CTCF

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CTCF topic overview

The analysis highlights Function, Observed activity and DNA binding as prominent areas in the source structure around CTCF.

Related topics: 28
Source areas: 6
Connected nodes: 34
Extracted relationships: 163
Concept neighborhoods: 16
Bridge connections: 34

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 6 topics

Overview · 6 topics

DNA binding · 5 topics

Observed activity · 5 topics

Protein-protein interactions · 5 topics

Discovery · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: CTCF, MRD21, CCCTC-binding factor, FAP108, CFAP108
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1X6H, 2CT1
Band: 16q22.1 · 8|8 D3
Bgee: ventricular zone · ganglionic eminence · thymus · cerebellar vermis · paraflocculus of cerebellum
BioGPS: More reference expression data
Chr.: Chromosome 16 (human) · Chromosome 8 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Observed activity

DNA binding

Consensus sequence
IUPAC notation Nucleic acid notation
Zinc fingers Zinc finger
CpG methylation DNA methylation
Nucleosome

Protein-protein interactions

Homodimers Protein dimer
Interact Protein-protein interaction
Y box binding protein 1
Chd4
SMARCA5

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CTCF connects Entity context

The extracted context around CTCF shows recurring relationship patterns in the source. For example, CTCF → chromatin binding, chromatin insulator sequence binding, chromatin organization, chromosome, chromosome segregation, chromosome, centromeric region, condensed chromosome, DNA binding, DNA methylation, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, maintenance of DNA methylation, metal ion binding, negative regulation of cell population proliferation, negative regulation of gene expression, negative regulation of transcription by RNA polymerase II, negative regulation of transcription, DNA-templated, nucleic acid binding Another extracted example is CTCF → bone marrow, cerebellar vermis, epiblast, ganglionic eminence, genital tubercle, lymph node, neural layer of retina, otic placode, otic vesicle, paraflocculus of cerebellum, Rostral migratory stream, saccule, Skeletal muscle tissue of rectus abdominis, skin of thigh, tail of embryo, thymus, trabecular bone, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 39

CTCF → chromatin binding, chromatin insulator sequence binding, chromatin organization, chromosome, chromosome segregation, chromosome, centromeric region, condensed chromosome, DNA binding, DNA methylation, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, maintenance of DNA methylation, metal ion binding, negative regulation of cell population proliferation, negative regulation of gene expression, negative regulation of transcription by RNA polymerase II, negative regulation of transcription, DNA-templated, nucleic acid binding

Bgee · 18

CTCF → bone marrow, cerebellar vermis, epiblast, ganglionic eminence, genital tubercle, lymph node, neural layer of retina, otic placode, otic vesicle, paraflocculus of cerebellum, Rostral migratory stream, saccule, Skeletal muscle tissue of rectus abdominis, skin of thigh, tail of embryo, thymus, trabecular bone, ventricular zone

RNA expression pattern · 18

related to Regulation of chromatin architecture · 14

CTCF → Cohesin, Computer, CTCF-CTCF, DNA, DNA-bound CTCF, In, N-terminal, Recent, Stable CTCF-CTCF, Structural, TAD, TADs, The, This

related to DNA binding · 12

CTCF → CpG, CTCF's, CTCF-binding, DNA, In, IUPAC, Methylation, More, On, RCCASNAGRKGGCRS, The, This

related to Function · 9

CTCF → Although CTCF, DNA, DNA-bound CTCF, In, Loop, SMC, TADs, The, Through

related to External links · 7

CTCF → CCCTC-binding, FactorBookCTCFHuman CTCF, Group, Medicine Medical Subject Headings, MeSH, National Library, UCSC Genome Browser

related to Transcriptional regulation · 5

CTCF → DMR1, H-19, ICR, MAR3, The

related to Protein-protein interactions · 4

CTCF → Chd4, DNA, SMARCA5, Snf2h

related to Discovery · 3

CTCF → CCCTC, CCCTC-Binding, This

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

binding chromatin gene human dna factor cohesin role bp chromosome activity extrusion also protein chr band regulation loops loop barrier

