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MAP3K3

Mitogen-activated protein kinase kinase kinase 3 is an enzyme that in humans is encoded by the MAP3K3 gene, which is located on the long arm of chromosome 17 (17q23.3).

Interactions, MAP3K3 in cancer & Function

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Interactions

5 related topics

MAP3K3 in cancer

4 related topics

Function

1 related topics

Overview

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2.7.11.25
Aliases
MAP3K3, MAPKKK3, MEKK3, mitogen-activated protein kinase kinase kinase 3
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2C60, 2JRH, 2PPH, 4Y5O, 4YL6, 2O2V
Band
17q23.3 · 11|11 E1
Bgee
monocyte · granulocyte · blood · gastric mucosa · apex of heart
BioGPS
More reference expression data

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Overview

Function

Interactions

MAP3K3 in cancer

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Map overview Semantic statistics

MAP3K3

Nodes17
Edges16
Triples125
Avg. degree1.88
Density0.117647
Components1

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MAP3K3

Top relations

Gene ontology · 28
MAP3K3 → activation of protein kinase activity, ATP binding, blood vessel development, cytoplasm, cytosol, interleukin-1-mediated signaling pathway, intracellular signal transduction, kinase activity, MAP kinase kinase kinase activity, MAPK cascade, metal ion binding, negative regulation of cellular senescence, nucleotide binding, phosphorylation, positive regulation of cell migration involved in sprouting angiogenesis, positive regulation of cell proliferation in bone marrow, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of p38MAPK cascade, protein autophosphorylation, protein binding
Bgee · 18
MAP3K3 → aortic valve, apex of heart, ascending aorta, blood, condyle, external carotid artery, fossa, gastric mucosa, granulocyte, internal carotid artery, monocyte, popliteal artery, right coronary artery, right lung, Rostral migratory stream, spleen, tibial arteries, tunica media of zone of aorta
RNA expression pattern · 18
MAP3K3 → aortic valve, apex of heart, ascending aorta, blood, condyle, external carotid artery, fossa, gastric mucosa, granulocyte, internal carotid artery, monocyte, popliteal artery, right coronary artery, right lung, Rostral migratory stream, spleen, tibial arteries, tunica media of zone of aorta
related to Function · 17
MAP3K3 → Alternatively, ERK, ERK1/2, In, Its, JNK, MAP3Ks, MEK1/2, MEKK2, MEKK3, NF-κB, Northern, NPK, SAPK, SEK, STE11, This
related to MAP3K3 in cancer · 14
MAP3K3 → AKT, Also, DOV13, Genes, Hey, High, IKK, In, MEKK3, NFκB, OVCA429, SKOv3, This, Two SNPs
related to Interactions · 5
MAP3K3 → AKT, BRCA1, GAB1, MAP2K5, SQSTM1/p62
Band · 2
MAP3K3 → 11|11 E1, 17q23.3
Chr. · 2
MAP3K3 → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
MAP3K3 → 106,046,272 bp, 63,696,305 bp
2.7.11.25 · 1
MAP3K3 → ↗

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Important terminology

mekk3 kinase gene bp chromosome 17 cancer chr human band brca1 activity protein mouse expression cell nfκb cells 11 location

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
MAP3K32.7.11.251.00infobox
MAP3K3AliasesMAP3K3, MAPKKK3, MEKK3, mitogen-activated protein kinase kinase kinase 31.00infobox
MAP3K3Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2C60, 2JRH, 2PPH, 4Y5O, 4YL6, 2O2V1.00infobox
MAP3K3Band17q23.31.00infobox
MAP3K3Band11|11 E11.00infobox
MAP3K3Bgeemonocyte1.00infobox
MAP3K3Bgeegranulocyte1.00infobox
MAP3K3Bgeeblood1.00infobox
MAP3K3Bgeegastric mucosa1.00infobox
MAP3K3Bgeeapex of heart1.00infobox
MAP3K3Bgeeright lung1.00infobox
MAP3K3Bgeeright coronary artery1.00infobox
MAP3K3Bgeepopliteal artery1.00infobox
MAP3K3Bgeetibial arteries1.00infobox
MAP3K3Bgeespleen1.00infobox
MAP3K3Bgeeinternal carotid artery1.00infobox
MAP3K3Bgeeascending aorta1.00infobox
MAP3K3Bgeeaortic valve1.00infobox
MAP3K3Bgeeexternal carotid artery1.00infobox
MAP3K3Bgeefossa1.00infobox
MAP3K3BgeeRostral migratory stream1.00infobox
MAP3K3Bgeecondyle1.00infobox
MAP3K3Bgeetunica media of zone of aorta1.00infobox
MAP3K3BioGPSMore reference expression data1.00infobox
MAP3K3Chr.Chromosome 17 (human)1.00infobox
MAP3K3Chr.Chromosome 11 (mouse)1.00infobox
MAP3K3DatabasesNCBI: entry; OMA: entry1.00infobox
MAP3K3End63,696,305 bp1.00infobox
MAP3K3End106,046,272 bp1.00infobox
MAP3K3EnsemblENSG000001989091.00infobox

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