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Fanconi anemia group D2 protein (FANCD2) is a nuclear protein that in humans is encoded by the FANCD2 gene that plays a central role in the Fanconi anemia (FA)/BRCA pathway, which safeguards genome stability by coordinating the repair of DNA interstrand crosslinks and other DNA replication‑blocking lesions. In response to DNA damage or S phase…
Function, Clinical significance & Interactions
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fancd2 dna anemia fanconi repair protein group nuclear d2 fa complex complementation chromosome fanci brca1 function gene cancer pathway damage
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Fanconi anemia group D2 protein | Aliases | FANCD2, FA-D2, FA4, FACD, FAD, FAD2, FANCD, Fanconi anemia complementation group D2, FA complementation group D2 | 1.00 | infobox |
| Fanconi anemia group D2 protein | Band | 3p25.3 | 1.00 | infobox |
| Fanconi anemia group D2 protein | Bgee | testicle | 1.00 | infobox |
| Fanconi anemia group D2 protein | Bgee | ventricular zone | 1.00 | infobox |
| Fanconi anemia group D2 protein | Bgee | secondary oocyte | 1.00 | infobox |
| Fanconi anemia group D2 protein | Bgee | right testis | 1.00 | infobox |
| Fanconi anemia group D2 protein | Bgee | left testis | 1.00 | infobox |
| Fanconi anemia group D2 protein | Bgee | ganglionic eminence | 1.00 | infobox |
| Fanconi anemia group D2 protein | Bgee | bone marrow cell | 1.00 | infobox |
| Fanconi anemia group D2 protein | Bgee | buccal mucosa cell | 1.00 | infobox |
| Fanconi anemia group D2 protein | Bgee | mucosa of transverse colon | 1.00 | infobox |
| Fanconi anemia group D2 protein | Bgee | gonad | 1.00 | infobox |
| Fanconi anemia group D2 protein | BioGPS | n/a | 1.00 | infobox |
| Fanconi anemia group D2 protein | Chr. | Chromosome 3 (human) | 1.00 | infobox |
| Fanconi anemia group D2 protein | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Fanconi anemia group D2 protein | End | 10,101,932 bp | 1.00 | infobox |
| Fanconi anemia group D2 protein | Ensembl | ENSG00000144554 | 1.00 | infobox |
| Fanconi anemia group D2 protein | Entrez | 2177 | 1.00 | infobox |
| Fanconi anemia group D2 protein | External IDs | OMIM: 613984; MGI: 2448480; GeneCards: FANCD2 | 1.00 | infobox |
| Fanconi anemia group D2 protein | Gene location (Human) | Gene location (Human)Chr.Chromosome 3 (human)Band3p25.3Start10,026,370 bpEnd10,101,932 bp | 1.00 | infobox |
| Fanconi anemia group D2 protein | Gene ontology | protein binding | 1.00 | infobox |
| Fanconi anemia group D2 protein | Gene ontology | DNA polymerase binding | 1.00 | infobox |
| Fanconi anemia group D2 protein | Gene ontology | nucleolus | 1.00 | infobox |
| Fanconi anemia group D2 protein | Gene ontology | nucleus | 1.00 | infobox |
| Fanconi anemia group D2 protein | Gene ontology | nucleoplasm | 1.00 | infobox |
| Fanconi anemia group D2 protein | Gene ontology | condensed chromosome | 1.00 | infobox |
| Fanconi anemia group D2 protein | Gene ontology | cytosol | 1.00 | infobox |
| Fanconi anemia group D2 protein | Gene ontology | nuclear body | 1.00 | infobox |
| Fanconi anemia group D2 protein | Gene ontology | cell cycle | 1.00 | infobox |
| Fanconi anemia group D2 protein | Gene ontology | gamete generation | 1.00 | infobox |
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