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Cancer epigenetics: Mechanisms, MicroRNA and DNA repair & Cancer subtypes

Cancer epigenetics is the study of epigenetic modifications to the DNA of cancer cells that do not involve a change in the nucleotide sequence, but instead involve a change in the way the genetic code is expressed. Epigenetic mechanisms are necessary to maintain normal sequences of tissue specific gene expression and are crucial for normal development.…

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Cancer epigenetics topic overview

The analysis highlights Mechanisms, MicroRNA and DNA repair and Cancer subtypes as prominent areas in the source structure around Cancer epigenetics.

Related topics
212
Source areas
9
Connected nodes
221
Extracted relationships
22
Concept neighborhoods
62
Bridge connections
221

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Mechanisms · 86 topics
Cancer subtypes · 26 topics
MicroRNA and DNA repair · 23 topics
Treatment · 15 topics
Overview · 14 topics
Diagnosis and prognosis · 13 topics
DNA repair pathways · 13 topics
Identification methods · 13 topics
Epigenetic carcinogens · 9 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Mechanisms

MicroRNA and DNA repair

DNA repair pathways

Epigenetic carcinogens

Cancer subtypes

Identification methods

Diagnosis and prognosis

Treatment

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Cancer epigenetics connects Entity context

The extracted context around Cancer epigenetics shows recurring relationship patterns in the source. For example, Cancer epigenetics → Cancer, Cancer-induced, Cancer-related, DNA, Dysregulation, In, The, These Another extracted example is Cancer epigenetics → study of epigenetic modifications to the DNA of cancer cells that do not involve a change in the nucleotide sequence. Use these groups to spot repeated connection types before inspecting the individual relationships.

Cancer epigenetics

Top relations

related to Metabolic recoding of epigenetics in cancer · 8
Cancer epigenetics → Cancer, Cancer-induced, Cancer-related, DNA, Dysregulation, In, The, These
is a · 1
Cancer epigenetics → study of epigenetic modifications to the DNA of cancer cells that do not involve a change in the nucleotide sequence

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

epigenetic cancer dna genes histone cells repair methylation expression cpg cancers mutations gene tumor promoter may increased protein due also

Cancer epigenetics relationships Subject–Predicate–Object triples

TTTA extracted 22 structured relationships around Cancer epigenetics. Examples in this analysis include Cancer epigenetics → is a → study of epigenetic modifications to the DNA of cancer cells that do not involve a change in the nucleotide sequence and loss of imprinting → instance of → a process known as epigenetic addiction.Hypomethylation of CpG dinucleotides in other parts of the genome leads to chromosome instability due to mechanisms. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Cancer epigeneticsis astudy of epigenetic modifications to the DNA of cancer cells that do not involve a change in the nucleotide sequence0.90text
loss of imprintinginstance ofa process known as epigenetic addiction.Hypomethylation of CpG dinucleotides in other parts of the genome leads to chromosome instability due to mechanisms0.80text
reactivation of transposable elementsinstance ofa process known as epigenetic addiction.Hypomethylation of CpG dinucleotides in other parts of the genome leads to chromosome instability due to mechanisms0.80text
RAD51instance ofThese cancers ordinarily have epigenetic deficiencies in other DNA repair genes0.80text
BRCA2instance ofThese cancers ordinarily have epigenetic deficiencies in other DNA repair genes0.80text
diethylstilbestrol throughout the life of an affected childinstance ofWhile epigenetic effects may preserve the effect of a teratogen0.80text
the possibility of birth defects resulting from exposure of fathers or in secondinstance ofWhile epigenetic effects may preserve the effect of a teratogen0.80text
succeeding generations of offspring has generally been rejected on theoretical groundsinstance ofWhile epigenetic effects may preserve the effect of a teratogen0.80text
for lack of evidenceinstance ofWhile epigenetic effects may preserve the effect of a teratogen0.80text
that of the BMI1 component of the PRC1 complex is deregulated in chondrosarcomainstance ofExpression of epigenetic modifiers0.80text
Ewing's sarcomainstance ofExpression of epigenetic modifiers0.80text
and osteosarcomainstance ofExpression of epigenetic modifiers0.80text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Cancer epigenetics bring nearby vocabulary together. In this analysis, examples include Cells, Epigenetic and Tumor. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Cancer epigenetics
    • Cells
    • Epigenetic
    • Tumor
    • Genes
    • Methylation
    • Dna
    • Mutations
    • Cpg
    • Silencing
    • Histone
    • Cause
    • Alterations
  • cancer epigenetics
    • Cells
    • Epigenetic
    • Tumor
    • Genes
    • Methylation
    • Dna
    • Mutations
    • Cpg
    • Silencing
    • Histone
    • Cause
    • Alterations
  • epigenetic
    • Dna
    • Alterations
    • Cells
    • Genes
    • Repair
    • Cancers
    • Methylation
    • Expression
    • Due
    • Mechanisms
    • Histone
    • Silencing
  • dna
    • Repair
    • Methylation
    • Epigenetic
    • Genes
    • Gene
    • Histone
    • May
    • Expression
    • Damages
    • Cancers
    • Cells
    • Due
  • cancer cells
    • Cells
    • Epigenetic
    • Cancerous
    • Tumor
    • Cpg
    • Gene
    • Methylation
    • Genes
    • Dna
    • Silencing
    • Mutations
    • Histone
  • expression of genes
    • Cancers
    • Gene
    • Protein
    • Tumor
    • Repair
    • Due
    • Silencing
    • Suppressor
    • Reduced
    • Methylation
    • Promoter
    • Mgmt
  • cpg islands
    • Methylation
    • Found
    • Hypermethylation
    • Promoter
    • Gene
    • Increased
    • Tumor
    • Silencing
    • Suppressor
    • Genes
    • Dna
    • Mechanisms
  • tumor suppressor genes
    • Suppressor
    • Tumor
    • Genes
    • Silencing
    • Repair
    • Cancer
    • Methylation
    • Cells
    • Epigenetic
    • Hypermethylation
    • Modifications
    • Found

Connections between topic areas Semantic bridges

For Cancer epigenetics, one of the stronger structural bridges in this analysis connects Cancer epigenetics with Mechanisms. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Cancer epigenetics — Mechanisms · splits 135 ⟂ 87
Cancer epigenetics — Cancer subtypes · splits 195 ⟂ 27
Cancer epigenetics — MicroRNA and DNA repair · splits 198 ⟂ 24
Cancer epigenetics — Treatment · splits 206 ⟂ 16
Cancer epigenetics — Overview · splits 207 ⟂ 15
Cancer epigenetics — DNA repair pathways · splits 208 ⟂ 14
Cancer epigenetics — Identification methods · splits 208 ⟂ 14
Cancer epigenetics — Diagnosis and prognosis · splits 208 ⟂ 14
Cancer epigenetics — Epigenetic carcinogens · splits 212 ⟂ 10

Map overview Semantic statistics

Cancer epigenetics

Nodes222
Edges221
Triples22
Avg. degree1.99
Density0.009009
Components1

Source & methodology

TTTA analyzes the structure around Cancer epigenetics to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Mechanisms, MicroRNA and DNA repair & Cancer subtypes, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Cancer epigenetics · EN edition · Analysis: TopicsToTalkAbout

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