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DNA-directed RNA polymerase II subunit RPB1, also known as RPB1, is an enzyme that is encoded by the POLR2A gene in humans.
The analysis highlights Measurement, Interactions and Function as prominent areas in the source structure around POLR2A.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around POLR2A shows recurring relationship patterns in the source. For example, POLR2A → 7-methylguanosine mRNA capping, cytoplasm, DNA binding, DNA-directed 5'-3' RNA polymerase activity, DNA-templated transcription, termination, fibroblast growth factor receptor signaling pathway, metal ion binding, mRNA splicing, via spliceosome, nucleolus, nucleoplasm, nucleotidyltransferase activity, nucleus, positive regulation of RNA splicing, positive regulation of viral transcription, promoter-specific chromatin binding, protein binding, protein C-terminus binding, Prp19 complex, regulation of gene silencing by miRNA, regulation of transcription, DNA-templated Another extracted example is POLR2A → BRCA1, CDK8, CREBBP, CTDP1, GTF2B, GTF2F1, GTF2H4, MED21, MED26, PCAF, POLR2C, POLR2E, POLR2H, POLR2L, PQBP1, SMARCA2, SMARCA4SMARCB1, SMYD3, SND1, SUPT5H. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
polymerase bp gene rna chr human band ii chromosome 17 subunit location activity enzyme mouse dna-directed rpb1 function external search
TTTA extracted 125 structured relationships around POLR2A. Examples in this analysis include POLR2A → 2.7.7.48 → ↗ and POLR2A → Aliases → POLR2A, POLR2, POLRA, RPB1, RPBh1, RPO2, RPOL2, RpIILS, hRPB220, hsRPB1, polymerase (RNA) II subunit A, RNA polymerase II subunit A, NEDHIB. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| POLR2A | 2.7.7.48 | ↗ | 1.00 | infobox |
| POLR2A | 2.7.7.6 | ↗ | 1.00 | infobox |
| POLR2A | Aliases | POLR2A, POLR2, POLRA, RPB1, RPBh1, RPO2, RPOL2, RpIILS, hRPB220, hsRPB1, polymerase (RNA) II subunit A, RNA polymerase II subunit A, NEDHIB | 1.00 | infobox |
| POLR2A | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2GHQ, 2GHT, 2LTO, 3D9K, 3D9L, 3D9M, 3D9N, 3D9O, 3D9P, 4JXT, 5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6 | 1.00 | infobox |
| POLR2A | Band | 17p13.1 | 1.00 | infobox |
| POLR2A | Band | 11 B3|11 42.86 cM | 1.00 | infobox |
| POLR2A | Bgee | right testis | 1.00 | infobox |
| POLR2A | Bgee | left testis | 1.00 | infobox |
| POLR2A | Bgee | stromal cell of endometrium | 1.00 | infobox |
| POLR2A | Bgee | mucosa of esophagus | 1.00 | infobox |
| POLR2A | Bgee | skin of leg | 1.00 | infobox |
| POLR2A | Bgee | right adrenal cortex | 1.00 | infobox |
| POLR2A | Bgee | right uterine tube | 1.00 | infobox |
| POLR2A | Bgee | pituitary gland | 1.00 | infobox |
| POLR2A | Bgee | left adrenal gland | 1.00 | infobox |
| POLR2A | Bgee | skin of abdomen | 1.00 | infobox |
| POLR2A | Bgee | neural layer of retina | 1.00 | infobox |
| POLR2A | Bgee | tail of embryo | 1.00 | infobox |
| POLR2A | Bgee | genital tubercle | 1.00 | infobox |
| POLR2A | Bgee | epiblast | 1.00 | infobox |
| POLR2A | Bgee | ventricular zone | 1.00 | infobox |
| POLR2A | Bgee | internal carotid artery | 1.00 | infobox |
| POLR2A | Bgee | Ileal epithelium | 1.00 | infobox |
| POLR2A | Bgee | tracheobronchial tree | 1.00 | infobox |
| POLR2A | Bgee | external carotid artery | 1.00 | infobox |
| POLR2A | Bgee | perirhinal cortex | 1.00 | infobox |
| POLR2A | BioGPS | More reference expression data | 1.00 | infobox |
| POLR2A | Chr. | Chromosome 17 (human) | 1.00 | infobox |
| POLR2A | Chr. | Chromosome 11 (mouse) | 1.00 | infobox |
| POLR2A | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
The concept neighborhoods around POLR2A bring nearby vocabulary together. In this analysis, examples include Subunit, External and Function. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For POLR2A, one of the stronger structural bridges in this analysis connects POLR2A with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around POLR2A to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Interactions & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — POLR2A · EN edition · Analysis: TopicsToTalkAbout