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MSH6: Epigenetic control of MSH6 in cancer, Interactions & Function

MSH6 or mutS homolog 6 is a gene that codes for DNA mismatch repair protein Msh6 in the budding yeast Saccharomyces cerevisiae. It is the homologue of the human "G/T binding protein," (GTBP) also called p160 or hMSH6 (human MSH6). The MSH6 protein is a member of the Mutator S (MutS) family of proteins that are involved in DNA damage repair.

Language: English [EN]
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MSH6 topic overview

The analysis highlights Epigenetic control of MSH6 in cancer, Interactions and Function as prominent areas in the source structure around MSH6.

Related topics
22
Source areas
6
Connected nodes
28
Extracted relationships
155
Concept neighborhoods
12
Bridge connections
28

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Epigenetic control of MSH6 in cancer · 9 topics
Overview · 6 topics
Interactions · 3 topics
Function · 2 topics
Cancer · 1 topics
Structure · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
MSH6, mutS homolog 6, GTBP, GTMBP, HNPCC5, HSAP, p160, MMRCS3, MSH-6
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2O8F, 2GFU, 2O8B, 2O8C, 2O8D, 2O8E
Band
2p16.3 · 17 E4|17 57.87 cM
Bgee
ventricular zone · embryo · ganglionic eminence · secondary oocyte · gonad
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 17 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Cancer

Epigenetic control of MSH6 in cancer

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How MSH6 connects Entity context

The extracted context around MSH6 shows recurring relationship patterns in the source. For example, MSH6 → ADP binding, ATP binding, ATP-dependent activity, acting on DNA, ATPase activity, cellular response to DNA damage stimulus, chromatin binding, chromosome, cytosol, damaged DNA binding, determination of adult lifespan, DNA binding, DNA mismatch repair, DNA repair, double-stranded DNA binding, enzyme binding, four-way junction DNA binding, Golgi apparatus, guanine/thymine mispair binding, interstrand cross-link repair, intracellular membrane-bounded organelle Another extracted example is MSH6 → abdominal wall, Achilles tendon, cartilage tissue, embryo, epiblast, ganglionic eminence, genital tubercle, gonad, Gonadal ridge, left ovary, ovary, primary oocyte, primitive streak, secondary oocyte, tail of embryo, tendon of biceps brachii, thymus, ventricular zone, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

MSH6

Top relations

Gene ontology · 50
MSH6 → ADP binding, ATP binding, ATP-dependent activity, acting on DNA, ATPase activity, cellular response to DNA damage stimulus, chromatin binding, chromosome, cytosol, damaged DNA binding, determination of adult lifespan, DNA binding, DNA mismatch repair, DNA repair, double-stranded DNA binding, enzyme binding, four-way junction DNA binding, Golgi apparatus, guanine/thymine mispair binding, interstrand cross-link repair, intracellular membrane-bounded organelle
Bgee · 19
MSH6 → abdominal wall, Achilles tendon, cartilage tissue, embryo, epiblast, ganglionic eminence, genital tubercle, gonad, Gonadal ridge, left ovary, ovary, primary oocyte, primitive streak, secondary oocyte, tail of embryo, tendon of biceps brachii, thymus, ventricular zone, zygote
RNA expression pattern · 19
MSH6 → abdominal wall, Achilles tendon, cartilage tissue, embryo, epiblast, ganglionic eminence, genital tubercle, gonad, Gonadal ridge, left ovary, ovary, primary oocyte, primitive streak, secondary oocyte, tail of embryo, tendon of biceps brachii, thymus, ventricular zone, zygote
related to Epigenetic control of MSH6 in cancer · 9
MSH6 → CpG, DNA, High, Hypomethylation, If, In, MMR, One, Two
related to External links · 9
MSH6 → FAQs, HealthGeneReviews/NCBI/NIH/UW, HNPCC Archived, Lynch, Medicine Medical Subject Headings, MeSH, National Institute, National Library, Wayback Machine
related to Cancer · 8
MSH6 → Although, At, DNA, Endometrial, HNPCC, Mutations, The, This
related to Structure · 6
MSH6 → As, ATPase, In, It, MutS, Walker-A/B
related to Discovery · 5
MSH6 → GTBP, MSH2, MutS, The, Thus
related to Importance of mismatch repair · 4
MSH6 → DNA, HNPCC, Mismatches, Recognizing
related to Interactions · 3
MSH6 → BRCA1, MSH2, PCNA

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

hmsh6 dna human repair mismatch protein gene cancer muts bp also chromosome hmsh2 mutations chr band complex atp gtbp mir-155

