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MSH6 or mutS homolog 6 is a gene that codes for DNA mismatch repair protein Msh6 in the budding yeast Saccharomyces cerevisiae. It is the homologue of the human "G/T binding protein," (GTBP) also called p160 or hMSH6 (human MSH6). The MSH6 protein is a member of the Mutator S (MutS) family of proteins that are involved in DNA damage repair.
The analysis highlights Epigenetic control of MSH6 in cancer, Interactions and Function as prominent areas in the source structure around MSH6.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around MSH6 shows recurring relationship patterns in the source. For example, MSH6 → ADP binding, ATP binding, ATP-dependent activity, acting on DNA, ATPase activity, cellular response to DNA damage stimulus, chromatin binding, chromosome, cytosol, damaged DNA binding, determination of adult lifespan, DNA binding, DNA mismatch repair, DNA repair, double-stranded DNA binding, enzyme binding, four-way junction DNA binding, Golgi apparatus, guanine/thymine mispair binding, interstrand cross-link repair, intracellular membrane-bounded organelle Another extracted example is MSH6 → abdominal wall, Achilles tendon, cartilage tissue, embryo, epiblast, ganglionic eminence, genital tubercle, gonad, Gonadal ridge, left ovary, ovary, primary oocyte, primitive streak, secondary oocyte, tail of embryo, tendon of biceps brachii, thymus, ventricular zone, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
hmsh6 dna human repair mismatch protein gene cancer muts bp also chromosome hmsh2 mutations chr band complex atp gtbp mir-155
TTTA extracted 155 structured relationships around MSH6. Examples in this analysis include MSH6 → Aliases → MSH6, mutS homolog 6, GTBP, GTMBP, HNPCC5, HSAP, p160, MMRCS3, MSH-6 and MSH6 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2O8F, 2GFU, 2O8B, 2O8C, 2O8D, 2O8E. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| MSH6 | Aliases | MSH6, mutS homolog 6, GTBP, GTMBP, HNPCC5, HSAP, p160, MMRCS3, MSH-6 | 1.00 | infobox |
| MSH6 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2O8F, 2GFU, 2O8B, 2O8C, 2O8D, 2O8E | 1.00 | infobox |
| MSH6 | Band | 2p16.3 | 1.00 | infobox |
| MSH6 | Band | 17 E4|17 57.87 cM | 1.00 | infobox |
| MSH6 | Bgee | ventricular zone | 1.00 | infobox |
| MSH6 | Bgee | embryo | 1.00 | infobox |
| MSH6 | Bgee | ganglionic eminence | 1.00 | infobox |
| MSH6 | Bgee | secondary oocyte | 1.00 | infobox |
| MSH6 | Bgee | gonad | 1.00 | infobox |
| MSH6 | Bgee | ovary | 1.00 | infobox |
| MSH6 | Bgee | tendon of biceps brachii | 1.00 | infobox |
| MSH6 | Bgee | left ovary | 1.00 | infobox |
| MSH6 | Bgee | cartilage tissue | 1.00 | infobox |
| MSH6 | Bgee | Achilles tendon | 1.00 | infobox |
| MSH6 | Bgee | zygote | 1.00 | infobox |
| MSH6 | Bgee | epiblast | 1.00 | infobox |
| MSH6 | Bgee | primitive streak | 1.00 | infobox |
| MSH6 | Bgee | primary oocyte | 1.00 | infobox |
| MSH6 | Bgee | tail of embryo | 1.00 | infobox |
| MSH6 | Bgee | genital tubercle | 1.00 | infobox |
| MSH6 | Bgee | abdominal wall | 1.00 | infobox |
| MSH6 | Bgee | Gonadal ridge | 1.00 | infobox |
| MSH6 | Bgee | thymus | 1.00 | infobox |
| MSH6 | BioGPS | More reference expression data | 1.00 | infobox |
| MSH6 | Chr. | Chromosome 2 (human) | 1.00 | infobox |
| MSH6 | Chr. | Chromosome 17 (mouse) | 1.00 | infobox |
| MSH6 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| MSH6 | End | 47,810,063 bp | 1.00 | infobox |
| MSH6 | End | 88,298,320 bp | 1.00 | infobox |
| MSH6 | Ensembl | ENSG00000116062 | 1.00 | infobox |
The concept neighborhoods around MSH6 bring nearby vocabulary together. In this analysis, examples include Human, Muts and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For MSH6, one of the stronger structural bridges in this analysis connects MSH6 with Epigenetic control of MSH6 in cancer. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around MSH6 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Epigenetic control of MSH6 in cancer, Interactions & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — MSH6 · EN edition · Analysis: TopicsToTalkAbout