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Myc

Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. The Myc family consists of three related human genes: c-myc (MYC), l-myc (MYCL), and n-myc (MYCN). c-myc (also sometimes referred to as MYC) was the first gene to be discovered in this family, due to homology with the viral gene v-myc.

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Alt. symbols
c-Myc, v-myc
Domains
InterPro
HGNC
7553
Locus
Chr. 8 q24.21
NCBI gene
4609
OMIM
190080

Topics to explore

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Overview

Discovery

Structure

Function

Myc-nick

Clinical significance

MYC rearrangements

Animal models

Relationship to stem cells

Interactions

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Map overview Semantic statistics

Myc

Nodes128
Edges127
Triples140
Avg. degree1.98
Density0.015625
Components1

How this topic connects Entity context

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Myc

Top relations

related to Animal models · 23
Myc → AKT, Also, AMPK, Burkitt, Classical, CML, CR, Cre-Loxp, Drosophila, During, Haplo-insufficient, IgM, In, In Drosophila Myc, John, Later, Less TOR, One, S6K, Sedivy
related to External links · 20
Myc → Cells, Forced Expression, Generating, Human Myc, InterPro, IPR002418, IPR003327The Myc ProteinNCBI Human, IPR011598, Klf4 Archived, Medicine Medical Subject Headings, MEFS, MeSH, National Library, Oct-4, PDB, Proteins, Proto-Oncogene, Sox-2, The Interactive FlyFactorBookC-MycPDBe-KB, Wayback MachineDrosophila Myc
related to MYC rearrangements · 18
Myc → AICDA, Although AICDA, B-cell, BCL2, BCL6, CSR, DLBCL/HGBCL, DLBCLs, Double, HGBCL, IG, MYC-R, NHL, Non-Hodgkin Lymphoma, Patients, SHM, The, These
related to Function · 16
Myc → Bcl-2, By, DNA, E-boxes, EGF, HATs, In, It, MAPK/ERK, Miz-1, Nucleotide, RNA, Shh, The, This, Wnt
related to Discovery · 10
Myc → Avian, Burkitt's, Ig, In Burkitt's, Later, Myelocytomatosis, P10395, The, The Myc, This
related to Clinical significance · 9
Myc → Except, Furthermore, Genes, Hence, Inactivation, SAE1, SAE2, SUMO-activating, SUMOylation
related to Relationship to stem cells · 9
Myc → Enforced, In, It, Klf4, LT-HSCs, N-Myc, Oct4, Sox2, Yamanaka
related to Myc-nick · 7
Myc → C-terminus, DNA, Myc-nick, N-Myc, N-terminal, The, Upon
related to Structure · 7
Myc → DNA, IRES, LZ, Max, RNA, TF-binding, The
related to Interactions · 2
Myc → ACTL6ABRCA1Bcl-2Cyclin T1CHD8DNMT3AEP400GTF2IHTATIPlet-7MAPK1MAPK8MAXMLH1MYCBP2MYCBPNMINFYBNFYCP73PCAFPFDN5RuvB-like, C2orf16

Important terminology Word statistics

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Important terminology

c-myc genes expression cells cancer cell also stem gene family transcription human factors lymphoma role n-myc myc-nick proteins differentiation myc-r

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
MycAlt. symbolsc-Myc, v-myc1.00infobox
MycDomainsInterPro1.00infobox
MycHGNC75531.00infobox
MycLocusChr. 8 q24.211.00infobox
MycNCBI gene46091.00infobox
MycOMIM1900801.00infobox
MycRefSeqNM_001354870.11.00infobox
MycSearch forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
MycStructuresSwiss-model1.00infobox
MycSymbolMYC1.00infobox
MycUniProtP011061.00infobox
MycWikidataQ209699391.00infobox
Myccausestumorigenesis0.90text
Mycis afamily of regulator genes and proto-oncogenes that code for transcription factors0.90text

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