CTCF relationships Subject–Predicate–Object triples

TTTA extracted 163 structured relationships around CTCF. Examples in this analysis include CTCF → Aliases → CTCF, MRD21, CCCTC-binding factor, FAP108, CFAP108 and CTCF → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1X6H, 2CT1. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
CTCF	Aliases	CTCF, MRD21, CCCTC-binding factor, FAP108, CFAP108	1.00	infobox
CTCF	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1X6H, 2CT1	1.00	infobox
CTCF	Band	16q22.1	1.00	infobox
CTCF	Band	8\|8 D3	1.00	infobox
CTCF	Bgee	ventricular zone	1.00	infobox
CTCF	Bgee	ganglionic eminence	1.00	infobox
CTCF	Bgee	thymus	1.00	infobox
CTCF	Bgee	cerebellar vermis	1.00	infobox
CTCF	Bgee	paraflocculus of cerebellum	1.00	infobox
CTCF	Bgee	lymph node	1.00	infobox
CTCF	Bgee	trabecular bone	1.00	infobox
CTCF	Bgee	Skeletal muscle tissue of rectus abdominis	1.00	infobox
CTCF	Bgee	bone marrow	1.00	infobox
CTCF	Bgee	skin of thigh	1.00	infobox
CTCF	Bgee	Rostral migratory stream	1.00	infobox
CTCF	Bgee	neural layer of retina	1.00	infobox
CTCF	Bgee	tail of embryo	1.00	infobox
CTCF	Bgee	saccule	1.00	infobox
CTCF	Bgee	genital tubercle	1.00	infobox
CTCF	Bgee	otic placode	1.00	infobox
CTCF	Bgee	otic vesicle	1.00	infobox
CTCF	Bgee	epiblast	1.00	infobox
CTCF	BioGPS	More reference expression data	1.00	infobox
CTCF	Chr.	Chromosome 16 (human)	1.00	infobox
CTCF	Chr.	Chromosome 8 (mouse)	1.00	infobox
CTCF	Databases	NCBI: entry; OMA: entry	1.00	infobox
CTCF	End	67,639,177 bp	1.00	infobox
CTCF	End	105,682,922 bp	1.00	infobox
CTCF	Ensembl	ENSG00000102974	1.00	infobox
CTCF	Entrez	10664	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CTCF bring nearby vocabulary together. In this analysis, examples include Binding, Chromatin and Role. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

CTCF
- Binding
- Chromatin
- Role
- Gene
- Dna
- Also
- Activity
- Barrier
- Sites
- Cohesin
- Extrusion
- Genomic
ctcf
- Binding
- Chromatin
- Role
- Gene
- Dna
- Also
- Activity
- Barrier
- Sites
- Cohesin
- Extrusion
- Genomic
transcription factor
- Protein
- Rna
- Transcription
- Gene
- Transcriptional
- Architecture
- Function
- Location
- Binding
- Bp
- Chr
- Chromosome
gene
- Expression
- Location
- Human
- Regulation
- Bp
- Chr
- Chromosome
- Activity
- Protein
- Binding
- Rna
- Transcriptional
transcriptional regulation
- Architecture
- Ccctc-binding
- Regulation
- Rna
- Transcriptional
- Human
- Activity
- Cell
- Expression
- Function
- Location
- Bp
chromatin
- Loops
- Architecture
- Mechanism
- Ctcf
- Regulation
- Dna
- Loop
- Extrusion
- Role
- Chromosome
- Cohesin
- Factor
insulin-like growth factor 2
- Protein
- Transcription
- Gene
- Rna
- Transcriptional
- Architecture
- Function
- Location
- Binding
- Bp
- Chr
- Chromosome
y box binding protein 1
- Factor
- Ctcf
- Ccctc-binding
- Transcription
- Cell
- Shown
- Gene
- Dna
- Methylation
- Sequence
- Binding
- Protein

Connections between topic areas Semantic bridges

For CTCF, one of the stronger structural bridges in this analysis connects CTCF with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

CTCF — Overview · splits 28 ⟂ 7

CTCF — Function · splits 28 ⟂ 7

CTCF — Observed activity · splits 29 ⟂ 6

CTCF — DNA binding · splits 29 ⟂ 6

CTCF — Protein-protein interactions · splits 29 ⟂ 6

Map overview Semantic statistics

CTCF

Nodes35

Edges34

Triples163

Avg. degree1.94

Density0.057143

Components1

Source & methodology

TTTA analyzes the structure around CTCF to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Observed activity & DNA binding, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CTCF · EN edition · Analysis: TopicsToTalkAbout