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Myc: Interactions, Function & Overview

Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. The Myc family consists of three related human genes: c-myc (MYC), l-myc (MYCL), and n-myc (MYCN). c-myc (also sometimes referred to as MYC) was the first gene to be discovered in this family, due to homology with the viral gene v-myc.

Language: English [EN]
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Myc topic overview

The analysis highlights Interactions, Function and Overview as prominent areas in the source structure around Myc.

Related topics
116
Source areas
10
Connected nodes
127
Extracted relationships
140
Concept neighborhoods
30
Bridge connections
127

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 37 topics
Overview · 23 topics
Function · 13 topics
Myc-nick · 10 topics
Clinical significance · 9 topics
Structure · 6 topics
Animal models · 5 topics
MYC rearrangements · 5 topics
Discovery · 4 topics
Relationship to stem cells · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Alt. symbols
c-Myc, v-myc
Domains
InterPro
HGNC
7553
Locus
Chr. 8 q24.21
NCBI gene
4609
OMIM
190080

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Discovery

Structure

Function

Myc-nick

Clinical significance

MYC rearrangements

Animal models

Relationship to stem cells

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Myc connects Entity context

The extracted context around Myc shows recurring relationship patterns in the source. For example, Myc → AKT, Also, AMPK, Burkitt, Classical, CML, CR, Cre-Loxp, Drosophila, During, Haplo-insufficient, IgM, In, In Drosophila Myc, John, Later, Less TOR, One, S6K, Sedivy Another extracted example is Myc → Cells, Forced Expression, Generating, Human Myc, InterPro, IPR002418, IPR003327The Myc ProteinNCBI Human, IPR011598, Klf4 Archived, Medicine Medical Subject Headings, MEFS, MeSH, National Library, Oct-4, PDB, Proteins, Proto-Oncogene, Sox-2, The Interactive FlyFactorBookC-MycPDBe-KB, Wayback MachineDrosophila Myc. Use these groups to spot repeated connection types before inspecting the individual relationships.

Myc

Top relations

related to Animal models · 23
Myc → AKT, Also, AMPK, Burkitt, Classical, CML, CR, Cre-Loxp, Drosophila, During, Haplo-insufficient, IgM, In, In Drosophila Myc, John, Later, Less TOR, One, S6K, Sedivy
related to External links · 20
Myc → Cells, Forced Expression, Generating, Human Myc, InterPro, IPR002418, IPR003327The Myc ProteinNCBI Human, IPR011598, Klf4 Archived, Medicine Medical Subject Headings, MEFS, MeSH, National Library, Oct-4, PDB, Proteins, Proto-Oncogene, Sox-2, The Interactive FlyFactorBookC-MycPDBe-KB, Wayback MachineDrosophila Myc
related to MYC rearrangements · 18
Myc → AICDA, Although AICDA, B-cell, BCL2, BCL6, CSR, DLBCL/HGBCL, DLBCLs, Double, HGBCL, IG, MYC-R, NHL, Non-Hodgkin Lymphoma, Patients, SHM, The, These
related to Function · 16
Myc → Bcl-2, By, DNA, E-boxes, EGF, HATs, In, It, MAPK/ERK, Miz-1, Nucleotide, RNA, Shh, The, This, Wnt
related to Discovery · 10
Myc → Avian, Burkitt's, Ig, In Burkitt's, Later, Myelocytomatosis, P10395, The, The Myc, This
related to Clinical significance · 9
Myc → Except, Furthermore, Genes, Hence, Inactivation, SAE1, SAE2, SUMO-activating, SUMOylation
related to Relationship to stem cells · 9
Myc → Enforced, In, It, Klf4, LT-HSCs, N-Myc, Oct4, Sox2, Yamanaka
related to Myc-nick · 7
Myc → C-terminus, DNA, Myc-nick, N-Myc, N-terminal, The, Upon
related to Structure · 7
Myc → DNA, IRES, LZ, Max, RNA, TF-binding, The
related to Interactions · 2
Myc → ACTL6ABRCA1Bcl-2Cyclin T1CHD8DNMT3AEP400GTF2IHTATIPlet-7MAPK1MAPK8MAXMLH1MYCBP2MYCBPNMINFYBNFYCP73PCAFPFDN5RuvB-like, C2orf16

