MiR-155

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MiR-155 topic overview

The analysis highlights Physiological roles, Clinical significance and Targets as prominent areas in the source structure around MiR-155.

Related topics: 137
Source areas: 9
Connected nodes: 146
Extracted relationships: 194
Concept neighborhoods: 26
Bridge connections: 146

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Physiological roles · 34 topics

Clinical significance · 21 topics

Targets · 19 topics

Biogenesis · 17 topics

Overview · 17 topics

Tissue distribution · 12 topics

Activity and phenotypes · 8 topics

Discovery · 8 topics

Evolutionary conservation · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Domain: Eukaryota;
miRBase family: MIPF0000157
PDB structures: PDBe
Rfam: RF00731
RNA type: microRNA
Symbol: miR-155

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

MicroRNA
Gene
Physiological Physiology
Pathological Pathology
Exogenous
In vivo
Malignant
Viral Virus
Cardiovascular
IgG1 Immunoglobulin G
IgM Immunoglobulin M
Pu.1-protein SPI1
Affinity Dissociation constant
Germinal center
Affinity maturation
Apoptotic termination Apoptosis
Bcl-2 protein Bcl-2

Discovery

Activity and phenotypes

Cardiovascular diseases Cardiovascular disease
Genomic instability Genome instability
Differentiation Cellular differentiation
Diabetes mellitus
Mutations Mutation
Malignant Malignant transformation
AID Activation-induced (cytidine) deaminase
Chromosomal translocations Chromosomal translocation

Clinical significance

Angiotensin II Angiotensin
AT1R Angiotensin II receptor type 1
Hypertension
SNP polymorphism Single-nucleotide polymorphism
Lesions Lesion
Macrophages Macrophage
Dendritic cells Dendritic cell
Immune system
TNF-α Tumor necrosis factor-alpha
Autoimmune disorders Autoimmune disease
DNA viruses DNA virus
Herpesviruses Herpes simplex virus
EBV Epstein-Barr virus
Adenoviruses Adenoviridae
Kaposi's-sarcoma-associated Herpesvirus Kaposi's sarcoma-associated herpesvirus
Orthologous Homology (biology)
TP53INP1
Adenocarcinomas Adenocarcinoma
MMR DNA mismatch repair
Lynch Syndrome Hereditary nonpolyposis colorectal cancer
Expression profiles Gene expression profiling

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How MiR-155 connects Entity context

The extracted context around MiR-155 shows recurring relationship patterns in the source. For example, MiR-155 → AP-1, Besides, DCs, Downstream, Furthermore, I/JNK/NF-κB, IFN-β, Importantly, In, Indeed, INPP5D, Its, LPS, MIR155HG, NF-κB, NF-κB-mediated, Once, PAMPs, Raw264, SHIP1 Another extracted example is MiR-155 → Additionally, B-cells, B-lymphoid/T-lymphoid, CD34, CLP, CLPs, CMP, CMPs, During, Finally, Given, Hematopoiesis, HOXA9, HSPCs, Hu, IL-2, In, It, MIR155HG, PU. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

related to Immune system · 32

MiR-155 → AP-1, Besides, DCs, Downstream, Furthermore, I/JNK/NF-κB, IFN-β, Importantly, In, Indeed, INPP5D, Its, LPS, MIR155HG, NF-κB, NF-κB-mediated, Once, PAMPs, Raw264, SHIP1

related to Hematopoiesis · 29

MiR-155 → Additionally, B-cells, B-lymphoid/T-lymphoid, CD34, CLP, CLPs, CMP, CMPs, During, Finally, Given, Hematopoiesis, HOXA9, HSPCs, Hu, IL-2, In, It, MIR155HG, PU

related to Targets · 25

MiR-155 → AICDA, Although, BACH1, Bioinformatic, CEBPβ, ETS1, FADD, Figures, IKBKE, IL17RB, INPP5D, IRAK3, JARID2, June, MYD88, PCCD4, RIPK1, SHIP-1, SOCS, SPI1

related to Biogenesis · 18

MiR-155 → Ago, Argonaute, DGCR8, Dicer, DiGeorge, Drosha, Figure, Following, Following Dicer, In, Once, ORF, RISC, RNA, RNA-induced, RNase III, The MIR155HG RNA, This

related to Tissue distribution · 11

MiR-155 → Additionally, Although, B-cells, Even, Landgraf, Northern, PCR, RNA, Sequence, T-cells, Together

related to Cardiovascular · 10

MiR-155 → AT1R, Defective, Furthermore, II, II-related, In, SNP, This, Transfection, UTR

related to Cancer · 9

MiR-155 → DNA Mismatch Repair, HNPCC, Inactivation, LS, Lynch Syndrome, MMR, Over-silencing, TP53INP1, Tumour Protein-53-induced-nuclear-protein1

related to DNA viruses · 9

MiR-155 → EBV, EBV-infected, Humans-Epstein-Barr Virus, In DNA, K12-11, Kaposi's-sarcoma-associated Herpesvirus, MDV-1, MDV-2, Viruses

related to Immunity · 8

MiR-155 → Activated, AID, B-lymphocytes, Details, In, Rodriguez, The, UTR

related to Inflammation · 8

MiR-155 → CNS-resident, CTLA-4, In, In Autoimmune, Inflammatory, It, Overexpression, TNF-α

