Fas ligand

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Fas ligand topic overview

The analysis highlights Function, Interactions and Structure as prominent areas in the source structure around Fas ligand.

Related topics: 35
Source areas: 6
Connected nodes: 41
Extracted relationships: 176
Concept neighborhoods: 19
Bridge connections: 41

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 10 topics

Overview · 8 topics

Interactions · 7 topics

Regulation · 4 topics

Structure · 4 topics

Expression · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6, TNLG1A, Fas ligand
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4MSV
Band: 1q24.3 · 1 H2.1|1 69.95 cM
Bgee: granulocyte · blood · lymph node · spleen · jejunal mucosa
BioGPS: More reference expression data
Chr.: Chromosome 1 (human) · Chromosome 1 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Tumor necrosis factor
Fas receptor
Apoptosis
NF-κB
MAPK Mitogen-activated protein kinase
Cytotoxic T lymphocytes
Natural killer cells Natural killer cell
Immune homeostasis. Homeostasis

Structure

Function

Expression

Tumor necrosis factor-alpha
Interferon-gamma Interferon gamma

Regulation

NFAT
RNA-binding proteins RNA-binding protein
MicroRNAs MicroRNA
Caspase-8 Caspase 8

Interactions

Interact Protein-protein interaction
EZR Ezrin
FNBP1
FYN
Grb2
PACSIN2
TNFRSF6B

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Fas ligand connects Entity context

The extracted context around Fas ligand shows recurring relationship patterns in the source. For example, Fas ligand → activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, apoptotic signaling pathway, caveola, cell surface, cell-cell signaling, cellular chloride ion homeostasis, cytokine activity, cytokine-mediated signaling pathway, cytoplasmic vesicle, cytoplasmic vesicle lumen, death receptor binding, endosomal lumen acidification, external side of plasma membrane, extracellular exosome, extracellular region, extracellular space, extrinsic apoptotic signaling pathway, extrinsic apoptotic signaling pathway via death domain receptors, immune response Another extracted example is Fas ligand → blastocyst, blood, bone marrow, decidua, duodenum, embryo, gallbladder, granulocyte, jejunal mucosa, lumbar subsegment of spinal cord, lymph node, mucosa of ileum, placenta, rectum, spermatid, spleen. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 54

Fas ligand → activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, apoptotic signaling pathway, caveola, cell surface, cell-cell signaling, cellular chloride ion homeostasis, cytokine activity, cytokine-mediated signaling pathway, cytoplasmic vesicle, cytoplasmic vesicle lumen, death receptor binding, endosomal lumen acidification, external side of plasma membrane, extracellular exosome, extracellular region, extracellular space, extrinsic apoptotic signaling pathway, extrinsic apoptotic signaling pathway via death domain receptors, immune response

Bgee · 16

Fas ligand → blastocyst, blood, bone marrow, decidua, duodenum, embryo, gallbladder, granulocyte, jejunal mucosa, lumbar subsegment of spinal cord, lymph node, mucosa of ileum, placenta, rectum, spermatid, spleen

RNA expression pattern · 16

related to Receptor · 15

Fas ligand → CD95, DcR3, Decoy, Fas, FasL, FasR, FasR-FasL, It, LIGHT, Many, Studies, The, The Fas, TL1A, TNF

related to Structure · 14

Fas ligand → Apo-1L, C-terminal, CD95L, Despite, Fas, FasL, II, It, MMP-7, N-terminal, The, The FasL, TNF, With

related to Function · 10

Fas ligand → CD95, DISC, FADD, Fas, Fas-associated, FasL, FasL-mediated, The, The DISC, The Fas

related to Expression · 9

Fas ligand → Active, CTLs, Fas, FasL, IFN-γ, IL-2, NK, The, TNF-α

related to Interactions · 8

Fas ligand → CASP8, EZR, FADD, Fas, FNBP1, FYN, Grb2, PACSIN2

related to Immune privilege · 7

Fas ligand → Fas, Fas-expressing, FasL, Immune-privileged, In, Likewise, These

Band · 2

Fas ligand → 1 H2.1|1 69.95 cM, 1q24.3

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

fasl fas immune receptor ligand apoptosis expression signaling cells protein apoptotic function also cell tumor factor bp non-apoptotic human soluble

