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Janus kinase 1: Interactions & Overview

Janus kinase 1 (JAK1) is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (γc) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor…

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Janus kinase 1 topic overview

The analysis highlights Interactions and Overview as prominent areas in the source structure around Janus kinase 1.

Related topics
39
Source areas
2
Connected nodes
41
Extracted relationships
127
Concept neighborhoods
11
Bridge connections
41

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 25 topics
Interactions · 14 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.10.2
↗
Aliases
JAK1, JAK1A, JAK1B, JTK3, Janus kinase 1, AIIDE
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3EYG, 3EYH, 4E4L, 4E4N, 4E5W, 4EHZ, 4EI4, 4FK6, 4I5C, 4IVB, 4IVC, 4IVD, 4K6Z, 4K77, 4L00, 4L01, 5E1E, 5HX8,…
Band
1p31.3 · 4 C6|4 46.19 cM
Bgee
beta cell · skin of hip · Achilles tendon · epithelium of nasopharynx · lymph node
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Janus kinase 1 connects Entity context

The extracted context around Janus kinase 1 shows recurring relationship patterns in the source. For example, Janus kinase 1 → ATP binding, CCR5 chemokine receptor binding, cell differentiation, cell migration, cytokine-mediated signaling pathway, cytoplasm, cytoskeleton, cytosol, endomembrane system, endosome, extrinsic component of cytoplasmic side of plasma membrane, focal adhesion, growth hormone receptor binding, innate immune response, interferon-gamma-mediated signaling pathway, interleukin-12-mediated signaling pathway, interleukin-15-mediated signaling pathway, interleukin-2-mediated signaling pathway, interleukin-21-mediated signaling pathway, interleukin-27-mediated signaling pathway Another extracted example is Janus kinase 1 → Achilles tendon, ankle, beta cell, blood, cartilage tissue, epithelium of nasopharynx, gastrula, glutes, granulocyte, lymph node, mesenteric lymph nodes, parietal pleura, skin of hip, skin of thigh, sternocleidomastoid muscle, superficial temporal artery, temporal muscle, tibiofemoral joint, triceps brachii muscle. Use these groups to spot repeated connection types before inspecting the individual relationships.

Janus kinase 1

Top relations

Gene ontology · 52
Janus kinase 1 → ATP binding, CCR5 chemokine receptor binding, cell differentiation, cell migration, cytokine-mediated signaling pathway, cytoplasm, cytoskeleton, cytosol, endomembrane system, endosome, extrinsic component of cytoplasmic side of plasma membrane, focal adhesion, growth hormone receptor binding, innate immune response, interferon-gamma-mediated signaling pathway, interleukin-12-mediated signaling pathway, interleukin-15-mediated signaling pathway, interleukin-2-mediated signaling pathway, interleukin-21-mediated signaling pathway, interleukin-27-mediated signaling pathway
Bgee · 19
Janus kinase 1 → Achilles tendon, ankle, beta cell, blood, cartilage tissue, epithelium of nasopharynx, gastrula, glutes, granulocyte, lymph node, mesenteric lymph nodes, parietal pleura, skin of hip, skin of thigh, sternocleidomastoid muscle, superficial temporal artery, temporal muscle, tibiofemoral joint, triceps brachii muscle
RNA expression pattern · 19
Janus kinase 1 → Achilles tendon, ankle, beta cell, blood, cartilage tissue, epithelium of nasopharynx, gastrula, glutes, granulocyte, lymph node, mesenteric lymph nodes, parietal pleura, skin of hip, skin of thigh, sternocleidomastoid muscle, superficial temporal artery, temporal muscle, tibiofemoral joint, triceps brachii muscle
related to Interactions · 12
Janus kinase 1 → ELP2, GNB2L1IL6ST, Grb2, IL10RA, IL2RB, IRS1, Janus, PTPN11, STAM2, STAT3, STAT5A, STAT5B
Band · 2
Janus kinase 1 → 1p31.3, 4 C6|4 46.19 cM
Chr. · 2
Janus kinase 1 → Chromosome 1 (human), Chromosome 4 (mouse)
End · 2
Janus kinase 1 → 101,265,282 bp, 65,067,754 bp
2.7.10.2 · 1
Janus kinase 1 → ↗
Aliases · 1
Janus kinase 1 → JAK1, JAK1A, JAK1B, JTK3, Janus kinase 1, AIIDE
Available structures · 1
Janus kinase 1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3EYG, 3EYH, 4E4L, 4E4N, 4E5W, 4EHZ, 4EI4, 4FK6, 4I5C, 4IVB, 4IVC, 4IVD, 4K6Z, 4K77, 4L00, 4L01, 5E1E, 5HX8,…

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

jak1 receptor human bp family chr type band kinase chromosome cytokine janus gene location ii receptors also mouse tyrosine protein

