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CDKN2A, also known as cyclin-dependent kinase inhibitor 2A, is a gene which in humans is located at chromosome 9, band p21.3. It is ubiquitously expressed in many tissues and cell types. The gene codes for two proteins, including the INK4 family member p16 (or p16INK4a) and p14arf. Both act as tumor suppressors by regulating the cell cycle. p16 inhibits…
The analysis highlights Music, Clinical relevance and Overview as prominent areas in the source structure around CDKN2A. 1 topic appears in more than one source area, which can help identify connections that are less obvious in a linear reading.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around CDKN2A shows recurring relationship patterns in the source. For example, CDKN2A → activation of cysteine-type endopeptidase activity involved in apoptotic process, amyloid fibril formation, apoptotic mitochondrial changes, apoptotic process, autophagy of mitochondrion, cell cycle, cellular senescence, cyclin-dependent protein serine/threonine kinase inhibitor activity, cytoplasm, cytosol, disordered domain specific binding, DNA binding, G1 phase, G1/S transition of mitotic cell cycle, MDM2/MDM4 family protein binding, mitochondrial depolarization, mitochondrion, negative regulation of B cell proliferation, negative regulation of cell growth, negative regulation of cell population proliferation Another extracted example is CDKN2A → anterior pituitary, calvaria, embryo, endothelial cell of lymphatic vessel, external globus pallidus, glossopharyngeal ganglion, greater petrosal nerve, lumbar subsegment of spinal cord, morula, mucosa of pharynx, muscle of thigh, parotid gland, pituitary gland, stroma of bone marrow, subthalamic nucleus, superior surface of tongue, testicle, tongue, ventral tegmental area, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
gene p16 melanoma p14arf cell cancer human tumor chromosome band also kinase bp family proteins rb cycle chr p53 inhibitor
TTTA extracted 184 structured relationships around CDKN2A. Examples in this analysis include CDKN2A → Aliases → CDKN2A, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16, cyclin-dependent kinase inhibitor 2A, cyclin depend… and CDKN2A → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2A5E, 1A5E, 1BI7, 1DC2,%%s1A5E, 1BI7, 1DC2, 2A5E. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| CDKN2A | Aliases | CDKN2A, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16, cyclin-dependent kinase inhibitor 2A, cyclin depend… | 1.00 | infobox |
| CDKN2A | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2A5E, 1A5E, 1BI7, 1DC2,%%s1A5E, 1BI7, 1DC2, 2A5E | 1.00 | infobox |
| CDKN2A | Band | 9p21.3 | 1.00 | infobox |
| CDKN2A | Band | 4 C4|4 42.15 cM | 1.00 | infobox |
| CDKN2A | Bgee | parotid gland | 1.00 | infobox |
| CDKN2A | Bgee | pituitary gland | 1.00 | infobox |
| CDKN2A | Bgee | testicle | 1.00 | infobox |
| CDKN2A | Bgee | anterior pituitary | 1.00 | infobox |
| CDKN2A | Bgee | subthalamic nucleus | 1.00 | infobox |
| CDKN2A | Bgee | tongue | 1.00 | infobox |
| CDKN2A | Bgee | ventral tegmental area | 1.00 | infobox |
| CDKN2A | Bgee | mucosa of pharynx | 1.00 | infobox |
| CDKN2A | Bgee | superior surface of tongue | 1.00 | infobox |
| CDKN2A | Bgee | external globus pallidus | 1.00 | infobox |
| CDKN2A | Bgee | yolk sac | 1.00 | infobox |
| CDKN2A | Bgee | stroma of bone marrow | 1.00 | infobox |
| CDKN2A | Bgee | morula | 1.00 | infobox |
| CDKN2A | Bgee | embryo | 1.00 | infobox |
| CDKN2A | Bgee | glossopharyngeal ganglion | 1.00 | infobox |
| CDKN2A | Bgee | endothelial cell of lymphatic vessel | 1.00 | infobox |
| CDKN2A | Bgee | lumbar subsegment of spinal cord | 1.00 | infobox |
| CDKN2A | Bgee | calvaria | 1.00 | infobox |
| CDKN2A | Bgee | greater petrosal nerve | 1.00 | infobox |
| CDKN2A | Bgee | muscle of thigh | 1.00 | infobox |
| CDKN2A | BioGPS | More reference expression data | 1.00 | infobox |
| CDKN2A | Chr. | Chromosome 9 (human) | 1.00 | infobox |
| CDKN2A | Chr. | Chromosome 4 (mouse) | 1.00 | infobox |
| CDKN2A | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| CDKN2A | End | 21,995,301 bp | 1.00 | infobox |
| CDKN2A | End | 89,212,890 bp | 1.00 | infobox |
The concept neighborhoods around CDKN2A bring nearby vocabulary together. In this analysis, examples include Gene, Cancer and Human. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For CDKN2A, one of the stronger structural bridges in this analysis connects CDKN2A with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around CDKN2A to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Music, Clinical relevance & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — CDKN2A · EN edition · Analysis: TopicsToTalkAbout