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Estrogen receptor alpha

Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear receptor (mainly found as a chromatin-binding protein) that is activated by the sex hormone estrogen. In humans, ERα is encoded by the gene ESR1 (EStrogen Receptor 1).

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Aliases
ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1, estrogen receptor 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A52, 1ERE, 1ERR, 1G50, 1GWQ, 1GWR, 1HCP, 1HCQ, 1L2I, 1PCG, 1QKT, 1QKU, 1R5K, 1SJ0, 1UOM, 1X7E, 1X7R, 1XP1,…
Band
6q25.1-q25.2 · 10 A1|10 2.03 cM
Bgee
cervix epithelium · vulva · endometrium · canal of the cervix · right uterine tube
BioGPS
n/a
Chr.
Chromosome 6 (human) · Chromosome 10 (mouse)

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Ligands

Tissue distribution and function

Clinical significance

Coactivators

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Map overview Semantic statistics

Estrogen receptor alpha

Nodes212
Edges211
Triples155
Avg. degree1.99
Density0.009434
Components1

How this topic connects Entity context

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Estrogen receptor alpha

Top relations

Gene ontology · 90
Estrogen receptor alpha → androgen metabolic process, antral ovarian follicle growth, ATPase binding, beta-catenin binding, cellular response to estradiol stimulus, cellular response to estrogen stimulus, chromatin binding, chromatin remodeling, core promoter sequence-specific DNA binding, cytoplasm, cytosol, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, enzyme binding, epithelial cell development, epithelial cell proliferation involved in mammary gland duct elongation, estrogen receptor activity, estrogen receptor binding
Bgee · 20
Estrogen receptor alpha → body of uterus, canal of the cervix, cervix epithelium, decidua, ectocervix, efferent ductule, endometrium, epithelium of lactiferous gland, gastrula, intercostal muscle, lactiferous duct, lumbar spinal ganglion, right uterine tube, sternocleidomastoid muscle, temporal muscle, triceps brachii muscle, uterus, vagina, vas deferens, vulva
RNA expression pattern · 20
Estrogen receptor alpha → body of uterus, canal of the cervix, cervix epithelium, decidua, ectocervix, efferent ductule, endometrium, epithelium of lactiferous gland, gastrula, intercostal muscle, lactiferous duct, lumbar spinal ganglion, right uterine tube, sternocleidomastoid muscle, temporal muscle, triceps brachii muscle, uterus, vagina, vas deferens, vulva
Band · 2
Estrogen receptor alpha → 10 A1|10 2.03 cM, 6q25.1-q25.2
Chr. · 2
Estrogen receptor alpha → Chromosome 10 (mouse), Chromosome 6 (human)
End · 2
Estrogen receptor alpha → 152,129,619 bp, 4,955,614 bp
related to Interactions · 2
Estrogen receptor alpha → AKAP13AHRBRCA1CAV1CCNCCDC25BCEBPBCOBRA1COUP-TFICREBBPCRSP3Cyclin D1DNTTIP2EP300ESR2FOXO1GREB1GTF2H1HSPA1AHSPA8HSP90AA1ISL1JARID1AMVPMED1MED12MED14MED16MED24MED6MGMTMNAT1MTA1NCOA…, Estrogen
Aliases · 1
Estrogen receptor alpha → ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1, estrogen receptor 1
Available structures · 1
Estrogen receptor alpha → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A52, 1ERE, 1ERR, 1G50, 1GWQ, 1GWR, 1HCP, 1HCQ, 1L2I, 1PCG, 1QKT, 1QKU, 1R5K, 1SJ0, 1UOM, 1X7E, 1X7R, 1XP1,…
BioGPS · 1
Estrogen receptor alpha → n/a

Important terminology Word statistics

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Important terminology

erα estrogen erko mice receptor uterus reproductive bp gene development function male bone female esr1 chr human band mouse hypothalamus

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Estrogen receptor alphaAliasesESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1, estrogen receptor 11.00infobox
Estrogen receptor alphaAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A52, 1ERE, 1ERR, 1G50, 1GWQ, 1GWR, 1HCP, 1HCQ, 1L2I, 1PCG, 1QKT, 1QKU, 1R5K, 1SJ0, 1UOM, 1X7E, 1X7R, 1XP1,…1.00infobox
Estrogen receptor alphaBand6q25.1-q25.21.00infobox
Estrogen receptor alphaBand10 A1|10 2.03 cM1.00infobox
Estrogen receptor alphaBgeecervix epithelium1.00infobox
Estrogen receptor alphaBgeevulva1.00infobox
Estrogen receptor alphaBgeeendometrium1.00infobox
Estrogen receptor alphaBgeecanal of the cervix1.00infobox
Estrogen receptor alphaBgeeright uterine tube1.00infobox
Estrogen receptor alphaBgeeectocervix1.00infobox
Estrogen receptor alphaBgeeepithelium of lactiferous gland1.00infobox
Estrogen receptor alphaBgeelactiferous duct1.00infobox
Estrogen receptor alphaBgeebody of uterus1.00infobox
Estrogen receptor alphaBgeevagina1.00infobox
Estrogen receptor alphaBgeegastrula1.00infobox
Estrogen receptor alphaBgeevas deferens1.00infobox
Estrogen receptor alphaBgeeefferent ductule1.00infobox
Estrogen receptor alphaBgeeuterus1.00infobox
Estrogen receptor alphaBgeedecidua1.00infobox
Estrogen receptor alphaBgeeintercostal muscle1.00infobox
Estrogen receptor alphaBgeetriceps brachii muscle1.00infobox
Estrogen receptor alphaBgeesternocleidomastoid muscle1.00infobox
Estrogen receptor alphaBgeelumbar spinal ganglion1.00infobox
Estrogen receptor alphaBgeetemporal muscle1.00infobox
Estrogen receptor alphaBioGPSn/a1.00infobox
Estrogen receptor alphaChr.Chromosome 6 (human)1.00infobox
Estrogen receptor alphaChr.Chromosome 10 (mouse)1.00infobox
Estrogen receptor alphaDatabasesNCBI: entry; OMA: entry1.00infobox
Estrogen receptor alphaEnd152,129,619 bp1.00infobox
Estrogen receptor alphaEnd4,955,614 bp1.00infobox

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