FHL2

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Explore the main themes, entities and connections around FHL2. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Interactions

Interact CTNNB1 CD18 CD29 CD49c

17 related topics

Clinical significance

Posttranslational modifications Familial dilated cardiomyopathy Pathogenesis BRCA1 Gastrointestinal cancers

16 related topics

Family

LIN-11 ISL-1 MEC-3 FHL4 FHL5

5 related topics

Tissue distribution

Thymus Leukocytes Transcription factors

3 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: FHL2, AAG11, DRAL, FHL-2, SLIM-3, SLIM3, four and a half LIM domains 2
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1X4K, 1X4L, 2D8Z, 2MIU
Band: 2q12.2 · 1|1 C1.1
Bgee: myocardium of left ventricle · right ventricle · apex of heart · left ovary · right ovary
BioGPS: More reference expression data
Chr.: Chromosome 2 (human) · Chromosome 1 (mouse)

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Function

Presenilin-2

Family

LIN-11 LIN-11?action=edit&redlink=1
ISL-1 ISL1
MEC-3 MEC3?action=edit&redlink=1
FHL4 FHL4?action=edit&redlink=1
FHL5

Gene

Promoters Gene promoter
Transcript variants Transcript variant

Tissue distribution

Thymus
Leukocytes Leukocyte
Transcription factors Transcription factor

Regulation of expression

P53
Adaptor protein Signal transducing adaptor protein

Clinical significance

Posttranslational modifications Posttranslational modification
Familial dilated cardiomyopathy
Pathogenesis
BRCA1
Gastrointestinal cancers Gastrointestinal cancer
Colon cancer
Oncogenic
Transforming growth factor beta 1 TGF beta 1
Hepatocellular carcinoma
Androgen receptor
Prostate-specific antigen
Serum response factor
RhoA
Actin
Megakaryocytic acute leukemia Acute megakaryoblastic leukemia
Filamin

Interactions

Interact Protein-protein interaction
CTNNB1 Beta-catenin
CD18
CD29
CD49c
CREB1
EIF6
FHL3
IGFBP5
ITGA7
ITGB6 Integrin, beta 6
MAPK1
PSEN2
TRAF6
TTN Titin
ZNF638
ZBTB16 Zinc finger and BTB domain-containing protein 16

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Nodes59

Edges58

Triples204

Avg. degree1.97

Density0.033898

Components1

How this topic connects Entity context

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FHL2

Top relations

Gene ontology · 27

FHL2 → androgen receptor binding, androgen receptor signaling pathway, atrial cardiac muscle cell development, cytoplasm, focal adhesion, heart trabecula formation, identical protein binding, M band, metal ion binding, negative regulation of apoptotic process, negative regulation of calcineurin-NFAT signaling cascade, negative regulation of transcription by RNA polymerase II, negative regulation of transcription, DNA-templated, nucleoplasm, nucleus, osteoblast differentiation, positive regulation of transcription, DNA-templated, protein binding, regulation of lipid metabolic process, regulation of transcription by RNA polymerase II

related to Family · 22

FHL2 → ACT, CREM, DNA, FHL, FHL1, FHL3, FHL4, FHL5, Instead, ISL-1, LIM, LIM-containing, LIM-only, LIN-11, MEC-3, N-terminus, No, Protein, The, The Four-and-a-half LIM

Bgee · 19

FHL2 → apex of heart, atrioventricular valve, atrium, cardiac muscle tissue of left ventricle, cardiac muscle tissue of right atrium, cardiac muscles, endocardial cushion, interventricular septum, left ovary, mucous cell of stomach, myocardium of left ventricle, myocardium of ventricle, right auricle of heart, right ovary, right ventricle, saphenous vein, stroma of bone marrow, stromal cell of endometrium, urethra

RNA expression pattern · 19

related to Interactions · 17

FHL2 → Androgen, BRCA1, CD18, CD29, CD49c, CREB1, CTNNB1, EIF6, FHL3, IGFBP5, ITGA7, ITGB6, MAPK1, PSEN2, TRAF6, TTN, ZNF638

related to Clinical significance · 13

FHL2 → A7FIL, DCM, FHL-2, However, In, It, NIH, Phosphorylation, Provided, Similar, The, Therefore, This

related to External links · 13

FHL2 → Four, LIM, Medicine, Medicine Medical Subject Headings, MeSH, National Library, Overview, PDB, PDBe-KB, Q14192, This, UniProt, United States National Library

related to Prostate cancer · 11

FHL2 → AhR, AR, Aryl, Calpain, MAL, On, PSA, RhoA, SFR, SRF, The

related to Regulation of expression · 11

FHL2 → AP-1, Apart, Different, GI, IL-1β, In, LIM, MEF-2, Sp1, SRF, Therefore

related to Liver cancer · 10

FHL2 → D1, FHL2-regulated, HCC, HCC Hep3B, In, Of, P21, P27, Similar, Therefore

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cancer expression protein lim human gene bp transcription chr band factors different chromosome prostate cell signaling colon also domain liver

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
FHL2	Aliases	FHL2, AAG11, DRAL, FHL-2, SLIM-3, SLIM3, four and a half LIM domains 2	1.00	infobox
FHL2	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1X4K, 1X4L, 2D8Z, 2MIU	1.00	infobox
FHL2	Band	2q12.2	1.00	infobox
FHL2	Band	1\|1 C1.1	1.00	infobox
FHL2	Bgee	myocardium of left ventricle	1.00	infobox
FHL2	Bgee	right ventricle	1.00	infobox
FHL2	Bgee	apex of heart	1.00	infobox
FHL2	Bgee	left ovary	1.00	infobox
FHL2	Bgee	right ovary	1.00	infobox
FHL2	Bgee	cardiac muscle tissue of right atrium	1.00	infobox
FHL2	Bgee	right auricle of heart	1.00	infobox
FHL2	Bgee	stromal cell of endometrium	1.00	infobox
FHL2	Bgee	urethra	1.00	infobox
FHL2	Bgee	saphenous vein	1.00	infobox
FHL2	Bgee	cardiac muscles	1.00	infobox
FHL2	Bgee	myocardium of ventricle	1.00	infobox
FHL2	Bgee	cardiac muscle tissue of left ventricle	1.00	infobox
FHL2	Bgee	interventricular septum	1.00	infobox
FHL2	Bgee	atrioventricular valve	1.00	infobox
FHL2	Bgee	atrium	1.00	infobox
FHL2	Bgee	endocardial cushion	1.00	infobox
FHL2	Bgee	stroma of bone marrow	1.00	infobox
FHL2	Bgee	mucous cell of stomach	1.00	infobox
FHL2	BioGPS	More reference expression data	1.00	infobox
FHL2	Chr.	Chromosome 2 (human)	1.00	infobox
FHL2	Chr.	Chromosome 1 (mouse)	1.00	infobox
FHL2	Databases	NCBI: entry; OMA: entry	1.00	infobox
FHL2	End	105,438,513 bp	1.00	infobox
FHL2	End	43,236,144 bp	1.00	infobox
FHL2	Ensembl	ENSG00000115641	1.00	infobox

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