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CTCF

Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. CTCF is involved in many cellular processes, including transcriptional regulation, insulator activity, V(D)J recombination and regulation of chromatin architecture.

Function, Observed activity & DNA binding

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Aliases
CTCF, MRD21, CCCTC-binding factor, FAP108, CFAP108
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1X6H, 2CT1
Band
16q22.1 · 8|8 D3
Bgee
ventricular zone · ganglionic eminence · thymus · cerebellar vermis · paraflocculus of cerebellum
BioGPS
More reference expression data
Chr.
Chromosome 16 (human) · Chromosome 8 (mouse)

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Overview

Discovery

Function

Observed activity

DNA binding

Protein-protein interactions

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Map overview Semantic statistics

CTCF

Nodes35
Edges34
Triples163
Avg. degree1.94
Density0.057143
Components1

How this topic connects Entity context

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CTCF

Top relations

Gene ontology · 39
CTCF → chromatin binding, chromatin insulator sequence binding, chromatin organization, chromosome, chromosome segregation, chromosome, centromeric region, condensed chromosome, DNA binding, DNA methylation, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, maintenance of DNA methylation, metal ion binding, negative regulation of cell population proliferation, negative regulation of gene expression, negative regulation of transcription by RNA polymerase II, negative regulation of transcription, DNA-templated, nucleic acid binding
Bgee · 18
CTCF → bone marrow, cerebellar vermis, epiblast, ganglionic eminence, genital tubercle, lymph node, neural layer of retina, otic placode, otic vesicle, paraflocculus of cerebellum, Rostral migratory stream, saccule, Skeletal muscle tissue of rectus abdominis, skin of thigh, tail of embryo, thymus, trabecular bone, ventricular zone
RNA expression pattern · 18
CTCF → bone marrow, cerebellar vermis, epiblast, ganglionic eminence, genital tubercle, lymph node, neural layer of retina, otic placode, otic vesicle, paraflocculus of cerebellum, Rostral migratory stream, saccule, Skeletal muscle tissue of rectus abdominis, skin of thigh, tail of embryo, thymus, trabecular bone, ventricular zone
related to Regulation of chromatin architecture · 14
CTCF → Cohesin, Computer, CTCF-CTCF, DNA, DNA-bound CTCF, In, N-terminal, Recent, Stable CTCF-CTCF, Structural, TAD, TADs, The, This
related to DNA binding · 12
CTCF → CpG, CTCF's, CTCF-binding, DNA, In, IUPAC, Methylation, More, On, RCCASNAGRKGGCRS, The, This
related to Function · 9
CTCF → Although CTCF, DNA, DNA-bound CTCF, In, Loop, SMC, TADs, The, Through
related to External links · 7
CTCF → CCCTC-binding, FactorBookCTCFHuman CTCF, Group, Medicine Medical Subject Headings, MeSH, National Library, UCSC Genome Browser
related to Transcriptional regulation · 5
CTCF → DMR1, H-19, ICR, MAR3, The
related to Protein-protein interactions · 4
CTCF → Chd4, DNA, SMARCA5, Snf2h
related to Discovery · 3
CTCF → CCCTC, CCCTC-Binding, This

Important terminology Word statistics

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Important terminology

binding chromatin gene human dna factor cohesin role bp chromosome activity extrusion also protein chr band regulation loops loop barrier

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CTCFAliasesCTCF, MRD21, CCCTC-binding factor, FAP108, CFAP1081.00infobox
CTCFAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1X6H, 2CT11.00infobox
CTCFBand16q22.11.00infobox
CTCFBand8|8 D31.00infobox
CTCFBgeeventricular zone1.00infobox
CTCFBgeeganglionic eminence1.00infobox
CTCFBgeethymus1.00infobox
CTCFBgeecerebellar vermis1.00infobox
CTCFBgeeparaflocculus of cerebellum1.00infobox
CTCFBgeelymph node1.00infobox
CTCFBgeetrabecular bone1.00infobox
CTCFBgeeSkeletal muscle tissue of rectus abdominis1.00infobox
CTCFBgeebone marrow1.00infobox
CTCFBgeeskin of thigh1.00infobox
CTCFBgeeRostral migratory stream1.00infobox
CTCFBgeeneural layer of retina1.00infobox
CTCFBgeetail of embryo1.00infobox
CTCFBgeesaccule1.00infobox
CTCFBgeegenital tubercle1.00infobox
CTCFBgeeotic placode1.00infobox
CTCFBgeeotic vesicle1.00infobox
CTCFBgeeepiblast1.00infobox
CTCFBioGPSMore reference expression data1.00infobox
CTCFChr.Chromosome 16 (human)1.00infobox
CTCFChr.Chromosome 8 (mouse)1.00infobox
CTCFDatabasesNCBI: entry; OMA: entry1.00infobox
CTCFEnd67,639,177 bp1.00infobox
CTCFEnd105,682,922 bp1.00infobox
CTCFEnsemblENSG000001029741.00infobox
CTCFEntrez106641.00infobox

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