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Bcl-2

Bcl-2, encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins. BCL2 blocks programmed cell death (apoptosis) while other BCL2 family members can either inhibit or induce it. It was the first apoptosis regulator identified in any organism.

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Aliases
BCL2, Bcl-2, PPP1R50, B-cell CLL/lymphoma 2, apoptosis regulator, BCL2 apoptosis regulator, Genes, bcl-2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1G5M, 1GJH, 1YSW, 2O21, 2O22, 2O2F, 2W3L, 2XA0, 4AQ3, 4IEH, 4LVT, 4LXD, 4MAN, 5AGW, 5AGX, 5FCG
Band
18q21.33 · 1 E2.1|1 49.76 cM
Bgee
dorsal motor nucleus of vagus nerve · superficial temporal artery · Achilles tendon · epithelium of colon · inferior olivary nucleus
BioGPS
More reference expression data
Chr.
Chromosome 18 (human) · Chromosome 1 (mouse)

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Function

Role in disease

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Map overview Semantic statistics

Bcl-2

Nodes114
Edges113
Triples374
Avg. degree1.98
Density0.017544
Components1

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Bcl-2

Top relations

Gene ontology · 172
Bcl-2 → actin filament organization, animal organ morphogenesis, apoptotic mitochondrial changes, apoptotic process, axon regeneration, axonogenesis, B cell differentiation, B cell homeostasis, B cell lineage commitment, B cell proliferation, B cell receptor signaling pathway, behavioral fear response, BH3 domain binding, branching involved in ureteric bud morphogenesis, CD8-positive, alpha-beta T cell lineage commitment, cell morphogenesis, cell population proliferation, cell-cell adhesion, cellular calcium ion homeostasis, cellular response to DNA damage stimulus
related to Interactions · 28
Bcl-2 → BADBAX, BAK1, BCAP31, BCL2-like, BCL2L11, BECN1, BID, BIK, BMF, BNIP2, BNIP3, BNIPL, C-Raf, CAPN2, CASP8, Cdk1, HRK, IRS1, Myc, Noxa
Bgee · 20
Bcl-2 → Achilles tendon, aortic valve, ascending aorta, blood, caput epididymis, ciliary body, dorsal motor nucleus of vagus nerve, epithelium of colon, external globus pallidus, inferior olivary nucleus, internal globus pallidus, iris, lumbar spinal ganglion, mesenteric lymph nodes, optic nerve, Rostral migratory stream, superficial temporal artery, trigeminal ganglion, vas deferens, vestibular membrane of cochlear duct
RNA expression pattern · 20
Bcl-2 → Achilles tendon, aortic valve, ascending aorta, blood, caput epididymis, ciliary body, dorsal motor nucleus of vagus nerve, epithelium of colon, external globus pallidus, inferior olivary nucleus, internal globus pallidus, iris, lumbar spinal ganglion, mesenteric lymph nodes, optic nerve, Rostral migratory stream, superficial temporal artery, trigeminal ganglion, vas deferens, vestibular membrane of cochlear duct
related to External links · 16
Bcl-2 → Bcl-2 Family, BCL2, Genes, Human Apoptosis, Human BCL2, Medicine Medical Subject Headings, MeSH, National Library, Overview, P10415, PDB, PDBe-KB, Proteins, The Bcl-2 Family DatabaseThe, UCSC Genome Browser, UniProt
related to Venetoclax (ABT-199) · 16
Bcl-2 → Abbvie, ABT-199, April, Bcl-w, Bcl-xL, BH3-mimetic, Clinical, CLL, Dec, Due, FDA, Good, In June, It, This, US FDA
related to ABT-737 and navitoclax (ABT-263) · 15
Bcl-2 → A1, Abbott Laboratories, ABT-263, ABT-737, B-cell, Bcl-w, Bcl-xL, Because, BH3, In, Mcl-1, SCLC, SMI, This, While
related to Function · 10
Bcl-2 → Additionally, Bak, Bax, BCL-2/Xl, BCL-Xl, BH3-only, ROS, The, There, These
related to Auto-immune diseases · 9
Bcl-2 → AICD, Apoptosis, Bim, Due, In, Other, Researchers, The, When
see also · 9
Bcl-2 → ApoptosomeBcl-2, BAK, BAX, Bcl-2-associated, BH3, BID, CaspasesNoxaMicrophthalmia-associated, PUMA, Senolytics

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Important terminology

apoptosis lymphoma cell bcl2 gene 18 human proteins cancer bp abt-737 protein bcl-xl cells chr band family chromosome venetoclax death

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Bcl-2AliasesBCL2, Bcl-2, PPP1R50, B-cell CLL/lymphoma 2, apoptosis regulator, BCL2 apoptosis regulator, Genes, bcl-21.00infobox
Bcl-2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1G5M, 1GJH, 1YSW, 2O21, 2O22, 2O2F, 2W3L, 2XA0, 4AQ3, 4IEH, 4LVT, 4LXD, 4MAN, 5AGW, 5AGX, 5FCG1.00infobox
Bcl-2Band18q21.331.00infobox
Bcl-2Band1 E2.1|1 49.76 cM1.00infobox
Bcl-2Bgeedorsal motor nucleus of vagus nerve1.00infobox
Bcl-2Bgeesuperficial temporal artery1.00infobox
Bcl-2BgeeAchilles tendon1.00infobox
Bcl-2Bgeeepithelium of colon1.00infobox
Bcl-2Bgeeinferior olivary nucleus1.00infobox
Bcl-2Bgeeoptic nerve1.00infobox
Bcl-2Bgeetrigeminal ganglion1.00infobox
Bcl-2Bgeeinternal globus pallidus1.00infobox
Bcl-2Bgeeexternal globus pallidus1.00infobox
Bcl-2Bgeecaput epididymis1.00infobox
Bcl-2Bgeeascending aorta1.00infobox
Bcl-2Bgeeaortic valve1.00infobox
Bcl-2BgeeRostral migratory stream1.00infobox
Bcl-2Bgeevestibular membrane of cochlear duct1.00infobox
Bcl-2Bgeeiris1.00infobox
Bcl-2Bgeelumbar spinal ganglion1.00infobox
Bcl-2Bgeemesenteric lymph nodes1.00infobox
Bcl-2Bgeeciliary body1.00infobox
Bcl-2Bgeeblood1.00infobox
Bcl-2Bgeevas deferens1.00infobox
Bcl-2BioGPSMore reference expression data1.00infobox
Bcl-2Chr.Chromosome 18 (human)1.00infobox
Bcl-2Chr.Chromosome 1 (mouse)1.00infobox
Bcl-2DatabasesNCBI: entry; OMA: entry1.00infobox
Bcl-2End63,320,128 bp1.00infobox
Bcl-2End106,642,004 bp1.00infobox

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