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PTPN11: Regions, Clinical significance & Interactions

Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D), Src homology region 2 domain-containing phosphatase-2 (SHP-2), or protein-tyrosine phosphatase 2C (PTP-2C) is an enzyme that in humans is encoded by the PTPN11 gene. PTPN11 is a protein tyrosine phosphatase (PTP) Shp2.

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PTPN11 topic overview

The analysis highlights Regions, Clinical significance and Interactions as prominent areas in the source structure around PTPN11. 1 topic appears in more than one source area, which can help identify connections that are less obvious in a linear reading.

Related topics
87
Source areas
6
Connected nodes
94
Extracted relationships
237
Concept neighborhoods
27
Bridge connections
94

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 33 topics
Clinical significance · 25 topics
Function · 14 topics
Overview · 6 topics
Ligands · 5 topics
Structure · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.1.3.48
↗
Aliases
PTPN11, BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2, protein tyrosine phosphatase, non-receptor type 11, protein tyrosine phosphatase non-receptor type 11
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2SHP, 3B7O, 3MOW, 3O5X, 3TKZ, 3TL0, 4DGP, 4DGX, 4GWF, 4H1O, 4JE4, 4JEG, 3ZM0, 3ZM1, 3ZM2, 3ZM3, 4H34, 4JMG,…
Band
12q24.13 · 5|5 F
Bgee
internal globus pallidus · dorsal motor nucleus of vagus nerve · Brodmann area 23 · visceral pleura · parietal pleura
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Interactions

Ligands

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PTPN11 connects Entity context

The extracted context around PTPN11 shows recurring relationship patterns in the source. For example, PTPN11 → 1-phosphatidylinositol-3-kinase activity, abortive mitotic cell cycle, atrioventricular canal development, axon guidance, axonogenesis, Bergmann glial cell differentiation, brain development, cell adhesion molecule binding, cellular response to cytokine stimulus, cellular response to epidermal growth factor stimulus, cellular response to mechanical stimulus, cerebellar cortex formation, cytokine-mediated signaling pathway, cytoplasm, cytosol, D1 dopamine receptor binding, dephosphorylation, development of the heart, DNA damage checkpoint signaling, ephrin receptor signaling pathway Another extracted example is PTPN11 → AktPLCG2, CagA, Cbl, CD117, CD31, CEACAM1, Epidermal, ErkFRS2, GAB1, GAB2, GAB3, Glycoprotein, Grb2, Growth, HoxA10, Insulin, Insulin-like, IRS1, Janus, LAIR1. Use these groups to spot repeated connection types before inspecting the individual relationships.

PTPN11

Top relations

Gene ontology · 90
PTPN11 → 1-phosphatidylinositol-3-kinase activity, abortive mitotic cell cycle, atrioventricular canal development, axon guidance, axonogenesis, Bergmann glial cell differentiation, brain development, cell adhesion molecule binding, cellular response to cytokine stimulus, cellular response to epidermal growth factor stimulus, cellular response to mechanical stimulus, cerebellar cortex formation, cytokine-mediated signaling pathway, cytoplasm, cytosol, D1 dopamine receptor binding, dephosphorylation, development of the heart, DNA damage checkpoint signaling, ephrin receptor signaling pathway
related to Interactions · 29
PTPN11 → AktPLCG2, CagA, Cbl, CD117, CD31, CEACAM1, Epidermal, ErkFRS2, GAB1, GAB2, GAB3, Glycoprotein, Grb2, Growth, HoxA10, Insulin, Insulin-like, IRS1, Janus, LAIR1
Bgee · 19
PTPN11 → Brodmann area 23, ciliary body, dorsal motor nucleus of vagus nerve, endocardial cushion, Epithelium of choroid plexus, external globus pallidus, inferior olivary nucleus, internal globus pallidus, iris, medullary collecting duct, parietal pleura, pars reticulata, primitive streak, renal corpuscle, retinal pigment epithelium, substantia nigra, subthalamic nucleus, utricle, visceral pleura
RNA expression pattern · 19
PTPN11 → Brodmann area 23, ciliary body, dorsal motor nucleus of vagus nerve, endocardial cushion, Epithelium of choroid plexus, external globus pallidus, inferior olivary nucleus, internal globus pallidus, iris, medullary collecting duct, parietal pleura, pars reticulata, primitive streak, renal corpuscle, retinal pigment epithelium, substantia nigra, subthalamic nucleus, utricle, visceral pleura
related to Cancer · 17
PTPN11 → Activating Shp2, CagA, Decreased PTPN11/Shp2, HCC, Helicobacter, However, In, JMML, Noonan, NPM1-mutated, Patients, PTPN11/Shp2, Recently, Shp2, STAT3, The, These
related to Structure · 16
PTPN11 → C-SH2, C-terminal, In, Mutations, N-SH2, N-terminus, Noonan, PTP, PTPs, SH2, SHP2, Src, The, This, Upon, WPD
related to Function · 10
PTPN11 → During, Germline, In, LEOPARD, Noonan, PTPN11/SHP2, RAS/MAPK, RAS/RAF/MAPK, SHP2, Thus
related to Clinical significance · 4
PTPN11 → At, Leopard, Missense, Noonan
Band · 2
PTPN11 → 12q24.13, 5|5 F
Chr. · 2
PTPN11 → Chromosome 12 (human), Chromosome 5 (mouse)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

shp2 mutations gene protein phosphatase ptp noonan syndrome signaling cell tyrosine human bp function shp-2 growth chr band factor caga

