Fanconi anemia group A protein

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Function

FANCB FANCC BRCA2 FANCD2 FANCE

23 related topics

Clinical significance

Mutations Fanconi's anaemia Autosomal recessive disorder Leukemia Diepoxybutane

31 related topics

Mouse knockout

Knockout mice Infertility MMC Stem cell transplant Hypogonadism

14 related topics

Interactions

Interact CHUK ERCC4 FANCC IKK2

9 related topics

Key facts & relationships

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Aliases: FANCA, FA, FA-H, FA1, FAA, FACA, FAH, FANCH, Fanconi anemia complementation group A, FA complementation group A
Band: 16q24.3 · 8 E1|8 72.1 cM
Bgee: right testis · ventricular zone · left testis · ganglionic eminence · mucosa of transverse colon
BioGPS: More reference expression data
Chr.: Chromosome 16 (human) · Chromosome 8 (mouse)
Databases: NCBI: entry; OMA: entry

Topics to explore

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Overview

Function

FANCB
FANCC
BRCA2
FANCD2
FANCE
FANCF
FANCG
FANCL
Chromosome 16
Amino acids
DNA damage
Assay
SsDNA
DsDNA
Nucleic acid-binding domain DNA-binding domain
Cytoplasm
Lymphoid
Testis
Ovary
Cellular proliferation Cell growth
Lymphoblasts
Leukaemia
Immunoprecipitation

Clinical significance

Mutations
Fanconi's anaemia Fanconi anemia
Autosomal recessive disorder
Leukemia
Diepoxybutane
Mitomycin-C
Oxygen
Apoptosis
Telomere
Exons
Alu Alu sequence
Homozygous
Anaemia
Compound heterozygotes
Ubiquitination
Phenotypes
Yeast two-hybrid analysis
Coimmunoprecipitation
BRCA1
Crosslink
Upregulation
Haematopoiesis
Haematopoietic stem cells Hematopoietic stem cell
Progenitor cells
Pancytopenia
Granulomonocytopoiesis Granulopoiesis
Myeloid
Bone marrow
DNA repair
Cell division

Mouse knockout

Interactions

Interact Protein-protein interaction
CHUK
ERCC4
FANCC Fanconi anemia, complementation group C
IKK2
SMARCA4
SNX5
SPTAN1
HES1

Advanced semantic analysis

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Map overview Semantic statistics

Nodes100

Edges99

Triples78

Avg. degree1.98

Density0.02

Components1

How this topic connects Entity context

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Fanconi anemia group A protein

Top relations

Bgee · 18

Fanconi anemia group A protein → blastocyst, bone marrow cell, embryo, epiblast, ganglionic eminence, genital tubercle, gonad, granulocyte, left testis, medullary collecting duct, monocyte, mucosa of transverse colon, right testis, spermatocyte, tail of embryo, testicle, ventricular zone, yolk sac

RNA expression pattern · 18

Gene ontology · 17

Fanconi anemia group A protein → cellular response to DNA damage stimulus, cytoplasm, DNA repair, Fanconi anaemia nuclear complex, female gonad development, interstrand cross-link repair, male gonad development, male meiotic nuclear division, nucleoplasm, nucleus, protein binding, protein-containing complex assembly, regulation of CD40 signaling pathway, regulation of cell population proliferation, regulation of DNA-binding transcription factor activity, regulation of inflammatory response, regulation of regulatory T cell differentiation

Band · 2

Fanconi anemia group A protein → 16q24.3, 8 E1|8 72.1 cM

Chr. · 2

Fanconi anemia group A protein → Chromosome 16 (human), Chromosome 8 (mouse)

End · 2

Fanconi anemia group A protein → 124,045,315 bp, 89,816,977 bp

Aliases · 1

Fanconi anemia group A protein → FANCA, FA, FA-H, FA1, FAA, FACA, FAH, FANCH, Fanconi anemia complementation group A, FA complementation group A

BioGPS · 1

Fanconi anemia group A protein → More reference expression data

Databases · 1

Fanconi anemia group A protein → NCBI: entry; OMA: entry

Ensembl · 1

Fanconi anemia group A protein → ENSG00000187741

Important terminology Word statistics

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Important terminology

fanca anaemia fanconi mutations dna protein gene also complex fa cells cell proteins repair patients group fancg brca1 increased chromosome

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Fanconi anemia group A protein	Aliases	FANCA, FA, FA-H, FA1, FAA, FACA, FAH, FANCH, Fanconi anemia complementation group A, FA complementation group A	1.00	infobox
Fanconi anemia group A protein	Band	16q24.3	1.00	infobox
Fanconi anemia group A protein	Band	8 E1\|8 72.1 cM	1.00	infobox
Fanconi anemia group A protein	Bgee	right testis	1.00	infobox
Fanconi anemia group A protein	Bgee	ventricular zone	1.00	infobox
Fanconi anemia group A protein	Bgee	left testis	1.00	infobox
Fanconi anemia group A protein	Bgee	ganglionic eminence	1.00	infobox
Fanconi anemia group A protein	Bgee	mucosa of transverse colon	1.00	infobox
Fanconi anemia group A protein	Bgee	testicle	1.00	infobox
Fanconi anemia group A protein	Bgee	granulocyte	1.00	infobox
Fanconi anemia group A protein	Bgee	gonad	1.00	infobox
Fanconi anemia group A protein	Bgee	monocyte	1.00	infobox
Fanconi anemia group A protein	Bgee	bone marrow cell	1.00	infobox
Fanconi anemia group A protein	Bgee	tail of embryo	1.00	infobox
Fanconi anemia group A protein	Bgee	medullary collecting duct	1.00	infobox
Fanconi anemia group A protein	Bgee	spermatocyte	1.00	infobox
Fanconi anemia group A protein	Bgee	epiblast	1.00	infobox
Fanconi anemia group A protein	Bgee	genital tubercle	1.00	infobox
Fanconi anemia group A protein	Bgee	embryo	1.00	infobox
Fanconi anemia group A protein	Bgee	yolk sac	1.00	infobox
Fanconi anemia group A protein	Bgee	blastocyst	1.00	infobox
Fanconi anemia group A protein	BioGPS	More reference expression data	1.00	infobox
Fanconi anemia group A protein	Chr.	Chromosome 16 (human)	1.00	infobox
Fanconi anemia group A protein	Chr.	Chromosome 8 (mouse)	1.00	infobox
Fanconi anemia group A protein	Databases	NCBI: entry; OMA: entry	1.00	infobox
Fanconi anemia group A protein	End	89,816,977 bp	1.00	infobox
Fanconi anemia group A protein	End	124,045,315 bp	1.00	infobox
Fanconi anemia group A protein	Ensembl	ENSG00000187741	1.00	infobox
Fanconi anemia group A protein	Entrez	2175	1.00	infobox
Fanconi anemia group A protein	External IDs	OMIM: 607139; MGI: 1341823; GeneCards: FANCA	1.00	infobox

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