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Four and a half LIM domains protein 2 also known as FHL-2 is a protein that in humans is encoded by the FHL2 gene. LIM proteins contain a highly conserved double zinc finger motif called the LIM domain.
The analysis highlights Interactions, Clinical significance and Tissue distribution as prominent areas in the source structure around FHL2.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
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The extracted context around FHL2 shows recurring relationship patterns in the source. For example, FHL2 → androgen receptor binding, androgen receptor signaling pathway, atrial cardiac muscle cell development, cytoplasm, focal adhesion, heart trabecula formation, identical protein binding, M band, metal ion binding, negative regulation of apoptotic process, negative regulation of calcineurin-NFAT signaling cascade, negative regulation of transcription by RNA polymerase II, negative regulation of transcription, DNA-templated, nucleoplasm, nucleus, osteoblast differentiation, positive regulation of transcription, DNA-templated, protein binding, regulation of lipid metabolic process, regulation of transcription by RNA polymerase II Another extracted example is FHL2 → apex of heart, atrioventricular valve, atrium, cardiac muscle tissue of left ventricle, cardiac muscle tissue of right atrium, cardiac muscles, endocardial cushion, interventricular septum, left ovary, mucous cell of stomach, myocardium of left ventricle, myocardium of ventricle, right auricle of heart, right ovary, right ventricle, saphenous vein, stroma of bone marrow, stromal cell of endometrium, urethra. Use these groups to spot repeated connection types before inspecting the individual relationships.
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cancer expression protein lim human gene bp transcription chr band factors different chromosome prostate cell signaling colon also domain liver
TTTA extracted 171 structured relationships around FHL2. Examples in this analysis include FHL2 → Aliases → FHL2, AAG11, DRAL, FHL-2, SLIM-3, SLIM3, four and a half LIM domains 2 and FHL2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1X4K, 1X4L, 2D8Z, 2MIU. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| FHL2 | Aliases | FHL2, AAG11, DRAL, FHL-2, SLIM-3, SLIM3, four and a half LIM domains 2 | 1.00 | infobox |
| FHL2 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1X4K, 1X4L, 2D8Z, 2MIU | 1.00 | infobox |
| FHL2 | Band | 2q12.2 | 1.00 | infobox |
| FHL2 | Band | 1|1 C1.1 | 1.00 | infobox |
| FHL2 | Bgee | myocardium of left ventricle | 1.00 | infobox |
| FHL2 | Bgee | right ventricle | 1.00 | infobox |
| FHL2 | Bgee | apex of heart | 1.00 | infobox |
| FHL2 | Bgee | left ovary | 1.00 | infobox |
| FHL2 | Bgee | right ovary | 1.00 | infobox |
| FHL2 | Bgee | cardiac muscle tissue of right atrium | 1.00 | infobox |
| FHL2 | Bgee | right auricle of heart | 1.00 | infobox |
| FHL2 | Bgee | stromal cell of endometrium | 1.00 | infobox |
| FHL2 | Bgee | urethra | 1.00 | infobox |
| FHL2 | Bgee | saphenous vein | 1.00 | infobox |
| FHL2 | Bgee | cardiac muscles | 1.00 | infobox |
| FHL2 | Bgee | myocardium of ventricle | 1.00 | infobox |
| FHL2 | Bgee | cardiac muscle tissue of left ventricle | 1.00 | infobox |
| FHL2 | Bgee | interventricular septum | 1.00 | infobox |
| FHL2 | Bgee | atrioventricular valve | 1.00 | infobox |
| FHL2 | Bgee | atrium | 1.00 | infobox |
| FHL2 | Bgee | endocardial cushion | 1.00 | infobox |
| FHL2 | Bgee | stroma of bone marrow | 1.00 | infobox |
| FHL2 | Bgee | mucous cell of stomach | 1.00 | infobox |
| FHL2 | BioGPS | More reference expression data | 1.00 | infobox |
| FHL2 | Chr. | Chromosome 2 (human) | 1.00 | infobox |
| FHL2 | Chr. | Chromosome 1 (mouse) | 1.00 | infobox |
| FHL2 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| FHL2 | End | 105,438,513 bp | 1.00 | infobox |
| FHL2 | End | 43,236,144 bp | 1.00 | infobox |
| FHL2 | Ensembl | ENSG00000115641 | 1.00 | infobox |
The concept neighborhoods around FHL2 bring nearby vocabulary together. In this analysis, examples include Cancer, Expression and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For FHL2, one of the stronger structural bridges in this analysis connects FHL2 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around FHL2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Clinical significance & Tissue distribution, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — FHL2 · EN edition · Analysis: TopicsToTalkAbout
