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PTPN11

Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D), Src homology region 2 domain-containing phosphatase-2 (SHP-2), or protein-tyrosine phosphatase 2C (PTP-2C) is an enzyme that in humans is encoded by the PTPN11 gene. PTPN11 is a protein tyrosine phosphatase (PTP) Shp2.

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3.1.3.48
↗
Aliases
PTPN11, BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2, protein tyrosine phosphatase, non-receptor type 11, protein tyrosine phosphatase non-receptor type 11
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2SHP, 3B7O, 3MOW, 3O5X, 3TKZ, 3TL0, 4DGP, 4DGX, 4GWF, 4H1O, 4JE4, 4JEG, 3ZM0, 3ZM1, 3ZM2, 3ZM3, 4H34, 4JMG,…
Band
12q24.13 · 5|5 F
Bgee
internal globus pallidus · dorsal motor nucleus of vagus nerve · Brodmann area 23 · visceral pleura · parietal pleura
BioGPS
More reference expression data

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Ligands

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Map overview Semantic statistics

PTPN11

Nodes95
Edges94
Triples237
Avg. degree1.98
Density0.021053
Components1

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PTPN11

Top relations

Gene ontology · 90
PTPN11 → 1-phosphatidylinositol-3-kinase activity, abortive mitotic cell cycle, atrioventricular canal development, axon guidance, axonogenesis, Bergmann glial cell differentiation, brain development, cell adhesion molecule binding, cellular response to cytokine stimulus, cellular response to epidermal growth factor stimulus, cellular response to mechanical stimulus, cerebellar cortex formation, cytokine-mediated signaling pathway, cytoplasm, cytosol, D1 dopamine receptor binding, dephosphorylation, development of the heart, DNA damage checkpoint signaling, ephrin receptor signaling pathway
related to Interactions · 29
PTPN11 → AktPLCG2, CagA, Cbl, CD117, CD31, CEACAM1, Epidermal, ErkFRS2, GAB1, GAB2, GAB3, Glycoprotein, Grb2, Growth, HoxA10, Insulin, Insulin-like, IRS1, Janus, LAIR1
Bgee · 19
PTPN11 → Brodmann area 23, ciliary body, dorsal motor nucleus of vagus nerve, endocardial cushion, Epithelium of choroid plexus, external globus pallidus, inferior olivary nucleus, internal globus pallidus, iris, medullary collecting duct, parietal pleura, pars reticulata, primitive streak, renal corpuscle, retinal pigment epithelium, substantia nigra, subthalamic nucleus, utricle, visceral pleura
RNA expression pattern · 19
PTPN11 → Brodmann area 23, ciliary body, dorsal motor nucleus of vagus nerve, endocardial cushion, Epithelium of choroid plexus, external globus pallidus, inferior olivary nucleus, internal globus pallidus, iris, medullary collecting duct, parietal pleura, pars reticulata, primitive streak, renal corpuscle, retinal pigment epithelium, substantia nigra, subthalamic nucleus, utricle, visceral pleura
related to Cancer · 17
PTPN11 → Activating Shp2, CagA, Decreased PTPN11/Shp2, HCC, Helicobacter, However, In, JMML, Noonan, NPM1-mutated, Patients, PTPN11/Shp2, Recently, Shp2, STAT3, The, These
related to Structure · 16
PTPN11 → C-SH2, C-terminal, In, Mutations, N-SH2, N-terminus, Noonan, PTP, PTPs, SH2, SHP2, Src, The, This, Upon, WPD
related to Function · 10
PTPN11 → During, Germline, In, LEOPARD, Noonan, PTPN11/SHP2, RAS/MAPK, RAS/RAF/MAPK, SHP2, Thus
related to Clinical significance · 4
PTPN11 → At, Leopard, Missense, Noonan
Band · 2
PTPN11 → 12q24.13, 5|5 F
Chr. · 2
PTPN11 → Chromosome 12 (human), Chromosome 5 (mouse)

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Important terminology

shp2 mutations gene protein phosphatase ptp noonan syndrome signaling cell tyrosine human bp function shp-2 growth chr band factor caga

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PTPN113.1.3.48↗1.00infobox
PTPN11AliasesPTPN11, BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2, protein tyrosine phosphatase, non-receptor type 11, protein tyrosine phosphatase non-receptor type 111.00infobox
PTPN11Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2SHP, 3B7O, 3MOW, 3O5X, 3TKZ, 3TL0, 4DGP, 4DGX, 4GWF, 4H1O, 4JE4, 4JEG, 3ZM0, 3ZM1, 3ZM2, 3ZM3, 4H34, 4JMG,…1.00infobox
PTPN11Band12q24.131.00infobox
PTPN11Band5|5 F1.00infobox
PTPN11Bgeeinternal globus pallidus1.00infobox
PTPN11Bgeedorsal motor nucleus of vagus nerve1.00infobox
PTPN11BgeeBrodmann area 231.00infobox
PTPN11Bgeevisceral pleura1.00infobox
PTPN11Bgeeparietal pleura1.00infobox
PTPN11Bgeesubthalamic nucleus1.00infobox
PTPN11Bgeepars reticulata1.00infobox
PTPN11Bgeeinferior olivary nucleus1.00infobox
PTPN11BgeeEpithelium of choroid plexus1.00infobox
PTPN11Bgeeexternal globus pallidus1.00infobox
PTPN11Bgeerenal corpuscle1.00infobox
PTPN11Bgeeutricle1.00infobox
PTPN11Bgeemedullary collecting duct1.00infobox
PTPN11Bgeeretinal pigment epithelium1.00infobox
PTPN11Bgeesubstantia nigra1.00infobox
PTPN11Bgeeciliary body1.00infobox
PTPN11Bgeeiris1.00infobox
PTPN11Bgeeendocardial cushion1.00infobox
PTPN11Bgeeprimitive streak1.00infobox
PTPN11BioGPSMore reference expression data1.00infobox
PTPN11Chr.Chromosome 12 (human)1.00infobox
PTPN11Chr.Chromosome 5 (mouse)1.00infobox
PTPN11DatabasesNCBI: entry; OMA: entry1.00infobox
PTPN11End112,509,918 bp1.00infobox
PTPN11End121,329,460 bp1.00infobox

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