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HMGA2

High-mobility group AT-hook 2, also known as HMGA2, is a protein that, in humans, is encoded by the HMGA2 gene.

Clinical significance, Function & Interactions

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Clinical significance

25 related topics

Function

16 related topics

Interactions

4 related topics

Regulation by let-7

2 related topics

Key facts & relationships

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Aliases
HMGA2, BABL, HMGI-C, HMGIC, LIPO, STQTL9, high mobility group AT-hook 2, SRS5
Band
12q14.3 · 10 D2|10 67.94 cM
Bgee
sural nerve · embryo · stromal cell of endometrium · ventricular zone · cartilage tissue
BioGPS
n/a
Chr.
Chromosome 12 (human) · Chromosome 10 (mouse)
Databases
NCBI: entry; OMA: entry

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Overview

Function

Regulation by let-7

Clinical significance

Interactions

Advanced semantic analysis

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Map overview Semantic statistics

HMGA2

Nodes55
Edges54
Triples202
Avg. degree1.96
Density0.036364
Components1

How this topic connects Entity context

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HMGA2

Top relations

Gene ontology · 73
HMGA2 → 5'-deoxyribose-5-phosphate lyase activity, base-excision repair, C2H2 zinc finger domain binding, cAMP response element binding, cell cycle, cell division, chondrocyte differentiation, chondrocyte proliferation, chromatin, chromatin organization, chromosome breakage, chromosome condensation, DNA binding, DNA binding, bending, DNA-(apurinic or apyrimidinic site) endonuclease activity, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, DNA-dependent protein kinase activity, endodermal cell differentiation
Bgee · 20
HMGA2 → abdominal wall, amniotic fluid, buccal mucosa cell, cartilage tissue, embryo, endothelial cell of lymphatic vessel, ganglionic eminence, genital tubercle, hand, mandibular prominence, maxillary prominence, medullary collecting duct, primitive streak, retinal pigment epithelium, somite, stromal cell of endometrium, sural nerve, tail of embryo, testicle, ventricular zone
RNA expression pattern · 20
HMGA2 → abdominal wall, amniotic fluid, buccal mucosa cell, cartilage tissue, embryo, endothelial cell of lymphatic vessel, ganglionic eminence, genital tubercle, hand, mandibular prominence, maxillary prominence, medullary collecting duct, primitive streak, retinal pigment epithelium, somite, stromal cell of endometrium, sural nerve, tail of embryo, testicle, ventricular zone
related to Relationship with cancer · 15
HMGA2 → Artificial, As, DNA, Heightened, HMGA2's, HMGA2-high, However, Its, Many, The, These, This, To, UTR, Without
related to ERCC1 · 11
HMGA2 → As, Borrmann, DNA, ERCC1, HGMA2, Let-7, Overexpressed HMGA2, Reduction, See, The, These
related to Function · 8
HMGA2 → Alternate, DNA-binding, HMG, Homologous, Identification, Mus, The, This
related to Chromatin immunoprecipitation · 7
HMGA2 → Genome-wide, MAPK, Notch, TGF, The, VEGF, Wnt
related to External links · 7
HMGA2 → Ellensburg, Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, United States National Library
related to Base excision repair pathway · 6
HMGA2 → An, AP, BER, DNA, In, Increased
related to Non-homologous end joining DNA repair · 5
HMGA2 → DNA, DNA-PKcs, NHEJ-mediated DNA, Overexpression, These

Important terminology Word statistics

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Important terminology

protein let-7 gene human expression dna also ercc1 bp cancers cancer chr band repair mrna function chromosome 12 end mouse

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
HMGA2AliasesHMGA2, BABL, HMGI-C, HMGIC, LIPO, STQTL9, high mobility group AT-hook 2, SRS51.00infobox
HMGA2Band12q14.31.00infobox
HMGA2Band10 D2|10 67.94 cM1.00infobox
HMGA2Bgeesural nerve1.00infobox
HMGA2Bgeeembryo1.00infobox
HMGA2Bgeestromal cell of endometrium1.00infobox
HMGA2Bgeeventricular zone1.00infobox
HMGA2Bgeecartilage tissue1.00infobox
HMGA2Bgeeganglionic eminence1.00infobox
HMGA2Bgeetesticle1.00infobox
HMGA2Bgeeretinal pigment epithelium1.00infobox
HMGA2Bgeebuccal mucosa cell1.00infobox
HMGA2Bgeeamniotic fluid1.00infobox
HMGA2Bgeegenital tubercle1.00infobox
HMGA2Bgeeendothelial cell of lymphatic vessel1.00infobox
HMGA2Bgeetail of embryo1.00infobox
HMGA2Bgeeabdominal wall1.00infobox
HMGA2Bgeemaxillary prominence1.00infobox
HMGA2Bgeemandibular prominence1.00infobox
HMGA2Bgeeprimitive streak1.00infobox
HMGA2Bgeesomite1.00infobox
HMGA2Bgeehand1.00infobox
HMGA2Bgeemedullary collecting duct1.00infobox
HMGA2BioGPSn/a1.00infobox
HMGA2Chr.Chromosome 12 (human)1.00infobox
HMGA2Chr.Chromosome 10 (mouse)1.00infobox
HMGA2DatabasesNCBI: entry; OMA: entry1.00infobox
HMGA2End65,966,291 bp1.00infobox
HMGA2End120,312,374 bp1.00infobox
HMGA2EnsemblENSG000001499481.00infobox

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