PTPN11 relationships Subject–Predicate–Object triples

TTTA extracted 237 structured relationships around PTPN11. Examples in this analysis include PTPN11 → 3.1.3.48 → ↗ and PTPN11 → Aliases → PTPN11, BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2, protein tyrosine phosphatase, non-receptor type 11, protein tyrosine phosphatase non-receptor type 11. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PTPN113.1.3.48↗1.00infobox
PTPN11AliasesPTPN11, BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2, protein tyrosine phosphatase, non-receptor type 11, protein tyrosine phosphatase non-receptor type 111.00infobox
PTPN11Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2SHP, 3B7O, 3MOW, 3O5X, 3TKZ, 3TL0, 4DGP, 4DGX, 4GWF, 4H1O, 4JE4, 4JEG, 3ZM0, 3ZM1, 3ZM2, 3ZM3, 4H34, 4JMG,…1.00infobox
PTPN11Band12q24.131.00infobox
PTPN11Band5|5 F1.00infobox
PTPN11Bgeeinternal globus pallidus1.00infobox
PTPN11Bgeedorsal motor nucleus of vagus nerve1.00infobox
PTPN11BgeeBrodmann area 231.00infobox
PTPN11Bgeevisceral pleura1.00infobox
PTPN11Bgeeparietal pleura1.00infobox
PTPN11Bgeesubthalamic nucleus1.00infobox
PTPN11Bgeepars reticulata1.00infobox
PTPN11Bgeeinferior olivary nucleus1.00infobox
PTPN11BgeeEpithelium of choroid plexus1.00infobox
PTPN11Bgeeexternal globus pallidus1.00infobox
PTPN11Bgeerenal corpuscle1.00infobox
PTPN11Bgeeutricle1.00infobox
PTPN11Bgeemedullary collecting duct1.00infobox
PTPN11Bgeeretinal pigment epithelium1.00infobox
PTPN11Bgeesubstantia nigra1.00infobox
PTPN11Bgeeciliary body1.00infobox
PTPN11Bgeeiris1.00infobox
PTPN11Bgeeendocardial cushion1.00infobox
PTPN11Bgeeprimitive streak1.00infobox
PTPN11BioGPSMore reference expression data1.00infobox
PTPN11Chr.Chromosome 12 (human)1.00infobox
PTPN11Chr.Chromosome 5 (mouse)1.00infobox
PTPN11DatabasesNCBI: entry; OMA: entry1.00infobox
PTPN11End112,509,918 bp1.00infobox
PTPN11End121,329,460 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around PTPN11 bring nearby vocabulary together. In this analysis, examples include Tyrosine, Shp2 and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • PTPN11
    • Tyrosine
    • Shp2
    • Protein
    • Noonan
    • Syndrome
    • Type
    • Mutations
    • Factor
    • Human
    • Signaling
    • External
    • Activation
  • ptpn11
    • Tyrosine
    • Shp2
    • Protein
    • Noonan
    • Syndrome
    • Type
    • Mutations
    • Factor
    • Human
    • Signaling
    • External
    • Activation
  • enzyme
    • Known
    • Type
    • Binding
    • Catalytic
    • N-sh2
    • Domain
    • Phosphatase
    • Gene
    • External
    • Noonan
    • Syndrome
    • Mutations
  • gene
    • Type
    • Chromosome
    • Bp
    • Chr
    • Factor
    • Human
    • External
    • Phosphatase
    • Protein
    • Noonan
    • Syndrome
    • Band
  • protein tyrosine phosphatase
    • Phosphatase
    • Tyrosine
    • Protein
    • Type
    • Ptpn11
    • External
    • Factor
    • Ptp
    • Chromosome
    • Differentiation
    • Gene
    • Migration
  • cell signaling
    • Signaling
    • Differentiation
    • Migration
    • Growth
    • Activation
    • Cellular
    • Function
    • Tyrosine
    • Shp2
    • Phosphatase
    • Protein
    • External
  • cell proliferation
    • Signaling
    • Differentiation
    • Migration
    • Growth
    • Activation
    • Cellular
    • Function
    • Tyrosine
    • Shp2
    • Phosphatase
    • Protein
    • External
  • growth factor
    • Signaling
    • Differentiation
    • Pylori
    • External
    • Factor
    • Growth
    • Type
    • Gene
    • Protein
    • Chromosome
    • Migration
    • Bp

Connections between topic areas Semantic bridges

For PTPN11, one of the stronger structural bridges in this analysis connects PTPN11 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PTPN11 — Interactions · splits 61 ⟂ 34
PTPN11 — Clinical significance · splits 69 ⟂ 26
PTPN11 — Function · splits 80 ⟂ 15
PTPN11 — Overview · splits 88 ⟂ 7
PTPN11 — Structure · splits 89 ⟂ 6
PTPN11 — Ligands · splits 89 ⟂ 6

Map overview Semantic statistics

PTPN11

Nodes95
Edges94
Triples237
Avg. degree1.98
Density0.021053
Components1

Source & methodology

TTTA analyzes the structure around PTPN11 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions, Clinical significance & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PTPN11 · EN edition · Analysis: TopicsToTalkAbout

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