Cyclin-dependent kinase 2

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Cyclin-dependent kinase 2 topic overview

The analysis highlights Products, Interactions and Inhibitors as prominent areas in the source structure around Cyclin-dependent kinase 2.

Related topics: 41
Source areas: 7
Connected nodes: 48
Extracted relationships: 158
Concept neighborhoods: 27
Bridge connections: 48

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 14 topics

Overview · 13 topics

Inhibitors · 4 topics

Dispensability in normally functioning tissue · 3 topics

Role in DNA replication · 3 topics

Gene regulation · 2 topics

Mechanism of activation · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.11.22: ↗
Aliases: CDK2, cyclin-dependent kinase 2, A630093N05Rik, CDKN2, p33(CDK2), cyclin dependent kinase 2
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1AQ1, 1B38, 1B39, 1BUH, 1CKP, 1DI8, 1DM2, 1E1V, 1E1X, 1E9H, 1F5Q, 1FIN, 1FQ1, 1FVT, 1FVV, 1G5S, 1GIH, 1GII,…
Band: 12q13.2 · 10|10 D3
Bgee: ventricular zone · ganglionic eminence · left uterine tube · gastric mucosa · stromal cell of endometrium
BioGPS: More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Enzyme
Gene
Protein
Cyclin-dependent kinase
Ser/Thr protein kinases Serine/threonine-specific protein kinase
S. cerevisiae Saccharomyces cerevisiae
Cdc28
S. pombe Schizosaccharomyces pombe
Cdk1
Cell cycle
Cyclin E
Phosphorylation
G1-S transition

Dispensability in normally functioning tissue

Mechanism of activation

Cyclins Cyclin
Activation loop

Role in DNA replication

Cdk2/Cyclin E Cyclin E/Cdk2
Phase transition
Retinoblastoma Retinoblastoma protein

Inhibitors

Gene regulation

Melanocytic Melanocyte
Microphthalmia-associated transcription factor

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Cyclin-dependent kinase 2 connects Entity context

The extracted context around Cyclin-dependent kinase 2 shows recurring relationship patterns in the source. For example, Cyclin-dependent kinase 2 → anaphase-promoting complex-dependent catabolic process, ATP binding, Cajal body, cell cycle, cell division, cellular response to DNA damage stimulus, cellular response to nitric oxide, centriole replication, centrosome, centrosome duplication, condensed chromosome, cyclin A1-CDK2 complex, cyclin A2-CDK2 complex, cyclin binding, cyclin E1-CDK2 complex, cyclin E2-CDK2 complex, cyclin-dependent protein kinase activity, cyclin-dependent protein kinase holoenzyme complex, cyclin-dependent protein serine/threonine kinase activity, cytoplasm Another extracted example is Cyclin-dependent kinase 2 → Activation, Asp, ATP, C-helix, C-lobe, C-terminus, Cdk1, Cdk2, Cyclin-dependent, Due, Finally, Glu, Hydrophobic, Lys, N-lobe, N-terminus, PSTAIRE-helix, Recent, The, This. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 60

Cyclin-dependent kinase 2 → anaphase-promoting complex-dependent catabolic process, ATP binding, Cajal body, cell cycle, cell division, cellular response to DNA damage stimulus, cellular response to nitric oxide, centriole replication, centrosome, centrosome duplication, condensed chromosome, cyclin A1-CDK2 complex, cyclin A2-CDK2 complex, cyclin binding, cyclin E1-CDK2 complex, cyclin E2-CDK2 complex, cyclin-dependent protein kinase activity, cyclin-dependent protein kinase holoenzyme complex, cyclin-dependent protein serine/threonine kinase activity, cytoplasm

related to Mechanism of activation · 22

Cyclin-dependent kinase 2 → Activation, Asp, ATP, C-helix, C-lobe, C-terminus, Cdk1, Cdk2, Cyclin-dependent, Due, Finally, Glu, Hydrophobic, Lys, N-lobe, N-terminus, PSTAIRE-helix, Recent, The, This

