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HMGA: Function, Genomic distribution & Overview

HMGA is a family of high mobility group proteins characterized by an AT-hook. They code for a "small, nonhistone, chromatin-associated protein that has no intrinsic transcriptional activity but can modulate transcription by altering the chromatin architecture". Mammals have two orthologs: HMGA1 and HMGA2.

Language: English [EN]
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HMGA topic overview

The analysis highlights Function, Genomic distribution and Overview as prominent areas in the source structure around HMGA.

Related topics
8
Source areas
3
Connected nodes
11
Extracted relationships
31
Concept neighborhoods
10
Bridge connections
11

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 5 topics
Overview · 2 topics
Genomic distribution · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Alt. symbols
HMGIY
Domains
InterPro
HGNC
5010
Locus
Chr. 6 p21
NCBI gene
3159
OMIM
600701

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Genomic distribution

Function

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How HMGA connects Entity context

The extracted context around HMGA shows recurring relationship patterns in the source. For example, HMGA → DNA, HMGA1, HMGA2, However, Normally, O-methylguanine, Thus Another extracted example is HMGA → AT-hook, AT-rich, DNA, In, Such. Use these groups to spot repeated connection types before inspecting the individual relationships.

HMGA

Top relations

related to Function · 7
HMGA → DNA, HMGA1, HMGA2, However, Normally, O-methylguanine, Thus
related to Genomic distribution · 5
HMGA → AT-hook, AT-rich, DNA, In, Such
related to External links · 4
HMGA → Medicine Medical Subject Headings, MeSH, National Library, Proteins
related to Association with human traits · 2
HMGA → HMGA2, Variations
Alt. symbols · 1
HMGA → HMGIY
Domains · 1
HMGA → InterPro
HGNC · 1
HMGA → 5010
Locus · 1
HMGA → Chr. 6 p21
NCBI gene · 1
HMGA → 3159
OMIM · 1
HMGA → 600701

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

hmga1 hmga2 proteins dna p21 at-hook cells damage transcriptional activity chromatin chr function association apoptosis domains family high mobility group

HMGA relationships Subject–Predicate–Object triples

TTTA extracted 31 structured relationships around HMGA. Examples in this analysis include HMGA → Alt. symbols → HMGIY and HMGA → Domains → InterPro. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
HMGAAlt. symbolsHMGIY1.00infobox
HMGADomainsInterPro1.00infobox
HMGAHGNC50101.00infobox
HMGALocusChr. 6 p211.00infobox
HMGANCBI gene31591.00infobox
HMGAOMIM6007011.00infobox
HMGARefSeqNM_1459011.00infobox
HMGASearch forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
HMGAStructuresSwiss-model1.00infobox
HMGASymbolHMGA11.00infobox
HMGAUniProtP170961.00infobox
HMGAis afamily of high mobility group proteins characterized by an AT-hook0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around HMGA bring nearby vocabulary together. In this analysis, examples include At-hook, Proteins and Characterized. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • hmga1
    • Hmga2
    • Proteins
    • Function
    • Damage
    • Dna
    • Distribution
    • Genomic
    • Human
    • Mammals
    • Orthologs
    • See
    • Traits
  • HMGA
    • At-hook
    • Proteins
    • Characterized
    • Domains
    • Group
    • Mobility
    • Chromatin
    • P21
    • Transcriptional
    • Cells
    • Dna
    • Hmga1
  • hmga
    • At-hook
    • Proteins
    • Characterized
    • Domains
    • Group
    • Mobility
    • Chromatin
    • P21
    • Transcriptional
    • Cells
    • Dna
    • Hmga1
  • at-hook
    • Hmga
    • Characterized
    • Domains
    • Family
    • Group
    • High
    • Mobility
    • Proteins
    • Chromatin
    • P21
    • Transcriptional
    • Cells
  • function
    • Genomic
    • Human
    • See
    • Traits
    • Hmga1
    • Apoptosis
    • Association
    • Chr
    • Damage
    • Dna
    • Hmga2
    • Proteins
  • dna damage
    • Damage
    • Dna
    • Apoptosis
    • Proteins
    • Hmga1
    • Hmga2
    • Domains
    • Function
    • P21
    • Transcriptional
    • Hmga
  • hmga2
    • Proteins
    • Damage
    • Dna
    • Mammals
    • Orthologs
    • Two
    • Apoptosis
    • Association
    • Function
    • Cells
  • genomic distribution
    • Genomic
    • Human
    • See
    • Traits
    • Association
    • Chr
    • Function
    • Hmga1

Connections between topic areas Semantic bridges

For HMGA, one of the stronger structural bridges in this analysis connects HMGA with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
HMGAFunction · splits 6 ⟂ 6
HMGAOverview · splits 9 ⟂ 3

Map overview Semantic statistics

HMGA

Nodes12
Edges11
Triples31
Avg. degree1.83
Density0.166667
Components1

Source & methodology

TTTA analyzes the structure around HMGA to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Genomic distribution & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — HMGA · EN edition · Analysis: TopicsToTalkAbout

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