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Explore the main themes, entities and connections around CDKN2A. Start with the topic map, then use the sections below for research and deeper semantic analysis.
Explore this topic
Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.
Clinical relevance
24 related topics
Overview
31 related topics
Function
8 related topics
Structure
6 related topics
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
- Aliases
- CDKN2A, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16, cyclin-dependent kinase inhibitor 2A, cyclin depend…
- Available structures
- Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2A5E, 1A5E, 1BI7, 1DC2,%%s1A5E, 1BI7, 1DC2, 2A5E
- Band
- 9p21.3 · 4 C4|4 42.15 cM
- Bgee
- parotid gland · pituitary gland · testicle · anterior pituitary · subthalamic nucleus
- BioGPS
- More reference expression data
- Chr.
- Chromosome 9 (human) · Chromosome 4 (mouse)
Topics to explore
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.Browse the full topic structure. Each item opens a new analysis centered on that subject.
Overview
- Gene
- Chromosome 9 Chromosome 9 (human)
- Proteins Protein
- INK4 family INK4
- P16
- P14arf
- Tumor suppressors Tumor suppressor gene
- Cell cycle
- CDK4 Cyclin-dependent kinase 4
- CDK6 Cyclin-dependent kinase 6
- Retinoblastoma Retinoblastoma protein
- G1 G1 phase
- S-phase S phase
- P53
- Germline mutations Germline mutation
- Melanoma
- Glioblastoma
- Pancreatic cancer
- SNPs Single-nucleotide polymorphism
- Coronary artery disease
- Cyclin-dependent kinase inhibitor Cyclin-dependent kinase inhibitor proteins
- Ankyrin repeats
- Tertiary structure Tertiary structures
- Helix-turn-helix motif
- Solvent
- Negatively charged
- Positively charged
- KDa Dalton (unit)
- N-terminal N-terminus
- Hydrophobic Hydrophobic effect
Structure
- Exons Exon
- P14ARF
- Reading frames Reading frame
- Amino acid sequences Amino acid sequence
- Isoforms
- Alternative splicing
Function
- MDM2
- E2F
- G2 phase
- Apoptosis
- Phase transition
- CDK4
- Reactive oxygen species
- Protein kinase C delta Protein kinase C delta?action=edit&redlink=1
Clinical relevance
- Epigenetic
- Promoter Promoter (genetics)
- Hyper-methylation DNA methylation in cancer
- Homozygous
- Gastric lymphoma
- Burkitt's lymphoma
- Squamous cell carcinoma
- Glioma
- Oral cancer
- Pancreatic adenocarcinoma
- Non-small cell lung carcinomas
- Esophageal squamous cell carcinoma
- Gastric cancer
- Bladder cancer
- Osteosarcoma
- Colorectal cancer
- Breast cancer
- Cervical cancer
- Epithelial ovarian carcinoma
- Endometrial cancer
- Prostate cancer
- Immunosuppression
- Cellular senescence
- Histiocytic sarcoma
Sources
Advanced semantic analysis
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
Map overview Semantic statistics
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.CDKN2A
Nodes77
Edges76
Triples184
Avg. degree1.97
Density0.025974
Components1
How this topic connects Entity context
Quick relationship hints grouped by predicate. Useful for spotting recurring semantic connections around the current entity.See the strongest relationship patterns around the current topic before diving into the raw triples.
