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CDKN2A: Music, Clinical relevance & Overview

CDKN2A, also known as cyclin-dependent kinase inhibitor 2A, is a gene which in humans is located at chromosome 9, band p21.3. It is ubiquitously expressed in many tissues and cell types. The gene codes for two proteins, including the INK4 family member p16 (or p16INK4a) and p14arf. Both act as tumor suppressors by regulating the cell cycle. p16 inhibits…

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CDKN2A topic overview

The analysis highlights Music, Clinical relevance and Overview as prominent areas in the source structure around CDKN2A. 1 topic appears in more than one source area, which can help identify connections that are less obvious in a linear reading.

Related topics
68
Source areas
4
Connected nodes
76
Extracted relationships
184
Concept neighborhoods
30
Bridge connections
76

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 31 topics
Clinical relevance · 24 topics
Function · 8 topics
Structure · 6 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CDKN2A, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16, cyclin-dependent kinase inhibitor 2A, cyclin depend…
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2A5E, 1A5E, 1BI7, 1DC2,%%s1A5E, 1BI7, 1DC2, 2A5E
Band
9p21.3 · 4 C4|4 42.15 cM
Bgee
parotid gland · pituitary gland · testicle · anterior pituitary · subthalamic nucleus
BioGPS
More reference expression data
Chr.
Chromosome 9 (human) · Chromosome 4 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical relevance

Sources

  • Doi Doi (identifier)
  • PMID PMID (identifier)

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CDKN2A connects Entity context

The extracted context around CDKN2A shows recurring relationship patterns in the source. For example, CDKN2A → activation of cysteine-type endopeptidase activity involved in apoptotic process, amyloid fibril formation, apoptotic mitochondrial changes, apoptotic process, autophagy of mitochondrion, cell cycle, cellular senescence, cyclin-dependent protein serine/threonine kinase inhibitor activity, cytoplasm, cytosol, disordered domain specific binding, DNA binding, G1 phase, G1/S transition of mitotic cell cycle, MDM2/MDM4 family protein binding, mitochondrial depolarization, mitochondrion, negative regulation of B cell proliferation, negative regulation of cell growth, negative regulation of cell population proliferation Another extracted example is CDKN2A → anterior pituitary, calvaria, embryo, endothelial cell of lymphatic vessel, external globus pallidus, glossopharyngeal ganglion, greater petrosal nerve, lumbar subsegment of spinal cord, morula, mucosa of pharynx, muscle of thigh, parotid gland, pituitary gland, stroma of bone marrow, subthalamic nucleus, superior surface of tongue, testicle, tongue, ventral tegmental area, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.

CDKN2A

Top relations

Gene ontology · 75
CDKN2A → activation of cysteine-type endopeptidase activity involved in apoptotic process, amyloid fibril formation, apoptotic mitochondrial changes, apoptotic process, autophagy of mitochondrion, cell cycle, cellular senescence, cyclin-dependent protein serine/threonine kinase inhibitor activity, cytoplasm, cytosol, disordered domain specific binding, DNA binding, G1 phase, G1/S transition of mitotic cell cycle, MDM2/MDM4 family protein binding, mitochondrial depolarization, mitochondrion, negative regulation of B cell proliferation, negative regulation of cell growth, negative regulation of cell population proliferation
Bgee · 20
CDKN2A → anterior pituitary, calvaria, embryo, endothelial cell of lymphatic vessel, external globus pallidus, glossopharyngeal ganglion, greater petrosal nerve, lumbar subsegment of spinal cord, morula, mucosa of pharynx, muscle of thigh, parotid gland, pituitary gland, stroma of bone marrow, subthalamic nucleus, superior surface of tongue, testicle, tongue, ventral tegmental area, yolk sac
RNA expression pattern · 20
CDKN2A → anterior pituitary, calvaria, embryo, endothelial cell of lymphatic vessel, external globus pallidus, glossopharyngeal ganglion, greater petrosal nerve, lumbar subsegment of spinal cord, morula, mucosa of pharynx, muscle of thigh, parotid gland, pituitary gland, stroma of bone marrow, subthalamic nucleus, superior surface of tongue, testicle, tongue, ventral tegmental area, yolk sac
related to Familial melanoma · 18
CDKN2A → Also, Australia, Australian, CDK4, Europe, European, For, If, Melanoma, Out, People, Protein, The, These, This, Those, UV, When
related to Clinical marker · 7
CDKN2A → ASCOT, Cancer, CARE, JUPITER, Malmo Diet, PROVE IT-TIMI, The
related to Clinical relevance · 5
CDKN2A → Accordingly, First, In, Second, The CDKN2A
related to Gene · 5
CDKN2A → ARF, As, In, The CDKN2A, This
related to Aging · 3
CDKN2A → Activation, As, Notably
Band · 2
CDKN2A → 4 C4|4 42.15 cM, 9p21.3
Chr. · 2
CDKN2A → Chromosome 4 (mouse), Chromosome 9 (human)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene p16 melanoma p14arf cell cancer human tumor chromosome band also kinase bp family proteins rb cycle chr p53 inhibitor

