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CHEK2

CHEK2 (Checkpoint kinase 2) is a tumor suppressor gene that encodes the protein CHK2, a serine-threonine kinase. CHK2 is involved in DNA repair, cell cycle arrest or apoptosis in response to DNA damage. Mutations to the CHEK2 gene have been linked to a wide range of cancers.

Geography, Association with cancer & Meiosis

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2.7.11.1
Aliases
CHEK2, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1, checkpoint kinase 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GXC, 2CN5, 2CN8, 2W0J, 2W7X, 2WTC, 2WTD, 2XBJ, 2XM8, 2XM9, 2YCF, 2YCQ, 2YCR, 2YCS, 2YIQ, 2YIR, 2YIT, 3I6U,…
Band
22q12.1 · 5|5 F
Bgee
gonad · testicle · mucosa of transverse colon · tibial nerve · oocyte
BioGPS
More reference expression data

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Overview

Gene location

Protein structure

Function and mechanism

Association with cancer

Meiosis

Interactions

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Map overview Semantic statistics

CHEK2

Nodes71
Edges70
Triples197
Avg. degree1.97
Density0.028169
Components1

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CHEK2

Top relations

Gene ontology · 54
CHEK2 → apoptotic process, ATP binding, cell cycle, cell division, cellular response to bisphenol A, cellular response to DNA damage stimulus, cellular response to gamma radiation, cytoplasm, DNA damage checkpoint signaling, DNA damage induced protein phosphorylation, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, DNA repair, double-strand break repair, G2/M transition of mitotic cell cycle, Golgi apparatus, identical protein binding, intrinsic apoptotic signaling pathway in response to DNA damage, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, kinase activity
Bgee · 19
CHEK2 → blastocyst, embryo, epiblast, fetal liver hematopoietic progenitor cell, gonad, Ileal epithelium, left ovary, morula, mucosa of transverse colon, oocyte, Paneth cell, primitive streak, rectum, right ovary, secondary oocyte, testicle, thymus, tibial nerve, ventricular zone
RNA expression pattern · 19
CHEK2 → blastocyst, embryo, epiblast, fetal liver hematopoietic progenitor cell, gonad, Ileal epithelium, left ovary, morula, mucosa of transverse colon, oocyte, Paneth cell, primitive streak, rectum, right ovary, secondary oocyte, testicle, thymus, tibial nerve, ventricular zone
related to Function and mechanism · 18
CHEK2 → ATM, CDC25, CDKs, CHK2, CHK2's, DNA, E2F1, Furthermore, G1, Once, PIKK, PML, Specifically, Stabilization, The CHEK2, Thr68, Thus, When DNA
related to Breast cancer · 17
CHEK2 → CHK2, DNA, Eastern, FHA, However, I157T, India, Inherited, Most, North America, Northern European, Spain, Studies, The, The CHEK2, US, Within
related to External links · 13
CHEK2 → Archived, CDS1, Educational, Human CDS1, Human CHEK2, Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, UCSC Genome Browser, United States National Library, Wayback MachineGene ReviewsGene Tests
related to Meiosis · 9
CHEK2 → Although CHEK2, ATM, ATR, DNA, Drosophila, In, Rad3, The, The Drosophila CHEK2
related to Other cancers · 8
CHEK2 → BRCA2, However, Ile157Thr, Links, Mutations, OR, Studies, Unlike BRCA1
related to Protein structure · 7
CHEK2 → Central, FHA, KD, N-terminal SQ/TQ, SCD, The, The CHEK2
related to Association with cancer · 4
CHEK2 → DNA, In, The CHK2, Thus

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Important terminology

gene chk2 protein dna kinase cell human cancer damage location bp domain mutations chromosome 22 chr band mutation checkpoint cancers

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CHEK22.7.11.11.00infobox
CHEK2AliasesCHEK2, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1, checkpoint kinase 21.00infobox
CHEK2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GXC, 2CN5, 2CN8, 2W0J, 2W7X, 2WTC, 2WTD, 2XBJ, 2XM8, 2XM9, 2YCF, 2YCQ, 2YCR, 2YCS, 2YIQ, 2YIR, 2YIT, 3I6U,…1.00infobox
CHEK2Band22q12.11.00infobox
CHEK2Band5|5 F1.00infobox
CHEK2Bgeegonad1.00infobox
CHEK2Bgeetesticle1.00infobox
CHEK2Bgeemucosa of transverse colon1.00infobox
CHEK2Bgeetibial nerve1.00infobox
CHEK2Bgeeoocyte1.00infobox
CHEK2Bgeesecondary oocyte1.00infobox
CHEK2Bgeerectum1.00infobox
CHEK2Bgeeventricular zone1.00infobox
CHEK2Bgeeleft ovary1.00infobox
CHEK2Bgeeright ovary1.00infobox
CHEK2Bgeemorula1.00infobox
CHEK2Bgeefetal liver hematopoietic progenitor cell1.00infobox
CHEK2Bgeeepiblast1.00infobox
CHEK2BgeeIleal epithelium1.00infobox
CHEK2Bgeeblastocyst1.00infobox
CHEK2Bgeeembryo1.00infobox
CHEK2BgeePaneth cell1.00infobox
CHEK2Bgeeprimitive streak1.00infobox
CHEK2Bgeethymus1.00infobox
CHEK2BioGPSMore reference expression data1.00infobox
CHEK2Chr.Chromosome 22 (human)1.00infobox
CHEK2Chr.Chromosome 5 (mouse)1.00infobox
CHEK2DatabasesNCBI: entry; OMA: entry1.00infobox
CHEK2End28,742,422 bp1.00infobox
CHEK2End111,022,011 bp1.00infobox

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