CDKN2A
Top relations
Gene ontology · 75
CDKN2A → activation of cysteine-type endopeptidase activity involved in apoptotic process, amyloid fibril formation, apoptotic mitochondrial changes, apoptotic process, autophagy of mitochondrion, cell cycle, cellular senescence, cyclin-dependent protein serine/threonine kinase inhibitor activity, cytoplasm, cytosol, disordered domain specific binding, DNA binding, G1 phase, G1/S transition of mitotic cell cycle, MDM2/MDM4 family protein binding, mitochondrial depolarization, mitochondrion, negative regulation of B cell proliferation, negative regulation of cell growth, negative regulation of cell population proliferation
Bgee · 20
CDKN2A → anterior pituitary, calvaria, embryo, endothelial cell of lymphatic vessel, external globus pallidus, glossopharyngeal ganglion, greater petrosal nerve, lumbar subsegment of spinal cord, morula, mucosa of pharynx, muscle of thigh, parotid gland, pituitary gland, stroma of bone marrow, subthalamic nucleus, superior surface of tongue, testicle, tongue, ventral tegmental area, yolk sac
RNA expression pattern · 20
CDKN2A → anterior pituitary, calvaria, embryo, endothelial cell of lymphatic vessel, external globus pallidus, glossopharyngeal ganglion, greater petrosal nerve, lumbar subsegment of spinal cord, morula, mucosa of pharynx, muscle of thigh, parotid gland, pituitary gland, stroma of bone marrow, subthalamic nucleus, superior surface of tongue, testicle, tongue, ventral tegmental area, yolk sac
related to Familial melanoma · 18
CDKN2A → Also, Australia, Australian, CDK4, Europe, European, For, If, Melanoma, Out, People, Protein, The, These, This, Those, UV, When
related to Clinical marker · 7
CDKN2A → ASCOT, Cancer, CARE, JUPITER, Malmo Diet, PROVE IT-TIMI, The
related to Clinical relevance · 5
CDKN2A → Accordingly, First, In, Second, The CDKN2A
related to Gene · 5
CDKN2A → ARF, As, In, The CDKN2A, This
related to Aging · 3
CDKN2A → Activation, As, Notably
Band · 2
CDKN2A → 4 C4|4 42.15 cM, 9p21.3
Chr. · 2
CDKN2A → Chromosome 4 (mouse), Chromosome 9 (human)
Important terminology Word statistics
Frequent words and multi-word phrases across the lead, headings, infobox and body. Useful for terminology coverage.Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
Important terminology
gene p16 melanoma p14arf cell cancer human tumor chromosome band also kinase bp family proteins rb cycle chr p53 inhibitor
Entity relationships Subject–Predicate–Object triples
Extracted RDF-like relationships with confidence and source. The table includes structured facts and lower-confidence contextual relations.| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| CDKN2A | Aliases | CDKN2A, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16, cyclin-dependent kinase inhibitor 2A, cyclin depend… | 1.00 | infobox |
| CDKN2A | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2A5E, 1A5E, 1BI7, 1DC2,%%s1A5E, 1BI7, 1DC2, 2A5E | 1.00 | infobox |
| CDKN2A | Band | 9p21.3 | 1.00 | infobox |
| CDKN2A | Band | 4 C4|4 42.15 cM | 1.00 | infobox |
| CDKN2A | Bgee | parotid gland | 1.00 | infobox |
| CDKN2A | Bgee | pituitary gland | 1.00 | infobox |
| CDKN2A | Bgee | testicle | 1.00 | infobox |
| CDKN2A | Bgee | anterior pituitary | 1.00 | infobox |
| CDKN2A | Bgee | subthalamic nucleus | 1.00 | infobox |
| CDKN2A | Bgee | tongue | 1.00 | infobox |
| CDKN2A | Bgee | ventral tegmental area | 1.00 | infobox |
| CDKN2A | Bgee | mucosa of pharynx | 1.00 | infobox |
| CDKN2A | Bgee | superior surface of tongue | 1.00 | infobox |
| CDKN2A | Bgee | external globus pallidus | 1.00 | infobox |
| CDKN2A | Bgee | yolk sac | 1.00 | infobox |
| CDKN2A | Bgee | stroma of bone marrow | 1.00 | infobox |
| CDKN2A | Bgee | morula | 1.00 | infobox |
| CDKN2A | Bgee | embryo | 1.00 | infobox |
| CDKN2A | Bgee | glossopharyngeal ganglion | 1.00 | infobox |
| CDKN2A | Bgee | endothelial cell of lymphatic vessel | 1.00 | infobox |
| CDKN2A | Bgee | lumbar subsegment of spinal cord | 1.00 | infobox |
| CDKN2A | Bgee | calvaria | 1.00 | infobox |
| CDKN2A | Bgee | greater petrosal nerve | 1.00 | infobox |
| CDKN2A | Bgee | muscle of thigh | 1.00 | infobox |
| CDKN2A | BioGPS | More reference expression data | 1.00 | infobox |
| CDKN2A | Chr. | Chromosome 9 (human) | 1.00 | infobox |
| CDKN2A | Chr. | Chromosome 4 (mouse) | 1.00 | infobox |
| CDKN2A | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| CDKN2A | End | 21,995,301 bp | 1.00 | infobox |
| CDKN2A | End | 89,212,890 bp | 1.00 | infobox |
No triples extracted yet.
Related concept clusters Concept neighborhoods
Clusters of nearby vocabulary surrounding the topic. Scan them for adjacent concepts and language you may have missed.These clusters group vocabulary that occurs around closely connected concepts in the source material.
Connections between topic areas Semantic bridges
Bridge nodes connect otherwise separate parts of the map. Expand a row to inspect the topic groups on each side.Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.
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