Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

Colony stimulating factor 1 receptor: Gene, Protein & Function

Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115 (Cluster of Differentiation 115), is a cell-surface protein encoded by the human CSF1R gene (known also as c-FMS). CSF1R is a receptor that can be activated by two ligands: colony stimulating factor 1 (CSF-1) and interleukin-34…

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

Colony stimulating factor 1 receptor topic overview

The analysis highlights Gene, Protein and Function as prominent areas in the source structure around Colony stimulating factor 1 receptor.

Related topics
211
Source areas
8
Connected nodes
219
Extracted relationships
177
Concept neighborhoods
49
Bridge connections
219

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 44 topics
Function · 42 topics
Clinical significance · 33 topics
Therapeutics · 31 topics
Gene · 23 topics
Protein · 22 topics
Controversy · 11 topics
Interactions · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.10.1
Aliases
CSF1R, C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R, colony stimulating factor 1 receptor, BANDDOS, HDLS1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2I0V, 2I0Y, 2I1M, 2OGV, 3BEA, 3DPK, 3KRJ, 3KRL, 3LCD, 3LCO, 4DKD, 4HW7, 4LIQ, 4R7H, 4R7I, 4WRL, 4WRM
Band
5q32 · 18 E1|18 34.41 cM
Bgee
granulocyte · monocyte · spleen · right coronary artery · placenta
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Gene

Protein

Function

Clinical significance

Therapeutics

Controversy

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Colony stimulating factor 1 receptor connects Entity context

The extracted context around Colony stimulating factor 1 receptor shows recurring relationship patterns in the source. For example, Colony stimulating factor 1 receptor → ATP binding, axon guidance, cell differentiation, cell population proliferation, cell surface, cell-cell junction maintenance, cellular response to cytokine stimulus, cellular response to macrophage colony-stimulating factor stimulus, CSF1-CSF1R complex, cytokine binding, cytokine-mediated signaling pathway, cytoplasm, forebrain neuron differentiation, hematopoietic progenitor cell differentiation, hemopoiesis, immune system process, inflammatory response, innate immune response, integral component of membrane, integral component of plasma membrane Another extracted example is Colony stimulating factor 1 receptor → ankle, appendix, calvaria, gallbladder, gastrula, globus pallidus, granulocyte, inferior ganglion of vagus nerve, internal carotid artery, lymph node, monocyte, motor neuron, placenta, retinal pigment epithelium, right coronary artery, spleen, stroma of bone marrow, substantia nigra, tibiofemoral joint. Use these groups to spot repeated connection types before inspecting the individual relationships.

Colony stimulating factor 1 receptor

Top relations

Gene ontology · 71
Colony stimulating factor 1 receptor → ATP binding, axon guidance, cell differentiation, cell population proliferation, cell surface, cell-cell junction maintenance, cellular response to cytokine stimulus, cellular response to macrophage colony-stimulating factor stimulus, CSF1-CSF1R complex, cytokine binding, cytokine-mediated signaling pathway, cytoplasm, forebrain neuron differentiation, hematopoietic progenitor cell differentiation, hemopoiesis, immune system process, inflammatory response, innate immune response, integral component of membrane, integral component of plasma membrane
Bgee · 19
Colony stimulating factor 1 receptor → ankle, appendix, calvaria, gallbladder, gastrula, globus pallidus, granulocyte, inferior ganglion of vagus nerve, internal carotid artery, lymph node, monocyte, motor neuron, placenta, retinal pigment epithelium, right coronary artery, spleen, stroma of bone marrow, substantia nigra, tibiofemoral joint
RNA expression pattern · 19
Colony stimulating factor 1 receptor → ankle, appendix, calvaria, gallbladder, gastrula, globus pallidus, granulocyte, inferior ganglion of vagus nerve, internal carotid artery, lymph node, monocyte, motor neuron, placenta, retinal pigment epithelium, right coronary artery, spleen, stroma of bone marrow, substantia nigra, tibiofemoral joint
related to Interactions · 7
Colony stimulating factor 1 receptor → Cbl, Colony, FYN, Grb2, MPS, Suppressor, This
Band · 2
Colony stimulating factor 1 receptor → 18 E1|18 34.41 cM, 5q32
Chr. · 2
Colony stimulating factor 1 receptor → Chromosome 18 (mouse), Chromosome 5 (human)
End · 2
Colony stimulating factor 1 receptor → 150,113,372 bp, 61,265,221 bp
2.7.10.1 · 1
Colony stimulating factor 1 receptor → ↗
Aliases · 1
Colony stimulating factor 1 receptor → CSF1R, C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R, colony stimulating factor 1 receptor, BANDDOS, HDLS1
Available structures · 1
Colony stimulating factor 1 receptor → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2I0V, 2I0Y, 2I1M, 2OGV, 3BEA, 3DPK, 3KRJ, 3KRL, 3LCD, 3LCO, 4DKD, 4HW7, 4LIQ, 4R7H, 4R7I, 4WRL, 4WRM

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

csf1r signaling microglia cells macrophages survival gene csf-1 osteoclasts also bone disease brain human differentiation mouse osteoclast receptor loss-of-function cancer

Colony stimulating factor 1 receptor relationships Subject–Predicate–Object triples

