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MiR-155

MiR-155 is a microRNA that in humans is encoded by the MIR155 host gene or MIR155HG. MiR-155 plays a role in various physiological and pathological processes. Exogenous molecular control in vivo of miR-155 expression may inhibit malignant growth, viral infections, and enhance the progression of cardiovascular diseases.

Physiological roles, Clinical significance & Targets

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Key facts & relationships

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Domain
Eukaryota;
miRBase family
MIPF0000157
PDB structures
PDBe
Rfam
RF00731
RNA type
microRNA
Symbol
miR-155

Topics to explore

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Overview

Discovery

Biogenesis

Evolutionary conservation

Tissue distribution

Targets

Physiological roles

Activity and phenotypes

Clinical significance

Advanced semantic analysis

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Map overview Semantic statistics

MiR-155

Nodes147
Edges146
Triples194
Avg. degree1.99
Density0.013605
Components1

How this topic connects Entity context

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MiR-155

Top relations

related to Immune system · 32
MiR-155 → AP-1, Besides, DCs, Downstream, Furthermore, I/JNK/NF-κB, IFN-β, Importantly, In, Indeed, INPP5D, Its, LPS, MIR155HG, NF-κB, NF-κB-mediated, Once, PAMPs, Raw264, SHIP1
related to Hematopoiesis · 29
MiR-155 → Additionally, B-cells, B-lymphoid/T-lymphoid, CD34, CLP, CLPs, CMP, CMPs, During, Finally, Given, Hematopoiesis, HOXA9, HSPCs, Hu, IL-2, In, It, MIR155HG, PU
related to Targets · 25
MiR-155 → AICDA, Although, BACH1, Bioinformatic, CEBPβ, ETS1, FADD, Figures, IKBKE, IL17RB, INPP5D, IRAK3, JARID2, June, MYD88, PCCD4, RIPK1, SHIP-1, SOCS, SPI1
related to Biogenesis · 18
MiR-155 → Ago, Argonaute, DGCR8, Dicer, DiGeorge, Drosha, Figure, Following, Following Dicer, In, Once, ORF, RISC, RNA, RNA-induced, RNase III, The MIR155HG RNA, This
related to Tissue distribution · 11
MiR-155 → Additionally, Although, B-cells, Even, Landgraf, Northern, PCR, RNA, Sequence, T-cells, Together
related to Cardiovascular · 10
MiR-155 → AT1R, Defective, Furthermore, II, II-related, In, SNP, This, Transfection, UTR
related to Cancer · 9
MiR-155 → DNA Mismatch Repair, HNPCC, Inactivation, LS, Lynch Syndrome, MMR, Over-silencing, TP53INP1, Tumour Protein-53-induced-nuclear-protein1
related to DNA viruses · 9
MiR-155 → EBV, EBV-infected, Humans-Epstein-Barr Virus, In DNA, K12-11, Kaposi's-sarcoma-associated Herpesvirus, MDV-1, MDV-2, Viruses
related to Immunity · 8
MiR-155 → Activated, AID, B-lymphocytes, Details, In, Rodriguez, The, UTR
related to Inflammation · 8
MiR-155 → CNS-resident, CTLA-4, In, In Autoimmune, Inflammatory, It, Overexpression, TNF-α

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Important terminology

expression mir-155-5p cells mir155hg mirna rna also human may mrna target found role inflammation pre-mir-155 conserved protein levels macrophages immune

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
MiR-155DomainEukaryota;1.00infobox
MiR-155miRBase familyMIPF00001571.00infobox
MiR-155PDB structuresPDBe1.00infobox
MiR-155RfamRF007311.00infobox
MiR-155RNA typemicroRNA1.00infobox
MiR-155SymbolmiR-1551.00infobox
MiR-155is amicroRNA that in humans is encoded by the MIR155 host gene or MIR155HG0.90text
Toll-like receptorsinstance ofby pattern recognition receptors0.80text
TLR3 ligand polyinstance ofSupport for a role of AP-1 in MIR155HG activation comes from studies using stimuli relevant to viral infection0.80text
TNF-α involve macrophages with components that include miR-155. miR-155 is overexpressed in atopic dermatitisinstance ofa protein that was found to be involved in B Cell malignancies and to be controlled by miR-155.InflammationInflammatory responses to triggers0.80text
contributes to chronic skin inflammation by increasing the proliferative response of Tinstance ofa protein that was found to be involved in B Cell malignancies and to be controlled by miR-155.InflammationInflammatory responses to triggers0.80text
rheumatoid arthritisinstance ofIn Autoimmune disorders0.80text

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