Colony stimulating factor 1 receptor

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Gene

Chromosome 5 Chromosome 18 Hematopoietic stem cells More differentiated Monocytes

23 related topics

Protein

Tyrosine kinase Transmembrane receptor PDGF receptor Molecular weight Daltons

22 related topics

Function

Bone remodeling cycle Osteoblasts Bcl-X(L)Caspase-9 MTOR/S6

42 related topics

Clinical significance

Rheumatoid arthritis Psoriatic arthritis Crohn's disease Proinflammatory cytokine TNF-α

33 related topics

Key facts & relationships

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2.7.10.1: ↗
Aliases: CSF1R, C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R, colony stimulating factor 1 receptor, BANDDOS, HDLS1
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2I0V, 2I0Y, 2I1M, 2OGV, 3BEA, 3DPK, 3KRJ, 3KRL, 3LCD, 3LCO, 4DKD, 4HW7, 4LIQ, 4R7H, 4R7I, 4WRL, 4WRM
Band: 5q32 · 18 E1|18 34.41 cM
Bgee: granulocyte · monocyte · spleen · right coronary artery · placenta
BioGPS: More reference expression data

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Overview

Protein
Gene
Receptor Immune receptor
Ligands Ligand
Colony stimulating factor 1 Macrophage colony-stimulating factor
Interleukin-34 Interleukin 34
Myeloid Myeloid tissue
Survival Cell survival
Proliferation Cell proliferation
Differentiation Cell differentiation
In vivo
In vitro
Cancer
Neurodegeneration
Inflammatory bone diseases Bone disease
Heterozygous
Autosomal dominant
Adult-onset leukoencephalopathy Leukoencephalopathy with neuroaxonal spheroids
Dementia
Executive dysfunction
Seizures Seizure
Phagocytosis
Axonal Axon
Demyelination Demyelinating disease
DAP12
TREM2
Nasu-Hakola disease
Central nervous system
Epilepsy
Kainic acid

Gene

Chromosome 5
Chromosome 18
Hematopoietic stem cells Hematopoietic stem cell
More differentiated Cellular differentiation
Monocytes Monocyte
Macrophages Macrophage
Osteoclasts Osteoclast
Myeloid dendritic cells Dendritic cell
Microglia
Paneth cells Paneth cell
Promoters Promoter (genetics)
Exon
Transcribed Transcription (biology)
Trophoblastic cells Trophoblast
Ets ETS transcription factor family
PU.1
Upstream Upstream and downstream (transduction)
Conserved Conserved sequence
Intron
Peritoneum
Transcriptionally Transcription (genetics)
Ribosomal protein L7 RPL7
Pseudogene

Controversy

Preclinical models Animal models
Stroke
Traumatic brain injury
Aging Aging brain
Bioavailability
University of Queensland
UCI University of California, Irvine
PNAS Proceedings of the National Academy of Sciences of the United States of America
Primary research paper Research
HMS Harvard Medical School
Confounded Confounding

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Nodes220

Edges219

Triples177

Avg. degree1.99

Density0.009091

Components1

How this topic connects Entity context

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Colony stimulating factor 1 receptor

Top relations

Gene ontology · 71

Colony stimulating factor 1 receptor → ATP binding, axon guidance, cell differentiation, cell population proliferation, cell surface, cell-cell junction maintenance, cellular response to cytokine stimulus, cellular response to macrophage colony-stimulating factor stimulus, CSF1-CSF1R complex, cytokine binding, cytokine-mediated signaling pathway, cytoplasm, forebrain neuron differentiation, hematopoietic progenitor cell differentiation, hemopoiesis, immune system process, inflammatory response, innate immune response, integral component of membrane, integral component of plasma membrane

Bgee · 19

Colony stimulating factor 1 receptor → ankle, appendix, calvaria, gallbladder, gastrula, globus pallidus, granulocyte, inferior ganglion of vagus nerve, internal carotid artery, lymph node, monocyte, motor neuron, placenta, retinal pigment epithelium, right coronary artery, spleen, stroma of bone marrow, substantia nigra, tibiofemoral joint

RNA expression pattern · 19

related to Interactions · 7

Colony stimulating factor 1 receptor → Cbl, Colony, FYN, Grb2, MPS, Suppressor, This

Band · 2

Colony stimulating factor 1 receptor → 18 E1|18 34.41 cM, 5q32

Chr. · 2

Colony stimulating factor 1 receptor → Chromosome 18 (mouse), Chromosome 5 (human)