CDKN2A relationships Subject–Predicate–Object triples

TTTA extracted 184 structured relationships around CDKN2A. Examples in this analysis include CDKN2A → Aliases → CDKN2A, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16, cyclin-dependent kinase inhibitor 2A, cyclin depend… and CDKN2A → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2A5E, 1A5E, 1BI7, 1DC2,%%s1A5E, 1BI7, 1DC2, 2A5E. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
CDKN2AAliasesCDKN2A, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16, cyclin-dependent kinase inhibitor 2A, cyclin depend…1.00infobox
CDKN2AAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2A5E, 1A5E, 1BI7, 1DC2,%%s1A5E, 1BI7, 1DC2, 2A5E1.00infobox
CDKN2ABand9p21.31.00infobox
CDKN2ABand4 C4|4 42.15 cM1.00infobox
CDKN2ABgeeparotid gland1.00infobox
CDKN2ABgeepituitary gland1.00infobox
CDKN2ABgeetesticle1.00infobox
CDKN2ABgeeanterior pituitary1.00infobox
CDKN2ABgeesubthalamic nucleus1.00infobox
CDKN2ABgeetongue1.00infobox
CDKN2ABgeeventral tegmental area1.00infobox
CDKN2ABgeemucosa of pharynx1.00infobox
CDKN2ABgeesuperior surface of tongue1.00infobox
CDKN2ABgeeexternal globus pallidus1.00infobox
CDKN2ABgeeyolk sac1.00infobox
CDKN2ABgeestroma of bone marrow1.00infobox
CDKN2ABgeemorula1.00infobox
CDKN2ABgeeembryo1.00infobox
CDKN2ABgeeglossopharyngeal ganglion1.00infobox
CDKN2ABgeeendothelial cell of lymphatic vessel1.00infobox
CDKN2ABgeelumbar subsegment of spinal cord1.00infobox
CDKN2ABgeecalvaria1.00infobox
CDKN2ABgeegreater petrosal nerve1.00infobox
CDKN2ABgeemuscle of thigh1.00infobox
CDKN2ABioGPSMore reference expression data1.00infobox
CDKN2AChr.Chromosome 9 (human)1.00infobox
CDKN2AChr.Chromosome 4 (mouse)1.00infobox
CDKN2ADatabasesNCBI: entry; OMA: entry1.00infobox
CDKN2AEnd21,995,301 bp1.00infobox
CDKN2AEnd89,212,890 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CDKN2A bring nearby vocabulary together. In this analysis, examples include Gene, Cancer and Human. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • CDKN2A
    • Gene
    • Cancer
    • Human
    • Chromosome
    • Cell
    • Cyclin-dependent
    • Location
    • Inhibitor
    • Skin
    • Kinase
    • Melanoma
    • Disease
  • cdkn2a
    • Gene
    • Cancer
    • Human
    • Chromosome
    • Cell
    • Cyclin-dependent
    • Location
    • Inhibitor
    • Skin
    • Kinase
    • Melanoma
    • Disease
  • gene
    • Human
    • Chromosome
    • Location
    • Kinase
    • P16
    • Melanoma
    • Arf
    • Bp
    • Chr
    • Inhibitor
    • Mutation
    • Proteins
  • ink4 family
    • Mouse
    • P53
    • G1
    • Inhibitor
    • Proteins
    • Two
    • Cycle
    • Protein
    • Kinase
    • P16
    • P14arf
    • Activates
  • cell cycle
    • Cycle
    • Activates
    • Mouse
    • P14arf
    • P53
    • G1
    • Suppressor
    • Family
    • Protein
    • Tumor
    • Kinase
    • Rb
  • cyclin-dependent kinase inhibitor
    • Inhibitor
    • Kinase
    • Protein
    • P53
    • Family
    • Cdk4
    • Chromosome
    • P16
    • Cycle
    • Gene
    • Known
    • Mouse
  • protein kinase c delta
    • Inhibitor
    • Protein
    • Cdk4
    • P16
    • Cycle
    • Family
    • Chromosome
    • Gene
    • Rb
    • Tumor
    • Cell
    • Activates
  • squamous cell carcinoma
    • Cycle
    • Activates
    • Tumor
    • P14arf
    • Mouse
    • P53
    • G1
    • Suppressor
    • Family
    • Protein
    • Human
    • Kinase

Connections between topic areas Semantic bridges

For CDKN2A, one of the stronger structural bridges in this analysis connects CDKN2A with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
CDKN2AOverview · splits 45 ⟂ 32
CDKN2AClinical relevance · splits 52 ⟂ 25
CDKN2AFunction · splits 68 ⟂ 9
CDKN2AStructure · splits 70 ⟂ 7
CDKN2ASources · splits 74 ⟂ 3

Map overview Semantic statistics

CDKN2A

Nodes77
Edges76
Triples184
Avg. degree1.97
Density0.025974
Components1

Source & methodology

TTTA analyzes the structure around CDKN2A to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Music, Clinical relevance & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CDKN2A · EN edition · Analysis: TopicsToTalkAbout

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