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HMGA2: Clinical significance, Function & Interactions

High-mobility group AT-hook 2, also known as HMGA2, is a protein that, in humans, is encoded by the HMGA2 gene.

Language: English [EN]
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HMGA2 topic overview

The analysis highlights Clinical significance, Function and Interactions as prominent areas in the source structure around HMGA2.

Related topics
49
Source areas
5
Connected nodes
54
Extracted relationships
202
Concept neighborhoods
19
Bridge connections
54

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 25 topics
Function · 16 topics
Interactions · 4 topics
Overview · 2 topics
Regulation by let-7 · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
HMGA2, BABL, HMGI-C, HMGIC, LIPO, STQTL9, high mobility group AT-hook 2, SRS5
Band
12q14.3 · 10 D2|10 67.94 cM
Bgee
sural nerve · embryo · stromal cell of endometrium · ventricular zone · cartilage tissue
BioGPS
n/a
Chr.
Chromosome 12 (human) · Chromosome 10 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Regulation by let-7

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How HMGA2 connects Entity context

The extracted context around HMGA2 shows recurring relationship patterns in the source. For example, HMGA2 → 5'-deoxyribose-5-phosphate lyase activity, base-excision repair, C2H2 zinc finger domain binding, cAMP response element binding, cell cycle, cell division, chondrocyte differentiation, chondrocyte proliferation, chromatin, chromatin organization, chromosome breakage, chromosome condensation, DNA binding, DNA binding, bending, DNA-(apurinic or apyrimidinic site) endonuclease activity, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, DNA-dependent protein kinase activity, endodermal cell differentiation Another extracted example is HMGA2 → abdominal wall, amniotic fluid, buccal mucosa cell, cartilage tissue, embryo, endothelial cell of lymphatic vessel, ganglionic eminence, genital tubercle, hand, mandibular prominence, maxillary prominence, medullary collecting duct, primitive streak, retinal pigment epithelium, somite, stromal cell of endometrium, sural nerve, tail of embryo, testicle, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

HMGA2

Top relations

Gene ontology · 73
HMGA2 → 5'-deoxyribose-5-phosphate lyase activity, base-excision repair, C2H2 zinc finger domain binding, cAMP response element binding, cell cycle, cell division, chondrocyte differentiation, chondrocyte proliferation, chromatin, chromatin organization, chromosome breakage, chromosome condensation, DNA binding, DNA binding, bending, DNA-(apurinic or apyrimidinic site) endonuclease activity, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, DNA-dependent protein kinase activity, endodermal cell differentiation
Bgee · 20
HMGA2 → abdominal wall, amniotic fluid, buccal mucosa cell, cartilage tissue, embryo, endothelial cell of lymphatic vessel, ganglionic eminence, genital tubercle, hand, mandibular prominence, maxillary prominence, medullary collecting duct, primitive streak, retinal pigment epithelium, somite, stromal cell of endometrium, sural nerve, tail of embryo, testicle, ventricular zone
RNA expression pattern · 20
HMGA2 → abdominal wall, amniotic fluid, buccal mucosa cell, cartilage tissue, embryo, endothelial cell of lymphatic vessel, ganglionic eminence, genital tubercle, hand, mandibular prominence, maxillary prominence, medullary collecting duct, primitive streak, retinal pigment epithelium, somite, stromal cell of endometrium, sural nerve, tail of embryo, testicle, ventricular zone
related to Relationship with cancer · 15
HMGA2 → Artificial, As, DNA, Heightened, HMGA2's, HMGA2-high, However, Its, Many, The, These, This, To, UTR, Without
related to ERCC1 · 11
HMGA2 → As, Borrmann, DNA, ERCC1, HGMA2, Let-7, Overexpressed HMGA2, Reduction, See, The, These
related to Function · 8
HMGA2 → Alternate, DNA-binding, HMG, Homologous, Identification, Mus, The, This
related to Chromatin immunoprecipitation · 7
HMGA2 → Genome-wide, MAPK, Notch, TGF, The, VEGF, Wnt
related to External links · 7
HMGA2 → Ellensburg, Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, United States National Library
related to Base excision repair pathway · 6
HMGA2 → An, AP, BER, DNA, In, Increased
related to Non-homologous end joining DNA repair · 5
HMGA2 → DNA, DNA-PKcs, NHEJ-mediated DNA, Overexpression, These

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein let-7 gene human expression dna also ercc1 bp cancers cancer chr band repair mrna function chromosome 12 end mouse