End · 2

Colony stimulating factor 1 receptor → 150,113,372 bp, 61,265,221 bp

2.7.10.1 · 1

Colony stimulating factor 1 receptor → ↗

Aliases · 1

Colony stimulating factor 1 receptor → CSF1R, C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R, colony stimulating factor 1 receptor, BANDDOS, HDLS1

Available structures · 1

Colony stimulating factor 1 receptor → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2I0V, 2I0Y, 2I1M, 2OGV, 3BEA, 3DPK, 3KRJ, 3KRL, 3LCD, 3LCO, 4DKD, 4HW7, 4LIQ, 4R7H, 4R7I, 4WRL, 4WRM

Important terminology Word statistics

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Important terminology

csf1r signaling microglia cells macrophages survival gene csf-1 osteoclasts also bone disease brain human differentiation mouse osteoclast receptor loss-of-function cancer

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Colony stimulating factor 1 receptor	2.7.10.1	↗	1.00	infobox
Colony stimulating factor 1 receptor	Aliases	CSF1R, C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R, colony stimulating factor 1 receptor, BANDDOS, HDLS1	1.00	infobox
Colony stimulating factor 1 receptor	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2I0V, 2I0Y, 2I1M, 2OGV, 3BEA, 3DPK, 3KRJ, 3KRL, 3LCD, 3LCO, 4DKD, 4HW7, 4LIQ, 4R7H, 4R7I, 4WRL, 4WRM	1.00	infobox
Colony stimulating factor 1 receptor	Band	5q32	1.00	infobox
Colony stimulating factor 1 receptor	Band	18 E1\|18 34.41 cM	1.00	infobox
Colony stimulating factor 1 receptor	Bgee	granulocyte	1.00	infobox
Colony stimulating factor 1 receptor	Bgee	monocyte	1.00	infobox
Colony stimulating factor 1 receptor	Bgee	spleen	1.00	infobox
Colony stimulating factor 1 receptor	Bgee	right coronary artery	1.00	infobox
Colony stimulating factor 1 receptor	Bgee	placenta	1.00	infobox
Colony stimulating factor 1 receptor	Bgee	inferior ganglion of vagus nerve	1.00	infobox
Colony stimulating factor 1 receptor	Bgee	retinal pigment epithelium	1.00	infobox
Colony stimulating factor 1 receptor	Bgee	gallbladder	1.00	infobox
Colony stimulating factor 1 receptor	Bgee	appendix	1.00	infobox
Colony stimulating factor 1 receptor	Bgee	lymph node	1.00	infobox
Colony stimulating factor 1 receptor	Bgee	stroma of bone marrow	1.00	infobox
Colony stimulating factor 1 receptor	Bgee	ankle	1.00	infobox
Colony stimulating factor 1 receptor	Bgee	motor neuron	1.00	infobox
Colony stimulating factor 1 receptor	Bgee	tibiofemoral joint	1.00	infobox
Colony stimulating factor 1 receptor	Bgee	internal carotid artery	1.00	infobox
Colony stimulating factor 1 receptor	Bgee	calvaria	1.00	infobox
Colony stimulating factor 1 receptor	Bgee	substantia nigra	1.00	infobox
Colony stimulating factor 1 receptor	Bgee	gastrula	1.00	infobox
Colony stimulating factor 1 receptor	Bgee	globus pallidus	1.00	infobox
Colony stimulating factor 1 receptor	BioGPS	More reference expression data	1.00	infobox
Colony stimulating factor 1 receptor	Chr.	Chromosome 5 (human)	1.00	infobox
Colony stimulating factor 1 receptor	Chr.	Chromosome 18 (mouse)	1.00	infobox
Colony stimulating factor 1 receptor	Databases	NCBI: entry; OMA: entry	1.00	infobox
Colony stimulating factor 1 receptor	End	150,113,372 bp	1.00	infobox
Colony stimulating factor 1 receptor	End	61,265,221 bp	1.00	infobox

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Gene

Protein

Function

Clinical significance

Key facts & relationships

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Overview

Gene

Protein

Function

Clinical significance

Therapeutics

Controversy

Interactions

Advanced semantic analysis

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Colony stimulating factor 1 receptor

How this topic connects Entity context

Colony stimulating factor 1 receptor

Top relations

Important terminology Word statistics

Important terminology

Entity relationships Subject–Predicate–Object triples

Related concept clusters Concept neighborhoods

Connections between topic areas Semantic bridges