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MSH2

DNA mismatch repair protein Msh2 also known as MutS homolog 2 or MSH2 is a protein that in humans is encoded by the MSH2 gene, which is located on chromosome 2. MSH2 is a tumor suppressor gene and more specifically a caretaker gene that codes for a DNA mismatch repair (MMR) protein, MSH2, which forms a heterodimer with MSH6 to make the human MutSα…

Epigenetic MSH2 deficiencies in cancer, Interactions & Clinical significance

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Aliases
MSH2, mutS homolog 2, COCA1, FCC1, HNPCC, HNPCC1, LCFS2, hMMRCS2, MSH-2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2O8B, 2O8C, 2O8D, 2O8E, 2O8F, 3THW, 3THX, 3THY, 3THZ
Band
2p21-p16.3 · 17 E4|17 57.87 cM
Bgee
secondary oocyte · ventricular zone · ganglionic eminence · gonad · retinal pigment epithelium
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 17 (mouse)

Topics to explore

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Overview

Clinical significance

Microsatellite instability

Role in mismatch repair

Double-strand break repair

Interactions

Epigenetic MSH2 deficiencies in cancer

Advanced semantic analysis

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Map overview Semantic statistics

MSH2

Nodes52
Edges51
Triples188
Avg. degree1.96
Density0.038462
Components1

How this topic connects Entity context

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MSH2

Top relations

Gene ontology · 67
MSH2 → ADP binding, ATP binding, ATP-dependent activity, acting on DNA, ATPase activity, B cell differentiation, B cell mediated immunity, cellular response to DNA damage stimulus, centromeric DNA binding, chromatin binding, chromosome, damaged DNA binding, determination of adult lifespan, dinucleotide insertion or deletion binding, dinucleotide repeat insertion binding, DNA binding, DNA mismatch repair, DNA recombination, DNA repair, double-strand break repair, double-strand/single-strand DNA junction binding
Bgee · 19
MSH2 → abdominal wall, Brodmann area 10, cerebellar hemisphere, epiblast, ganglionic eminence, gonad, middle frontal gyrus, otic placode, otic vesicle, primitive streak, rectum, retinal pigment epithelium, saccule, secondary oocyte, somite, tail of embryo, testicle, ventricular zone, zygote
RNA expression pattern · 19
MSH2 → abdominal wall, Brodmann area 10, cerebellar hemisphere, epiblast, ganglionic eminence, gonad, middle frontal gyrus, otic placode, otic vesicle, primitive streak, rectum, retinal pigment epithelium, saccule, secondary oocyte, somite, tail of embryo, testicle, ventricular zone, zygote
related to Role in mismatch repair · 17
MSH2 → ADP, ATP, ATPase, Conversely, DNA, In, MLH1, MSH3, MSH6, MutSα, MutSβ, N-terminal, NLS, Studies, The MSH2, The MutSα, When
related to Microsatellite instability · 13
MSH2 → Because, Currently, Detection, DNA, HNPCC, If, IHC, MMR, MSI, PCR, PCR-based MSI, The, This
related to Epigenetic MSH2 deficiencies in cancer · 10
MSH2 → ALL, DNA, Elevated DNA, If DNA, In, NSCLC, Reductions, See Frequencies, Such, There
related to Clinical significance · 9
MSH2 → DNA, Hereditary, HNPCC, Lynch, MLH1, MSH2-MSH6, Mutations, MutSα, These
related to Interactions · 7
MSH2 → ATR, BRCA1, CHEK2, EXO1, MAX, MSH3, MSH6
Band · 2
MSH2 → 17 E4|17 57.87 cM, 2p21-p16.3
Chr. · 2
MSH2 → Chromosome 17 (mouse), Chromosome 2 (human)

Important terminology Word statistics

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Important terminology

dna repair mutations gene mismatch msh6 protein mutsα cancer human complex chromosome microsatellite bp instability damage genes msh3 chr band

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
MSH2AliasesMSH2, mutS homolog 2, COCA1, FCC1, HNPCC, HNPCC1, LCFS2, hMMRCS2, MSH-21.00infobox
MSH2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2O8B, 2O8C, 2O8D, 2O8E, 2O8F, 3THW, 3THX, 3THY, 3THZ1.00infobox
MSH2Band2p21-p16.31.00infobox
MSH2Band17 E4|17 57.87 cM1.00infobox
MSH2Bgeesecondary oocyte1.00infobox
MSH2Bgeeventricular zone1.00infobox
MSH2Bgeeganglionic eminence1.00infobox
MSH2Bgeegonad1.00infobox
MSH2Bgeeretinal pigment epithelium1.00infobox
MSH2Bgeetesticle1.00infobox
MSH2Bgeemiddle frontal gyrus1.00infobox
MSH2BgeeBrodmann area 101.00infobox
MSH2Bgeerectum1.00infobox
MSH2Bgeecerebellar hemisphere1.00infobox
MSH2Bgeeprimitive streak1.00infobox
MSH2Bgeesaccule1.00infobox
MSH2Bgeeepiblast1.00infobox
MSH2Bgeeotic placode1.00infobox
MSH2Bgeeotic vesicle1.00infobox
MSH2Bgeetail of embryo1.00infobox
MSH2Bgeesomite1.00infobox
MSH2Bgeezygote1.00infobox
MSH2Bgeeabdominal wall1.00infobox
MSH2BioGPSMore reference expression data1.00infobox
MSH2Chr.Chromosome 2 (human)1.00infobox
MSH2Chr.Chromosome 17 (mouse)1.00infobox
MSH2DatabasesNCBI: entry; OMA: entry1.00infobox
MSH2End47,663,146 bp1.00infobox
MSH2End88,031,141 bp1.00infobox
MSH2EnsemblENSG000000950021.00infobox

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