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AKT1: History, Interactions & Function

RAC(Rho family)-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1 gene. This enzyme belongs to the AKT subfamily of serine/threonine kinases that contain SH2 (Src homology 2-like) protein domains. It is commonly referred to as PKB, or by both names as "Akt/PKB".

Language: English [EN]
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AKT1 topic overview

The analysis highlights History, Interactions and Function as prominent areas in the source structure around AKT1.

Related topics
57
Source areas
4
Connected nodes
61
Extracted relationships
307
Concept neighborhoods
14
Bridge connections
61

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 31 topics
Function · 15 topics
Overview · 6 topics
History · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.11.1
↗
Aliases
AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA, AKT serine/threonine kinase 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1H10, 1UNP, 1UNQ, 1UNR, 2UVM, 2UZR, 2UZS, 3CQU, 3CQW, 3MV5, 3MVH, 3O96, 3OCB, 3OW4, 3QKK, 3QKL, 3QKM, 4EJN,…
Band
14q32.33 · 12 F1|12 61.2 cM
Bgee
stromal cell of endometrium · ganglionic eminence · left adrenal cortex · right adrenal gland · right adrenal cortex
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

History

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How AKT1 connects Entity context

The extracted context around AKT1 shows recurring relationship patterns in the source. For example, AKT1 → 14-3-3 protein binding, activation of protein kinase B activity, activation-induced cell death of T cells, ageing, anoikis, apoptotic mitochondrial changes, apoptotic process, ATP binding, calmodulin binding, carbohydrate metabolic process, carbohydrate transport, cell differentiation, cell migration involved in sprouting angiogenesis, cell population proliferation, cell projection organization, cell-cell junction, cellular response to cadmium ion, cellular response to decreased oxygen levels, cellular response to DNA damage stimulus, cellular response to epidermal growth factor stimulus Another extracted example is AKT1 → AKTIP, BRAF, BRCA1, C-Raf, CDKN1B, CHUKGAB2, HSP90AA1, ILK, KRT10, MAP2K4, MAP3K11, MAP3K8, MAPK14, MAPKAPK2, MARK2, MTCP1, MTOR, NPM1, NR3C4, NR4A1. Use these groups to spot repeated connection types before inspecting the individual relationships.

AKT1

Top relations

Gene ontology · 189
AKT1 → 14-3-3 protein binding, activation of protein kinase B activity, activation-induced cell death of T cells, ageing, anoikis, apoptotic mitochondrial changes, apoptotic process, ATP binding, calmodulin binding, carbohydrate metabolic process, carbohydrate transport, cell differentiation, cell migration involved in sprouting angiogenesis, cell population proliferation, cell projection organization, cell-cell junction, cellular response to cadmium ion, cellular response to decreased oxygen levels, cellular response to DNA damage stimulus, cellular response to epidermal growth factor stimulus
related to Interactions · 28
AKT1 → AKTIP, BRAF, BRCA1, C-Raf, CDKN1B, CHUKGAB2, HSP90AA1, ILK, KRT10, MAP2K4, MAP3K11, MAP3K8, MAPK14, MAPKAPK2, MARK2, MTCP1, MTOR, NPM1, NR3C4, NR4A1
Bgee · 19
AKT1 → atrium, body of stomach, efferent ductule, endothelial cell of lymphatic vessel, gallbladder, ganglionic eminence, granulocyte, human fetus, left adrenal cortex, lip, molar, muscle layer of sigmoid colon, right adrenal cortex, right adrenal gland, right coronary artery, stroma of bone marrow, stromal cell of endometrium, submandibular gland, ventricular zone
RNA expression pattern · 19
AKT1 → atrium, body of stomach, efferent ductule, endothelial cell of lymphatic vessel, gallbladder, ganglionic eminence, granulocyte, human fetus, left adrenal cortex, lip, molar, muscle layer of sigmoid colon, right adrenal cortex, right adrenal gland, right coronary artery, stroma of bone marrow, stromal cell of endometrium, submandibular gland, ventricular zone
related to history · 12
AKT1 → AKR, AKT, Akt2, AKT8, Elephant Man, In, Johns Hopkins Oncology Center, Proteus, Rowe, Stephen Staal, The, Wallace
related to Function · 11
AKT1 → AKT, AKT2, IGF1, In, It, Mice, Neu, Proteus, Survival, The, They
related to External links · 4
AKT1 → AKT1 Reference ControlsHuman AKT1, AKT1 Standards, Learn, UCSC Genome Browser
Band · 2
AKT1 → 12 F1|12 61.2 cM, 14q32.33
Chr. · 2
AKT1 → Chromosome 12 (mouse), Chromosome 14 (human)
End · 2
AKT1 → 104,795,751 bp, 112,641,318 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

akt human bp gene serine enzyme chr band mice kinase threonine chromosome 14 mouse location akt2 transforming growth protein also

