathway, cytoplasm, cytoskeleton, cytosol, endomembrane system, endosome lumen Another extracted example is Janus kinase 2 → Achilles tendon, ascending aorta, blood, Descending thoracic aorta, fossa, glutes, jejunum, left coronary artery, mesenteric lymph nodes, monocyte, Paneth cell, popliteal artery, primary oocyte, Rostral migratory stream, secondary oocyte, sural nerve, tibia, tibial arteries, uterus, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 131

Janus kinase 2 → acetylcholine receptor binding, actin filament polymerization, activation of cysteine-type endopeptidase activity involved in apoptotic process, activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway, activation of Janus kinase activity, adaptive immune response, apoptotic process, ATP binding, axon regeneration, blood coagulation, caveola, cell differentiation, cell migration, chromatin organization, cytokine-mediated signaling pathway, cytoplasm, cytoskeleton, cytosol, endomembrane system, endosome lumen

Bgee · 20

Janus kinase 2 → Achilles tendon, ascending aorta, blood, Descending thoracic aorta, fossa, glutes, jejunum, left coronary artery, mesenteric lymph nodes, monocyte, Paneth cell, popliteal artery, primary oocyte, Rostral migratory stream, secondary oocyte, sural nerve, tibia, tibial arteries, uterus, zygote

RNA expression pattern · 20

Band · 2

Janus kinase 2 → 19 C1|19 23.73 cM, 9p24.1

Chr. · 2

Janus kinase 2 → Chromosome 19 (mouse), Chromosome 9 (human)

End · 2

Janus kinase 2 → 29,290,480 bp, 5,129,948 bp

related to Interactions · 2

Janus kinase 2 → DNAJA3EGFREPORFYNGrb2GHRIRS1IL12RB2IL5RAPIK3R1PPP2R4PTK2PTPN11PTPN6PRMT5SH2B1SHC1SOCS3STAT5ASTAT5BSTAMSOCS1TECTNFRSF1AVAV1YES1, Janus

2.7.10.2 · 1

Janus kinase 2 → ↗

Aliases · 1

Janus kinase 2 → JAK2, JTK10, THCYT3, Janus kinase 2, MAX2

Available structures · 1

Janus kinase 2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5AEP, 2B7A, 2W1I, 2XA4, 3E62, 3E63, 3E64, 3FUP, 3IO7, 3IOK, 3JY9, 3KCK, 3KRR, 3LPB, 3Q32, 3RVG, 3TJC, 3TJD,…

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

kinase jak2 janus bp chr human band chromosome domains gene tyrosine receptor location orthologs family homology jh sh2 mouse signaling

Janus kinase 2 relationships Subject–Predicate–Object triples

TTTA extracted 201 structured relationships around Janus kinase 2. Examples in this analysis include Janus kinase 2 → 2.7.10.2 → ↗ and Janus kinase 2 → Aliases → JAK2, JTK10, THCYT3, Janus kinase 2, MAX2. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Janus kinase 2	2.7.10.2	↗	1.00	infobox
Janus kinase 2	Aliases	JAK2, JTK10, THCYT3, Janus kinase 2, MAX2	1.00	infobox
Janus kinase 2	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5AEP, 2B7A, 2W1I, 2XA4, 3E62, 3E63, 3E64, 3FUP, 3IO7, 3IOK, 3JY9, 3KCK, 3KRR, 3LPB, 3Q32, 3RVG, 3TJC, 3TJD,…	1.00	infobox
Janus kinase 2	Band	9p24.1	1.00	infobox
Janus kinase 2	Band	19 C1\|19 23.73 cM	1.00	infobox
Janus kinase 2	Bgee	Achilles tendon	1.00	infobox
Janus kinase 2	Bgee	monocyte	1.00	infobox
Janus kinase 2	Bgee	popliteal artery	1.00	infobox
Janus kinase 2	Bgee	tibial arteries	1.00	infobox
Janus kinase 2	Bgee	glutes	1.00	infobox
Janus kinase 2	Bgee	Descending thoracic aorta	1.00	infobox
Janus kinase 2	Bgee	ascending aorta	1.00	infobox
Janus kinase 2	Bgee	sural nerve	1.00	infobox
Janus kinase 2	Bgee	tibia	1.00	infobox
Janus kinase 2	Bgee	left coronary artery	1.00	infobox
Janus kinase 2	Bgee	zygote	1.00	infobox
Janus kinase 2	Bgee	secondary oocyte	1.00	infobox
Janus kinase 2	Bgee	primary oocyte	1.00	infobox
Janus kinase 2	Bgee	blood	1.00	infobox
Janus kinase 2	Bgee	Paneth cell	1.00	infobox
Janus kinase 2	Bgee	jejunum	1.00	infobox
Janus kinase 2	Bgee	uterus	1.00	infobox
Janus kinase 2	Bgee	Rostral migratory stream	1.00	infobox
Janus kinase 2	Bgee	fossa	1.00	infobox
Janus kinase 2	Bgee	mesenteric lymph nodes	1.00	infobox
Janus kinase 2	BioGPS	n/a	1.00	infobox
Janus kinase 2	Chr.	Chromosome 9 (human)	1.00	infobox
Janus kinase 2	Chr.	Chromosome 19 (mouse)	1.00	infobox
Janus kinase 2	Databases	NCBI: entry; OMA: entry	1.00	infobox
Janus kinase 2	End	5,129,948 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Janus kinase 2 bring nearby vocabulary together. In this analysis, examples include Kinase, Domains and Jak2. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Janus kinase 2
- Kinase
- Domains
- Jak2
- Activity
- Binding
- Enzyme
- Ii
- Receptor
- Search
- Sh2
- Signaling
- Type
janus kinase 2
- Kinase
- Domains
- Jak2
- Tyrosine
- Activity
- Binding
- Enzyme
- Ii
- Receptor
- Search
- Sh2
- Signaling
non-receptor tyrosine kinase
- Domains
- Kinase
- Tyrosine
- Activity
- Binding
- Data
- Domain
- End
- Enzyme
- Found
- Function
- Homology
type ii cytokine receptor
- Receptor
- Signaling
- Type
- Activity
- Binding
- Data
- Domain
- End
- Enzyme
- Found
- Function
- Implicated
pseudokinase domain
- Found
- Function
- Activity
- Data
- End
- Enzyme
- Ii
- Jh
- Mouse
- One
- Orthologs
- Receptor
jak homology domains
- Domains
- Homology
- Jh
- Binding
- Kinase
- Sh2
- Domain
- Found
- Function
- One
- Tyrosine
- Janus
orthologs
- Receptor
- Search
- Sh2
- Signaling
- Type
- Tyrosine
sh2
- Orthologs
- Search
- Signaling
- Type
- Tyrosine

Connections between topic areas Semantic bridges

For Janus kinase 2, one of the stronger structural bridges in this analysis connects Janus kinase 2 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Janus kinase 2 — Interactions · splits 34 ⟂ 30

Janus kinase 2 — Overview · splits 44 ⟂ 20

Janus kinase 2 — Clinical significance · splits 51 ⟂ 13

Map overview Semantic statistics

Janus kinase 2

Nodes64

Edges63

Triples201

Avg. degree1.97

Density0.03125

Components1

Source & methodology

TTTA analyzes the structure around Janus kinase 2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Clinical significance & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Janus kinase 2 · EN edition · Analysis: TopicsToTalkAbout