Bgee · 19

Cyclin-dependent kinase 2 → abdominal wall, blastocyst, epiblast, epithelium of colon, ganglionic eminence, gastric mucosa, granulocyte, left ovary, left uterine tube, maxillary prominence, right lung, skin of abdomen, skin of leg, spermatocyte, stromal cell of endometrium, thymus, tibiofemoral joint, ventricular zone, yolk sac

RNA expression pattern · 19

related to Interactions · 13

Cyclin-dependent kinase 2 → BRCA1, CDK2AP1, CDKN1BCDKN3, CEBPA, Cyclin A1, Cyclin E1, Cyclin-dependent, Flap, ORC1L, P21, PPM1B, PPP2CA, Retinoblastoma-like

Band · 2

Cyclin-dependent kinase 2 → 10|10 D3, 12q13.2

Chr. · 2

Cyclin-dependent kinase 2 → Chromosome 10 (mouse), Chromosome 12 (human)

End · 2

Cyclin-dependent kinase 2 → 128,540,900 bp, 55,972,789 bp

2.7.11.22 · 1

Cyclin-dependent kinase 2 → ↗

Aliases · 1

Cyclin-dependent kinase 2 → CDK2, cyclin-dependent kinase 2, A630093N05Rik, CDKN2, p33(CDK2), cyclin dependent kinase 2

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cdk2 cyclin gene cell kinase protein binding phase cells cyclin-dependent cycle also site activity inhibitors human bp g1 complex dna