AKT1 relationships Subject–Predicate–Object triples

TTTA extracted 307 structured relationships around AKT1. Examples in this analysis include AKT1 → 2.7.11.1 → ↗ and AKT1 → Aliases → AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA, AKT serine/threonine kinase 1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
AKT12.7.11.1↗1.00infobox
AKT1AliasesAKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA, AKT serine/threonine kinase 11.00infobox
AKT1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1H10, 1UNP, 1UNQ, 1UNR, 2UVM, 2UZR, 2UZS, 3CQU, 3CQW, 3MV5, 3MVH, 3O96, 3OCB, 3OW4, 3QKK, 3QKL, 3QKM, 4EJN,…1.00infobox
AKT1Band14q32.331.00infobox
AKT1Band12 F1|12 61.2 cM1.00infobox
AKT1Bgeestromal cell of endometrium1.00infobox
AKT1Bgeeganglionic eminence1.00infobox
AKT1Bgeeleft adrenal cortex1.00infobox
AKT1Bgeeright adrenal gland1.00infobox
AKT1Bgeeright adrenal cortex1.00infobox
AKT1Bgeeventricular zone1.00infobox
AKT1Bgeeright coronary artery1.00infobox
AKT1Bgeegallbladder1.00infobox
AKT1Bgeebody of stomach1.00infobox
AKT1Bgeemuscle layer of sigmoid colon1.00infobox
AKT1Bgeegranulocyte1.00infobox
AKT1Bgeeatrium1.00infobox
AKT1Bgeemolar1.00infobox
AKT1Bgeehuman fetus1.00infobox
AKT1Bgeeefferent ductule1.00infobox
AKT1Bgeeendothelial cell of lymphatic vessel1.00infobox
AKT1Bgeesubmandibular gland1.00infobox
AKT1Bgeestroma of bone marrow1.00infobox
AKT1Bgeelip1.00infobox
AKT1BioGPSMore reference expression data1.00infobox
AKT1Chr.Chromosome 14 (human)1.00infobox
AKT1Chr.Chromosome 12 (mouse)1.00infobox
AKT1DatabasesNCBI: entry; OMA: entry1.00infobox
AKT1End104,795,751 bp1.00infobox
AKT1End112,641,318 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around AKT1 bring nearby vocabulary together. In this analysis, examples include Human, Akt2 and Kinase. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • AKT1
    • Human
    • Akt2
    • Kinase
    • Serine
    • Gene
    • Also
    • Enzyme
    • Growth
    • Location
    • Threonine
    • Akt
    • Activity
  • akt1
    • Human
    • Akt2
    • Kinase
    • Serine
    • Gene
    • Also
    • Enzyme
    • Growth
    • Location
    • Threonine
    • Akt
    • Activity
  • enzyme
    • Serine
    • Kinase
    • Threonine
    • Activity
    • Function
    • Protein
    • Rac
    • Search
    • Gene
    • Chromosome
    • Location
    • Bp
  • gene
    • Location
    • Human
    • Chromosome
    • Kinase
    • Bp
    • Chr
    • Serine
    • Activity
    • Function
    • Rac
    • Search
    • Proteus
  • akt
    • Pkb
    • Also
    • Enzyme
    • Location
    • Threonine
    • Serine
    • Transforming
    • Gene
    • Akt1
    • Human
    • External
    • Activity
  • serine/threonine kinases
    • Serine
    • Threonine
    • Enzyme
    • Kinase
    • Activity
    • Function
    • Protein
    • Search
    • Chromosome
    • Location
    • Bp
    • Chr
  • serine-threonine protein kinase
    • Serine
    • Enzyme
    • Threonine
    • Activity
    • Function
    • Rac
    • Search
    • Gene
    • Chromosome
    • Location
    • Akt1
    • Bp
  • function
    • Activity
    • Search
    • Chromosome
    • Kinase
    • Location
    • Threonine
    • Bp
    • Chr
    • Serine
    • Gene
    • Pkb
    • Protein

Connections between topic areas Semantic bridges

For AKT1, one of the stronger structural bridges in this analysis connects AKT1 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
AKT1 — Interactions · splits 30 ⟂ 32
AKT1 — Function · splits 46 ⟂ 16
AKT1 — Overview · splits 55 ⟂ 7
AKT1 — History · splits 56 ⟂ 6

Map overview Semantic statistics

AKT1

Nodes62
Edges61
Triples307
Avg. degree1.97
Density0.032258
Components1

Source & methodology

TTTA analyzes the structure around AKT1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Interactions & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — AKT1 · EN edition · Analysis: TopicsToTalkAbout

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