Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

CpG site

The CpG sites or CG sites are regions of DNA where a cytosine nucleotide is followed by a guanine nucleotide in the linear sequence of bases along its 5' → 3' direction. CpG sites occur with high frequency in genomic regions called CpG islands. CpGs are the common unit of methylation because their information is double stranded (the GpC complement is…

Characters, Regions & Measurement

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Research this topic

Explore the main themes, entities and connections around CpG site. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

CpG characteristics

CpG islands

Methylation, silencing, cancer, and aging

Role of CpG sites in memory

CpG loss

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

CpG site

Nodes113
Edges112
Triples73
Avg. degree1.98
Density0.017699
Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

CpG site

Top relations

related to Demethylation at CpG sites requires ROS activity · 25
CpG site → AID/APOBEC, AP, As, BER, CpG, Cyt, DNA, In, MBD4, Nei-Like DNA Glycosylase, NEIL1, OGG1, OHdG, Reactive, ROS, SMUG1, TDG, TET, TET1, TET2
related to CpG islands · 8
CpG site → Because, CG, CpG, CpGs, GC, Many, The, Though
related to CpG loss · 7
CpG site → CpG, DNA, Older, TEs, Therefore, This, Transposable Elements
related to Genome size and CpG ratio are negatively correlated · 7
CpG site → Cp, CpG, DNA, Selective, Since, TE's, There
related to Role of CpG sites in memory · 7
CpG site → As, CpG, DNA, Duke, In, Most, Neuron DNA
related to Methylation of CpG islands stably silences genes · 5
CpG site → CpG, DNA, In, Silencing, The
related to Under-representation caused by high mutation rate · 5
CpG site → CpG, For, GC, The, This
related to Methylation of CpG sites with age · 3
CpG site → CpG, DNA, Since
see also · 2
CpG site → CpG, TLR9

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cpg dna methylation genes islands promoters sites methylated cancers cytosine gene promoter repair cancer genome expression loss guanine sequence cytosines

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Alu repeatsinstance ofthe number of CpG dinucleotides is much lower than would be expected.A 2002 study revised the rules of CpG island prediction to exclude other GC-rich genomic sequences0.80text
microRNAs.Methylation of CpG islands stably silences genesIn humansinstance ofCpG islands also occur frequently in promoters for functional noncoding RNAs0.80text
DNA methylation occurs at the 5 position of the pyrimidine ring of the cytosine residues within CpG sites to form 5-methylcytosinesinstance ofCpG islands also occur frequently in promoters for functional noncoding RNAs0.80text
microRNAsinstance ofCpG islands also occur frequently in promoters for functional noncoding RNAs0.80text
CpG siterelated to CpG islandsCpG0.60section
CpG siterelated to CpG islandsCG0.60section
CpG siterelated to CpG islandsThough0.60section
CpG siterelated to CpG islandsGC0.60section
CpG siterelated to CpG islandsThe0.60section
CpG siterelated to CpG islandsCpGs0.60section
CpG siterelated to CpG islandsMany0.60section
CpG siterelated to CpG islandsBecause0.60section

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

    Connections between topic areas Semantic bridges

    Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

    Min side: 3
    For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.