Romidepsin

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Romidepsin topic overview

The analysis highlights History and Products as prominent areas in the source structure around Romidepsin.

Related topics: 49
Source areas: 4
Connected nodes: 53
Extracted relationships: 84
Concept neighborhoods: 11
Bridge connections: 53

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

History · 23 topics

Adverse effects · 12 topics

Overview · 9 topics

Mechanism of action · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol): Interactive image
ATC code: L01XH02 (WHO)
Bioavailability: Not applicable (IV only)
CAS Number: 128517-07-7 N
ChEBI: CHEBI:61080 N
ChEMBL: ChEMBL1213490 N

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Romidepsin connects Entity context

The extracted context around Romidepsin shows recurring relationship patterns in the source. For example, Romidepsin → CTCL, European Medicines Agency, Fast Track, FDA, FK228, FR901228, III, In, Phase, Phase II, PTCLs, T-cell, The Another extracted example is Romidepsin → Astellas Pharma, Chromobacterium, Fujisawa, Fujisawa Pharmaceutical Company, Harvard, It, Its, Japan, The, Tokyo, Tsukuba, University, Yamagata Prefecture. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

related to Clinical trials · 13

Romidepsin → CTCL, European Medicines Agency, Fast Track, FDA, FK228, FR901228, III, In, Phase, Phase II, PTCLs, T-cell, The

related to history · 13

Romidepsin → Astellas Pharma, Chromobacterium, Fujisawa, Fujisawa Pharmaceutical Company, Harvard, It, Its, Japan, The, Tokyo, Tsukuba, University, Yamagata Prefecture

related to Pharmacodynamics · 9

Romidepsin → ABCB1, CTCL, Expression, HDAC, In, Increased, PBMCs, Phase II, PTCL

related to Pre-clinical HIV study · 8

Romidepsin → HIV, HIV RNA, In, Latently, PLOS Pathogens, T-cells, The, Vorinostat

related to Mechanism of action · 5

Romidepsin → HDAC, Many HDAC, The, Thus, Zn-dependent

related to Dosage and administration · 4

Romidepsin → CTCL, PTCL, The, This

has effect · 3

Romidepsin → In, It, The

related to Pharmacokinetics · 3

Romidepsin → Age, In, No

Legal status · 2

Romidepsin → AU: S4 (Prescription only), US: ℞-only

3D model (JSmol) · 1

Romidepsin → Interactive image

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

histone ctcl peripheral administration t-cell lymphoma trials model cell effect inhibitor phase treatment trial patients involving also increased hdac cutaneous

Romidepsin relationships Subject–Predicate–Object triples

TTTA extracted 84 structured relationships around Romidepsin. Examples in this analysis include Romidepsin → 3D model (JSmol) → Interactive image and Romidepsin → ATC code → L01XH02 (WHO). The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Romidepsin	3D model (JSmol)	Interactive image	1.00	infobox
Romidepsin	ATC code	L01XH02 (WHO)	1.00	infobox
Romidepsin	Bioavailability	Not applicable (IV only)	1.00	infobox
Romidepsin	CAS Number	128517-07-7 N	1.00	infobox
Romidepsin	ChEBI	CHEBI:61080 N	1.00	infobox
Romidepsin	ChEMBL	ChEMBL1213490 N	1.00	infobox
Romidepsin	ChemSpider	10122002	1.00	infobox
Romidepsin	CompTox Dashboard (EPA)	DTXSID8048579	1.00	infobox
Romidepsin	DrugBank	DB06176 Y	1.00	infobox
Romidepsin	ECHA InfoCard	100.211.884	1.00	infobox
Romidepsin	Elimination half-life	3 hours	1.00	infobox
Romidepsin	Formula	C24H36N4O6S2	1.00	infobox
Romidepsin	IUPHAR/BPS	7006	1.00	infobox
Romidepsin	Legal status	AU: S4 (Prescription only)	1.00	infobox
Romidepsin	Legal status	US: ℞-only	1.00	infobox
Romidepsin	License data	US FDA: Romidepsin	1.00	infobox
Romidepsin	MedlinePlus	a610005	1.00	infobox
Romidepsin	Metabolism	Liver (mostly CYP3A4-mediated)	1.00	infobox
Romidepsin	Molar mass	540.69 g·mol−1	1.00	infobox
Romidepsin	Other names	FK228; FR901228; Istodax	1.00	infobox
Romidepsin	Protein binding	92–94%	1.00	infobox
Romidepsin	PubChem CID	5352062	1.00	infobox
Romidepsin	Routes of administration	Intravenous infusion	1.00	infobox
Romidepsin	Trade names	Istodax	1.00	infobox
Romidepsin	UNII	CX3T89XQBK	1.00	infobox
Romidepsin	is a	natural product obtained from the bacterium Chromobacterium violaceum	0.90	text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Romidepsin bring nearby vocabulary together. In this analysis, examples include Involving, Trial and Ctcl. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Romidepsin
- Involving
- Trial
- Ctcl
- Peripheral
- Histone
- Administration
- Fda
- Hiv
- Hours
- Pharmacokinetics
- Study
- Lymphoma
romidepsin
- Involving
- Trial
- Ctcl
- Peripheral
- Histone
- Administration
- Fda
- Hiv
- Hours
- Pharmacokinetics
- Study
- Lymphoma
histone deacetylases
- Acetylation
- Deacetylase
- Increased
- Inhibitor
- Blood
- Also
- Effect
- Hdac
- Involving
- Trial
- Romidepsin
- Apoptosis
histone deacetylase inhibitor
- Acetylation
- Deacetylase
- Histone
- Inhibitor
- Increased
- Hdac
- Blood
- Model
- Also
- Effect
- Involving
- Trial
peripheral t-cell lymphomas
- Ptcls
- T-cell
- Lymphomas
- Peripheral
- Treatment
- Patients
- Phase
- Trial
- Name
- Fda
- Found
- Romidepsin
adverse effects
- Researchers
- Istodax
- Model
- Name
- Associated
- Deacetylase
- Fda
- Found
- Hiv
- Hours
- Normal
- Pharmacokinetics
cutaneous t-cell lymphoma
- Lymphoma
- T-cell
- Lymphomas
- Peripheral
- Ptcls
- Treatment
- Ctcl
- Istodax
- Name
- Fda
- Found
- Romidepsin
cell lines
- Normal
- Expression
- Found
- Effect
- Hdac
- Lymphoma
- Patients
- Phase
- Trial
- Peripheral
- Romidepsin

Connections between topic areas Semantic bridges

For Romidepsin, one of the stronger structural bridges in this analysis connects Romidepsin with History. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Romidepsin — History · splits 30 ⟂ 24

Romidepsin — Adverse effects · splits 41 ⟂ 13

Romidepsin — Overview · splits 44 ⟂ 10

Romidepsin — Mechanism of action · splits 48 ⟂ 6

Map overview Semantic statistics

Romidepsin

Nodes54

Edges53

Triples84

Avg. degree1.96

Density0.037037

Components1

Source & methodology

TTTA analyzes the structure around Romidepsin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Products, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Romidepsin · EN edition · Analysis: TopicsToTalkAbout