Janus kinase 1 relationships Subject–Predicate–Object triples

TTTA extracted 127 structured relationships around Janus kinase 1. Examples in this analysis include Janus kinase 1 → 2.7.10.2 → ↗ and Janus kinase 1 → Aliases → JAK1, JAK1A, JAK1B, JTK3, Janus kinase 1, AIIDE. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Janus kinase 12.7.10.2↗1.00infobox
Janus kinase 1AliasesJAK1, JAK1A, JAK1B, JTK3, Janus kinase 1, AIIDE1.00infobox
Janus kinase 1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3EYG, 3EYH, 4E4L, 4E4N, 4E5W, 4EHZ, 4EI4, 4FK6, 4I5C, 4IVB, 4IVC, 4IVD, 4K6Z, 4K77, 4L00, 4L01, 5E1E, 5HX8,…1.00infobox
Janus kinase 1Band1p31.31.00infobox
Janus kinase 1Band4 C6|4 46.19 cM1.00infobox
Janus kinase 1Bgeebeta cell1.00infobox
Janus kinase 1Bgeeskin of hip1.00infobox
Janus kinase 1BgeeAchilles tendon1.00infobox
Janus kinase 1Bgeeepithelium of nasopharynx1.00infobox
Janus kinase 1Bgeelymph node1.00infobox
Janus kinase 1Bgeecartilage tissue1.00infobox
Janus kinase 1Bgeesuperficial temporal artery1.00infobox
Janus kinase 1Bgeeskin of thigh1.00infobox
Janus kinase 1Bgeeparietal pleura1.00infobox
Janus kinase 1Bgeeglutes1.00infobox
Janus kinase 1Bgeetibiofemoral joint1.00infobox
Janus kinase 1Bgeegastrula1.00infobox
Janus kinase 1Bgeetriceps brachii muscle1.00infobox
Janus kinase 1Bgeegranulocyte1.00infobox
Janus kinase 1Bgeemesenteric lymph nodes1.00infobox
Janus kinase 1Bgeeankle1.00infobox
Janus kinase 1Bgeesternocleidomastoid muscle1.00infobox
Janus kinase 1Bgeeblood1.00infobox
Janus kinase 1Bgeetemporal muscle1.00infobox
Janus kinase 1BioGPSMore reference expression data1.00infobox
Janus kinase 1Chr.Chromosome 1 (human)1.00infobox
Janus kinase 1Chr.Chromosome 4 (mouse)1.00infobox
Janus kinase 1DatabasesNCBI: entry; OMA: entry1.00infobox
Janus kinase 1End65,067,754 bp1.00infobox
Janus kinase 1End101,265,282 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Janus kinase 1 bring nearby vocabulary together. In this analysis, examples include Kinase, Activity and Human. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Janus kinase 1
    • Kinase
    • Activity
    • Human
    • Protein
    • Search
    • Signaling
    • Tyrosine
    • Jak1
    • Gene
    • Location
    • Chromosome
    • Type
  • janus kinase 1
    • Kinase
    • Activity
    • Human
    • Protein
    • Search
    • Signaling
    • Tyrosine
    • Jak1
    • Gene
    • Location
    • Chromosome
    • Type
  • tyrosine kinase
    • Protein
    • Signaling
    • Activity
    • Cytokines
    • Janus
    • Kinase
    • Search
    • Type
    • Tyrosine
    • Gene
    • Human
    • Location
  • type ii cytokine receptors
    • Receptors
    • Cytokines
    • Family
    • Il-2
    • Signal
    • Type
    • Tyrosine
    • Cytokine
    • Also
    • Protein
    • Signaling
    • Receptor
  • type i cytokine receptors
    • Receptors
    • Family
    • Il-2
    • Signal
    • Type
    • Tyrosine
    • Cytokine
    • Also
    • Receptor
    • Ii
    • Activity
    • C6
  • ciliary neurotrophic factor receptor
    • Family
    • Type
    • Il-2r
    • Il-7r
    • Il-9r
    • Activity
    • C6
    • End
    • Expression
    • Mouse
    • Receptors
    • Search
  • il-10 family
    • Receptors
    • Receptor
    • Type
    • Il-2
    • Il-2r
    • Il-7r
    • Il-9r
    • Also
    • Ii
    • Signal
  • cytokines
    • Ii
    • Protein
    • Signaling
    • Tyrosine
    • Janus
    • Kinase
    • Type
    • Human
    • Jak1

Connections between topic areas Semantic bridges

For Janus kinase 1, one of the stronger structural bridges in this analysis connects Janus kinase 1 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Janus kinase 1 — Overview · splits 16 ⟂ 26
Janus kinase 1 — Interactions · splits 27 ⟂ 15

Map overview Semantic statistics

Janus kinase 1

Nodes42
Edges41
Triples127
Avg. degree1.95
Density0.047619
Components1

Source & methodology

TTTA analyzes the structure around Janus kinase 1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Janus kinase 1 · EN edition · Analysis: TopicsToTalkAbout

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