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STAT1

Signal transducer and activator of transcription 1 (STAT1) is a transcription factor which in humans is encoded by the STAT1 gene. It is a member of the STAT protein family.

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Aliases
STAT1, CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91, signal transducer and activator of transcription 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3WWT, 1BF5, 1YVL, 2KA6
Band
2q32.2 · 1 C1.1|1 26.81 cM
Bgee
epithelium of nasopharynx · appendix · mononuclear cell · monocyte · decidua
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 1 (mouse)

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Map overview Semantic statistics

STAT1

Nodes50
Edges49
Triples211
Avg. degree1.96
Density0.04
Components1

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STAT1

Top relations

Gene ontology · 89
STAT1 → axon, blood circulation, cadherin binding, CCR5 chemokine receptor binding, cellular response to cytokine stimulus, cellular response to insulin stimulus, cellular response to interferon-beta, cellular response to interferon-gamma, cellular response to organic cyclic compound, cytokine-mediated signaling pathway, cytoplasm, cytosol, defense response, defense response to virus, dendrite, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, double-stranded DNA binding
related to Function · 28
STAT1 → All STAT, C-terminus, EGF, Epidermal Growth Factor, Factor, IFN-ß, IFN-α, IFN-γ-dependent, IFNα, IFNγ, IL-27, IL-6, Interferon, Interleukin, ISGF3G/IRF-9, Jak, JAK1, PDGF, Platelet Derived Growth Factor, Specifically STAT1
related to Interactions · 20
STAT1 → BRCA1, C-jun, Calcitriol, CD117, CREB-binding, Epidermal, Fanconi, GNB2L1, IFNAR2, IRF1, ISGF3GInterleukin, Mammalian, MCM5, PIAS1, PRKCD, Protein, PTK2, Src, STAT2, STAT3
Bgee · 19
STAT1 → appendix, blood, decidua, endothelial cell, epithelium of lens, epithelium of nasopharynx, gastrula, glomerulus, granulocyte, lymph node, mesenteric lymph nodes, metanephric glomerulus, monocyte, mononuclear cell, mucous cell of stomach, spleen, subcutaneous adipose tissue, submandibular gland, thymus
RNA expression pattern · 19
STAT1 → appendix, blood, decidua, endothelial cell, epithelium of lens, epithelium of nasopharynx, gastrula, glomerulus, granulocyte, lymph node, mesenteric lymph nodes, metanephric glomerulus, monocyte, mononuclear cell, mucous cell of stomach, spleen, subcutaneous adipose tissue, submandibular gland, thymus
related to Mutations of STAT1 · 6
STAT1 → Both, GOF, In, LOF, Mutations, Recurring
Band · 2
STAT1 → 1 C1.1|1 26.81 cM, 2q32.2
Chr. · 2
STAT1 → Chromosome 1 (mouse), Chromosome 2 (human)
End · 2
STAT1 → 191,020,960 bp, 52,201,024 bp
Aliases · 1
STAT1 → STAT1, CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91, signal transducer and activator of transcription 1

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Important terminology

patients mutation infections human bp gene response viral function factor protein chr band also caused cmc type interferons bacterial signal

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
STAT1AliasesSTAT1, CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91, signal transducer and activator of transcription 11.00infobox
STAT1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3WWT, 1BF5, 1YVL, 2KA61.00infobox
STAT1Band2q32.21.00infobox
STAT1Band1 C1.1|1 26.81 cM1.00infobox
STAT1Bgeeepithelium of nasopharynx1.00infobox
STAT1Bgeeappendix1.00infobox
STAT1Bgeemononuclear cell1.00infobox
STAT1Bgeemonocyte1.00infobox
STAT1Bgeedecidua1.00infobox
STAT1Bgeeendothelial cell1.00infobox
STAT1Bgeelymph node1.00infobox
STAT1Bgeeglomerulus1.00infobox
STAT1Bgeegranulocyte1.00infobox
STAT1Bgeemetanephric glomerulus1.00infobox
STAT1Bgeethymus1.00infobox
STAT1Bgeespleen1.00infobox
STAT1Bgeemesenteric lymph nodes1.00infobox
STAT1Bgeegastrula1.00infobox
STAT1Bgeesubmandibular gland1.00infobox
STAT1Bgeeblood1.00infobox
STAT1Bgeeepithelium of lens1.00infobox
STAT1Bgeesubcutaneous adipose tissue1.00infobox
STAT1Bgeemucous cell of stomach1.00infobox
STAT1BioGPSMore reference expression data1.00infobox
STAT1Chr.Chromosome 2 (human)1.00infobox
STAT1Chr.Chromosome 1 (mouse)1.00infobox
STAT1DatabasesNCBI: entry; OMA: entry1.00infobox
STAT1End191,020,960 bp1.00infobox
STAT1End52,201,024 bp1.00infobox
STAT1EnsemblENSG000001154151.00infobox

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