Fas ligand relationships Subject–Predicate–Object triples

TTTA extracted 176 structured relationships around Fas ligand. Examples in this analysis include Fas ligand → Aliases → FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6, TNLG1A, Fas ligand and Fas ligand → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4MSV. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Fas ligand	Aliases	FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6, TNLG1A, Fas ligand	1.00	infobox
Fas ligand	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4MSV	1.00	infobox
Fas ligand	Band	1q24.3	1.00	infobox
Fas ligand	Band	1 H2.1\|1 69.95 cM	1.00	infobox
Fas ligand	Bgee	granulocyte	1.00	infobox
Fas ligand	Bgee	blood	1.00	infobox
Fas ligand	Bgee	lymph node	1.00	infobox
Fas ligand	Bgee	spleen	1.00	infobox
Fas ligand	Bgee	jejunal mucosa	1.00	infobox
Fas ligand	Bgee	mucosa of ileum	1.00	infobox
Fas ligand	Bgee	gallbladder	1.00	infobox
Fas ligand	Bgee	duodenum	1.00	infobox
Fas ligand	Bgee	rectum	1.00	infobox
Fas ligand	Bgee	bone marrow	1.00	infobox
Fas ligand	Bgee	blastocyst	1.00	infobox
Fas ligand	Bgee	lumbar subsegment of spinal cord	1.00	infobox
Fas ligand	Bgee	embryo	1.00	infobox
Fas ligand	Bgee	spermatid	1.00	infobox
Fas ligand	Bgee	placenta	1.00	infobox
Fas ligand	Bgee	decidua	1.00	infobox
Fas ligand	BioGPS	More reference expression data	1.00	infobox
Fas ligand	Chr.	Chromosome 1 (human)	1.00	infobox
Fas ligand	Chr.	Chromosome 1 (mouse)	1.00	infobox
Fas ligand	Databases	NCBI: entry; OMA: entry	1.00	infobox
Fas ligand	End	172,666,876 bp	1.00	infobox
Fas ligand	End	161,616,064 bp	1.00	infobox
Fas ligand	Ensembl	ENSG00000117560	1.00	infobox
Fas ligand	Entrez	356	1.00	infobox
Fas ligand	External IDs	OMIM: 134638; MGI: 99255; GeneCards: FASLG	1.00	infobox
Fas ligand	Gene location (Human)	Gene location (Human)Chr.Chromosome 1 (human)Band1q24.3Start172,659,103 bpEnd172,666,876 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Fas ligand bring nearby vocabulary together. In this analysis, examples include Ligand, Receptor and Immune. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Fas ligand
- Ligand
- Receptor
- Immune
- Apoptotic
- Binding
- Signaling
- Also
- Apoptosis
- Protein
- Tumor
- Domain
- Non-apoptotic
fas ligand
- Ligand
- Receptor
- Immune
- Binding
- Apoptotic
- Regulation
- Signaling
- Also
- Protein
- Necrosis
- Privilege
- Apoptosis
tumor necrosis factor
- Necrosis
- Tumor
- Factor
- Protein
- Gene
- Activated
- Ligand
- Receptor
- Apoptotic
- Band
- Expression
- Regulation
fas receptor
- Ligand
- Domain
- Receptor
- Immune
- Apoptotic
- Binding
- Signaling
- Also
- Cell
- Apoptosis
- Pathway
- Protein
immune homeostasis.
- Expression
- Function
- Privilege
- Signaling
- Tissues
- Ligand
- Regulation
- Lymphocytes
- Apoptotic
- Cancer
- Non-apoptotic
- Receptor
transmembrane protein
- Domain
- Receptor
- Binding
- Necrosis
- Gene
- Tumor
- Function
- Apoptotic
- Expression
- Band
- Nf-κb
- Regulation
chromosome 10
- Bp
- Human
- Gene
- Band
- Regulation
- Function
- Expression
- Signaling
- Ligand
- Binding
- Cleavage
- Necrosis
type i transmembrane protein
- Domain
- Receptor
- Binding
- Necrosis
- Gene
- Tumor
- Function
- Apoptotic
- Expression
- Band
- Nf-κb
- Regulation

Connections between topic areas Semantic bridges

For Fas ligand, one of the stronger structural bridges in this analysis connects Fas ligand with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Fas ligand — Function · splits 31 ⟂ 11

Fas ligand — Overview · splits 33 ⟂ 9

Fas ligand — Interactions · splits 34 ⟂ 8

Fas ligand — Structure · splits 37 ⟂ 5

Fas ligand — Regulation · splits 37 ⟂ 5

Fas ligand — Expression · splits 39 ⟂ 3

Map overview Semantic statistics

Fas ligand

Nodes42

Edges41

Triples176

Avg. degree1.95

Density0.047619

Components1

Source & methodology

TTTA analyzes the structure around Fas ligand to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Fas ligand · EN edition · Analysis: TopicsToTalkAbout