MSH6 relationships Subject–Predicate–Object triples

TTTA extracted 155 structured relationships around MSH6. Examples in this analysis include MSH6 → Aliases → MSH6, mutS homolog 6, GTBP, GTMBP, HNPCC5, HSAP, p160, MMRCS3, MSH-6 and MSH6 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2O8F, 2GFU, 2O8B, 2O8C, 2O8D, 2O8E. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
MSH6AliasesMSH6, mutS homolog 6, GTBP, GTMBP, HNPCC5, HSAP, p160, MMRCS3, MSH-61.00infobox
MSH6Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2O8F, 2GFU, 2O8B, 2O8C, 2O8D, 2O8E1.00infobox
MSH6Band2p16.31.00infobox
MSH6Band17 E4|17 57.87 cM1.00infobox
MSH6Bgeeventricular zone1.00infobox
MSH6Bgeeembryo1.00infobox
MSH6Bgeeganglionic eminence1.00infobox
MSH6Bgeesecondary oocyte1.00infobox
MSH6Bgeegonad1.00infobox
MSH6Bgeeovary1.00infobox
MSH6Bgeetendon of biceps brachii1.00infobox
MSH6Bgeeleft ovary1.00infobox
MSH6Bgeecartilage tissue1.00infobox
MSH6BgeeAchilles tendon1.00infobox
MSH6Bgeezygote1.00infobox
MSH6Bgeeepiblast1.00infobox
MSH6Bgeeprimitive streak1.00infobox
MSH6Bgeeprimary oocyte1.00infobox
MSH6Bgeetail of embryo1.00infobox
MSH6Bgeegenital tubercle1.00infobox
MSH6Bgeeabdominal wall1.00infobox
MSH6BgeeGonadal ridge1.00infobox
MSH6Bgeethymus1.00infobox
MSH6BioGPSMore reference expression data1.00infobox
MSH6Chr.Chromosome 2 (human)1.00infobox
MSH6Chr.Chromosome 17 (mouse)1.00infobox
MSH6DatabasesNCBI: entry; OMA: entry1.00infobox
MSH6End47,810,063 bp1.00infobox
MSH6End88,298,320 bp1.00infobox
MSH6EnsemblENSG000001160621.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around MSH6 bring nearby vocabulary together. In this analysis, examples include Human, Muts and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • MSH6
    • Human
    • Muts
    • Protein
    • Gtbp
    • Repair
    • Gene
    • Homolog
    • Yeast
    • Function
    • Mismatch
    • Binding
    • Location
  • msh6
    • Human
    • Muts
    • Protein
    • Gtbp
    • Repair
    • Gene
    • Homolog
    • Yeast
    • Function
    • Mismatch
    • Binding
    • Location
  • gene
    • Homolog
    • Location
    • Yeast
    • Bp
    • Chr
    • Chromosome
    • Human
    • Repair
    • Msh6
    • Mouse
    • Muts
    • Protein
  • dna mismatch repair
    • Repair
    • Adp
    • Proteins
    • Protein
    • Atp
    • Complex
    • Msh6
    • Mismatch
    • Muts
    • Gene
    • Human
    • Location
  • dna replication
    • Repair
    • Protein
    • Proteins
    • Mismatch
    • Atp
    • Gene
    • Msh6
    • Yeast
    • Cause
    • Expression
    • Two
    • Alpha
  • epigenetic control of msh6 in cancer
    • Endometrial
    • Human
    • Muts
    • Protein
    • Gtbp
    • Repair
    • Gene
    • Homolog
    • Mutations
    • Yeast
    • Colorectal
    • Function
  • hereditary nonpolyposis colorectal cancer
    • Endometrial
    • Mutations
    • Cancer
    • Colorectal
    • Hnpcc
    • Muts
    • Mir-155
    • Two
    • Hmsh6
    • Human
    • Mismatch
    • Repair
  • function
    • Location
    • Bp
    • Chr
    • Chromosome
    • Msh6
    • Gene
    • Mouse
    • Human
    • Mismatch
    • Repair
    • Adp
    • Epigenetic

Connections between topic areas Semantic bridges

For MSH6, one of the stronger structural bridges in this analysis connects MSH6 with Epigenetic control of MSH6 in cancer. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
MSH6Epigenetic control of MSH6 in cancer · splits 19 ⟂ 10
MSH6Overview · splits 22 ⟂ 7
MSH6Interactions · splits 25 ⟂ 4
MSH6Function · splits 26 ⟂ 3

Map overview Semantic statistics

MSH6

Nodes29
Edges28
Triples155
Avg. degree1.93
Density0.068966
Components1

Source & methodology

TTTA analyzes the structure around MSH6 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Epigenetic control of MSH6 in cancer, Interactions & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — MSH6 · EN edition · Analysis: TopicsToTalkAbout

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