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Romidepsin

Romidepsin, sold under the brand name Istodax, is an anticancer agent used in cutaneous T-cell lymphoma (CTCL) and other peripheral T-cell lymphomas (PTCLs). Romidepsin is a natural product obtained from the bacterium Chromobacterium violaceum, and works by blocking enzymes known as histone deacetylases, thus inducing apoptosis. It is sometimes referred…

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3D model (JSmol)
Interactive image
ATC code
L01XH02 (WHO)
Bioavailability
Not applicable (IV only)
CAS Number
128517-07-7 N
ChEBI
CHEBI:61080 N
ChEMBL
ChEMBL1213490 N

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Map overview Semantic statistics

Romidepsin

Nodes54
Edges53
Triples84
Avg. degree1.96
Density0.037037
Components1

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Romidepsin

Top relations

related to Clinical trials · 13
Romidepsin → CTCL, European Medicines Agency, Fast Track, FDA, FK228, FR901228, III, In, Phase, Phase II, PTCLs, T-cell, The
related to history · 13
Romidepsin → Astellas Pharma, Chromobacterium, Fujisawa, Fujisawa Pharmaceutical Company, Harvard, It, Its, Japan, The, Tokyo, Tsukuba, University, Yamagata Prefecture
related to Pharmacodynamics · 9
Romidepsin → ABCB1, CTCL, Expression, HDAC, In, Increased, PBMCs, Phase II, PTCL
related to Pre-clinical HIV study · 8
Romidepsin → HIV, HIV RNA, In, Latently, PLOS Pathogens, T-cells, The, Vorinostat
related to Mechanism of action · 5
Romidepsin → HDAC, Many HDAC, The, Thus, Zn-dependent
related to Dosage and administration · 4
Romidepsin → CTCL, PTCL, The, This
has effect · 3
Romidepsin → In, It, The
related to Pharmacokinetics · 3
Romidepsin → Age, In, No
Legal status · 2
Romidepsin → AU: S4 (Prescription only), US: ℞-only
3D model (JSmol) · 1
Romidepsin → Interactive image

Important terminology Word statistics

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Important terminology

histone ctcl peripheral administration t-cell lymphoma trials model cell effect inhibitor phase treatment trial patients involving also increased hdac cutaneous

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Romidepsin3D model (JSmol)Interactive image1.00infobox
RomidepsinATC codeL01XH02 (WHO)1.00infobox
RomidepsinBioavailabilityNot applicable (IV only)1.00infobox
RomidepsinCAS Number128517-07-7 N1.00infobox
RomidepsinChEBICHEBI:61080 N1.00infobox
RomidepsinChEMBLChEMBL1213490 N1.00infobox
RomidepsinChemSpider101220021.00infobox
RomidepsinCompTox Dashboard (EPA)DTXSID80485791.00infobox
RomidepsinDrugBankDB06176 Y1.00infobox
RomidepsinECHA InfoCard100.211.8841.00infobox
RomidepsinElimination half-life3 hours1.00infobox
RomidepsinFormulaC24H36N4O6S21.00infobox
RomidepsinIUPHAR/BPS70061.00infobox
RomidepsinLegal statusAU: S4 (Prescription only)1.00infobox
RomidepsinLegal statusUS: ℞-only1.00infobox
RomidepsinLicense dataUS FDA: Romidepsin1.00infobox
RomidepsinMedlinePlusa6100051.00infobox
RomidepsinMetabolismLiver (mostly CYP3A4-mediated)1.00infobox
RomidepsinMolar mass540.69 g·mol−11.00infobox
RomidepsinOther namesFK228; FR901228; Istodax1.00infobox
RomidepsinProtein binding92–94%1.00infobox
RomidepsinPubChem CID53520621.00infobox
RomidepsinRoutes of administrationIntravenous infusion1.00infobox
RomidepsinTrade namesIstodax1.00infobox
RomidepsinUNIICX3T89XQBK1.00infobox
Romidepsinis anatural product obtained from the bacterium Chromobacterium violaceum0.90text

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