Cyclin-dependent kinase 2 relationships Subject–Predicate–Object triples

TTTA extracted 158 structured relationships around Cyclin-dependent kinase 2. Examples in this analysis include Cyclin-dependent kinase 2 → 2.7.11.22 → ↗ and Cyclin-dependent kinase 2 → Aliases → CDK2, cyclin-dependent kinase 2, A630093N05Rik, CDKN2, p33(CDK2), cyclin dependent kinase 2. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Cyclin-dependent kinase 2	2.7.11.22	↗	1.00	infobox
Cyclin-dependent kinase 2	Aliases	CDK2, cyclin-dependent kinase 2, A630093N05Rik, CDKN2, p33(CDK2), cyclin dependent kinase 2	1.00	infobox
Cyclin-dependent kinase 2	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1AQ1, 1B38, 1B39, 1BUH, 1CKP, 1DI8, 1DM2, 1E1V, 1E1X, 1E9H, 1F5Q, 1FIN, 1FQ1, 1FVT, 1FVV, 1G5S, 1GIH, 1GII,…	1.00	infobox
Cyclin-dependent kinase 2	Band	12q13.2	1.00	infobox
Cyclin-dependent kinase 2	Band	10\|10 D3	1.00	infobox
Cyclin-dependent kinase 2	Bgee	ventricular zone	1.00	infobox
Cyclin-dependent kinase 2	Bgee	ganglionic eminence	1.00	infobox
Cyclin-dependent kinase 2	Bgee	left uterine tube	1.00	infobox
Cyclin-dependent kinase 2	Bgee	gastric mucosa	1.00	infobox
Cyclin-dependent kinase 2	Bgee	stromal cell of endometrium	1.00	infobox
Cyclin-dependent kinase 2	Bgee	skin of abdomen	1.00	infobox
Cyclin-dependent kinase 2	Bgee	left ovary	1.00	infobox
Cyclin-dependent kinase 2	Bgee	skin of leg	1.00	infobox
Cyclin-dependent kinase 2	Bgee	right lung	1.00	infobox
Cyclin-dependent kinase 2	Bgee	epithelium of colon	1.00	infobox
Cyclin-dependent kinase 2	Bgee	spermatocyte	1.00	infobox
Cyclin-dependent kinase 2	Bgee	granulocyte	1.00	infobox
Cyclin-dependent kinase 2	Bgee	thymus	1.00	infobox
Cyclin-dependent kinase 2	Bgee	yolk sac	1.00	infobox
Cyclin-dependent kinase 2	Bgee	tibiofemoral joint	1.00	infobox
Cyclin-dependent kinase 2	Bgee	epiblast	1.00	infobox
Cyclin-dependent kinase 2	Bgee	abdominal wall	1.00	infobox
Cyclin-dependent kinase 2	Bgee	maxillary prominence	1.00	infobox
Cyclin-dependent kinase 2	Bgee	blastocyst	1.00	infobox
Cyclin-dependent kinase 2	BioGPS	More reference expression data	1.00	infobox
Cyclin-dependent kinase 2	Chr.	Chromosome 12 (human)	1.00	infobox
Cyclin-dependent kinase 2	Chr.	Chromosome 10 (mouse)	1.00	infobox
Cyclin-dependent kinase 2	Databases	NCBI: entry; OMA: entry	1.00	infobox
Cyclin-dependent kinase 2	End	55,972,789 bp	1.00	infobox
Cyclin-dependent kinase 2	End	128,540,900 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Cyclin-dependent kinase 2 bring nearby vocabulary together. In this analysis, examples include Kinase, Protein and Dna. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Cyclin-dependent kinase 2
- Kinase
- Protein
- Dna
- Gene
- Activity
- Cell
- Chromosome
- Division
- Proliferation
- Bp
- Chr
- G1-s
cyclin-dependent kinase 2
- Kinase
- Protein
- Dna
- Gene
- Activity
- Cell
- Cyclin
- Chromosome
- Division
- Proliferation
- Bp
- Chr
gene
- Human
- Location
- Transcription
- Protein
- Kinase
- Chromosome
- Known
- Bp
- Chr
- Band
- Mouse
- Proliferation
cyclin-dependent kinase
- Kinase
- Protein
- Dna
- Gene
- Activity
- Cell
- Cyclin
- Chromosome
- Division
- Proliferation
- Bp
- Chr
cell cycle
- Cycle
- Dna
- G1-s
- Cells
- Phase
- Kinase
- G1
- Cyclin-dependent
- Cdk2
- Division
- Gene
- Complex
cyclin e
- G1
- Protein
- Phase
- Kinase
- Binding
- Proliferation
- Activation
- Cyclin-dependent
- Gene
- Phosphorylation
- Chromosome
- Transition
g1-s transition
- G1-s
- Transition
- Phase
- Active
- Dna
- G1
- Proteins
- Phosphorylation
- Protein
- Band
- Chromosome
- Division
activation loop
- Site
- Interactions
- Activity
- Atp
- Binding
- Cyclin
- Phosphorylation
- Cdk2
- Chromosome
- Proliferation
- Bp
- Chr

Connections between topic areas Semantic bridges

For Cyclin-dependent kinase 2, one of the stronger structural bridges in this analysis connects Cyclin-dependent kinase 2 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Cyclin-dependent kinase 2 — Interactions · splits 34 ⟂ 15

Cyclin-dependent kinase 2 — Overview · splits 35 ⟂ 14

Cyclin-dependent kinase 2 — Inhibitors · splits 44 ⟂ 5

Cyclin-dependent kinase 2 — Dispensability in normally functioning tissue · splits 45 ⟂ 4

Cyclin-dependent kinase 2 — Role in DNA replication · splits 45 ⟂ 4

Cyclin-dependent kinase 2 — Mechanism of activation · splits 46 ⟂ 3

Cyclin-dependent kinase 2 — Gene regulation · splits 46 ⟂ 3

Map overview Semantic statistics

Cyclin-dependent kinase 2

Nodes49

Edges48

Triples158

Avg. degree1.96

Density0.040816

Components1

Source & methodology

TTTA analyzes the structure around Cyclin-dependent kinase 2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Products, Interactions & Inhibitors, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Cyclin-dependent kinase 2 · EN edition · Analysis: TopicsToTalkAbout