HMGA2 relationships Subject–Predicate–Object triples

TTTA extracted 202 structured relationships around HMGA2. Examples in this analysis include HMGA2 → Aliases → HMGA2, BABL, HMGI-C, HMGIC, LIPO, STQTL9, high mobility group AT-hook 2, SRS5 and HMGA2 → Band → 12q14.3. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
HMGA2AliasesHMGA2, BABL, HMGI-C, HMGIC, LIPO, STQTL9, high mobility group AT-hook 2, SRS51.00infobox
HMGA2Band12q14.31.00infobox
HMGA2Band10 D2|10 67.94 cM1.00infobox
HMGA2Bgeesural nerve1.00infobox
HMGA2Bgeeembryo1.00infobox
HMGA2Bgeestromal cell of endometrium1.00infobox
HMGA2Bgeeventricular zone1.00infobox
HMGA2Bgeecartilage tissue1.00infobox
HMGA2Bgeeganglionic eminence1.00infobox
HMGA2Bgeetesticle1.00infobox
HMGA2Bgeeretinal pigment epithelium1.00infobox
HMGA2Bgeebuccal mucosa cell1.00infobox
HMGA2Bgeeamniotic fluid1.00infobox
HMGA2Bgeegenital tubercle1.00infobox
HMGA2Bgeeendothelial cell of lymphatic vessel1.00infobox
HMGA2Bgeetail of embryo1.00infobox
HMGA2Bgeeabdominal wall1.00infobox
HMGA2Bgeemaxillary prominence1.00infobox
HMGA2Bgeemandibular prominence1.00infobox
HMGA2Bgeeprimitive streak1.00infobox
HMGA2Bgeesomite1.00infobox
HMGA2Bgeehand1.00infobox
HMGA2Bgeemedullary collecting duct1.00infobox
HMGA2BioGPSn/a1.00infobox
HMGA2Chr.Chromosome 12 (human)1.00infobox
HMGA2Chr.Chromosome 10 (mouse)1.00infobox
HMGA2DatabasesNCBI: entry; OMA: entry1.00infobox
HMGA2End65,966,291 bp1.00infobox
HMGA2End120,312,374 bp1.00infobox
HMGA2EnsemblENSG000001499481.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around HMGA2 bring nearby vocabulary together. In this analysis, examples include Let-7, Expression and Dna. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • HMGA2
    • Let-7
    • Expression
    • Dna
    • Protein
    • Human
    • Repair
    • Cancer
    • Chromatin
    • Development
    • Regulation
    • Transcription
    • Function
  • hmga2
    • Let-7
    • Expression
    • Dna
    • Protein
    • Human
    • Repair
    • Cancer
    • Chromatin
    • Development
    • Regulation
    • Transcription
    • Function
  • gene
    • Group
    • Location
    • Chromatin
    • Chromosome
    • End
    • Mouse
    • Bp
    • Chr
    • Function
    • Human
    • Protein
    • Hmga2
  • high-mobility group
    • Joining
    • Location
    • Chromatin
    • Chromosome
    • End
    • Regulation
    • Bp
    • Chr
    • Function
    • Gene
    • Repair
    • Cell
  • transcription
    • Development
    • Cell
    • Group
    • Human
    • Humans
    • Joining
    • Location
    • Lyase
    • Dna
    • Band
    • Chromatin
    • Chromosome
  • breast cancer
    • Cells
    • Human
    • Associated
    • Expression
    • Repair
    • Ercc1
    • Hmga2
    • Dna
    • Cell
    • Group
    • High
    • Joining
  • ercc1
    • Expression
    • Chromatin
    • May
    • Role
    • Dna
    • Repair
    • Cancers
    • Gene
    • Human
    • Protein
    • Group
    • High
  • dna methylation
    • Repair
    • Joining
    • End
    • Hmga2
    • Protein
    • Ercc1
    • Group
    • Location
    • Lyase
    • Chromosome
    • Regulation
    • Transcription

Connections between topic areas Semantic bridges

For HMGA2, one of the stronger structural bridges in this analysis connects HMGA2 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
HMGA2Clinical significance · splits 29 ⟂ 26
HMGA2Function · splits 38 ⟂ 17
HMGA2Interactions · splits 50 ⟂ 5
HMGA2Overview · splits 52 ⟂ 3
HMGA2Regulation by let-7 · splits 52 ⟂ 3

Map overview Semantic statistics

HMGA2

Nodes55
Edges54
Triples202
Avg. degree1.96
Density0.036364
Components1

Source & methodology

TTTA analyzes the structure around HMGA2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Function & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — HMGA2 · EN edition · Analysis: TopicsToTalkAbout

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