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Mitogen-activated protein kinase kinase kinase 3 is an enzyme that in humans is encoded by the MAP3K3 gene, which is located on the long arm of chromosome 17 (17q23.3).
The analysis highlights Interactions, MAP3K3 in cancer and Function as prominent areas in the source structure around MAP3K3.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around MAP3K3 shows recurring relationship patterns in the source. For example, MAP3K3 → activation of protein kinase activity, ATP binding, blood vessel development, cytoplasm, cytosol, interleukin-1-mediated signaling pathway, intracellular signal transduction, kinase activity, MAP kinase kinase kinase activity, MAPK cascade, metal ion binding, negative regulation of cellular senescence, nucleotide binding, phosphorylation, positive regulation of cell migration involved in sprouting angiogenesis, positive regulation of cell proliferation in bone marrow, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of p38MAPK cascade, protein autophosphorylation, protein binding Another extracted example is MAP3K3 → aortic valve, apex of heart, ascending aorta, blood, condyle, external carotid artery, fossa, gastric mucosa, granulocyte, internal carotid artery, monocyte, popliteal artery, right coronary artery, right lung, Rostral migratory stream, spleen, tibial arteries, tunica media of zone of aorta. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
mekk3 kinase gene bp chromosome 17 cancer chr human band brca1 activity protein mouse expression cell nfκb cells 11 location
TTTA extracted 125 structured relationships around MAP3K3. Examples in this analysis include MAP3K3 → 2.7.11.25 → ↗ and MAP3K3 → Aliases → MAP3K3, MAPKKK3, MEKK3, mitogen-activated protein kinase kinase kinase 3. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| MAP3K3 | 2.7.11.25 | ↗ | 1.00 | infobox |
| MAP3K3 | Aliases | MAP3K3, MAPKKK3, MEKK3, mitogen-activated protein kinase kinase kinase 3 | 1.00 | infobox |
| MAP3K3 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2C60, 2JRH, 2PPH, 4Y5O, 4YL6, 2O2V | 1.00 | infobox |
| MAP3K3 | Band | 17q23.3 | 1.00 | infobox |
| MAP3K3 | Band | 11|11 E1 | 1.00 | infobox |
| MAP3K3 | Bgee | monocyte | 1.00 | infobox |
| MAP3K3 | Bgee | granulocyte | 1.00 | infobox |
| MAP3K3 | Bgee | blood | 1.00 | infobox |
| MAP3K3 | Bgee | gastric mucosa | 1.00 | infobox |
| MAP3K3 | Bgee | apex of heart | 1.00 | infobox |
| MAP3K3 | Bgee | right lung | 1.00 | infobox |
| MAP3K3 | Bgee | right coronary artery | 1.00 | infobox |
| MAP3K3 | Bgee | popliteal artery | 1.00 | infobox |
| MAP3K3 | Bgee | tibial arteries | 1.00 | infobox |
| MAP3K3 | Bgee | spleen | 1.00 | infobox |
| MAP3K3 | Bgee | internal carotid artery | 1.00 | infobox |
| MAP3K3 | Bgee | ascending aorta | 1.00 | infobox |
| MAP3K3 | Bgee | aortic valve | 1.00 | infobox |
| MAP3K3 | Bgee | external carotid artery | 1.00 | infobox |
| MAP3K3 | Bgee | fossa | 1.00 | infobox |
| MAP3K3 | Bgee | Rostral migratory stream | 1.00 | infobox |
| MAP3K3 | Bgee | condyle | 1.00 | infobox |
| MAP3K3 | Bgee | tunica media of zone of aorta | 1.00 | infobox |
| MAP3K3 | BioGPS | More reference expression data | 1.00 | infobox |
| MAP3K3 | Chr. | Chromosome 17 (human) | 1.00 | infobox |
| MAP3K3 | Chr. | Chromosome 11 (mouse) | 1.00 | infobox |
| MAP3K3 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| MAP3K3 | End | 63,696,305 bp | 1.00 | infobox |
| MAP3K3 | End | 106,046,272 bp | 1.00 | infobox |
| MAP3K3 | Ensembl | ENSG00000198909 | 1.00 | infobox |
The concept neighborhoods around MAP3K3 bring nearby vocabulary together. In this analysis, examples include Protein, Gene and Chromosome. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For MAP3K3, one of the stronger structural bridges in this analysis connects MAP3K3 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around MAP3K3 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, MAP3K3 in cancer & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — MAP3K3 · EN edition · Analysis: TopicsToTalkAbout