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

c-myc genes expression cells cancer cell also stem gene family transcription human factors lymphoma role n-myc myc-nick proteins differentiation myc-r

Myc relationships Subject–Predicate–Object triples

TTTA extracted 140 structured relationships around Myc. Examples in this analysis include Myc → Alt. symbols → c-Myc, v-myc and Myc → Domains → InterPro. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
MycAlt. symbolsc-Myc, v-myc1.00infobox
MycDomainsInterPro1.00infobox
MycHGNC75531.00infobox
MycLocusChr. 8 q24.211.00infobox
MycNCBI gene46091.00infobox
MycOMIM1900801.00infobox
MycRefSeqNM_001354870.11.00infobox
MycSearch forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
MycStructuresSwiss-model1.00infobox
MycSymbolMYC1.00infobox
MycUniProtP011061.00infobox
MycWikidataQ209699391.00infobox
Myccausestumorigenesis0.90text
Mycis afamily of regulator genes and proto-oncogenes that code for transcription factors0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Myc bring nearby vocabulary together. In this analysis, examples include Expression, Cells and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Myc
    • Expression
    • Cells
    • Gene
    • C-myc
    • Cancer
    • Also
    • Cell
    • Including
    • Protein
    • Factors
    • Proteins
    • Transcription
  • myc
    • Expression
    • Cells
    • Gene
    • C-myc
    • Cancer
    • Also
    • Cell
    • Including
    • Protein
    • Factors
    • Proteins
    • Transcription
  • regulator genes
    • Expression
    • Myc
    • Factors
    • Transcription
    • Gene
    • Binding
    • Human
    • First
    • Many
    • Proliferation
    • N-myc
    • C-myc
  • transcription factors
    • Factors
    • Transcription
    • One
    • Protein
    • Genes
    • Histone
    • May
    • Binding
    • Family
    • Proteins
    • Drugs
    • Mrna
  • cell proliferation
    • Proliferation
    • Stem
    • Differentiation
    • Role
    • Used
    • Including
    • Cells
    • Proteins
    • Myc
    • Cancer
    • Drugs
    • Mrna
  • stem cell
    • Differentiation
    • Proliferation
    • Stem
    • Role
    • Used
    • Cells
    • Myc
    • Via
    • Cancer
    • Function
    • Rearrangements
    • Drugs
  • somatic cells
    • Stem
    • Expression
    • Myc
    • One
    • Differentiation
    • Gene
    • Models
    • Protein
    • Study
    • Factors
    • Myc-nick
    • Role
  • induced pluripotent stem cells
    • Stem
    • Differentiation
    • Expression
    • Myc
    • One
    • Gene
    • Models
    • Protein
    • Study
    • Factors
    • Myc-nick
    • Role

Connections between topic areas Semantic bridges

For Myc, one of the stronger structural bridges in this analysis connects Myc with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Myc — Interactions · splits 90 ⟂ 38
Myc — Overview · splits 103 ⟂ 25
Myc — Function · splits 114 ⟂ 14
Myc — Myc-nick · splits 117 ⟂ 11
Myc — Clinical significance · splits 118 ⟂ 10
Myc — Structure · splits 121 ⟂ 7
Myc — MYC rearrangements · splits 122 ⟂ 6
Myc — Animal models · splits 122 ⟂ 6
Myc — Discovery · splits 123 ⟂ 5
Myc — Relationship to stem cells · splits 123 ⟂ 5

Map overview Semantic statistics

Myc

Nodes128
Edges127
Triples140
Avg. degree1.98
Density0.015625
Components1

Source & methodology

TTTA analyzes the structure around Myc to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Myc · EN edition · Analysis: TopicsToTalkAbout

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