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CHEK2: Geography, Association with cancer & Meiosis

CHEK2 (Checkpoint kinase 2) is a tumor suppressor gene that encodes the protein CHK2, a serine-threonine kinase. CHK2 is involved in DNA repair, cell cycle arrest or apoptosis in response to DNA damage. Mutations to the CHEK2 gene have been linked to a wide range of cancers.

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CHEK2 topic overview

The analysis highlights Geography, Association with cancer and Meiosis as prominent areas in the source structure around CHEK2.

Related topics
63
Source areas
7
Connected nodes
70
Extracted relationships
197
Concept neighborhoods
27
Bridge connections
70

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Association with cancer · 18 topics
Meiosis · 12 topics
Function and mechanism · 9 topics
Protein structure · 9 topics
Interactions · 7 topics
Overview · 6 topics
Gene location · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.11.1
Aliases
CHEK2, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1, checkpoint kinase 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GXC, 2CN5, 2CN8, 2W0J, 2W7X, 2WTC, 2WTD, 2XBJ, 2XM8, 2XM9, 2YCF, 2YCQ, 2YCR, 2YCS, 2YIQ, 2YIR, 2YIT, 3I6U,…
Band
22q12.1 · 5|5 F
Bgee
gonad · testicle · mucosa of transverse colon · tibial nerve · oocyte
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Gene location

Protein structure

Function and mechanism

Association with cancer

Meiosis

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CHEK2 connects Entity context

The extracted context around CHEK2 shows recurring relationship patterns in the source. For example, CHEK2 → apoptotic process, ATP binding, cell cycle, cell division, cellular response to bisphenol A, cellular response to DNA damage stimulus, cellular response to gamma radiation, cytoplasm, DNA damage checkpoint signaling, DNA damage induced protein phosphorylation, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, DNA repair, double-strand break repair, G2/M transition of mitotic cell cycle, Golgi apparatus, identical protein binding, intrinsic apoptotic signaling pathway in response to DNA damage, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, kinase activity Another extracted example is CHEK2 → blastocyst, embryo, epiblast, fetal liver hematopoietic progenitor cell, gonad, Ileal epithelium, left ovary, morula, mucosa of transverse colon, oocyte, Paneth cell, primitive streak, rectum, right ovary, secondary oocyte, testicle, thymus, tibial nerve, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

CHEK2

Top relations

Gene ontology · 54
CHEK2 → apoptotic process, ATP binding, cell cycle, cell division, cellular response to bisphenol A, cellular response to DNA damage stimulus, cellular response to gamma radiation, cytoplasm, DNA damage checkpoint signaling, DNA damage induced protein phosphorylation, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, DNA repair, double-strand break repair, G2/M transition of mitotic cell cycle, Golgi apparatus, identical protein binding, intrinsic apoptotic signaling pathway in response to DNA damage, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, kinase activity
Bgee · 19
CHEK2 → blastocyst, embryo, epiblast, fetal liver hematopoietic progenitor cell, gonad, Ileal epithelium, left ovary, morula, mucosa of transverse colon, oocyte, Paneth cell, primitive streak, rectum, right ovary, secondary oocyte, testicle, thymus, tibial nerve, ventricular zone
RNA expression pattern · 19
CHEK2 → blastocyst, embryo, epiblast, fetal liver hematopoietic progenitor cell, gonad, Ileal epithelium, left ovary, morula, mucosa of transverse colon, oocyte, Paneth cell, primitive streak, rectum, right ovary, secondary oocyte, testicle, thymus, tibial nerve, ventricular zone
related to Function and mechanism · 18
CHEK2 → ATM, CDC25, CDKs, CHK2, CHK2's, DNA, E2F1, Furthermore, G1, Once, PIKK, PML, Specifically, Stabilization, The CHEK2, Thr68, Thus, When DNA
related to Breast cancer · 17
CHEK2 → CHK2, DNA, Eastern, FHA, However, I157T, India, Inherited, Most, North America, Northern European, Spain, Studies, The, The CHEK2, US, Within
related to External links · 13
CHEK2 → Archived, CDS1, Educational, Human CDS1, Human CHEK2, Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, UCSC Genome Browser, United States National Library, Wayback MachineGene ReviewsGene Tests
related to Meiosis · 9
CHEK2 → Although CHEK2, ATM, ATR, DNA, Drosophila, In, Rad3, The, The Drosophila CHEK2
related to Other cancers · 8
CHEK2 → BRCA2, However, Ile157Thr, Links, Mutations, OR, Studies, Unlike BRCA1
related to Protein structure · 7
CHEK2 → Central, FHA, KD, N-terminal SQ/TQ, SCD, The, The CHEK2
related to Association with cancer · 4
CHEK2 → DNA, In, The CHK2, Thus

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene chk2 protein dna kinase cell human cancer damage location bp domain mutations chromosome 22 chr band mutation checkpoint cancers

