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CHEK2 (Checkpoint kinase 2) is a tumor suppressor gene that encodes the protein CHK2, a serine-threonine kinase. CHK2 is involved in DNA repair, cell cycle arrest or apoptosis in response to DNA damage. Mutations to the CHEK2 gene have been linked to a wide range of cancers.
Geography, Association with cancer & Meiosis
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gene chk2 protein dna kinase cell human cancer damage location bp domain mutations chromosome 22 chr band mutation checkpoint cancers
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| CHEK2 | 2.7.11.1 | ↗ | 1.00 | infobox |
| CHEK2 | Aliases | CHEK2, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1, checkpoint kinase 2 | 1.00 | infobox |
| CHEK2 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GXC, 2CN5, 2CN8, 2W0J, 2W7X, 2WTC, 2WTD, 2XBJ, 2XM8, 2XM9, 2YCF, 2YCQ, 2YCR, 2YCS, 2YIQ, 2YIR, 2YIT, 3I6U,… | 1.00 | infobox |
| CHEK2 | Band | 22q12.1 | 1.00 | infobox |
| CHEK2 | Band | 5|5 F | 1.00 | infobox |
| CHEK2 | Bgee | gonad | 1.00 | infobox |
| CHEK2 | Bgee | testicle | 1.00 | infobox |
| CHEK2 | Bgee | mucosa of transverse colon | 1.00 | infobox |
| CHEK2 | Bgee | tibial nerve | 1.00 | infobox |
| CHEK2 | Bgee | oocyte | 1.00 | infobox |
| CHEK2 | Bgee | secondary oocyte | 1.00 | infobox |
| CHEK2 | Bgee | rectum | 1.00 | infobox |
| CHEK2 | Bgee | ventricular zone | 1.00 | infobox |
| CHEK2 | Bgee | left ovary | 1.00 | infobox |
| CHEK2 | Bgee | right ovary | 1.00 | infobox |
| CHEK2 | Bgee | morula | 1.00 | infobox |
| CHEK2 | Bgee | fetal liver hematopoietic progenitor cell | 1.00 | infobox |
| CHEK2 | Bgee | epiblast | 1.00 | infobox |
| CHEK2 | Bgee | Ileal epithelium | 1.00 | infobox |
| CHEK2 | Bgee | blastocyst | 1.00 | infobox |
| CHEK2 | Bgee | embryo | 1.00 | infobox |
| CHEK2 | Bgee | Paneth cell | 1.00 | infobox |
| CHEK2 | Bgee | primitive streak | 1.00 | infobox |
| CHEK2 | Bgee | thymus | 1.00 | infobox |
| CHEK2 | BioGPS | More reference expression data | 1.00 | infobox |
| CHEK2 | Chr. | Chromosome 22 (human) | 1.00 | infobox |
| CHEK2 | Chr. | Chromosome 5 (mouse) | 1.00 | infobox |
| CHEK2 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| CHEK2 | End | 28,742,422 bp | 1.00 | infobox |
| CHEK2 | End | 111,022,011 bp | 1.00 | infobox |
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