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Cancer epigenetics

Cancer epigenetics is the study of epigenetic modifications to the DNA of cancer cells that do not involve a change in the nucleotide sequence, but instead involve a change in the way the genetic code is expressed. Epigenetic mechanisms are necessary to maintain normal sequences of tissue specific gene expression and are crucial for normal development.…

Mechanisms, MicroRNA and DNA repair & Cancer subtypes

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Overview

Mechanisms

MicroRNA and DNA repair

DNA repair pathways

Epigenetic carcinogens

Cancer subtypes

Identification methods

Diagnosis and prognosis

Treatment

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Cancer epigenetics

Nodes222
Edges221
Triples22
Avg. degree1.99
Density0.009009
Components1

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Cancer epigenetics

Top relations

related to Metabolic recoding of epigenetics in cancer · 8
Cancer epigenetics → Cancer, Cancer-induced, Cancer-related, DNA, Dysregulation, In, The, These
is a · 1
Cancer epigenetics → study of epigenetic modifications to the DNA of cancer cells that do not involve a change in the nucleotide sequence

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Important terminology

epigenetic cancer dna genes histone cells repair methylation expression cpg cancers mutations gene tumor promoter may increased protein due also

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Cancer epigeneticsis astudy of epigenetic modifications to the DNA of cancer cells that do not involve a change in the nucleotide sequence0.90text
loss of imprintinginstance ofa process known as epigenetic addiction.Hypomethylation of CpG dinucleotides in other parts of the genome leads to chromosome instability due to mechanisms0.80text
reactivation of transposable elementsinstance ofa process known as epigenetic addiction.Hypomethylation of CpG dinucleotides in other parts of the genome leads to chromosome instability due to mechanisms0.80text
RAD51instance ofThese cancers ordinarily have epigenetic deficiencies in other DNA repair genes0.80text
BRCA2instance ofThese cancers ordinarily have epigenetic deficiencies in other DNA repair genes0.80text
diethylstilbestrol throughout the life of an affected childinstance ofWhile epigenetic effects may preserve the effect of a teratogen0.80text
the possibility of birth defects resulting from exposure of fathers or in secondinstance ofWhile epigenetic effects may preserve the effect of a teratogen0.80text
succeeding generations of offspring has generally been rejected on theoretical groundsinstance ofWhile epigenetic effects may preserve the effect of a teratogen0.80text
for lack of evidenceinstance ofWhile epigenetic effects may preserve the effect of a teratogen0.80text
that of the BMI1 component of the PRC1 complex is deregulated in chondrosarcomainstance ofExpression of epigenetic modifiers0.80text
Ewing's sarcomainstance ofExpression of epigenetic modifiers0.80text
and osteosarcomainstance ofExpression of epigenetic modifiers0.80text

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