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MSH6

MSH6 or mutS homolog 6 is a gene that codes for DNA mismatch repair protein Msh6 in the budding yeast Saccharomyces cerevisiae. It is the homologue of the human "G/T binding protein," (GTBP) also called p160 or hMSH6 (human MSH6). The MSH6 protein is a member of the Mutator S (MutS) family of proteins that are involved in DNA damage repair.

Epigenetic control of MSH6 in cancer, Interactions & Function

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Epigenetic control of MSH6 in cancer

MiR21MiR-155MSH2Microsatellite instabilityEpigenetic
9 related topics

Interactions

InteractPCNABRCA1
3 related topics

Function

DNA replicationGenetic recombination
2 related topics

Structure

Conserved sequence
1 related topics

Key facts & relationships

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Aliases
MSH6, mutS homolog 6, GTBP, GTMBP, HNPCC5, HSAP, p160, MMRCS3, MSH-6
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2O8F, 2GFU, 2O8B, 2O8C, 2O8D, 2O8E
Band
2p16.3 · 17 E4|17 57.87 cM
Bgee
ventricular zone · embryo · ganglionic eminence · secondary oocyte · gonad
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 17 (mouse)

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Overview

Structure

Function

Cancer

Epigenetic control of MSH6 in cancer

Interactions

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Map overview Semantic statistics

MSH6

Nodes29
Edges28
Triples155
Avg. degree1.93
Density0.068966
Components1

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MSH6

Top relations

Gene ontology · 50
MSH6 → ADP binding, ATP binding, ATP-dependent activity, acting on DNA, ATPase activity, cellular response to DNA damage stimulus, chromatin binding, chromosome, cytosol, damaged DNA binding, determination of adult lifespan, DNA binding, DNA mismatch repair, DNA repair, double-stranded DNA binding, enzyme binding, four-way junction DNA binding, Golgi apparatus, guanine/thymine mispair binding, interstrand cross-link repair, intracellular membrane-bounded organelle
Bgee · 19
MSH6 → abdominal wall, Achilles tendon, cartilage tissue, embryo, epiblast, ganglionic eminence, genital tubercle, gonad, Gonadal ridge, left ovary, ovary, primary oocyte, primitive streak, secondary oocyte, tail of embryo, tendon of biceps brachii, thymus, ventricular zone, zygote
RNA expression pattern · 19
MSH6 → abdominal wall, Achilles tendon, cartilage tissue, embryo, epiblast, ganglionic eminence, genital tubercle, gonad, Gonadal ridge, left ovary, ovary, primary oocyte, primitive streak, secondary oocyte, tail of embryo, tendon of biceps brachii, thymus, ventricular zone, zygote
related to Epigenetic control of MSH6 in cancer · 9
MSH6 → CpG, DNA, High, Hypomethylation, If, In, MMR, One, Two
related to External links · 9
MSH6 → FAQs, HealthGeneReviews/NCBI/NIH/UW, HNPCC Archived, Lynch, Medicine Medical Subject Headings, MeSH, National Institute, National Library, Wayback Machine
related to Cancer · 8
MSH6 → Although, At, DNA, Endometrial, HNPCC, Mutations, The, This
related to Structure · 6
MSH6 → As, ATPase, In, It, MutS, Walker-A/B
related to Discovery · 5
MSH6 → GTBP, MSH2, MutS, The, Thus
related to Importance of mismatch repair · 4
MSH6 → DNA, HNPCC, Mismatches, Recognizing
related to Interactions · 3
MSH6 → BRCA1, MSH2, PCNA

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Important terminology

hmsh6 dna human repair mismatch protein gene cancer muts bp also chromosome hmsh2 mutations chr band complex atp gtbp mir-155

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
MSH6AliasesMSH6, mutS homolog 6, GTBP, GTMBP, HNPCC5, HSAP, p160, MMRCS3, MSH-61.00infobox
MSH6Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2O8F, 2GFU, 2O8B, 2O8C, 2O8D, 2O8E1.00infobox
MSH6Band2p16.31.00infobox
MSH6Band17 E4|17 57.87 cM1.00infobox
MSH6Bgeeventricular zone1.00infobox
MSH6Bgeeembryo1.00infobox
MSH6Bgeeganglionic eminence1.00infobox
MSH6Bgeesecondary oocyte1.00infobox
MSH6Bgeegonad1.00infobox
MSH6Bgeeovary1.00infobox
MSH6Bgeetendon of biceps brachii1.00infobox
MSH6Bgeeleft ovary1.00infobox
MSH6Bgeecartilage tissue1.00infobox
MSH6BgeeAchilles tendon1.00infobox
MSH6Bgeezygote1.00infobox
MSH6Bgeeepiblast1.00infobox
MSH6Bgeeprimitive streak1.00infobox
MSH6Bgeeprimary oocyte1.00infobox
MSH6Bgeetail of embryo1.00infobox
MSH6Bgeegenital tubercle1.00infobox
MSH6Bgeeabdominal wall1.00infobox
MSH6BgeeGonadal ridge1.00infobox
MSH6Bgeethymus1.00infobox
MSH6BioGPSMore reference expression data1.00infobox
MSH6Chr.Chromosome 2 (human)1.00infobox
MSH6Chr.Chromosome 17 (mouse)1.00infobox
MSH6DatabasesNCBI: entry; OMA: entry1.00infobox
MSH6End47,810,063 bp1.00infobox
MSH6End88,298,320 bp1.00infobox
MSH6EnsemblENSG000001160621.00infobox

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