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

expression mir-155-5p cells mir155hg mirna rna also human may mrna target found role inflammation pre-mir-155 conserved protein levels macrophages immune

MiR-155 relationships Subject–Predicate–Object triples

TTTA extracted 194 structured relationships around MiR-155. Examples in this analysis include MiR-155 → Domain → Eukaryota; and MiR-155 → miRBase family → MIPF0000157. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
MiR-155	Domain	Eukaryota;	1.00	infobox
MiR-155	miRBase family	MIPF0000157	1.00	infobox
MiR-155	PDB structures	PDBe	1.00	infobox
MiR-155	Rfam	RF00731	1.00	infobox
MiR-155	RNA type	microRNA	1.00	infobox
MiR-155	Symbol	miR-155	1.00	infobox
MiR-155	is a	microRNA that in humans is encoded by the MIR155 host gene or MIR155HG	0.90	text
Toll-like receptors	instance of	by pattern recognition receptors	0.80	text
TLR3 ligand poly	instance of	Support for a role of AP-1 in MIR155HG activation comes from studies using stimuli relevant to viral infection	0.80	text
TNF-α involve macrophages with components that include miR-155. miR-155 is overexpressed in atopic dermatitis	instance of	a protein that was found to be involved in B Cell malignancies and to be controlled by miR-155.InflammationInflammatory responses to triggers	0.80	text
contributes to chronic skin inflammation by increasing the proliferative response of T	instance of	a protein that was found to be involved in B Cell malignancies and to be controlled by miR-155.InflammationInflammatory responses to triggers	0.80	text
rheumatoid arthritis	instance of	In Autoimmune disorders	0.80	text

Related concept clusters Concept neighborhoods

The concept neighborhoods around MiR-155 bring nearby vocabulary together. In this analysis, examples include Expression, Cells and Target. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

MiR-155
- Expression
- Cells
- Target
- Protein
- Also
- Cancer
- Immune
- Levels
- Inflammation
- Cardiovascular
- At1r
- Growth
mir-155
- Expression
- Cells
- Target
- Protein
- Also
- Cancer
- Immune
- Levels
- Inflammation
- Cardiovascular
- At1r
- Growth
plasmacytoid dendritic cells
- Expression
- Mir-155
- Mir-155-5p
- Mirna
- Macrophages
- Cell
- Levels
- Found
- Differentiation
- Hematopoiesis
- Including
- Protein
hematopoietic stem-progenitor cells
- Expression
- Mir-155
- Mir-155-5p
- Mirna
- Macrophages
- Cell
- Levels
- Found
- Differentiation
- Hematopoiesis
- Including
- Protein
dendritic cells
- Expression
- Mir-155
- Mir-155-5p
- Mirna
- Macrophages
- Cell
- Levels
- Found
- Differentiation
- Hematopoiesis
- Including
- Protein
expression profiles
- Cells
- Mir-155
- May
- Mir-155-5p
- Mir155hg
- Mirna
- Also
- Growth
- Viral
- Activated
- Including
- Levels
gene
- Mir155hg
- May
- Cardiovascular
- Cancer
- Hematopoiesis
- Sequence
- Targets
- Viral
- Activated
- Activation
- Macrophages
- Cell
cardiovascular
- Cancer
- Inflammation
- Also
- At1r
- Differentiation
- Gene
- Growth
- Hematopoiesis
- Sequence
- Targets
- Viral
- Activated

Connections between topic areas Semantic bridges

For MiR-155, one of the stronger structural bridges in this analysis connects MiR-155 with Physiological roles. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

MiR-155 — Physiological roles · splits 112 ⟂ 35

MiR-155 — Clinical significance · splits 125 ⟂ 22

MiR-155 — Targets · splits 127 ⟂ 20

MiR-155 — Overview · splits 129 ⟂ 18

MiR-155 — Biogenesis · splits 129 ⟂ 18

MiR-155 — Tissue distribution · splits 134 ⟂ 13

MiR-155 — Discovery · splits 138 ⟂ 9

MiR-155 — Activity and phenotypes · splits 138 ⟂ 9

Map overview Semantic statistics

MiR-155

Nodes147

Edges146

Triples194

Avg. degree1.99

Density0.013605

Components1

Source & methodology

TTTA analyzes the structure around MiR-155 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Physiological roles, Clinical significance & Targets, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — MiR-155 · EN edition · Analysis: TopicsToTalkAbout