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Nucleophosmin (NPM), also known as nucleolar phosphoprotein B23 or numatrin, is a protein that in humans is encoded by the NPM1 gene.
The analysis highlights Function, Clinical significance and Interactions as prominent areas in the source structure around NPM1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around NPM1 shows recurring relationship patterns in the source. For example, NPM1 → cell growth, cell volume homeostasis, cellular response to UV, CENP-A containing chromatin assembly, centrosome, centrosome cycle, chromatin binding, chromatin remodeling, cytoplasm, cytoskeleton, cytosol, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, DNA repair, focal adhesion, granular component, histone binding, intracellular protein transport, large ribosomal subunit, membrane, microtubule organizing center Another extracted example is NPM1 → All, ARF, Colombo, Degradation, Furthermore, Grisendi, Huang, Interestingly, Internal, It, Itahana, ITS2, Knockdown, Lerch-Gaggl, Lindström, Maggi, Moreover, Most, NPM3, Other. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
human ribosome nucleolus biogenesis proteins protein gene histone nucleolar chaperone core also structure binding activity nucleoplasmin domain bp bind tumor
TTTA extracted 262 structured relationships around NPM1. Examples in this analysis include NPM1 → Aliases → NPM1, B23, NPM, nucleophosmin (nucleolar phosphoprotein B23, numatrin), nucleophosmin, nucleophosmin 1 and NPM1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LLH, 2P1B, 2VXD. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| NPM1 | Aliases | NPM1, B23, NPM, nucleophosmin (nucleolar phosphoprotein B23, numatrin), nucleophosmin, nucleophosmin 1 | 1.00 | infobox |
| NPM1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LLH, 2P1B, 2VXD | 1.00 | infobox |
| NPM1 | Band | 5q35.1 | 1.00 | infobox |
| NPM1 | Band | 11|11 A4 | 1.00 | infobox |
| NPM1 | Bgee | Achilles tendon | 1.00 | infobox |
| NPM1 | Bgee | left ovary | 1.00 | infobox |
| NPM1 | Bgee | ventricular zone | 1.00 | infobox |
| NPM1 | Bgee | right ovary | 1.00 | infobox |
| NPM1 | Bgee | canal of the cervix | 1.00 | infobox |
| NPM1 | Bgee | body of uterus | 1.00 | infobox |
| NPM1 | Bgee | ganglionic eminence | 1.00 | infobox |
| NPM1 | Bgee | body of pancreas | 1.00 | infobox |
| NPM1 | Bgee | right uterine tube | 1.00 | infobox |
| NPM1 | Bgee | ectocervix | 1.00 | infobox |
| NPM1 | Bgee | tail of embryo | 1.00 | infobox |
| NPM1 | Bgee | epiblast | 1.00 | infobox |
| NPM1 | Bgee | genital tubercle | 1.00 | infobox |
| NPM1 | Bgee | morula | 1.00 | infobox |
| NPM1 | Bgee | embryo | 1.00 | infobox |
| NPM1 | Bgee | primary oocyte | 1.00 | infobox |
| NPM1 | Bgee | zygote | 1.00 | infobox |
| NPM1 | Bgee | secondary oocyte | 1.00 | infobox |
| NPM1 | Bgee | blastocyst | 1.00 | infobox |
| NPM1 | BioGPS | More reference expression data | 1.00 | infobox |
| NPM1 | Chr. | Chromosome 5 (human) | 1.00 | infobox |
| NPM1 | Chr. | Chromosome 11 (mouse) | 1.00 | infobox |
| NPM1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| NPM1 | End | 171,411,810 bp | 1.00 | infobox |
| NPM1 | End | 33,113,206 bp | 1.00 | infobox |
| NPM1 | Ensembl | ENSG00000181163 | 1.00 | infobox |
The concept neighborhoods around NPM1 bring nearby vocabulary together. In this analysis, examples include Ribosome, Biogenesis and Human. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For NPM1, one of the stronger structural bridges in this analysis connects NPM1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around NPM1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — NPM1 · EN edition · Analysis: TopicsToTalkAbout