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DNA topoisomerase 2-binding protein 1 (TOPBP1) is a scaffold protein that in humans is encoded by the TOPBP1 gene.
The analysis highlights Standards, Function and Structure as prominent areas in the source structure around TOPBP1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around TOPBP1 shows recurring relationship patterns in the source. For example, TOPBP1 → actin cytoskeleton, cellular response to DNA damage stimulus, chromosome, condensed nuclear chromosome, cytoplasm, cytoskeleton, DNA binding, DNA metabolic process, DNA repair, DNA replication, DNA replication initiation, identical protein binding, isomerase activity, male germ cell nucleus, microtubule organizing center, mitotic DNA replication checkpoint signaling, mitotic G2 DNA damage checkpoint signaling, nuclear body, nucleoplasm, nucleus Another extracted example is TOPBP1 → As, As TOPBP1, BRCT5, BRCT7, BRCT7/8, BRCT8, DNA, Dpb11, During, However, II-α, In, It, MiDAS, Replication, SLX4, The, There, These, They. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
dna replication protein atr damage cell repair gene found brct domains cancer breast binding expression human domain specific activation associated
TTTA extracted 208 structured relationships around TOPBP1. Examples in this analysis include TOPBP1 → Aliases → TOPBP1, TOP2BP1, topoisomerase (DNA) II binding protein 1, DNA topoisomerase II binding protein 1, Dpb11 and TOPBP1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1WF6, 2XNH, 2XNK, 3AL2, 3AL3, 3JVE, 3OLC, 3PD7, 3UEN, 3UEO. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| TOPBP1 | Aliases | TOPBP1, TOP2BP1, topoisomerase (DNA) II binding protein 1, DNA topoisomerase II binding protein 1, Dpb11 | 1.00 | infobox |
| TOPBP1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1WF6, 2XNH, 2XNK, 3AL2, 3AL3, 3JVE, 3OLC, 3PD7, 3UEN, 3UEO | 1.00 | infobox |
| TOPBP1 | Band | 3q22.1 | 1.00 | infobox |
| TOPBP1 | Band | 9|9 F1 | 1.00 | infobox |
| TOPBP1 | Bgee | sperm | 1.00 | infobox |
| TOPBP1 | Bgee | ventricular zone | 1.00 | infobox |
| TOPBP1 | Bgee | ganglionic eminence | 1.00 | infobox |
| TOPBP1 | Bgee | bone marrow | 1.00 | infobox |
| TOPBP1 | Bgee | bone marrow cell | 1.00 | infobox |
| TOPBP1 | Bgee | rectum | 1.00 | infobox |
| TOPBP1 | Bgee | Achilles tendon | 1.00 | infobox |
| TOPBP1 | Bgee | appendix | 1.00 | infobox |
| TOPBP1 | Bgee | monocyte | 1.00 | infobox |
| TOPBP1 | Bgee | lymph node | 1.00 | infobox |
| TOPBP1 | Bgee | tail of embryo | 1.00 | infobox |
| TOPBP1 | Bgee | otic placode | 1.00 | infobox |
| TOPBP1 | Bgee | genital tubercle | 1.00 | infobox |
| TOPBP1 | Bgee | abdominal wall | 1.00 | infobox |
| TOPBP1 | Bgee | saccule | 1.00 | infobox |
| TOPBP1 | Bgee | otic vesicle | 1.00 | infobox |
| TOPBP1 | Bgee | primitive streak | 1.00 | infobox |
| TOPBP1 | Bgee | dermis | 1.00 | infobox |
| TOPBP1 | Bgee | mandibular prominence | 1.00 | infobox |
| TOPBP1 | BioGPS | More reference expression data | 1.00 | infobox |
| TOPBP1 | Chr. | Chromosome 3 (human) | 1.00 | infobox |
| TOPBP1 | Chr. | Chromosome 9 (mouse) | 1.00 | infobox |
| TOPBP1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| TOPBP1 | End | 133,662,380 bp | 1.00 | infobox |
| TOPBP1 | End | 103,227,627 bp | 1.00 | infobox |
| TOPBP1 | Ensembl | ENSG00000163781 | 1.00 | infobox |
The concept neighborhoods around TOPBP1 bring nearby vocabulary together. In this analysis, examples include Found, Replication and Atr. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For TOPBP1, one of the stronger structural bridges in this analysis connects TOPBP1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around TOPBP1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Standards, Function & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — TOPBP1 · EN edition · Analysis: TopicsToTalkAbout