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NPM1

Nucleophosmin (NPM), also known as nucleolar phosphoprotein B23 or numatrin, is a protein that in humans is encoded by the NPM1 gene.

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Aliases
NPM1, B23, NPM, nucleophosmin (nucleolar phosphoprotein B23, numatrin), nucleophosmin, nucleophosmin 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LLH, 2P1B, 2VXD
Band
5q35.1 · 11|11 A4
Bgee
Achilles tendon · left ovary · ventricular zone · right ovary · canal of the cervix
BioGPS
More reference expression data
Chr.
Chromosome 5 (human) · Chromosome 11 (mouse)

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Overview

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Gene

Structure

Function

Clinical significance

Interactions

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Map overview Semantic statistics

NPM1

Nodes44
Edges43
Triples262
Avg. degree1.95
Density0.045455
Components1

How this topic connects Entity context

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NPM1

Top relations

Gene ontology · 88
NPM1 → cell growth, cell volume homeostasis, cellular response to UV, CENP-A containing chromatin assembly, centrosome, centrosome cycle, chromatin binding, chromatin remodeling, cytoplasm, cytoskeleton, cytosol, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, DNA repair, focal adhesion, granular component, histone binding, intracellular protein transport, large ribosomal subunit, membrane, microtubule organizing center
related to Ribosome biogenesis · 29
NPM1 → All, ARF, Colombo, Degradation, Furthermore, Grisendi, Huang, Interestingly, Internal, It, Itahana, ITS2, Knockdown, Lerch-Gaggl, Lindström, Maggi, Moreover, Most, NPM3, Other
Bgee · 19
NPM1 → Achilles tendon, blastocyst, body of pancreas, body of uterus, canal of the cervix, ectocervix, embryo, epiblast, ganglionic eminence, genital tubercle, left ovary, morula, primary oocyte, right ovary, right uterine tube, secondary oocyte, tail of embryo, ventricular zone, zygote
RNA expression pattern · 19
NPM1 → Achilles tendon, blastocyst, body of pancreas, body of uterus, canal of the cervix, ectocervix, embryo, epiblast, ganglionic eminence, genital tubercle, left ovary, morula, primary oocyte, right ovary, right uterine tube, secondary oocyte, tail of embryo, ventricular zone, zygote
related to Structure · 17
NPM1 → All, Drosophila NLP, Drosophila Nucleoplasmin, Further, It, NES, NLS, NoLS, NPM, Nucleoplasmin, The, The N-terminal, The NPM1, This, Two, Xenopus NO38, Xenopus Nucleoplasmin
related to Clinical significance · 14
NPM1 → ARF, C-terminal, Chromosomal, DNMT3A, Heterozygous, Hodgkin, In, It, NPM, NPM1c, Of, Strategies, The NPM1, This
related to Gene · 11
NPM1 → B23, Both, C-terminal, DNA, HeLa, However, In, Nucleophosmin, The, Three, Transcript
related to Molecular and histone chaperone · 10
NPM1 → ATP, Both, Further, Furthermore, HIV-1 Rev, N-terminal, NES, NLS, Similarly, Since
related to Function · 8
NPM1 → G-quadruplex-forming, However, It, Its, SENP3, SENP5, SUMOylation, The
related to Discovery · 6
NPM1 → At, B23, It, Novikoff, Xenopus NO38, Xenopus Nucleoplasmin

Important terminology Word statistics

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Important terminology

human ribosome nucleolus biogenesis proteins protein gene histone nucleolar chaperone core also structure binding activity nucleoplasmin domain bp bind tumor

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
NPM1AliasesNPM1, B23, NPM, nucleophosmin (nucleolar phosphoprotein B23, numatrin), nucleophosmin, nucleophosmin 11.00infobox
NPM1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LLH, 2P1B, 2VXD1.00infobox
NPM1Band5q35.11.00infobox
NPM1Band11|11 A41.00infobox
NPM1BgeeAchilles tendon1.00infobox
NPM1Bgeeleft ovary1.00infobox
NPM1Bgeeventricular zone1.00infobox
NPM1Bgeeright ovary1.00infobox
NPM1Bgeecanal of the cervix1.00infobox
NPM1Bgeebody of uterus1.00infobox
NPM1Bgeeganglionic eminence1.00infobox
NPM1Bgeebody of pancreas1.00infobox
NPM1Bgeeright uterine tube1.00infobox
NPM1Bgeeectocervix1.00infobox
NPM1Bgeetail of embryo1.00infobox
NPM1Bgeeepiblast1.00infobox
NPM1Bgeegenital tubercle1.00infobox
NPM1Bgeemorula1.00infobox
NPM1Bgeeembryo1.00infobox
NPM1Bgeeprimary oocyte1.00infobox
NPM1Bgeezygote1.00infobox
NPM1Bgeesecondary oocyte1.00infobox
NPM1Bgeeblastocyst1.00infobox
NPM1BioGPSMore reference expression data1.00infobox
NPM1Chr.Chromosome 5 (human)1.00infobox
NPM1Chr.Chromosome 11 (mouse)1.00infobox
NPM1DatabasesNCBI: entry; OMA: entry1.00infobox
NPM1End171,411,810 bp1.00infobox
NPM1End33,113,206 bp1.00infobox
NPM1EnsemblENSG000001811631.00infobox

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