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TOPBP1

DNA topoisomerase 2-binding protein 1 (TOPBP1) is a scaffold protein that in humans is encoded by the TOPBP1 gene.

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Aliases
TOPBP1, TOP2BP1, topoisomerase (DNA) II binding protein 1, DNA topoisomerase II binding protein 1, Dpb11
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1WF6, 2XNH, 2XNK, 3AL2, 3AL3, 3JVE, 3OLC, 3PD7, 3UEN, 3UEO
Band
3q22.1 · 9|9 F1
Bgee
sperm · ventricular zone · ganglionic eminence · bone marrow · bone marrow cell
BioGPS
More reference expression data
Chr.
Chromosome 3 (human) · Chromosome 9 (mouse)

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Map overview Semantic statistics

TOPBP1

Nodes72
Edges71
Triples208
Avg. degree1.97
Density0.027778
Components1

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TOPBP1

Top relations

Gene ontology · 26
TOPBP1 → actin cytoskeleton, cellular response to DNA damage stimulus, chromosome, condensed nuclear chromosome, cytoplasm, cytoskeleton, DNA binding, DNA metabolic process, DNA repair, DNA replication, DNA replication initiation, identical protein binding, isomerase activity, male germ cell nucleus, microtubule organizing center, mitotic DNA replication checkpoint signaling, mitotic G2 DNA damage checkpoint signaling, nuclear body, nucleoplasm, nucleus
related to Cell cycle · 24
TOPBP1 → As, As TOPBP1, BRCT5, BRCT7, BRCT7/8, BRCT8, DNA, Dpb11, During, However, II-α, In, It, MiDAS, Replication, SLX4, The, There, These, They
related to BRCT domains · 23
TOPBP1 → AAD, ATR, BRCT, BRCT0, BRCT1, BRCT2, BRCT3, BRCT4, BRCT6, BRCT7, C-terminal BRCT, C-terminus, DNA, Dpb11, Human TOPBP1, In, It, N-terminal BRCT, Only, The
related to DNA damage repair · 20
TOPBP1 → ATM, ATR, ATRIP, BRCA1, BRCT0/1/2, DNA, DSBs, ETAA1, Following, Hus1, In, Rad1, Rad9, RPA, The, The BRCT1, This, To, TOPBP1/BRCA1, When DNA
Bgee · 19
TOPBP1 → abdominal wall, Achilles tendon, appendix, bone marrow, bone marrow cell, dermis, ganglionic eminence, genital tubercle, lymph node, mandibular prominence, monocyte, otic placode, otic vesicle, primitive streak, rectum, saccule, sperm, tail of embryo, ventricular zone
RNA expression pattern · 19
TOPBP1 → abdominal wall, Achilles tendon, appendix, bone marrow, bone marrow cell, dermis, ganglionic eminence, genital tubercle, lymph node, mandibular prominence, monocyte, otic placode, otic vesicle, primitive streak, rectum, saccule, sperm, tail of embryo, ventricular zone
related to DNA replication · 17
TOPBP1 → CDC45, CDK, CMG, DNA, Dpb11, GINs, HELB, Human TOPBP1, In, It, MCM, Polε, RecQ4, Sld2, Sld3, This, Treslin
related to Transcriptional regulation · 17
TOPBP1 → Akt, BRCT, BRCT6, DNA, E2F-1, G1, HDAC, It, Miz1, One, Rb, Ser1159, The, The E2F, These, This, When DNA
related to Pulmonary hypertension · 10
TOPBP1 → DNA, In, N1042S, PAH, R309C, S817L, This, Three PAH, Utilizing, While
related to Cancer · 5
TOPBP1 → Although, Changes, In, RT-PCR, The

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Important terminology

dna replication protein atr damage cell repair gene found brct domains cancer breast binding expression human domain specific activation associated

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
TOPBP1AliasesTOPBP1, TOP2BP1, topoisomerase (DNA) II binding protein 1, DNA topoisomerase II binding protein 1, Dpb111.00infobox
TOPBP1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1WF6, 2XNH, 2XNK, 3AL2, 3AL3, 3JVE, 3OLC, 3PD7, 3UEN, 3UEO1.00infobox
TOPBP1Band3q22.11.00infobox
TOPBP1Band9|9 F11.00infobox
TOPBP1Bgeesperm1.00infobox
TOPBP1Bgeeventricular zone1.00infobox
TOPBP1Bgeeganglionic eminence1.00infobox
TOPBP1Bgeebone marrow1.00infobox
TOPBP1Bgeebone marrow cell1.00infobox
TOPBP1Bgeerectum1.00infobox
TOPBP1BgeeAchilles tendon1.00infobox
TOPBP1Bgeeappendix1.00infobox
TOPBP1Bgeemonocyte1.00infobox
TOPBP1Bgeelymph node1.00infobox
TOPBP1Bgeetail of embryo1.00infobox
TOPBP1Bgeeotic placode1.00infobox
TOPBP1Bgeegenital tubercle1.00infobox
TOPBP1Bgeeabdominal wall1.00infobox
TOPBP1Bgeesaccule1.00infobox
TOPBP1Bgeeotic vesicle1.00infobox
TOPBP1Bgeeprimitive streak1.00infobox
TOPBP1Bgeedermis1.00infobox
TOPBP1Bgeemandibular prominence1.00infobox
TOPBP1BioGPSMore reference expression data1.00infobox
TOPBP1Chr.Chromosome 3 (human)1.00infobox
TOPBP1Chr.Chromosome 9 (mouse)1.00infobox
TOPBP1DatabasesNCBI: entry; OMA: entry1.00infobox
TOPBP1End133,662,380 bp1.00infobox
TOPBP1End103,227,627 bp1.00infobox
TOPBP1EnsemblENSG000001637811.00infobox

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