TTTA extracted 177 structured relationships around Colony stimulating factor 1 receptor. Examples in this analysis include Colony stimulating factor 1 receptor → 2.7.10.1 → ↗ and Colony stimulating factor 1 receptor → Aliases → CSF1R, C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R, colony stimulating factor 1 receptor, BANDDOS, HDLS1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Colony stimulating factor 1 receptor2.7.10.11.00infobox
Colony stimulating factor 1 receptorAliasesCSF1R, C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R, colony stimulating factor 1 receptor, BANDDOS, HDLS11.00infobox
Colony stimulating factor 1 receptorAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2I0V, 2I0Y, 2I1M, 2OGV, 3BEA, 3DPK, 3KRJ, 3KRL, 3LCD, 3LCO, 4DKD, 4HW7, 4LIQ, 4R7H, 4R7I, 4WRL, 4WRM1.00infobox
Colony stimulating factor 1 receptorBand5q321.00infobox
Colony stimulating factor 1 receptorBand18 E1|18 34.41 cM1.00infobox
Colony stimulating factor 1 receptorBgeegranulocyte1.00infobox
Colony stimulating factor 1 receptorBgeemonocyte1.00infobox
Colony stimulating factor 1 receptorBgeespleen1.00infobox
Colony stimulating factor 1 receptorBgeeright coronary artery1.00infobox
Colony stimulating factor 1 receptorBgeeplacenta1.00infobox
Colony stimulating factor 1 receptorBgeeinferior ganglion of vagus nerve1.00infobox
Colony stimulating factor 1 receptorBgeeretinal pigment epithelium1.00infobox
Colony stimulating factor 1 receptorBgeegallbladder1.00infobox
Colony stimulating factor 1 receptorBgeeappendix1.00infobox
Colony stimulating factor 1 receptorBgeelymph node1.00infobox
Colony stimulating factor 1 receptorBgeestroma of bone marrow1.00infobox
Colony stimulating factor 1 receptorBgeeankle1.00infobox
Colony stimulating factor 1 receptorBgeemotor neuron1.00infobox
Colony stimulating factor 1 receptorBgeetibiofemoral joint1.00infobox
Colony stimulating factor 1 receptorBgeeinternal carotid artery1.00infobox
Colony stimulating factor 1 receptorBgeecalvaria1.00infobox
Colony stimulating factor 1 receptorBgeesubstantia nigra1.00infobox
Colony stimulating factor 1 receptorBgeegastrula1.00infobox
Colony stimulating factor 1 receptorBgeeglobus pallidus1.00infobox
Colony stimulating factor 1 receptorBioGPSMore reference expression data1.00infobox
Colony stimulating factor 1 receptorChr.Chromosome 5 (human)1.00infobox
Colony stimulating factor 1 receptorChr.Chromosome 18 (mouse)1.00infobox
Colony stimulating factor 1 receptorDatabasesNCBI: entry; OMA: entry1.00infobox
Colony stimulating factor 1 receptorEnd150,113,372 bp1.00infobox
Colony stimulating factor 1 receptorEnd61,265,221 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Colony stimulating factor 1 receptor bring nearby vocabulary together. In this analysis, examples include Factor, Stimulating and Receptor. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Colony stimulating factor 1 receptor
    • Factor
    • Stimulating
    • Receptor
    • Gene
    • Also
    • Human
    • Protein
    • Bp
    • Chr
    • Csf-1
    • Monocytes
    • Function
  • colony stimulating factor 1 receptor
    • Factor
    • Stimulating
    • Receptor
    • Protein
    • Gene
    • Human
    • Bp
    • Chr
    • Also
    • Function
    • Macrophage
    • Progenitor
  • protein
    • Human
    • Receptor
    • Gene
    • Bp
    • Chr
    • Stimulating
    • Function
    • Cancer
    • Progenitor
    • Mouse
    • Tyrosine
    • Bone
  • gene
    • Protein
    • Receptor
    • Human
    • Macrophage
    • Bp
    • Chr
    • Stimulating
    • Function
    • Mouse
    • Cell
    • Progenitor
    • Tyrosine
  • receptor
    • Stimulating
    • Protein
    • Gene
    • Human
    • Bp
    • Chr
    • Function
    • Macrophage
    • Progenitor
    • Differentiation
    • Tyrosine
    • Bone
  • colony stimulating factor 1
    • Factor
    • Stimulating
    • Receptor
    • Human
    • Protein
    • Gene
    • Bp
    • Chr
    • Also
    • Function
    • Macrophage
    • Progenitor
  • differentiation
    • Myeloid
    • Human
    • Protein
    • Cell
    • Macrophage
    • Proliferation
    • Mouse
    • Gene
    • Factor
    • Receptor
    • Progenitor
    • Survival
  • cancer
    • Human
    • Protein
    • Inhibition
    • Mouse
    • Bone
    • Bp
    • Chr
    • Colony
    • Macrophages
    • Factor
    • Inflammatory
    • Monocytes

Connections between topic areas Semantic bridges

For Colony stimulating factor 1 receptor, one of the stronger structural bridges in this analysis connects Colony stimulating factor 1 receptor with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Colony stimulating factor 1 receptorOverview · splits 175 ⟂ 45
Colony stimulating factor 1 receptorFunction · splits 177 ⟂ 43
Colony stimulating factor 1 receptorClinical significance · splits 186 ⟂ 34
Colony stimulating factor 1 receptorTherapeutics · splits 188 ⟂ 32
Colony stimulating factor 1 receptorGene · splits 196 ⟂ 24
Colony stimulating factor 1 receptorProtein · splits 197 ⟂ 23
Colony stimulating factor 1 receptorControversy · splits 208 ⟂ 12
Colony stimulating factor 1 receptorInteractions · splits 214 ⟂ 6

Map overview Semantic statistics

Colony stimulating factor 1 receptor

Nodes220
Edges219
Triples177
Avg. degree1.99
Density0.009091
Components1

Source & methodology

TTTA analyzes the structure around Colony stimulating factor 1 receptor to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Gene, Protein & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Colony stimulating factor 1 receptor · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.