CHEK2 relationships Subject–Predicate–Object triples

TTTA extracted 197 structured relationships around CHEK2. Examples in this analysis include CHEK2 → 2.7.11.1 → ↗ and CHEK2 → Aliases → CHEK2, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1, checkpoint kinase 2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
CHEK22.7.11.11.00infobox
CHEK2AliasesCHEK2, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1, checkpoint kinase 21.00infobox
CHEK2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GXC, 2CN5, 2CN8, 2W0J, 2W7X, 2WTC, 2WTD, 2XBJ, 2XM8, 2XM9, 2YCF, 2YCQ, 2YCR, 2YCS, 2YIQ, 2YIR, 2YIT, 3I6U,…1.00infobox
CHEK2Band22q12.11.00infobox
CHEK2Band5|5 F1.00infobox
CHEK2Bgeegonad1.00infobox
CHEK2Bgeetesticle1.00infobox
CHEK2Bgeemucosa of transverse colon1.00infobox
CHEK2Bgeetibial nerve1.00infobox
CHEK2Bgeeoocyte1.00infobox
CHEK2Bgeesecondary oocyte1.00infobox
CHEK2Bgeerectum1.00infobox
CHEK2Bgeeventricular zone1.00infobox
CHEK2Bgeeleft ovary1.00infobox
CHEK2Bgeeright ovary1.00infobox
CHEK2Bgeemorula1.00infobox
CHEK2Bgeefetal liver hematopoietic progenitor cell1.00infobox
CHEK2Bgeeepiblast1.00infobox
CHEK2BgeeIleal epithelium1.00infobox
CHEK2Bgeeblastocyst1.00infobox
CHEK2Bgeeembryo1.00infobox
CHEK2BgeePaneth cell1.00infobox
CHEK2Bgeeprimitive streak1.00infobox
CHEK2Bgeethymus1.00infobox
CHEK2BioGPSMore reference expression data1.00infobox
CHEK2Chr.Chromosome 22 (human)1.00infobox
CHEK2Chr.Chromosome 5 (mouse)1.00infobox
CHEK2DatabasesNCBI: entry; OMA: entry1.00infobox
CHEK2End28,742,422 bp1.00infobox
CHEK2End111,022,011 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CHEK2 bring nearby vocabulary together. In this analysis, examples include Gene, Cancer and Mutations. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • CHEK2
    • Gene
    • Cancer
    • Mutations
    • Kinase
    • Protein
    • Breast
    • Human
    • Oocyte
    • 1100delc
    • Found
    • Linked
    • Cancers
  • chek2
    • Gene
    • Cancer
    • Mutations
    • Kinase
    • Protein
    • Breast
    • Human
    • Oocyte
    • 1100delc
    • Found
    • Linked
    • Cancers
  • tumor suppressor gene
    • Human
    • Checkpoint
    • Location
    • Kinase
    • Protein
    • Mutations
    • Function
    • Bp
    • Cancers
    • Chk2
    • Chr
    • Chromosome
  • protein
    • Dna
    • Damage
    • Function
    • Tumor
    • Human
    • Cell
    • Phosphorylation
    • Response
    • Bp
    • Chr
    • Chromosome
    • P53
  • serine-threonine kinase
    • Protein
    • Domain
    • Exon
    • Gene
    • Dna
    • Response
    • Chk2
    • Double-strand
    • Damage
    • Function
    • Phosphorylation
    • Tumor
  • dna repair
    • Damage
    • Response
    • Protein
    • Phosphorylation
    • Kinase
    • Double-strand
    • Function
    • P53
    • Domain
    • Mouse
    • Oocyte
    • Tumor
  • dna
    • Damage
    • Response
    • Protein
    • Phosphorylation
    • Kinase
    • Double-strand
    • Function
    • P53
    • Domain
    • Mouse
    • Oocyte
    • Tumor
  • cell division
    • Cycle
    • Arrest
    • Apoptosis
    • Oocyte
    • P53
    • Chk2
    • Damage
    • Function
    • Mouse
    • Dna
    • Response
    • Double-strand

Connections between topic areas Semantic bridges

For CHEK2, one of the stronger structural bridges in this analysis connects CHEK2 with Association with cancer. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
CHEK2Association with cancer · splits 52 ⟂ 19
CHEK2Meiosis · splits 58 ⟂ 13
CHEK2Protein structure · splits 61 ⟂ 10
CHEK2Function and mechanism · splits 61 ⟂ 10
CHEK2Interactions · splits 63 ⟂ 8
CHEK2Overview · splits 64 ⟂ 7
CHEK2Gene location · splits 68 ⟂ 3

Map overview Semantic statistics

CHEK2

Nodes71
Edges70
Triples197
Avg. degree1.97
Density0.028169
Components1

Source & methodology

TTTA analyzes the structure around CHEK2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Geography, Association with cancer & Meiosis, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CHEK2 · EN edition · Analysis: TopicsToTalkAbout

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